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Article ; Online: Breath: The Exhaust of Metabolism.

Stevenson, David K / Marić, Ivana / Wong, Ronald J

2023 Volume 257, Page(s) 113386

MeSH term(s)	Humans ; Vehicle Emissions ; Respiratory System
Chemical Substances	Vehicle Emissions
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2023.03.002
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Article: Therapeutic Potential of BMP7 in the Treatment of Osteoporosis Caused by the Interaction between Inflammation and Corticosteroids in Inflammatory Bowel Disease.

Smoljan, Ivana / Detel, Dijana / Buljevic, Suncica / Erjavec, Igor / Marić, Ivana

Biomedicines

2023 Volume 11, Issue 8

Abstract: Individuals with inflammatory bowel disease (IBD) have an increased risk of bone impairment, which is a process controlled by the RANKL/RANK/OPG system, mostly due to chronic inflammation and corticosteroid treatment. Bone morphogenic protein 7 (BMP7) ... ...

Abstract	Individuals with inflammatory bowel disease (IBD) have an increased risk of bone impairment, which is a process controlled by the RANKL/RANK/OPG system, mostly due to chronic inflammation and corticosteroid treatment. Bone morphogenic protein 7 (BMP7) has a complex role in maintaining inflammation and bone remodeling but little is known about its anti-inflammatory potential in chronic colitis. We investigated the effect of systemically administered BMP7 and corticosteroids on the severity of inflammation, macrophage differentiation, and bone regeneration in a chronic IBD model. Methods: Chronic colitis was induced in male Sprague Dawley rats via weekly administration of 2,4,6-trinitrobenzenesulfonic acid over 21 days following BMP7 or corticosteroid treatment for five days. The levels of serum and colon tissue inflammatory cytokines, RANKL/OPG system, as well as markers of macrophage polarization, were detected using RT-PCR, ELISA, or immunohistochemistry. Long bone and spine analyses were performed using microcomputed tomography (micro-CT). Results: The administration of BMP7 reduced the adverse effects of colitis and led to elevated OPG and RANK in the colon with a simultaneous decrease in TNF-α and an increase in IL-10 and TGF-β. Decreased expression of the M2 macrophage marker CD163 was found in the BMP7-treated rats compared with the colitis group, whereas the number of M1 marker iNOS-positive cells did not differ between the groups. As a result of the BMP7 treatment, morphometric parameters of trabecular bone increased, and increased trabecular separation noted in the colitis group did not appear. Conclusions: We showed that BMP7 suppressed the inflammatory response in chronic colitis, mainly by shifting the cytokine balance and by triggering alterations in the RANKL/OPG system rather than through a macrophage polarization imbalance. In addition, considering the demonstrated effect of BMP7 on bone morphology and structure, it can be suggested that BMP7 plays a role in the managing of osteoporosis in chronic colitis, and thus, its therapeutic potential in the treatment of IBD should be further evaluated.
Language	English
Publishing date	2023-08-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082161
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Article ; Online: Transovarial toxicity matters: lethal and sublethal effects of hexythiazox on the two-spotted spider mite (Acari: Tetranychidae).

Musa, Asma / Međo, Irena / Marić, Ivana / Marčić, Dejan

Experimental & applied acarology

2022 Volume 87, Issue 2-3, Page(s) 175–194

Abstract: The effects of hexythiazox on life-history traits and demographic parameters of Tetranychus urticae Koch (Acari: Tetranychidae) were evaluated using the age-stage two-sex life table (in fecundity-based and fertility-based variants), with emphasis on its ... ...

Abstract	The effects of hexythiazox on life-history traits and demographic parameters of Tetranychus urticae Koch (Acari: Tetranychidae) were evaluated using the age-stage two-sex life table (in fecundity-based and fertility-based variants), with emphasis on its transovarial toxicity. Hexythiazox was applied when T. urticae females were either in the preovipositional period or in the first day of oviposition. In the F
MeSH term(s)	Animals ; Female ; Life Tables ; Oviposition/drug effects ; Reproduction/drug effects ; Tetranychidae/drug effects ; Thiazolidines/toxicity
Chemical Substances	5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxothiazolidine-3 carboxamide ; Thiazolidines
Language	English
Publishing date	2022-07-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	11320-7
ISSN	1572-9702 ; 0168-8162
ISSN (online)	1572-9702
ISSN	0168-8162
DOI	10.1007/s10493-022-00733-8
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Article ; Online: Enhancing Sustainable Development

Ivana Marić / Ana Aleksić / Maja Knežević

Sustainability, Vol 14, Iss 9094, p

Examining Factors That Foster Creativity and Productivity in Organizations

2022 Volume 9094

Abstract: Innovation and creativity in organizations are becoming imperative to their advancement. These two categories are shaping the new culture of innovation, which managers should take into account when trying to maintain the sustainable development of their ... ...

Abstract	Innovation and creativity in organizations are becoming imperative to their advancement. These two categories are shaping the new culture of innovation, which managers should take into account when trying to maintain the sustainable development of their organizations. This paper examines the contribution of management practice, organizational motivation and resources as the important factors for fostering creativity and innovation in organizations and their effects on productivity. Empirical research using the KEYS methodology was conducted on a sample of employees from innovation-driven organizations. The research results show a positive and significant effect of creativity on organizational productivity. At the same time, the research reveals that challenging tasks, as an element of management practice, and realistic workload pressure, as a resource, strongly contribute to organizational productivity. The paper extends current knowledge on the contribution of management practice, organizational motivation, and resources as factors important for fostering creativity in organizations. Furthermore, the paper contributes by providing a deeper theoretical insight into the concept of the culture of innovation and creativity in an organizational environment.
Keywords	sustainable development ; innovation ; creativity ; culture of innovation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generalist versus Specialist Self-Replicators.

Komáromy, Dávid / Monzón, Diego M / Marić, Ivana / Monreal Santiago, Guillermo / Ottelé, Jim / Altay, Meniz / Schaeffer, Gaël / Otto, Sijbren

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 20, Page(s) e202303837

Abstract: Darwinian evolution, including the selection of the fittest species under given environmental conditions, is a major milestone in the development of synthetic living systems. In this regard, generalist or specialist behavior (the ability to replicate in ... ...

Abstract	Darwinian evolution, including the selection of the fittest species under given environmental conditions, is a major milestone in the development of synthetic living systems. In this regard, generalist or specialist behavior (the ability to replicate in a broader or narrower, more specific food environment) are of importance. Here we demonstrate generalist and specialist behavior in dynamic combinatorial libraries composed of a peptide-based and an oligo(ethylene glycol) based building block. Three different sets of macrocyclic replicators could be distinguished based on their supramolecular organization: two prepared from a single building block as well as one prepared from an equimolar mixture of them. Peptide-containing hexamer replicators were found to be generalists, i. e. they could replicate in a broad range of food niches, whereas the octamer peptide-based replicator and hexameric ethyleneoxide-based replicator were proven to be specialists, i. e. they only replicate in very specific food niches that correspond to their composition. However, sequence specificity cannot be demonstrated for either of the generalist replicators. The generalist versus specialist nature of these replicators was linked to their supramolecular organization. Assembly modes that accommodate structurally different building blocks lead to generalist replicators, while assembly modes that are more restrictive yield specialist replicators.
MeSH term(s)	Peptides
Chemical Substances	Peptides
Language	English
Publishing date	2024-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303837
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Article ; Online: Color and Chemical Stability of 3D-Printed and Thermoformed Polyurethane-Based Aligners.

Šimunović, Luka / Čekalović Agović, Sara / Marić, Antun Jakob / Bačić, Ivana / Klarić, Eva / Uribe, Flavio / Meštrović, Senka

Polymers

2024 Volume 16, Issue 8

Abstract: The significant rise in the use of clear aligners for orthodontic treatment is attributed to their aesthetic appeal, enhancing patient appearance and self-confidence. The aim of this study is to evaluate the aligners' response to common staining agents ( ... ...

Abstract	The significant rise in the use of clear aligners for orthodontic treatment is attributed to their aesthetic appeal, enhancing patient appearance and self-confidence. The aim of this study is to evaluate the aligners' response to common staining agents (coffee, black tea, Coca-Cola, and Red Bull) in color and chemical stability. Polyurethane-based thermoformed and 3D-printed aligners from four brands were exposed to common beverages to assess color change using a VITA Easyshade compact colorimeter after 24 h, 48 h, 72 h, and 7 days, as well as chemical stability using ATR-FTIR spectroscopy. The brand, beverage, and manufacturing method significantly influence color stability. ATR-FTIR analysis revealed compositional differences, with variations in response to beverage exposure affecting the integrity of polymer bonds. Color change analysis showed coffee as the most potent staining agent, particularly affecting Tera Harz TC85 aligners, while ClearCorrect aligners exhibited the least susceptibility. 3D-printed aligners showed a greater color change compared to thermoformed ones. Aligners with a PETG outer layer are more resistant to stains and chemical alterations than those made of polyurethane. Additionally, 3D-printed polyurethane aligners stain more than thermoformed ones. Therefore, PETG-layered aligners are a more reliable choice for maintaining the aesthetic integrity of aligners.
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16081067
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Article ; Online: Hydroxychloroquine in Lupus Pregnancy and Risk of Preeclampsia.

Rector, Amadeia / Marić, Ivana / Chaichian, Yashaar / Chakravarty, Eliza / Cantu, Miranda / Weisman, Michael H / Shaw, Gary M / Druzin, Maurice L / Simard, Julia F

Arthritis & rheumatology (Hoboken, N.J.)

2024

Abstract: Objective: Systemic lupus erythematosus (SLE) disproportionately affects women during childbearing years, and hydroxychloroquine (HCQ) is the standard first-line treatment. Preeclampsia complicates up to one-third of pregnancies in lupus patients, ... ...

Abstract	Objective: Systemic lupus erythematosus (SLE) disproportionately affects women during childbearing years, and hydroxychloroquine (HCQ) is the standard first-line treatment. Preeclampsia complicates up to one-third of pregnancies in lupus patients, although reports vary by parity and multifetal gestation. We investigated whether taking HCQ early in pregnancy may reduce the risk of preeclampsia. Methods: We studied 1,068 live birth singleton pregnancies among 1,020 privately insured patients with SLE (2007-2016). HCQ treatment was defined as three months preconception through the first trimester, and prescription fills were a proxy for taking HCQ. Modified Poisson regression estimated risk ratios (RRs) and 95% confidence intervals (CIs), stratified by parity. Propensity scores accounted for confounders, and stratified analyses examined effect modification. Results: Approximately 15% of pregnant patients were diagnosed with preeclampsia. In 52% of pregnancies, patients had one or more HCQ fills. Pregnant patients exposed to HCQ had more comorbidities, SLE activity, and azathioprine treatment. We found no evidence of a statistical association between HCQ and preeclampsia among nulliparous (RR 1.26 [95% CI 0.82-1.93]) and multiparous pregnancies (RR 1.20 [95% CI 0.80-1.70]). Additional controls for confounding decreased the RRs toward the null (nulliparous pregnancy, propensity score-adjusted [PS-adj] RR 1.09 [95% CI 0.68-1.76]; multiparous pregnancy, PS-adj RR 1.01 [95% CI 0.66-1.53]). Conclusion: Using a large insurance-based database, we did not observe a decreased risk of preeclampsia associated with HCQ treatment in pregnancy, although we cannot rule out residual and unmeasured confounding and misclassification. Further studies leveraging large population-based data and prospective collection could characterize how HCQ influences preeclampsia risk in pregnant patients with SLE and among persons at greater risk of hypertensive disorders of pregnancy.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42793
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Article ; Online: Quantitative profiling and baseline intervals of trace elements in healthy lung tissues.

Stojsavljević, Aleksandar / Marković, Katarina / Lukač, Aleksandar / Ristanović, Aleksandar / Marić, Nebojša / Marković, Stefan / Šarac, Ivana / Ščančar, Janez

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2024 Volume 84, Page(s) 127440

Abstract: Background: Human lung tissue, as an interface with the environment, is susceptible to various environmental pollutants, including trace metals. However, quantitative data on trace metals in human lung tissues remain poorly described.: Methods: This ... ...

Abstract	Background: Human lung tissue, as an interface with the environment, is susceptible to various environmental pollutants, including trace metals. However, quantitative data on trace metals in human lung tissues remain poorly described. Methods: This study aimed to characterize the elemental composition of histologically healthy, unaffected parts of human lung tissues, associated with non-infective, non-infiltrative, and non-malignant diseases (n = 60) for essential (Cr, Mn, Fe, Co, Cu, Zn, and Se) and toxic trace elements (Sr, Ni, As, Cd, and Pb). Additionally, we investigated the influence of personal factors (sex, age, and smoking habits) on the examined trace element profiles, as well as between the trace elements correlations in the healthy human lungs. Results: Among the analyzed trace elements, Fe was the most prevalent, while As was the least prevalent in healthy lung tissues. Stratifying by age revealed significantly higher Cr and Co (less Sr, Ni, and Pb) and lower Se levels in older individuals (above 65 years) compared to their younger counterparts. Sex-based differences were also notable, with Cu and Co 1.2- and 2.3-fold higher levels in females than in males. Exploring the impact of smoking habits revealed a striking 10-fold increase in Cd levels in the lung tissues of smokers compared to non-smokers. Correlation analyses showed significant positive associations between concentrations of certain toxic and essential trace elements in healthy lung tissues. Conclusions: This study could contribute to the establishment of baseline intervals for essential and toxic trace elements, valuable for toxicological and clinical assessment, in healthy, unaffected human lungs, and indicates the influence of sex, age, and smoking. However, further larger-scale studies are needed to make more stable conclusions.
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2024.127440
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Article ; Online: Persistent Bacterial Vaginosis and Risk for Spontaneous Preterm Birth.

Blumenfeld, Yair J / Marić, Ivana / Stevenson, David K / Gibbs, Ronald S / Shaw, Gary M

American journal of perinatology

2023

Abstract: Objective: The aim of this study was to determine the association between persistent bacterial vaginosis (BV) in pregnancy and risk for spontaneous preterm birth (sPTB).: Study design: Retrospective data from IBM MarketScan Commercial Database were ...

Abstract	Objective: The aim of this study was to determine the association between persistent bacterial vaginosis (BV) in pregnancy and risk for spontaneous preterm birth (sPTB). Study design: Retrospective data from IBM MarketScan Commercial Database were analyzed. Women aged between 12 and 55 years with singleton gestations were included and linked to an outpatient medications database and medications prescribed during the pregnancy were analyzed. BV in pregnancy was determined based on both a diagnosis of BV and treatment with metronidazole and/or clindamycin, and persistent treatment of BV was defined as BV in more than one trimester or BV requiring more than one antibiotic prescription. Odds ratios were calculated comparing sPTB frequencies in those with BV, or persistent BV, to women without BV in pregnancy. Survival analysis using Kaplan-Meier curves for the gestational age at delivery was also performed. Results: Among a cohort of 2,538,606 women, 216,611 had an associated International Classification of Diseases, 9th Revision or 10th Revision code for diagnosis of BV alone, and 63,817 had both a diagnosis of BV and were treated with metronidazole and/or clindamycin. Overall, the frequency of sPTB among women treated with BV was 7.5% compared with 5.7% for women without BV who did not receive antibiotics. Relative to those without BV in pregnancy, odds ratios for sPTB were highest in those treated for BV in both the first and second trimester (1.66 [95% confidence interval [CI]: 1.52, 1.81]) or those with three or more prescriptions in pregnancy (1.48 [95% CI: 1.35, 1.63]. Conclusion: Persistent BV may have a higher risk for sPTB than a single episode of BV in pregnancy. Key points: · Persistent BV beyond one trimester may increase the risk for sPTB.. · Persistent BV requiring more than one prescription may increase the risk for sPTB.. · Almost half of antibiotic prescriptions treating BV in pregnancy are filled after 20 weeks gestation..
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0043-1770703
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Article ; Online: Usage of marketing in politics

Marić Ivana

Politeia, Vol 4, Iss 8, Pp 431-

2014 Volume 442

Abstract: Multi-party political system led to competition between political parties which caused the need for marketing in politics that improves political reputation. Politics, based on rich experience of political practice, used existing, developed methods and ... ...

Abstract	Multi-party political system led to competition between political parties which caused the need for marketing in politics that improves political reputation. Politics, based on rich experience of political practice, used existing, developed methods and techniques of commercial marketing. Political marketing openly admits that politics and politicians are simply goods that are being sold on a political market. Political marketing is a whole way of operation by political parties which ask these questions: how do the voters choose; what affects their preference and how that preference can be influenced. Usage of political marketing in Bosnia and Herzegovina is still not on a satisfactory level but the knowledge about the importance of political marketing is increasing.
Keywords	political marketing ; elections ; political parties ; voters ; Social Sciences ; H
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Faculty of Political Sciences, University of Banja Luka, Bosnia and Hercegovina and Institute for Political Studies, Belgrade, Serbia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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