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  1. Article ; Online: Di-

    Beveridge, Ramsay E / Hu, Yiwei / Gregoire, Bruce / Batey, Robert A

    The Journal of organic chemistry

    2020  Volume 85, Issue 13, Page(s) 8447–8461

    Abstract: The reagent di- ...

    Abstract The reagent di-
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.0c00781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lactiplantibacillus plantarum RS20D Alleviates Male Reproductive Toxicity Induced by Pubertal Exposure to Di-n-butyl Phthalate and Mono-n-butyl Phthalate.

    Zhu, Yuan-Ting / Wang, Xing-Jie / Liu, Shu-Liang / Lai, Jing-Hui / Li, Jian-Long / Li, Qin / Hu, Kai-di / Liu, Ai-Ping / Yang, Yong / He, Li / Chen, Shu-Juan / Ao, Xiao-Lin / Zou, Li-Kou

    Probiotics and antimicrobial proteins

    2024  

    Abstract: Phthalate acid esters (PAEs) and their metabolites, such as di-n-butyl phthalate (DBP) and mono-n ...

    Abstract Phthalate acid esters (PAEs) and their metabolites, such as di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP), are known to cause male reproductive damage. Lactiplantibacillus plantarum RS20D has demonstrated the ability to remove both DBP and MBP in vitro, suggesting its potential as a detoxifying agent against these compounds. This study aimed to investigate the protective effects of RS20D on DBP or MBP-induced male reproductive toxicity in adolescent rats. Oral administration of RS20D significantly mitigated the histological damage to the testes caused by MBP or DBP, restored sperm concentration, morphological abnormalities, and the proliferation index in MBP-exposed rats, and partially reversed spermatogenic damage in DBP-exposed rats. Furthermore, RS20D restored serum levels of estradiol (E2) and testosterone, and superoxide dismutase (SOD) activity in DBP-exposed rats, significantly increased testosterone levels in MBP-exposed rats, and restored copper (Cu) concentrations in the testes after exposure to DBP or MBP. Additionally, RS20D effectively modulated the intestinal microbiota in DBP-exposed rats and partially ameliorated dysbiosis induced by MBP, which may be associated with the alleviation of reproductive toxic effects induced by DBP or MBP. In conclusion, this study demonstrates that RS20D administration can alleviate male reproductive toxicity and gut dysbacteriosis induced by DBP or MBP exposure, providing a dietary strategy for the bioremediation of PAEs and their metabolites.
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2487792-X
    ISSN 1867-1314 ; 1867-1306
    ISSN (online) 1867-1314
    ISSN 1867-1306
    DOI 10.1007/s12602-024-10276-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of Biofilm Forming on the Migration of Di(2-ethylhexyl)phthalate from PVC Plastics.

    Zhao, E / Xiong, Xiong / Li, Xin / Hu, Hongjuan / Wu, Chenxi

    Environmental science & technology

    2024  Volume 58, Issue 14, Page(s) 6326–6334

    Abstract: ... In this study, PVC plastics with different levels of di(2-ethylhexyl)phthalate (DEHP) content were investigated ...

    Abstract Plastic additives, represented by plasticizers, are important components of plastic pollution. Biofilms inevitably form on plastic surfaces when plastic enters the aqueous environment. However, little is known about the effect of biofilms on plastic surfaces on the release of additives therein. In this study, PVC plastics with different levels of di(2-ethylhexyl)phthalate (DEHP) content were investigated to study the effect of biofilm growth on DEHP release. The presence of biofilms promoted the migration of DEHP from PVC plastics to the external environment. Relative to biofilm-free controls, although the presence of surface biofilm resulted in 0.8 to 11.6 times lower DEHP concentrations in water, the concentrations of the degradation product, monoethylhexyl phthalate (MEHP) in water, were 2.3 to 57.3 times higher. When the total release amounts of DEHP in the biofilm and in the water were combined, they were increased by 0.6-73 times after biofilm growth. However, most of the released DEHP was adsorbed in the biofilms and was subsequently degraded. The results of this study suggest that the biofilm as a new interface between plastics and the surrounding environment can affect the transport and transformation of plastic additives in the environment through barrier, adsorption, and degradation. Future research endeavors should aim to explore the transport dynamics and fate of plastic additives under various biofilm compositions as well as evaluate the ecological risks associated with their enrichment by biofilms.
    MeSH term(s) Diethylhexyl Phthalate/metabolism ; Plasticizers ; Biofilms ; Environmental Pollution ; Water ; Plastics
    Chemical Substances Diethylhexyl Phthalate (C42K0PH13C) ; Plasticizers ; Water (059QF0KO0R) ; Plastics
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c09021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: D-DI/PLT can be a prognostic indicator for sepsis.

    Zhao, Xiaojun / Wu, Xiuhua / Si, Yi / Xie, Jiangang / Wang, Linxiao / Liu, Shanshou / Duan, Chujun / Wang, Qianmei / Wu, Dan / Wang, Yifan / Chen, Jijun / Yang, Jing / Hu, Shanbo / Yin, Wen / Li, Junjie

    PeerJ

    2023  Volume 11, Page(s) e15910

    Abstract: ... groups, D-dimer (D-DI), Sequential Organ Failure Assessment (SOFA) score, platelet (PLT ... international normalized ratio (INR), and D-DI/PLT were identified as independent risk factors affecting the prognosis of sepsis ... patients. Receiver operating characteristic (ROC) curves showed that D-DI/PLT (area under the curve (AUC ...

    Abstract Aims: To investigate the indicators affecting the early outcome of patients with sepsis and to explore its prognostic efficacy for sepsis.
    Methods: We collected clinical data from 201 patients with sepsis admitted to the emergency department of Xijing Hospital between June 2019 and June 2022. The patients were categorized into groups (survival or fatality) based on their 28-day prognosis. The clinical characteristics, biochemical indexes, organ function-related indicators, and disease scores of the patients were analyzed for both groups. Risk factor analysis was conducted for the indicators with significant differences.
    Results: Among the indicators with significant differences between the deceased and survival groups, D-dimer (D-DI), Sequential Organ Failure Assessment (SOFA) score, platelet (PLT), international normalized ratio (INR), and D-DI/PLT were identified as independent risk factors affecting the prognosis of sepsis patients. Receiver operating characteristic (ROC) curves showed that D-DI/PLT (area under the curve (AUC) = 93.9), D-DI (AUC = 89.6), PLT (AUC = 81.3), and SOFA (AUC = 78.4) had good judgment efficacy. Further, Kaplan Meier (K-M) survival analysis indicated that the 28-day survival rates of sepsis patients were significantly decreased when they had high levels of D-DI/PLT, D-DI, and SOFA as well as low PLTs. The hazard ratio (HR) of D-DI/PLT between the two groups was the largest (HR = 16.19).
    Conclusions: D-DI/PLT may be an independent risk factor for poor prognosis in sepsis as well as a clinical predictor of patient prognosis.
    MeSH term(s) Humans ; Prognosis ; Sepsis/diagnosis ; Area Under Curve ; Blood Platelets
    Chemical Substances fibrin fragment D
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.15910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biotoxicity responses of zebrafish in environmentally relevant concentration of di (2-ethylhexyl) phthalate.

    Li, Xianxu / Hu, Shichang / Jiang, Nan / Yao, Xiangfeng / Wang, Can / Wang, Qian / Yang, Zhongkang / Wang, Jun

    Environmental toxicology and pharmacology

    2024  Volume 107, Page(s) 104423

    Abstract: As an emerging environmental contaminant, di (2-ethylhexyl) phthalate (DEHP) is widely present ...

    Abstract As an emerging environmental contaminant, di (2-ethylhexyl) phthalate (DEHP) is widely present in the aquatic environment, however, the effects and underlying mechanisms of DEHP on the aquatic organisms are poorly understood. This study systematically investigated the ecotoxicity induced by chronic exposure to environmental relevant concentrations of DEHP (0.03 mg/L, 0.1 mg/L, and 0.3 mg/L) on zebrafish brain. Results indicated that DEHP exposure significantly increased the levels of ROS and disturbance of the antioxidant enzymes activities in the brain, which may further enhance lipid peroxidation and DNA damage. Furthermore, acetylcholinesterase activity was first stimulated and inhibited by exposure to DEHP, and the antioxidant and apoptosis related genes were mainly upregulated. Risk assessment indicated that the ecotoxicity of DEHP on the zebrafish showed an "enhancement-reduction" trend as the exposure time was prolonged. Overall, these results provided new insights and useful information to ecological risk assessment and environmental management of DEHP pollution.
    MeSH term(s) Animals ; Diethylhexyl Phthalate/toxicity ; Zebrafish/physiology ; Antioxidants ; Acetylcholinesterase ; Phthalic Acids
    Chemical Substances phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; Antioxidants ; Acetylcholinesterase (EC 3.1.1.7) ; Phthalic Acids
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2024.104423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of sleep in asthenospermia induced by di (2-ethyl-hexyl) phthalate.

    Li, Xiao-Lu / Cai, Xiao-Yue / Ning, Xia / Liang, Yue-Yue / Hong, Yun / Li, Qi-Meng / Hu, Die / Zheng, Yuan-Zhuo / Cai, Yang / Xu, Tao / Zhao, Ling-Li

    Environmental science and pollution research international

    2024  Volume 31, Issue 9, Page(s) 13965–13980

    Abstract: Di (2-ethyl-hexyl) phthalate (DEHP) mainly enters the human body through the digestive tract ...

    Abstract Di (2-ethyl-hexyl) phthalate (DEHP) mainly enters the human body through the digestive tract, respiratory tract, and skin. At the same time, it has reproductive and developmental toxicity, neurotoxicity, and so on, which can cause the decrease of sperm motility. Asthenospermia is also known as low sperm motility, and the semen quality of men in some areas of China is declining year by year. Interestingly, previous studies have shown that sleep disorders can also lead to asthenospermia. However, the relationship between sleep, DEHP, and asthenospermia is still unclear. Analysis of the National Health and Nutrition Examination Survey (NHANES) population database showed that DEHP was associated with sleep disorders, and subsequent experiments in mice and Drosophila indicated that DEHP exposure had certain effects on sleep and asthenospermia. Furthermore, we analyzed the Comparative Toxicogenomics Database (CTD) to find out the common signaling pathway among the three: hypoxia-inducible factor 1(HIF-1). Then Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) was used to screen out the proteins that DEHP affected the HIF-1 pathway: glyceraldehyde-3-phosphate dehydrogenase (GAPDH), serine/threonine-protein kinase (AKT1), epidermal growth factor receptor (EGFR), and finally Western blot analysis was used to detect the expression levels of the three proteins. Compared with the control group, DEHP decreased the protein expression levels of GAPDH and AKT1 in the HIF-1 pathway, and caused sleep disorders and decreased sperm motility. This study provides preliminary evidence for exploring the mechanism among DEHP, sleep disorders, and asthenospermia.
    MeSH term(s) Humans ; Male ; Animals ; Mice ; Diethylhexyl Phthalate/toxicity ; Semen Analysis ; Nutrition Surveys ; Sperm Motility ; Sleep ; Sleep Wake Disorders ; Phthalic Acids
    Chemical Substances phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; Phthalic Acids
    Language English
    Publishing date 2024-01-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32030-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: DI-Fusion

    Huang, Jiahui / Huang, Shi-Sheng / Song, Haoxuan / Hu, Shi-Min

    Online Implicit 3D Reconstruction with Deep Priors

    2020  

    Abstract: ... In this paper, we present DI-Fusion (Deep Implicit Fusion), based on a novel 3D representation, i.e ... at https://www.github.com/huangjh-pub/di-fusion. ...

    Abstract Previous online 3D dense reconstruction methods struggle to achieve the balance between memory storage and surface quality, largely due to the usage of stagnant underlying geometry representation, such as TSDF (truncated signed distance functions) or surfels, without any knowledge of the scene priors. In this paper, we present DI-Fusion (Deep Implicit Fusion), based on a novel 3D representation, i.e. Probabilistic Local Implicit Voxels (PLIVoxs), for online 3D reconstruction with a commodity RGB-D camera. Our PLIVox encodes scene priors considering both the local geometry and uncertainty parameterized by a deep neural network. With such deep priors, we are able to perform online implicit 3D reconstruction achieving state-of-the-art camera trajectory estimation accuracy and mapping quality, while achieving better storage efficiency compared with previous online 3D reconstruction approaches. Our implementation is available at https://www.github.com/huangjh-pub/di-fusion.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Graphics ; Computer Science - Robotics
    Subject code 004
    Publishing date 2020-12-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Antifungal Activity and Action Mechanisms of 2,4-Di-

    Fan, Kai / Yu, Yinan / Hu, Zheng / Qian, Shen'an / Zhao, Zhihui / Meng, Jiajia / Zheng, Simin / Huang, Qingwen / Zhang, Zhiqi / Nie, Dongxia / Han, Zheng

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 46, Page(s) 17723–17732

    Abstract: Ustilaginoidea ... ...

    Abstract Ustilaginoidea virens
    MeSH term(s) Antifungal Agents/pharmacology ; Hypocreales/genetics ; Phenols/pharmacology ; Oryza/genetics ; Plant Diseases/microbiology
    Chemical Substances 2,4-di-tert-butylphenol (FOB94G6HZT) ; Antifungal Agents ; Phenols
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c05157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bacterial c-di-GMP signaling gene affects mussel larval metamorphosis through outer membrane vesicles and lipopolysaccharides.

    Hu, Xiao-Meng / Peng, Lihua / Wu, Jingxian / Wu, Guanju / Liang, Xiao / Yang, Jin-Long

    NPJ biofilms and microbiomes

    2024  Volume 10, Issue 1, Page(s) 38

    Abstract: ... Within bacterial systems, c-di-GMP functions as a pivotal signaling molecule regulating both biofilm formation and ... dispersion. However, the molecular mechanism of how c-di-GMP modulates biofilm-induced larval metamorphosis ... remains elusive. Our study reveals that the deletion of a c-di-GMP related gene in Pseudoalteromonas ...

    Abstract Biofilms serve as crucial cues for settlement and metamorphosis in marine invertebrates. Within bacterial systems, c-di-GMP functions as a pivotal signaling molecule regulating both biofilm formation and dispersion. However, the molecular mechanism of how c-di-GMP modulates biofilm-induced larval metamorphosis remains elusive. Our study reveals that the deletion of a c-di-GMP related gene in Pseudoalteromonas marina led to an increase in the level of bacterial c-di-GMP by knockout technique, and the mutant strain had an enhanced ability to produce more outer membrane vesicles (OMVs) and lipopolysaccharides (LPS). The mutant biofilms had higher induction activity for larval metamorphosis in mussels Mytilus coruscus, and OMVs play a major role in the induction activity. We further explored the function of LPS in OMVs. Extracted LPS induced high larval metamorphosis rate, and LPS content were subject to c-di-GMP and LPS-biosynthesis gene. Thus, we postulate that the impact of c-di-GMP on biofilm-induced metamorphosis is mediated through OMVs and LPS.
    MeSH term(s) Animals ; Lipopolysaccharides ; Larva/microbiology ; Larva/physiology ; Metamorphosis, Biological/genetics ; Mytilus/genetics ; Mytilus/microbiology ; Bacteria ; Cyclic GMP/analogs & derivatives
    Chemical Substances Lipopolysaccharides ; bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2817021-0
    ISSN 2055-5008 ; 2055-5008
    ISSN (online) 2055-5008
    ISSN 2055-5008
    DOI 10.1038/s41522-024-00508-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria.

    Ling, Xiaocui / Liu, Xiao / Wang, Kun / Guo, Minhao / Ou, Yanzhe / Li, Danting / Xiang, Yulin / Zheng, Jiachen / Hu, Lihua / Zhang, Hongyun / Li, Weihui

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 695

    Abstract: Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial ... species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation ... in mycobacteria in a manner dependent on the nucleoid-associated protein Lsr2. We show that c-di-GMP specifically ...

    Abstract Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation in several bacterial species, but the mechanisms are often unclear. Here, we report that c-di-GMP promotes biofilm formation in mycobacteria in a manner dependent on the nucleoid-associated protein Lsr2. We show that c-di-GMP specifically binds to Lsr2 at a ratio of 1:1. Lsr2 upregulates the expression of HadD, a (3R)-hydroxyacyl-ACP dehydratase, thus promoting the synthesis of keto-mycolic acid and biofilm formation. Thus, Lsr2 acts as a c-di-GMP receptor that links the second messenger's function to lipid synthesis and biofilm formation in mycobacteria.
    MeSH term(s) Mycolic Acids ; Adipogenesis ; Mycobacterium ; Keto Acids ; Biofilms ; Cyclic GMP/analogs & derivatives
    Chemical Substances bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Mycolic Acids ; Keto Acids ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44774-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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