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  1. Article ; Online: Circle of Willis.

    Patel, Nitesh P / Rinaldo, Lorenzo / Lanzino, Giuseppe

    Mayo Clinic proceedings

    2024  Volume 99, Issue 4, Page(s) 677–678

    MeSH term(s) Humans ; Circle of Willis ; Magnetic Resonance Angiography
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.11.020
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  2. Article ; Online: Photon-Counting Detector CT Angiography in Cervical Artery Dissection.

    Keser, Zafer / Diehn, Felix E / Lanzino, Giuseppe

    Stroke

    2024  Volume 55, Issue 3, Page(s) e48–e49

    MeSH term(s) Humans ; Computed Tomography Angiography ; Tomography, X-Ray Computed ; Angiography ; Arteries ; Carotid Artery, Internal ; Carotid Artery, Internal, Dissection ; Magnetic Resonance Angiography
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.046174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  3. Article ; Online: Are there differences in clinical presentation, radiologic findings, and outcomes in female patients with cavernous malformation?

    Flemming, Kelly D / Lanzino, Giuseppe

    Acta neurochirurgica

    2023  Volume 165, Issue 7, Page(s) 1855–1861

    Abstract: Background: Little data exist regarding sex differences in cavernous malformations (CM) patients.: Methods: From an ongoing, prospective registry of consenting adults with CM, we assessed the differences between male and female patients in regard to ... ...

    Abstract Background: Little data exist regarding sex differences in cavernous malformations (CM) patients.
    Methods: From an ongoing, prospective registry of consenting adults with CM, we assessed the differences between male and female patients in regard to age at presentation, type of presentation, radiologic characteristics and prospective, symptomatic hemorrhage and or focal neurologic deficit (FND) risk and functional outcome. Cox proportional-hazard ratios and 95% confidence intervals with P values < 0.05 were considered significant in the outcome analysis. Familial form CM female patients were compared to sporadic form.
    Results: As of 1/1/2023, our cohort comprised 386 people (58.0% female) after excluding radiation-induced CM. There were no demographic or clinical presentation differences between male and female patients. Radiological features did not differ between sexes, except that female, sporadic patients were more likely to have an associated developmental venous anomaly (DVA) (43.2% male vs. 56.2% female; p = 0.03). Overall, there was no difference in prospective symptomatic hemorrhage or functional outcome between sexes. Female sex was a predictor of symptomatic hemorrhage or FND in sporadic patients with ruptured CM (39.6% males versus 65.7% females; p = 0.02). The latter was not due to presence or absence of DVA. Familial CM females were more likely to have a spinal cord CM (15.2% familial female vs. 3.9% sporadic female; p = 0.001) and had a longer time to recurrent hemorrhage than sporadic female (2.2 years sporadic vs. 8.2 years familial; p = 0.0006).
    Conclusion: Minimal differences in clinical, radiologic, and outcomes were found in male versus female patients and familial versus sporadic females in the overall CM patient group. The finding that sporadic form female patients with history of prior hemorrhage had increased rates of prospective hemorrhage or FND compared to male patients raise the question whether to "lump" or "split" ruptured versus unruptured CM patients when analyzing risk factors for prospective hemorrhage in natural history studies.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Risk Factors ; Hemorrhage/complications ; Longitudinal Studies ; Hemangioma, Cavernous, Central Nervous System/diagnostic imaging ; Hemangioma, Cavernous, Central Nervous System/complications ; Registries
    Language English
    Publishing date 2023-06-12
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-023-05652-0
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    Uk I Zs.180: Show issues Location:
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  4. Article: Neuropsychiatric Symptoms of Moyamoya Disease: Considerations for the Clinician.

    Oakley, Carlee I / Lanzino, Giuseppe / Klaas, James P

    Neuropsychiatric disease and treatment

    2024  Volume 20, Page(s) 663–669

    Abstract: Neurocognitive impairment in moyamoya disease is common, under recognized, and potentially devastating. The purpose of this paper is to provide an updated overview on this topic for the practicing clinician. We searched PubMed for keywords including ... ...

    Abstract Neurocognitive impairment in moyamoya disease is common, under recognized, and potentially devastating. The purpose of this paper is to provide an updated overview on this topic for the practicing clinician. We searched PubMed for keywords including cognitive impairment, neurocognitive dysfunction, and neuropsychological recovery in moyamoya disease. We summarized the literature to provide a concise review of the treatment and management of neuropsychiatric symptoms associated with moyamoya disease. Neuropsychiatric sequelae have conventionally been attributed to chronic cerebral hypoperfusion and/or stroke. Cognitive dysfunction in adults with moyamoya disease is most commonly in the form of impaired executive function, whereas intelligence is the predominant impairment in children with moyamoya disease. Pharmacotherapy for treatment of the neuropsychiatric symptoms associated with moyamoya disease is appropriate and can improve quality of life; however, careful consideration is needed to avoid adverse cerebrovascular events. It remains unclear as to whether surgical revascularization improves or stabilizes cognitive performance and outcomes. Additional prospective studies are warranted to better understand the long-term impact of revascularization on cognitive functioning in moyamoya disease.
    Language English
    Publishing date 2024-03-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S440975
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    Zs.A 6068: Show issues Location:
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  5. Article ; Online: Editorial. Curative embolization for low-grade AVMs: ready for prime time?

    Lanzino, Giuseppe / Rinaldo, Lorenzo

    Neurosurgical focus

    2022  Volume 53, Issue 1, Page(s) E9

    MeSH term(s) Embolization, Therapeutic ; Humans ; Intracranial Arteriovenous Malformations/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2022.4.FOCUS22246
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  6. Article: Pollination mechanism in

    Lanzino, Micaela / Palermo, Anna Maria / Pellegrino, Giuseppe

    AoB PLANTS

    2023  Volume 15, Issue 5, Page(s) plad054

    Abstract: Orchidaceae, one of the most numerous families in the world's flora, have evolved various pollination strategies to favour cross-pollination, such as deceptive pollination and pollinarium reconfiguration. Among the terrestrial orchids of the ... ...

    Abstract Orchidaceae, one of the most numerous families in the world's flora, have evolved various pollination strategies to favour cross-pollination, such as deceptive pollination and pollinarium reconfiguration. Among the terrestrial orchids of the Mediterranean, only species belonging to the genus
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2555823-7
    ISSN 2041-2851
    ISSN 2041-2851
    DOI 10.1093/aobpla/plad054
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  7. Article ; Online: Coronavirus Disease 2019 Infection in Cervical Artery Dissections.

    Wahood, Waseem / Flemming, Kelly D / Lanzino, Giuseppe / Keser, Zafer

    The neurologist

    2024  Volume 29, Issue 2, Page(s) 71–75

    Abstract: Objective: Most cervical artery dissection (CeAD) cases are spontaneous or due to minor traumas, and preceding viral infections have been suggested to be a triggering event for CeAD in some. Herein, we analyze the prevalence of coronavirus disease 2019 ( ...

    Abstract Objective: Most cervical artery dissection (CeAD) cases are spontaneous or due to minor traumas, and preceding viral infections have been suggested to be a triggering event for CeAD in some. Herein, we analyze the prevalence of coronavirus disease 2019 (COVID-19) in hospitalized patients with CeAD using a national database.
    Methods: The National Inpatient Sample was queried from April 2020 to December 2020 for patients with a diagnosis of CeAD using International Classification of Diseases, 10th edition-Clinical Modification codes. Among these, patients with COVID-19 were identified. Multivariable logistic regression was conducted to assess the patient profile of those with COVID-19, in-patient mortality, and home discharge among patients with CeAD.
    Results: There were 360 (2.32%) hospitalizations involving COVID-19 among 15,500 with CeAD. Concomitant acute ischemic stroke constituted 43.06% of those with a COVID-19 diagnosis, whereas it was 43.73% among those without a COVID-19 diagnosis ( P = 0.902). Home discharges were less common in patients with COVID-19 and CeAD compared to CeAD alone (34.85% vs. 48.63%; P = 0.03), but this was likely due to other factors as multivariate regression analysis did not show an association between COVID-19 and home discharges (odds ratio: 0.69; 95% CI: 0.39 to 1.25; P = 0.22). COVID-19 diagnosis had similar odds of inpatient mortality (odds ratio: 1.11; 95% CI: 0.43 to 2.84; P = 0.84).
    Conclusion: The prevalence of COVID-19 among hospitalized patients with CeAD is low with 2.32% of all CeAD cases. Concomitant COVID infection did not lead to an increased risk of stroke in CeAD. However, potentially worse functional outcomes (fewer home discharges) without an increase in mortality were seen in patients with COVID and CeAD.
    MeSH term(s) Humans ; Ischemic Stroke/complications ; COVID-19 Testing ; Risk Factors ; Vertebral Artery Dissection/complications ; Vertebral Artery Dissection/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Stroke/etiology ; Arteries
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000545
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    Zs.A 4641: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Congenital hydrocephalus diagnosed in a nonagenarian: Case report.

    Martinez, Frank / Rotter, Juliana / Graffeo, Christopher / Lanzino, Giuseppe

    The neuroradiology journal

    2023  Volume 36, Issue 6, Page(s) 752–754

    Abstract: Congenital hydrocephalus after peripartum infection usually presents early in life; however, we present a 92-year-old female patient with newly diagnosed hydrocephalus secondary to peripartum infection. Intracranial imaging showed ventriculomegaly, ... ...

    Abstract Congenital hydrocephalus after peripartum infection usually presents early in life; however, we present a 92-year-old female patient with newly diagnosed hydrocephalus secondary to peripartum infection. Intracranial imaging showed ventriculomegaly, calcifications bilaterally throughout the cerebral hemispheres, and findings suggesting a chronic process. This presentation is most likely to occur in low-resource settings, and given the risks of operation, conservative management was preferred.
    MeSH term(s) Female ; Humans ; Aged, 80 and over ; Nonagenarians ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/19714009221150850
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  9. Article ; Online: Vascular Surgery and Neurosurgery.

    Halliday, Alison W / Lanzino, Giuseppe

    Stroke

    2021  Volume 52, Issue 6, Page(s) 2174–2176

    MeSH term(s) Humans ; Neurosurgical Procedures ; Vascular Surgical Procedures
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.033293
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    Zs.A 448: Show issues Location:
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  10. Article ; Online: Fusiform aneurysms of anterior cerebral artery: center experience and systematic literature review.

    Conte, Matteo / Cagil, Emin / Lanzino, Giuseppe / Keser, Zafer

    Neurosurgical review

    2023  Volume 47, Issue 1, Page(s) 11

    Abstract: Fusiform aneurysms of the anterior cerebral artery (ACA) are uncommon, and the natural history of this entity is poorly characterized. Along with our center experience, we conducted a systematic literature review to help shed light on the clinical course ...

    Abstract Fusiform aneurysms of the anterior cerebral artery (ACA) are uncommon, and the natural history of this entity is poorly characterized. Along with our center experience, we conducted a systematic literature review to help shed light on the clinical course of ACA fusiform aneurysms. We queried our institutional database to identify cases with fusiform aneurysms of ACA. In addition, following the PRISMA algorithm, we identified all reported cases published in the English literature from the inception of PubMed until December 2022. We categorized clinical presentations into three categories: (i) traumatic/iatrogenic, (ii) spontaneous symptomatic ruptured/unruptured, and (iii) spontaneous asymptomatic aneurysms. We utilized descriptive statistics. We identified seven cases from our center along with 235 patients from published literature. Blunt trauma was responsible for the development of 19 aneurysms. Sixty-three percent of these aneurysms tend to rupture within 2 weeks from the initial trauma, and despite treatment, only 74% of these patients had good clinical outcomes. Spontaneous symptomatic presentation occurred in 207 patients and was often associated with previous/concomitant ACA dissection. Subarachnoid hemorrhage from ruptured aneurysms was the most common presentation. Spontaneous symptomatic fusiform aneurysm is rapidly evolving lesions, and treatment is necessary. Three of our own cases were treated with an endovascular flow diverter (pipeline) stenting with good outcomes. Spontaneous asymptomatic aneurysms were reported in nine patients. These lesions are often associated with other vascular abnormalities. Treatment included surgical clipping with good clinical outcomes. Instead, four patients from our center database were managed conservatively with equally good outcomes. Our study demonstrates good clinical outcomes when fusiform aneurysms of ACA, especially when symptomatic, are treated promptly with either reconstructive or deconstructive therapies.
    MeSH term(s) Humans ; Intracranial Aneurysm/surgery ; Intracranial Aneurysm/complications ; Anterior Cerebral Artery/surgery ; Subarachnoid Hemorrhage/complications ; Aneurysm, Ruptured/surgery ; Aneurysm, Ruptured/complications ; Stents ; Endovascular Procedures ; Rupture, Spontaneous/complications ; Treatment Outcome ; Cerebral Angiography ; Retrospective Studies
    Language English
    Publishing date 2023-12-13
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02247-2
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