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  1. Article ; Online: Decontamination of respirators in the covid-19 pandemic.

    Loh, Miranda / Cherrie, John W / Aitken, Robert J

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m1986

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Decontamination/methods ; Humans ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Ventilators, Mechanical/virology
    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m1986
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  2. Article ; Online: Long-acting reversible contraception and condom use: A cohort study of female adolescents and young adults in New York City.

    Loh, Miranda / Niu, Li / Arden, Martha / Burk, Robert D / Diaz, Angela / Schlecht, Nicolas F

    Contraception

    2023  Volume 125, Page(s) 110081

    Abstract: Objectives: This study aimed to determine whether condom use varied between adolescents and young women using long-acting reversible contraception (LARC) vs non-LARC hormonal methods and assess if the initiation of LARC was associated with lower condom ... ...

    Abstract Objectives: This study aimed to determine whether condom use varied between adolescents and young women using long-acting reversible contraception (LARC) vs non-LARC hormonal methods and assess if the initiation of LARC was associated with lower condom use.
    Study design: This study used data from a large longitudinal study of sexually active females aged 13-25 years. Questionnaires assessed contraception, condom use, sexual history, and partner characteristics at the baseline visit and every 6 months. Log-binomial regression analyses examined associations between hormonal contraceptive methods and condom use, and the moderating effects of age and number of sexual partners. Exploratory analyses compared condom use based on partner characteristics.
    Results: Of 1512 participants, 1116 reported LARC or non-LARC hormonal method use during any study visit. Among baseline and new LARC users, 75.7% and 84.7% reported intrauterine device (IUD) use, respectively. Condom use at baseline among hormonal non-LARC users (37.5%) was significantly higher (p < 0.01) than LARC users (23.5%). Condom use among LARC vs non-LARC users was moderated by age in that LARC was associated with lower condom use among participants aged 13-18 years, but not those aged 19-25 years. Number of sexual partners was not a significant moderator. Among participants with increased sexually transmitted infection (STI) risk based on partner characteristics, LARC users had lower condom use compared to non-LARC users.
    Conclusions: Condom discontinuation was common following initiation of LARC and hormonal non-LARC methods. However, condom use was lower in LARC users at baseline, among younger adolescents, and if partners had risk factors for STIs.
    Implications: Condom discontinuation following initiation of highly effective contraception increases the risk of STI. Young women using LARC may be at greater risk than non-LARC users given lower condom use despite having partners with risk factors for STIs. Condom use counseling for STI protection is critical for adolescents.
    MeSH term(s) Female ; Adolescent ; Young Adult ; Humans ; Condoms ; Long-Acting Reversible Contraception ; Cohort Studies ; Longitudinal Studies ; New York City ; Contraception/methods ; Sexually Transmitted Diseases/prevention & control
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2023.110081
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    Zs.A 629: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Exposure to urban greenspace and pathways to respiratory health: An exploratory systematic review.

    Mueller, William / Milner, James / Loh, Miranda / Vardoulakis, Sotiris / Wilkinson, Paul

    The Science of the total environment

    2022  Volume 829, Page(s) 154447

    Abstract: Background/objective: Urban greenspace may have a beneficial or adverse effect on respiratory health. Our objective was to perform an exploratory systematic review to synthesise the evidence and identify the potential causal pathways relating urban ... ...

    Abstract Background/objective: Urban greenspace may have a beneficial or adverse effect on respiratory health. Our objective was to perform an exploratory systematic review to synthesise the evidence and identify the potential causal pathways relating urban greenspace and respiratory health.
    Methods: We followed PRISMA guidelines on systematic reviews and searched five databases for eligible studies during 2000-2021. We incorporated a broad range of urban greenspace and respiratory health search terms, including both observational and experimental studies. Screening, data extraction, and risk of bias, assessed using the Navigation Guide criteria, were performed independently by two authors. We performed a narrative synthesis and discuss suggested pathways to respiratory health.
    Results: We identified 108 eligible papers (n = 104 observational, n = 4 experimental). The most common greenspace indicators were the overall greenery or vegetation (also known as greenness), green land use/land cover of physical area classes (e.g., parks, forests), and tree canopy cover. A wide range of respiratory health indicators were studied, with asthma prevalence being the most common. Two thirds (n = 195) of the associations in these studies were positive (i.e., beneficial) with health, with 31% (n = 91) statistically significant; only 9% (n = 25) of reported associations were negative (i.e., adverse) with health and statistically significant. The most consistent positive evidence was apparent for respiratory mortality. There were n = 35 (32%) 'probably low' and n = 73 (68%) 'probably high' overall ratings of bias. Hypothesised causal pathways for health benefits included lower air pollution, more physically active populations, and exposure to microbial diversity; suggested mechanisms with poorer health included exposure to pollen and other aeroallergens.
    Conclusion: Many studies showed positive association between urban greenspace and respiratory health, especially lower respiratory mortality; this is suggestive, but not conclusive, of causal effects. Results underscore the importance of contextual factors, greenspace metric employed, and the potential bias of subtle selection factors, which should be explored further.
    MeSH term(s) Air Pollution ; Allergens ; City Planning ; Humans ; Parks, Recreational ; Respiration ; Trees
    Chemical Substances Allergens
    Language English
    Publishing date 2022-03-11
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.154447
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  4. Article ; Online: Protecting healthcare workers from inhaled SARS-CoV-2 virus.

    Cherrie, John W / Loh, Miranda / Aitken, Robert J

    Occupational medicine (Oxford, England)

    2020  Volume 70, Issue 5, Page(s) 335–337

    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; Health Personnel ; Humans ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1103950-4
    ISSN 1471-8405 ; 0962-7480
    ISSN (online) 1471-8405
    ISSN 0962-7480
    DOI 10.1093/occmed/kqaa077
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 426: Show issues Location:
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  5. Article ; Online: Toxicity Weighting for Human Biomonitoring Mixture Risk Assessment: A Proof of Concept.

    Loh, Miranda M / Schmidt, Phillipp / Christopher de Vries, Yvette / Vogel, Nina / Kolossa-Gehring, Marike / Vlaanderen, Jelle / Lebret, Erik / Luijten, Mirjam

    Toxics

    2023  Volume 11, Issue 5

    Abstract: Chemical mixture risk assessment has, in the past, primarily focused on exposures quantified in the external environment. Assessing health risks using human biomonitoring (HBM) data provides information on the internal concentration, from which a dose ... ...

    Abstract Chemical mixture risk assessment has, in the past, primarily focused on exposures quantified in the external environment. Assessing health risks using human biomonitoring (HBM) data provides information on the internal concentration, from which a dose can be derived, of chemicals to which human populations are exposed. This study describes a proof of concept for conducting mixture risk assessment with HBM data, using the population-representative German Environmental Survey (GerES) V as a case study. We first attempted to identify groups of correlated biomarkers (also known as 'communities', reflecting co-occurrence patterns of chemicals) using a network analysis approach (
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11050408
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  7. Article ; Online: Regulation of Helicobacter pylori Urease and Acetone Carboxylase Genes by Nitric Oxide and the CrdRS Two-Component System.

    Allen, Madison G / Bate, Miranda Y / Tramonte, Lauren M / Avalos, Emely Y / Loh, John / Cover, Timothy L / Forsyth, Mark H

    Microbiology spectrum

    2023  Volume 11, Issue 1, Page(s) e0463322

    Abstract: Helicobacter pylori colonizes the human gastric mucosa and causes various gastroduodenal diseases, including peptic ulceration and gastric cancer. Colonization requires the actions of two-component systems (TCSs) to sense and respond to changes in the ... ...

    Abstract Helicobacter pylori colonizes the human gastric mucosa and causes various gastroduodenal diseases, including peptic ulceration and gastric cancer. Colonization requires the actions of two-component systems (TCSs) to sense and respond to changes in the host environment. In this study, we evaluated gene regulation mediated by the CrdRS TCS. Few studies have evaluated this TCS, leaving the signal(s) yet to be exhaustively determined and a need for a more complete regulon to be delineated. We performed RNA sequencing (RNA-Seq) on three isogenic H. pylori 26695 mutants: a control, a mutant with deletion of the sensory histidine kinase, Δ
    MeSH term(s) Humans ; Urease/genetics ; Urease/metabolism ; Helicobacter pylori/genetics ; Helicobacter pylori/metabolism ; Nitric Oxide ; Bacterial Proteins/metabolism ; Helicobacter Infections/genetics
    Chemical Substances Urease (EC 3.5.1.5) ; Nitric Oxide (31C4KY9ESH) ; acetone carboxylase (EC 4.1.1.-) ; Bacterial Proteins
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04633-22
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  8. Article ; Online: Options for Teens with No Options: A Self-Managed Second Trimester Abortion.

    Duroseau, Nathalie / Loh, Miranda / Sanders, Leslie / Arden, Martha

    Journal of pediatric and adolescent gynecology

    2020  Volume 34, Issue 2, Page(s) 226–227

    Abstract: Background: Several states have deemed abortions as nonessential services, effectively calling for a halt to abortion care during the COVID-19 pandemic. In response, women might elect for self-managed abortions by obtaining abortion medications online.!# ...

    Abstract Background: Several states have deemed abortions as nonessential services, effectively calling for a halt to abortion care during the COVID-19 pandemic. In response, women might elect for self-managed abortions by obtaining abortion medications online.
    Case: A 15-year-old girl presented with abdominal cramping and vaginal discharge after taking misoprostol obtained from an online retailer for a self-managed abortion in her second trimester during the COVID-19 pandemic. Her exam showed products of conception protruding from the vagina. The patient was emergently evaluated for an incomplete and possible septic abortion and underwent a dilation and evacuation procedure.
    MeSH term(s) Abortion, Induced/methods ; Adolescent ; COVID-19/epidemiology ; Female ; Humans ; Misoprostol/pharmacology ; Oxytocics/pharmacology ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Trimester, Second ; SARS-CoV-2
    Chemical Substances Oxytocics ; Misoprostol (0E43V0BB57)
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2020.11.013
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2337: Show issues Location:
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  9. Article ; Online: Medical Complications of Eating Disorders in Pediatric Patients.

    Monge, Maria C / Loh, Miranda

    Pediatric annals

    2018  Volume 47, Issue 6, Page(s) e238–e243

    Abstract: Eating disorders affect millions of children, adolescents, and their families worldwide, and the pediatric primary care provider is often the first line of evaluation for these patients. Eating disorders affect nearly every system in the body, and signs ... ...

    Abstract Eating disorders affect millions of children, adolescents, and their families worldwide, and the pediatric primary care provider is often the first line of evaluation for these patients. Eating disorders affect nearly every system in the body, and signs and symptoms vary depending on patient behaviors (restrictive eating, binge eating, purging). Because the diagnosis is not always straightforward, a clinician's ability to recognize the potential medical complications of eating disorders early in their course can help facilitate timely treatment and an appropriate level of support. Most of these medical complications improve or resolve with nutritional rehabilitation and cessation of eating disorder behaviors. Refeeding severely underweight patients should be approached with caution as there is potential for significant fluid and electrolyte derangement that may worsen a patient's clinical status. Prompt recognition of the medical complications of eating disorders can improve short-term and long-term health in these children and adolescents. [Pediatr Ann. 2018;47(6):e238-e243.].
    MeSH term(s) Adolescent ; Body Weight ; Child ; Feeding and Eating Disorders/complications ; Humans ; Risk Factors
    Language English
    Publishing date 2018-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20180518-01
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  10. Book ; Online: Decontamination of respirators in the covid-19 pandemic

    Loh, Miranda / Cherrie, John W / Aitken, Robert J

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-05-18 06:06:17.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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