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  1. Article: Hemorrhagic Rathkes Cleft Cyst Apoplexy Post COVID-19 Vaccination.

    Vora, Tarang K / Lath, Rahul / Swain, Meenakshi / Ray, Amitava

    Indian journal of endocrinology and metabolism

    2024  Volume 27, Issue 6, Page(s) 567–569

    Language English
    Publishing date 2024-01-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2600211-5
    ISSN 2230-9500 ; 2230-8210
    ISSN (online) 2230-9500
    ISSN 2230-8210
    DOI 10.4103/ijem.ijem_381_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Primary intracranial synovial sarcoma: A case report and review of literature.

    Vora, Tarang K / Lath, Rahul / Swain, Meenakshi / Ray, Amitava

    Surgical neurology international

    2022  Volume 13, Page(s) 447

    Abstract: Background: Primary intracranial synovial sarcomas (PrISS) are unusual dural based mesenchymal tumors seen most commonly in the supratentorial compartment. They can mimic a spontaneous intracranial hemorrhage or a high-grade glioma on imaging.: Case ... ...

    Abstract Background: Primary intracranial synovial sarcomas (PrISS) are unusual dural based mesenchymal tumors seen most commonly in the supratentorial compartment. They can mimic a spontaneous intracranial hemorrhage or a high-grade glioma on imaging.
    Case description: A 31-year-old male presented with headache and right hemiparesis for 2 weeks. CT brain revealed a left frontal spontaneous intracerebral hemorrhage. PrISS revealed a heterogeneously ring enhancing solid cystic lesion with attachment to convexity dura. Intraoperatively, it mimicked a high-grade glioma. Histopathology report showed features of a synovial sarcoma, which was later confirmed with IHC. Classical SYT-SSX2 translocation was confirmed only on RTPCR after fluorescent
    Conclusion: PrISS is an unusual aggressive intracranial neoplasm that carries a worse prognosis when compared nonintracranial synovial sarcomas. Molecular cytogenetics (FISH and RTPCR) are essential for confirming the diagnosis, though FISH seems to have a lower sensitivity and can yield false negative results as was noted in this case.
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_665_2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Management of Spontaneous Spinal CSF Leaks Using Noninvasive Dynamic MR Neurography: A Case Series

    Suman, Prabhat / Lath, Rahul / Ranjan, Alok / Gurrala, Shekhar Reddy / Ipilli, Kaushal / Prasad, Ravikanti Satya / Vora, Tarang K.

    Indian Journal of Neurosurgery

    2024  

    Abstract: Spontaneous spinal cerebrospinal fluid (CSF) leak presents with orthostatic headache and may lead to formation of subdural collection. Invasive magnetic resonance imaging or computed tomography myelography is routinely used to detect these leaks. ... ...

    Abstract Spontaneous spinal cerebrospinal fluid (CSF) leak presents with orthostatic headache and may lead to formation of subdural collection. Invasive magnetic resonance imaging or computed tomography myelography is routinely used to detect these leaks. Noninvasive dynamic magnetic resonance neurography can also detect these leaks and confirm its resolution post treatment. It includes three-dimensional NerveView, a high-resolution short-tau inversion recovery sequence for better visualization of spinal nerves and leak sites. This article showcases the diagnostic and therapeutic journey of three patients with spontaneous spinal CSF leak all of whom were diagnosed with dynamic magnetic resonance neurography and treated successfully with autologous targeted epidural blood patch. In one case, epidural blood patch was repeated after 2 months for recurrence of the leak.
    Keywords spontaneous spinal CSF leaks ; subdural hematoma ; dynamic MR Neurogram ; epidural blood patch ; spontaneous intracranial hypotension ; meningeal diverticula ; CSF-venous fistula ; orthostatic headache
    Language English
    Publishing date 2024-02-08
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2698542-1
    ISSN 2277-9167 ; 2277-954X ; 2277-9167
    ISSN (online) 2277-9167
    ISSN 2277-954X ; 2277-9167
    DOI 10.1055/s-0044-1779629
    Database Thieme publisher's database

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  4. Article: Establishment and Characterization of Brain Cancer Primary Cell Cultures From Patients to Enable Phenotypic Screening for New Drugs.

    dePadua, Michelle / Kulothungan, Preethi / Lath, Rahul / Prasad, Ravikanti / Madamchetty, Kranthi / Atmakuri, Shravya / Ragamouni, Sravanthi / Gandhari, Mukesh / Khandrika, Lakshmipathi / Jain, Jugnu

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 778193

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.778193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synchronous Glioma of the Brainstem in a Patient with Recurrent Aggressive Vestibular Schwannoma.

    Lath, Rahul / Sharma, Pankaj / Sannareddy, Rajesh R / Swain, Meenakshi / Ranjan, Alok

    Neurology India

    2019  Volume 67, Issue 4, Page(s) 1153–1155

    MeSH term(s) Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Brain Stem/pathology ; Female ; Glioma/diagnosis ; Glioma/pathology ; Humans ; Middle Aged ; Neurilemmoma/complications ; Neurilemmoma/pathology ; Neuroma, Acoustic/diagnosis ; Neuroma, Acoustic/pathology
    Language English
    Publishing date 2019-09-12
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.266250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
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  6. Article ; Online: Hyponatremia in neurological diseases in ICU

    Lath Rahul

    Indian Journal of Critical Care Medicine, Vol 9, Iss 1, Pp 47-

    2005  Volume 51

    Abstract: Hyponatremia is the commonest electrolyte disturbance encountered in the neurological and neurosurgical intensive care units. It can present with signs and symptoms mimicking a neurological disease and can worsen the existing neurological deficits. ... ...

    Abstract Hyponatremia is the commonest electrolyte disturbance encountered in the neurological and neurosurgical intensive care units. It can present with signs and symptoms mimicking a neurological disease and can worsen the existing neurological deficits. Hyponatremia in neurological disorders is usually of the hypo-osmolar type caused either due to the Syndrome of Inappropriate Secretion of Anti Diuretic Hormone (SIADH) or Cerebral Salt Wasting Syndrome (CSWS). It is important to distinguish between these two disorders, as the treatment of the two differ to a large extent. In SIADH, the fluid intake is restricted, whereas in CSWS the treatment involves fluid and salt replacement.
    Keywords CSWS ; Hyponatremia ; Neurological Disorders ; SIADH ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2005-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Arteriovenous fistula of the filum terminale misdiagnosed and previously operated as lower lumbar degenerative disease.

    Sharma, Pankaj / Ranjan, Alok / Lath, Rahul

    Asian spine journal

    2014  Volume 8, Issue 3, Page(s) 365–370

    Abstract: Filum terminale arteriovenous fistula (FTAVF) presenting as a cause of failed back surgery syndrome is a rare entity. We report a 48-year-old male patient who presented with clinical features of a conus medullaris/cauda equina lesion. He had upper and ... ...

    Abstract Filum terminale arteriovenous fistula (FTAVF) presenting as a cause of failed back surgery syndrome is a rare entity. We report a 48-year-old male patient who presented with clinical features of a conus medullaris/cauda equina lesion. He had upper and lower motor neuron signs in both the lower limbs with autonomic dysfunction. The patient was misdiagnosed and was operated twice earlier for lumbar canal stenosis and disc prolapse. After reviewing his clinical and radiological findings a diagnosis of FTAVF was made. He underwent surgery and there was a significant improvement in his neurological functions. We discuss the case and review the literature on FTAVF's.
    Language English
    Publishing date 2014-06-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2559763-2
    ISSN 1976-7846 ; 1976-1902
    ISSN (online) 1976-7846
    ISSN 1976-1902
    DOI 10.4184/asj.2014.8.3.365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6861: Show issues Location:
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  8. Article: Multifocal cns vasculopathy due to reactivation of latent varicella: a potentially reversible complication following radiofrequency ablation for trigeminal neuralgia.

    Reddy, Rajesh S / Ranjan, Alok / Lath, Rahul

    Neurology India

    2014  Volume 62, Issue 3, Page(s) 327–329

    MeSH term(s) Acyclovir/administration & dosage ; Acyclovir/pharmacology ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacology ; Catheter Ablation/adverse effects ; Central Nervous System Infections/diagnosis ; Central Nervous System Infections/drug therapy ; Central Nervous System Infections/etiology ; Chickenpox/complications ; Chickenpox/drug therapy ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Steroids/administration & dosage ; Steroids/pharmacology ; Treatment Outcome ; Trigeminal Neuralgia/therapy
    Chemical Substances Antiviral Agents ; Steroids ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2014-05
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.137017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 698: Show issues Location:
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  9. Article ; Online: Exosomal PTEN as a Predictive Marker of Aggressive Gliomas.

    Patnam, Sreekanth / Samal, Rasmita / Koyyada, Rajeswari / Joshi, Partha / Singh, Anula D / Nagalla, Balakrishna / Soma, Madan R / Sannareddy, Rajesh R / Ippili, Kaushal / Raju, Subodh / Boola, Ratnam G / Lath, Rahul / Ranjan, Alok / Ghosh, Siddharth / Balamurugan, M / Ray, Amitava / Manda, Sasidhar V

    Neurology India

    2022  Volume 70, Issue 1, Page(s) 215–222

    Abstract: Background: Liquid biopsies have emerged as convenient alternative diagnostic methods to invasive biopsies, by evaluating disease-specific biomarkers and monitoring the disease risk noninvasively. Phosphatase and tensin homolog deleted in chromosome 10 ( ...

    Abstract Background: Liquid biopsies have emerged as convenient alternative diagnostic methods to invasive biopsies, by evaluating disease-specific biomarkers and monitoring the disease risk noninvasively. Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) is a potent tumor suppressor, and its deletion/mutations are common in gliomas.
    Objective: Evaluate the feasibility of non-invasive detection of PTEN and its downstream genes in serum exosomes of glioma patients.
    Materials and methods: PTEN, Yes-associated-protein 1 (YAP1), and lysyl oxidase (LOX) transcript expression were monitored through polymerase chain reaction (PCR) in serum exosomes and their paired tumor tissues. The impact of PTEN and its axis genes expression on the overall survival (OS) was monitored.
    Results: Out of the 106 glioma serum samples evaluated, PTEN was retained/lost in 65.4%/34.6% of the tumor samples while it was retained/lost in 67.1%/32.9% of their paired exosomal fractions. PTEN expression in both tissue and paired exosomal fractions was observed in 48.11% of the samples. Sanger sequencing detected three mutations (Chr10: 89720791(A>G), Chr10:89720749(C>T), and Chr10:89720850(A>G). Both PTEN-responsive downstream genes (YAP1) and LOX axis were upregulated in the PTEN-deficient samples. PTEN loss was associated with poor survival in the glioma patients (hazard ratio (HR) 0.68, confidence interval (CI): 0.35-1.31, P = 0.28). The OS of the exosomal PTEN cohort coincided with the tumor-tissue PTEN devoid group (HR 1.08, CI: 0.49-2.36, P = 0.85). While, old age yielded the worst prognosis; gender, location, and grade were not prognostic of OS in the multivariate analysis.
    Conclusions: PTEN and its responsive genes YAP1 and LOX can be detected in serum exosomes and can serve as essential tools for the non-invasive evaluation/identification of aggressive gliomas.
    MeSH term(s) Biomarkers, Tumor ; Brain Neoplasms/diagnosis ; Brain Neoplasms/enzymology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Glioma/diagnosis ; Glioma/enzymology ; Glioma/genetics ; Glioma/pathology ; Humans ; Mutation ; PTEN Phosphohydrolase/genetics ; Prognosis
    Chemical Substances Biomarkers, Tumor ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
    Language English
    Publishing date 2022-03-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.338731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report and review of literature.

    Reddy, Soma Madhan / Lath, Rahul / Swain, Meenakshi / Ranjan, Alok

    Annals of Indian Academy of Neurology

    2015  Volume 18, Issue 3, Page(s) 345–347

    Abstract: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of central nervous system with distinct clinical and radiological features. The etiopathogenesis of this ...

    Abstract Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of central nervous system with distinct clinical and radiological features. The etiopathogenesis of this rare entity remains to be understood. The histopathological findings closely resemble chronic inflammatory diseases like sarcoidosis and malignancies like lymphoma. With advancements in serology, immunopathology and radiology CLIPPERS is identified as a distinct entity that differs considerably in its clinical presentation, immunopathology, radiological findings and response to steroids. We describe a case that presented to us with progressive quadriparesis and lower cranial nerve deficits whose radiological and pathological findings were consistent with CLIPPERS. The patient had a good outcome with long term immunosuppression.
    Language English
    Publishing date 2015-09-30
    Publishing country India
    Document type Case Reports
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/0972-2327.152085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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