LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Article ; Online: Decontamination and Reuse of N95 Filtering Facepiece Respirators: Where Do We Stand?

    Cassorla, Lydia

    Anesthesia and analgesia

    2020  Volume 132, Issue 1, Page(s) 2–14

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic created an extraordinary demand for N95 and similarly rated filtering facepiece respirators (FFR) that remains unmet due to limited stock, production constraints, and logistics. Interest in decontamination ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic created an extraordinary demand for N95 and similarly rated filtering facepiece respirators (FFR) that remains unmet due to limited stock, production constraints, and logistics. Interest in decontamination and reuse of FFR, a product class designed for single use in health care settings, has undergone a parallel surge due to shortages. A worthwhile decontamination method must provide effective inactivation of the targeted pathogen(s), and preserve particle filtration, mask fit, and safety for a subsequent user. This discussion reviews the background of the current shortage, classification, structure, and functional aspects of FFR, and potentially effective decontamination methods along with reference websites for those seeking updated information and guidance. The most promising techniques utilize heat, hydrogen peroxide, microwave-generated steam, or ultraviolet light. Many require special or repurposed equipment and a detailed operational roadmap specific to each setting. While limited, research is growing. There is significant variation between models with regard to the ability to withstand decontamination yet remain protective. The number of times an individual respirator can be reused is often limited by its ability to maintain a tight fit after multiple uses rather than by the decontamination method itself. There is no single solution for all settings; each individual or institution must choose according to their need, capability, and available resources. As the current pandemic is expected to continue for months to years, and the possibility of future airborne biologic threats persists, the need for plentiful, effective respiratory protection is stimulating research and innovation.
    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; Decontamination ; Equipment Contamination ; Equipment Reuse ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Inhalation Exposure/adverse effects ; Inhalation Exposure/prevention & control ; N95 Respirators/virology ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control ; Occupational Health ; Risk Assessment ; Risk Factors
    Keywords covid19
    Language English
    Publishing date 2020-09-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Decontamination and Reuse of N95 Filtering Facepiece Respirators - Where Do We Stand?

    Cassorla, Lydia

    Abstract: The coronavirus 2019 disease (COVID-19) pandemic created an extraordinary demand for N95 and similarly rated filtering facepiece respirators (FFR) that remains unmet due to limited stock, production constraints, and logistics. Interest in decontamination ...

    Abstract The coronavirus 2019 disease (COVID-19) pandemic created an extraordinary demand for N95 and similarly rated filtering facepiece respirators (FFR) that remains unmet due to limited stock, production constraints, and logistics. Interest in decontamination and reuse of FFR, a product class designed for single use in healthcare settings, has undergone a parallel surge due to shortages. A worthwhile decontamination method must provide effective inactivation of the targeted pathogen(s), and preserve particle filtration, mask fit, and safety for a subsequent user. This discussion reviews the background of the current shortage, classification, structure and functional aspects of FFR, and potentially effective decontamination methods along with reference websites for those seeking updated information and guidance. The most promising techniques utilize heat, hydrogen peroxide, microwave generated steam, or ultraviolet light. Many require special or repurposed equipment, and a detailed operational roadmap specific to each setting. While limited, research is growing. There is significant variation between models with regard to the ability to withstand decontamination yet remain protective. The number of times an individual respirator can be reused is often limited by its ability to maintain a tight fit after multiple uses rather than by the decontamination method itself. There is no single solution for all settings; each individual or institution must choose according to their need, capability, and available resources. As the current pandemic is expected to continue for months to years, and the possibility of future airborne biologic threats persists, the need for plentiful, effective respiratory protection is stimulating research and innovation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #810284
    Database COVID19

    Kategorien

  3. Article ; Online: The International Anesthesia Research Society Coronavirus Disease 2019 Pandemic Scientific Advisory Board: Supporting a Pandemic of Positivity.

    Lumb, Philip D / Cassorla, Lydia / Clement, David M / Coffey, Robert L / Hingorani, Anil / Kenepp, Nancy / Przybylo, Jay / Roth, Jonathan V / Shah, Jagdip / Schulman, Edward S / Tolpin, Eugene I / Wurm, W Heinrich / Sladen, Robert N

    Anesthesia and analgesia

    2022  Volume 134, Issue 3, Page(s) e14

    MeSH term(s) Advisory Committees/standards ; Anesthesia/standards ; Biomedical Research/standards ; COVID-19/epidemiology ; Humans ; Internationality ; Optimism ; Pandemics ; Societies, Scientific/standards
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005846
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Structural estimation of the newsvendor model

    Olivares, Marcelo / Cassorla, Lydia / Terwiesch, Christian

    Management science : journal of the Institute for Operations Research and the Management Sciences Vol. 54, No. 1 , p. 41-55

    an application to reserving operating room time

    2008  Volume 54, Issue 1, Page(s) 41–55

    Author's details Marcelo Olivares; Christian Terwiesch; Lydia Cassorla
    Keywords Lagerhaltungsmodell ; Strukturgleichungsmodell ; Kapazitätsplanung ; Gesundheitsversorgung ; Operations Research
    Language English
    Size graph. Darst.
    Publisher INFORMS
    Publishing place Hanover, Md.
    Document type Article
    ZDB-ID 206345-1
    Database ECONomics Information System

    More links

    Kategorien

  5. Article: Designing and testing a computer-based screening system for transfusion-related acute lung injury.

    Finlay, Heather E / Cassorla, Lydia / Feiner, John / Toy, Pearl

    American journal of clinical pathology

    2005  Volume 124, Issue 4, Page(s) 601–609

    Abstract: Computer-based systems can detect underreported adverse events. We hypothesized that a system could be designed to detect potential or unreported cases of transfusion-related acute lung injury (TRALI). We developed and tested a computer screening system ... ...

    Abstract Computer-based systems can detect underreported adverse events. We hypothesized that a system could be designed to detect potential or unreported cases of transfusion-related acute lung injury (TRALI). We developed and tested a computer screening system using retrospective computer blood gas data after transfusions during a 45-day period at a tertiary care academic hospital. The program identified cases of posttransfusion hypoxemia. Medical records of identified cases were reviewed to diagnose TRALI. During the 45-day period, 820 patients received 6,888 blood products. Seven cases of TRALI were diagnosed, whereas only 2 had been reported. The system had 99% accuracy and 26% positive predictive value for detecting potential TRALI. Computer screening finds more cases of TRALI than are reported voluntarily, and a prospective study using this system is feasible and needed to validate this method of detecting this important adverse transfusion reaction.
    MeSH term(s) Adolescent ; Adult ; Aged ; Blood Gas Analysis ; Blood Group Incompatibility/blood ; Blood Group Incompatibility/complications ; Blood Group Incompatibility/epidemiology ; Blood Group Incompatibility/pathology ; California/epidemiology ; Child ; Computer Systems ; Female ; Hospitals, University ; Humans ; Male ; Mass Screening/methods ; Medical Records ; Middle Aged ; Respiratory Distress Syndrome, Adult/blood ; Respiratory Distress Syndrome, Adult/diagnosis ; Respiratory Distress Syndrome, Adult/epidemiology ; Respiratory Distress Syndrome, Adult/etiology ; Retrospective Studies ; Safety Management/methods ; Transfusion Reaction
    Language English
    Publishing date 2005-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1309/1XKQKFF83CBU4D6H
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Case 6-2003: embolization of an atrial septal occluder device.

    Kapoor, Mukul Chandra / Singh, Sujan / Sharma, Suveer / Chatterjee, Soumitra / Cassorla, Lydia / Sommer, Robert J

    Journal of cardiothoracic and vascular anesthesia

    2003  Volume 17, Issue 6, Page(s) 755–763

    MeSH term(s) Adult ; Cardiac Catheterization/methods ; Device Removal/methods ; Equipment Failure ; Female ; Foreign-Body Migration/diagnostic imaging ; Foreign-Body Migration/etiology ; Foreign-Body Migration/surgery ; Heart Atria/surgery ; Heart Septal Defects, Atrial/surgery ; Heart Septal Defects, Atrial/therapy ; Humans ; Prostheses and Implants/adverse effects ; Pulmonary Artery/surgery ; Pulmonary Embolism/etiology ; Pulmonary Embolism/surgery ; Radiography
    Language English
    Publishing date 2003-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2003.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Reliability of intraoperative contrast transesophageal echocardiography for detecting interatrial communications in patients with other congenital cardiovascular malformations.

    Cassorla, Lydia / Miller-Hance, Wanda C / Rouine-Rapp, Kathryn / Reddy, V Mohan / Hanley, Frank L / Silverman, Norman H

    The American journal of cardiology

    2003  Volume 91, Issue 8, Page(s) 1027–31, A8–9

    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Echocardiography, Transesophageal/methods ; Heart Defects, Congenital/surgery ; Heart Septal Defects, Atrial/diagnostic imaging ; Humans ; Infant ; Intraoperative Period ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2003-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/s0002-9149(03)00134-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Preliminary results of fetal cardiac bypass in nonhuman primates.

    Ikai, Akio / Riemer, R Kirk / Ramamoorthy, Chandra / Malhotra, Sunil / Malhatra, Sunil / Cassorla, Lydia / Amir, Gabriel / Hanley, Frank L / Reddy, V Mohan

    The Journal of thoracic and cardiovascular surgery

    2005  Volume 129, Issue 1, Page(s) 175–181

    Abstract: Objective: Fetal cardiac surgery has potential benefits for treatment of some congenital heart defects. However, placental dysfunction as a result of fetal bypass, fetal stress, and fetal exposure to external milieu needs to be overcome to optimize the ... ...

    Abstract Objective: Fetal cardiac surgery has potential benefits for treatment of some congenital heart defects. However, placental dysfunction as a result of fetal bypass, fetal stress, and fetal exposure to external milieu needs to be overcome to optimize the outcomes of fetal cardiac bypass. In this study we evaluated the technical feasibility of cardiac bypass in the nonhuman primate fetus and the efficacy of different anesthetic approaches.
    Methods: Twelve baboon fetuses, average gestation 146 +/- 8 days and weight 696 +/- 184 g, were used. Three fetuses were excluded from the study because of nuchal cord presentations. The animals were separated into two anesthesia groups: isoflurane (n = 6) and fentanyl and midazolam (n = 3). A miniature roller pump circuit without oxygenator was used for fetal bypass for 30 minutes. No blood transfusion was performed. Fetal blood gas samples were collected before bypass, during bypass, and at 15 and 60 minutes after bypass.
    Results: All fetuses in the isoflurane group were successfully placed on the cardiac bypass circuit. However, 2 animals in the fentanyl and midazolam group were not placed on the bypass circuit because of sustained elevation in maternal uterine tone. All maternal baboons survived. Of the 6 fetuses in the isoflurane group, 5 survived for 60 minutes; however, placental function continued to deteriorate after bypass (Pa o 2 33 +/- 3 mm Hg before bypass, 23 +/- 6 mm Hg 15 minutes after, and 18 +/- 9 mm Hg 60 minutes after).
    Conclusion: The technical feasibility of cardiac bypass in nonhuman primate fetuses weighing less than 1000 g was confirmed. Isoflurane anesthesia appears to be superior to fentanyl and midazolam anesthesia for fetal cardiac surgery because of adequate uterine relaxation.
    MeSH term(s) Anesthesia, General/methods ; Anesthetics, Intravenous/administration & dosage ; Animals ; Blood Gas Analysis ; Blood Pressure Determination ; Cardiac Output ; Cardiopulmonary Bypass/methods ; Female ; Fentanyl/administration & dosage ; Fetal Heart/abnormalities ; Fetal Heart/surgery ; Hemodynamics/physiology ; Isoflurane/administration & dosage ; Papio ; Pregnancy ; Pregnancy, Animal ; Sensitivity and Specificity ; Statistics, Nonparametric ; Treatment Outcome
    Chemical Substances Anesthetics, Intravenous ; Isoflurane (CYS9AKD70P) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2005-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2004.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top