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  1. Article ; Online: The environmental impact of laboratory measurements in high-resource ICUs.

    Ostermann, Marlies / De Waele, Jan J / Schefold, Joerg C

    Intensive care medicine

    2024  Volume 50, Issue 3, Page(s) 449–452

    MeSH term(s) Humans ; Intensive Care Units ; Environment
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07318-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Severe infections in the ICU: new perspectives and challenges.

    De Waele, Jan J

    Current opinion in critical care

    2022  Volume 28, Issue 5, Page(s) 461–462

    MeSH term(s) Humans ; Intensive Care Units
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Editorial
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Environmental sustainability and antimicrobials: an underestimated problem with far-reaching consequences.

    De Waele, Jan J / Leroux-Roels, Isabel / Conway-Morris, Andrew

    Intensive care medicine

    2024  Volume 50, Issue 3, Page(s) 453–456

    MeSH term(s) Humans ; Anti-Infective Agents/therapeutic use
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07319-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: The gastrointestinal system in critical care: current insights and perspectives.

    de Waele, Jan J

    Current opinion in critical care

    2021  Volume 27, Issue 2, Page(s) 139–140

    MeSH term(s) Critical Care ; Gastrointestinal Tract ; Humans
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intra-abdominal hypertension and abdominal compartment syndrome.

    De Waele, Jan J

    Current opinion in critical care

    2022  Volume 28, Issue 6, Page(s) 695–701

    Abstract: Purpose of review: Intra-abdominal hypertension (IAH) has been acknowledged as an important contributor to organ dysfunction in critically ill patients, both in surgical and medical conditions. As our understanding of the pathophysiology evolves, risk ... ...

    Abstract Purpose of review: Intra-abdominal hypertension (IAH) has been acknowledged as an important contributor to organ dysfunction in critically ill patients, both in surgical and medical conditions. As our understanding of the pathophysiology evolves, risk factors are better recognized, preventive measures can now be implemented and therapeutic interventions tailored to the physiology of the patient. In the current review, we want to highlight developing insights in the epidemiology and treatment of patients with IAH and ACS.
    Recent findings: The impact of IAH and ACS on kidney function and other outcomes continues to draw attention in recent studies. New methods for IAP measurement are under development, and the search for biomarkers to detect IAH or ACS continues. In conditions wherein IAH and ACS are common, recent studies allow better prevention and treatment of these conditions, based on the contemporary ICU management consisting of IAP measurement, judicious fluid resuscitation and decompressive laparotomy where necessary. Surgical treatment options including open abdomen therapy continue to be improved with demonstrable impact on outcomes.
    Summary: In this manuscript, we provide an overview of recent insights and developments in the epidemiology, monitoring and treatment of patients with IAH and/or ACS.
    MeSH term(s) Humans ; Intra-Abdominal Hypertension/diagnosis ; Intra-Abdominal Hypertension/epidemiology ; Intra-Abdominal Hypertension/etiology ; Fluid Therapy ; Critical Illness ; Risk Factors ; Compartment Syndromes/etiology
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Antimicrobial stewardship and molecular diagnostics: a symbiotic approach to combating resistance in the ED and ICU.

    De Waele, Jan J / Boelens, Jerina

    Current opinion in critical care

    2024  

    Abstract: ... facilitates faster escalation when empirical therapy was inappropriate, as well as more efficient de ...

    Abstract Purpose of the review: This review aims to evaluate the incorporation of rapid molecular diagnostics (RMD) in antimicrobial stewardship programs (ASPs) in the management of patients in the emergency department (ED) and intensive care unit (ICU), highlighting a shift from conventional microbiological diagnostic tests to RMD strategies to optimize antimicrobial use and improve patient outcomes.
    Recent findings: Recent advances in RMD have demonstrated the superior accuracy of RMD in identifying pathogens, combined with shorter turnaround times. RMD allows speeding up of antimicrobial decision making in the ED and facilitates faster escalation when empirical therapy was inappropriate, as well as more efficient de-escalation of empirical therapy later in the course of the treatment. Implementation of RMD however may be challenging.
    Summary: RMD hold great value in simplifying patient management and mitigating antimicrobial exposure, particularly in settings with high levels of antimicrobial resistance where the use of broad-spectrum antimicrobials is high. While the impact on the use of antimicrobials is significant, the impact on patient outcomes is not yet clear. Successful integration of RMD in clinical decision making in the ED and ICU requires a team approach and continued education, and its use should be adapted to the local epidemiology and infrastructure.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An overview of point-of-care testing for infections in critically ill patients.

    Moerman, Alena / De Waele, Jan J / Boelens, Jerina

    Expert review of molecular diagnostics

    2024  Volume 24, Issue 3, Page(s) 193–200

    Abstract: Introduction: Molecular diagnostic systems for point-of-care (POC) testing are nowadays routinely used and are part of many labs. Although often intended for bedside use outside of the microbiology lab, there is still room for expansion.: Areas ... ...

    Abstract Introduction: Molecular diagnostic systems for point-of-care (POC) testing are nowadays routinely used and are part of many labs. Although often intended for bedside use outside of the microbiology lab, there is still room for expansion.
    Areas covered: This review discusses the two techniques that are currently the most widespread, real-time polymerase-chain reaction (RT-PCR) and loop-mediated isothermal amplification (LAMP). An overview is provided of the various manufacturers and products as well as the evidence and current use in clinical practice. The article further sheds light on some newer techniques, such as CRISPR-based diagnostics and lab-on-a-chip, which are still in development.
    Expert opinion: With many new platforms and techniques still in the pipeline and their potential currently not yet fully exploited, we expect the use of molecular POC testing to increase in the years to come. However, even when used in hospital - in lab, the main advantages of the tests being fast and easy to perform already provide significant benefits in terms of patient outcome.
    MeSH term(s) Humans ; Critical Illness ; Point-of-Care Testing ; Nucleic Acid Amplification Techniques/methods ; Molecular Diagnostic Techniques/methods ; Real-Time Polymerase Chain Reaction ; Point-of-Care Systems ; Sensitivity and Specificity
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2024.2322146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Selective digestive decontamination - Pro.

    De Waele, Jan J / Leroux-Roels, Isabel / Depuydt, Pieter

    Intensive care medicine

    2023  Volume 49, Issue 8, Page(s) 979–981

    MeSH term(s) Humans ; Decontamination ; Digestive System
    Language English
    Publishing date 2023-05-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07100-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Towards adequate and automated antibiotic dosing.

    Janssen, Alexander / De Waele, Jan J / Elbers, Paul W G

    Intensive care medicine

    2023  Volume 49, Issue 7, Page(s) 853–856

    MeSH term(s) Humans ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07047-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Post-ICU nutrition: the neglected side of metabolic support.

    De Waele, Elisabeth / Rosseel, Zenzi / Pen, Joeri J

    Current opinion in critical care

    2023  Volume 29, Issue 4, Page(s) 360–362

    Abstract: Purpose of this review: This review will focus on the neglected side of metabolic support in ICU survivors: nutritional therapy after critical illness. Knowledge of the evolution of the metabolism of patients that survived critical illness will be ... ...

    Abstract Purpose of this review: This review will focus on the neglected side of metabolic support in ICU survivors: nutritional therapy after critical illness. Knowledge of the evolution of the metabolism of patients that survived critical illness will be bundled, and current practices will be investigated. We will discuss some studies conducted to determine resting energy expenditure in ICU survivors and which identified barriers that cause interruptions in the feeding process based on published data between January 2022 and April 2023.
    Recent findings: Resting energy expenditure can be measured using indirect calorimetry, as predictive equations have proven to fail in their attempt to have good correlations with measured values. No guidelines or recommendations are available on post-ICU follow-up, including screening, assessment, dosing, timing, and monitoring of (artificial) nutrition. A limited number of publications shared treatment adequacy between 64-82% for energy (calories) and 72-83% for protein intake in a post-ICU setting. Loss of appetite, depression, and oropharyngeal dysphagia are the most prominent physiological barriers responsible for decreased feeding adequacy.
    Summary: Patients may be in a catabolic state during and after ICU discharge, with several factors impacting metabolism. Therefore, large prospective trials are needed to determine the physiological state of ICU survivors, determine nutritional requirements, and develop nutritional care protocols. Many barriers causing decreased feeding adequacy have already been identified, but solutions are scarce. This review depicts a variable metabolic rate among ICU survivors and a significant variation in feeding adequacy in-between world regions, institutions, and patient sub-phenotypes.
    MeSH term(s) Humans ; Critical Illness/therapy ; Prospective Studies ; Nutritional Status ; Nutritional Support/methods ; Energy Intake/physiology ; Energy Metabolism/physiology ; Nutritional Requirements ; Intensive Care Units
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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