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  1. Article ; Online: Ameliorative effect of cerium oxide nanoparticles against Freund's complete adjuvant-induced arthritis.

    Allawadhi, Prince / Khurana, Amit / Sayed, Nilofer / Godugu, Chandraiah / Vohora, Divya

    Nanomedicine (London, England)

    2022  Volume 17, Issue 6, Page(s) 383–404

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Cerium ; Cytokines ; Freund's Adjuvant/toxicity ; Nanoparticles ; Rats
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y) ; Freund's Adjuvant (9007-81-2)
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2021-0172
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  2. Article: It's all about the spaces between cells: role of extracellular matrix in liver fibrosis.

    Khurana, Amit / Sayed, Nilofer / Allawadhi, Prince / Weiskirchen, Ralf

    Annals of translational medicine

    2021  Volume 9, Issue 8, Page(s) 728

    Abstract: Liver fibrosis is one of the leading complications of a variety of chronic liver disorders, including the nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, liver cirrhosis and liver failure. The progression of liver fibrosis is driven by ... ...

    Abstract Liver fibrosis is one of the leading complications of a variety of chronic liver disorders, including the nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, liver cirrhosis and liver failure. The progression of liver fibrosis is driven by chronic inflammation, which activates the secretory fibroblasts to the myofibroblast phenotype. These specialized liver cells are called as hepatic stellate cells (HSCs). The excessive extracellular matrix (ECM) secretion creates a large number of complications. Fibrosis is the result of imbalance between the matrix synthesizing and matrix degrading factors. The major ECM proteins include the matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs), lysyl oxidases (LOX), lysyl oxidase-like (LOXLs) enzymes, tenascins and others. These ECM proteins present novel avenues for the therapeutics of liver fibrosis. The current review highlights the major role played by these critical matrix proteins in liver fibrosis. Further, some of the targeted formulations used against these proteins are discussed and suggestions are provided to select the course of research for successful clinical translation of basic research findings for the amelioration of liver fibrosis.
    Language English
    Publishing date 2021-05-10
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-20-2948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spotlight on liver macrophages for halting liver disease progression and injury.

    Khurana, Amit / Navik, Umashanker / Allawadhi, Prince / Yadav, Poonam / Weiskirchen, Ralf

    Expert opinion on therapeutic targets

    2022  Volume 26, Issue 8, Page(s) 707–719

    Abstract: Introduction: Over the past two decades, understanding of hepatic macrophage biology has provided astounding details of their role in the progression and regression of liver diseases. The hepatic macrophages constitute resident macrophages, Kupffer ... ...

    Abstract Introduction: Over the past two decades, understanding of hepatic macrophage biology has provided astounding details of their role in the progression and regression of liver diseases. The hepatic macrophages constitute resident macrophages, Kupffer cells, and circulating bone marrow monocyte-derived macrophages, which play a diverse role in liver injury and repair. Imbalance in the macrophage population leads to pathological consequences and is responsible for the initiation and progression of acute and chronic liver injuries. Further, distinct populations of hepatic macrophages and their high heterogeneity make their complex role enigmatic. The unique features of distinct phenotypes of macrophages have provided novel biomarkers for defining the stages of liver diseases. The distinct mechanisms of hepatic macrophages polarization and recruitment have been at the fore front of research. In addition, the secretome of hepatic macrophages and their immune regulation has provided clinically relevant therapeutic targets.
    Areas covered: Herein, we have highlighted the current understanding in the area of hepatic macrophages, and their role in the progression of liver injury.
    Expert opinion: It is essential to ascertain the physiological and pathological role of evolutionarily conserved distinct macrophage phenotypes in different liver diseases before viable approaches may see a clinical translation.
    MeSH term(s) Humans ; Kupffer Cells/pathology ; Liver Diseases ; Macrophages ; Biomarkers ; Disease Progression
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2133699
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  4. Article ; Online: Novel Insights Into Macrophage Diversity During the Course of Pancreatitis.

    Allawadhi, Prince / Beyer, Georg / Mahajan, Ujjwal M / Mayerle, Julia

    Gastroenterology

    2021  Volume 161, Issue 6, Page(s) 1802–1805

    MeSH term(s) Humans ; Macrophages ; Pancreatitis
    Language English
    Publishing date 2021-09-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.09.049
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  5. Article ; Online: Therapeutic potential of stem cells in regeneration of liver in chronic liver diseases: Current perspectives and future challenges.

    Yadav, Poonam / Singh, Sumeet Kumar / Rajput, Sonu / Allawadhi, Prince / Khurana, Amit / Weiskirchen, Ralf / Navik, Umashanker

    Pharmacology & therapeutics

    2023  Volume 253, Page(s) 108563

    Abstract: The deposition of extracellular matrix and hyperplasia of connective tissue characterizes chronic liver disease called hepatic fibrosis. Progression of hepatic fibrosis may lead to hepatocellular carcinoma. At this stage, only liver transplantation is a ... ...

    Abstract The deposition of extracellular matrix and hyperplasia of connective tissue characterizes chronic liver disease called hepatic fibrosis. Progression of hepatic fibrosis may lead to hepatocellular carcinoma. At this stage, only liver transplantation is a viable option. However, the number of possible liver donors is less than the number of patients needing transplantation. Consequently, alternative cell therapies based on non-stem cells (e.g., fibroblasts, chondrocytes, keratinocytes, and hepatocytes) therapy may be able to postpone hepatic disease, but they are often ineffective. Thus, novel stem cell-based therapeutics might be potentially important cutting-edge approaches for treating liver diseases and reducing patient' suffering. Several signaling pathways provide targets for stem cell interventions. These include pathways such as TGF-β, STAT3/BCL-2, NADPH oxidase, Raf/MEK/ERK, Notch, and Wnt/β-catenin. Moreover, mesenchymal stem cells (MSCs) stimulate interleukin (IL)-10, which inhibits T-cells and converts M1 macrophages into M2 macrophages, producing an anti-inflammatory environment. Furthermore, it inhibits the action of CD4
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes/pathology ; Liver ; Liver Diseases/therapy ; Liver Cirrhosis/pathology ; Mesenchymal Stem Cells ; Anti-Inflammatory Agents ; Mesenchymal Stem Cell Transplantation
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108563
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  6. Article ; Online: Allium sativum

    Kalkal, Ashish / Allawadhi, Prince / Pradhan, Rangadhar / Khurana, Amit / Bharani, Kala Kumar / Packirisamy, Gopinath

    Sensors international

    2021  Volume 2, Page(s) 100102

    Abstract: Coronavirus disease 2019 (COVID-19) is one of the worst pandemics to have hit the humanity. The manifestations are quite varied, ranging from severe lung infections to being asymptomatic. Hence, there is an urgent need to champion new tools to accelerate ...

    Abstract Coronavirus disease 2019 (COVID-19) is one of the worst pandemics to have hit the humanity. The manifestations are quite varied, ranging from severe lung infections to being asymptomatic. Hence, there is an urgent need to champion new tools to accelerate the end of this pandemic. Compromised immunity is a primary feature of COVID-19.
    Language English
    Publishing date 2021-05-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-3511
    ISSN (online) 2666-3511
    DOI 10.1016/j.sintl.2021.100102
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  7. Article: Emerging Role of PD-1/PD-L1 Inhibitors in Chronic Liver Diseases.

    Singh, Vishakha / Khurana, Amit / Allawadhi, Prince / Banothu, Anil Kumar / Bharani, Kala Kumar / Weiskirchen, Ralf

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 790963

    Abstract: Programmed cell death protein 1 (PD-1)/PD-ligand (L)1, the immune checkpoint inhibitors have emerged as a promising strategy for the treatment of various diseases including chronic liver diseases (CLDs) such as hepatitis, liver injury and hepatocellular ... ...

    Abstract Programmed cell death protein 1 (PD-1)/PD-ligand (L)1, the immune checkpoint inhibitors have emerged as a promising strategy for the treatment of various diseases including chronic liver diseases (CLDs) such as hepatitis, liver injury and hepatocellular carcinoma (HCC). The role of PD-1/PD-L1 has been widely inspected in the treatment of viral hepatitis and HCC. PD-1 is known to play a crucial role in inhibiting immunological responses and stimulates self-tolerance by regulating the T-cell activity. Further, it promotes apoptosis of antigen-specific T-cells while preventing apoptosis of T
    Language English
    Publishing date 2021-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.790963
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  8. Article ; Online: Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

    Vishakha Singh / Amit Khurana / Umashanker Navik / Prince Allawadhi / Kala Kumar Bharani / Ralf Weiskirchen

    Sci, Vol 4, Iss 15, p

    2022  Volume 15

    Abstract: Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and ... ...

    Abstract Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and tissues. Further, it plays a crucial role in the elimination of unnecessary cells through phagocytosis and prevents undesirable immune responses. Apoptosis is regulated by a complex signaling mechanism, which is driven by interactions among several protein families such as caspases, inhibitors of apoptosis proteins, B-cell lymphoma 2 (BCL-2) family proteins, and several other proteases such as perforins and granzyme. The signaling pathway consists of both pro-apoptotic and pro-survival members, which stabilize the selection of cellular survival or death. However, any aberration in this pathway can lead to abnormal cell proliferation, ultimately leading to the development of cancer, autoimmune disorders, etc. This review aims to elaborate on apoptotic signaling pathways and mechanisms, interacting members involved in signaling, and how apoptosis is associated with carcinogenesis, along with insights into targeting apoptosis for disease resolution.
    Keywords apoptosis ; carcinogenesis ; BCL-2 ; signaling ; therapy ; caspase ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Critical neurological features of COVID-19: Role of imaging methods and biosensors for effective diagnosis.

    Singh, Vishakha / Allawadhi, Prince / Khurana, Amit / Banothu, Anil Kumar / Bharani, Kala Kumar

    Sensors international

    2021  Volume 2, Page(s) 100098

    Abstract: COVID-19 is a respiratory infection that has been declared as a global health crisis by the WHO. It mainly affects the respiratory system. Apart from respiratory system, it also affects other organs as well including the brain. Numerous emerging reports ... ...

    Abstract COVID-19 is a respiratory infection that has been declared as a global health crisis by the WHO. It mainly affects the respiratory system. Apart from respiratory system, it also affects other organs as well including the brain. Numerous emerging reports have demonstrated that the COVID-19 has detrimental effects on neurological functions, and can lead to severe impairment of the central nervous system (CNS). The neurological manifestations linked with COVID-19 include headache, anosmia, encephalitis, epileptic seizures, Guillain-Barre syndrome, stroke and intracerebral hemorrhage alongwith multiple others complications. The CNS related complications may be severe and are linked with poor diagnosis which may worsen the condition. Therefore, there is a need to precisely understand the neurological sequelae along with upcoming clinical outcomes. Here, we present a brief review of the neurological complications and symptoms associated with COVID-19 along with brain imaging findings. Further, we have discussed about the emerging biosensing approaches which may aid in rapid, precise and mass diagnosis of COVID-19.
    Language English
    Publishing date 2021-05-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2666-3511
    ISSN (online) 2666-3511
    DOI 10.1016/j.sintl.2021.100098
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  10. Article ; Online: Severity of gallstone, sludge or microlithiasis induced pancreatitis - all of the same?

    Sirtl, Simon / Bretthauer, Katharina / Ahmad, Mahmood / Hohmann, Eric / Schmidt, Vanessa F / Allawadhi, Prince / Vornhülz, Marlies / Klauss, Sarah / Goni, Elisabetta / Vielhauer, Jakob / Orgler, Elisabeth / Saka, Didem / Knoblauch, Mathilda / Hofmann, Felix O / Schirra, Jörg / Schulz, Christian / Beyer, Georg / Mahajan, Ujjwal M / Mayerle, Julia /
    Zorniak, Michal

    Pancreas

    2024  

    Abstract: Background/aim: Severity of microlithiasis and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition. In order to understand whether bile duct obstruction or other mechanisms ... ...

    Abstract Background/aim: Severity of microlithiasis and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition. In order to understand whether bile duct obstruction or other mechanisms contribute to biliary pancreatitis severity we performed a monocentric, retrospective cohort study.
    Methods: In this retrospective cohort study 263 patients with acute biliary pancreatitis treated at a tertiary care center from 2005 to 2021 were stratified according to the recent consensus definition for microlithiasis and sludge. The gallstone-pancreatitis cohort was compared to microlithiasis, sludge and suspected stone passage pancreatitis cohorts in terms of pancreatitis outcome, liver function and EUS/ERCP results using one-way ANOVA and Chi2 test. Multinomial logistic regression analysis was performed to correct for bias.
    Results: Microlithiasis and sludge-induced pancreatitis classified according to the revised Atlanta classification, did not present with a milder course than gallstone-induced pancreatitis (p = 0.62). Microlithiasis and sludge showed an increase in bilirubin on the day of admission to hospital, which was not significantly different from gallstone-induced pancreatitis (p = 0.36). The likelihood of detecting biliary disease on EUS resulting in bile duct clearance was highest on the day of admission and day 1, respectively.
    Conclusion: Microlithiasis and sludge induce gallstone-equivalent impaired liver function tests and induce pancreatitis with similar severity compared with gallstone-induced acute biliary pancreatitis.
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002349
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