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Article ; Online: Assessing the disease burden of Yi people by years of life lost in Shilin county of Yunnan province, China.

Zhou, Shang-Cheng / Cai, Le / Wan, Chong-Hua / Lv, Yi-Ling / Fang, Peng-Qian

BMC public health

2009 Volume 9, Page(s) 188

Abstract: ... in terms of Yi people in China. This paper uses YLL to estimate the disease burden of Yi people in Shilin ... death certificates in 2003 in Shilin Yi Nationality Autonomous County (Shilin county).: Results: The male had ... premature mortality burden due to injuries in Shilin county. Among the top non-communicable diseases ...

Abstract	Background: Years of Life Lost (YLL) is one of the methods used to estimate the duration of time lost due to premature death. While previous studies of disease burden have been reported using YLL, there have been no studies investigating YLL of Yi people in rural China. Yunnan Province ranks first in terms of Yi people in China. This paper uses YLL to estimate the disease burden of Yi people in Shilin county of Yunnan Province. This study aims to address the differentials about YLL between Yi people and Han people for providing useful information for health planning. Methods: We applied the Global Burden of Disease (GBD) method created by WHO. YLL rate per 1,000 were calculated from medical death certificates in 2003 in Shilin Yi Nationality Autonomous County (Shilin county). Results: The male had greater YLL rate per 1,000 than did the female almost in each age group. It demonstrated a higher premature mortality burden due to injuries in Shilin county. Among the top non-communicable diseases, respiratory diseases are the most common mortality burden. Yi people are still suffering from maternal conditions, with two times the burden rates of Han people. For Yi people, while malignant neoplasm was one of the least burden of disease for male, it was the greatest for female, which is the opposite to Han people. Conclusion: Strategies of economic development should be reviewed to enhance the prevention and treatment of injuries, maternal conditions and respiratory diseases for Yi people.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Cause of Death ; Child ; Child, Preschool ; China/epidemiology ; Cost of Illness ; Female ; Humans ; Infant ; Life Expectancy ; Life Tables ; Male ; Middle Aged ; Mortality ; Sex Distribution ; Young Adult
Language	English
Publishing date	2009-06-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/1471-2458-9-188
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Article ; Online: Assessing the disease burden of Yi people by years of life lost in Shilin county of Yunnan province, China

Lv Yi-Ling / Wan Chong-Hua / Cai Le / Zhou Shang-Cheng / Fang Peng-Qian

BMC Public Health, Vol 9, Iss 1, p

2009 Volume 188

Abstract: ... in terms of Yi people in China. This paper uses YLL to estimate the disease burden of Yi people in Shilin ... in 2003 in Shilin Yi Nationality Autonomous County (Shilin county). Results The male had greater YLL rate ... burden due to injuries in Shilin county. Among the top non-communicable diseases, respiratory diseases ...

Abstract	Abstract Background Years of Life Lost (YLL) is one of the methods used to estimate the duration of time lost due to premature death. While previous studies of disease burden have been reported using YLL, there have been no studies investigating YLL of Yi people in rural China. Yunnan Province ranks first in terms of Yi people in China. This paper uses YLL to estimate the disease burden of Yi people in Shilin county of Yunnan Province. This study aims to address the differentials about YLL between Yi people and Han people for providing useful information for health planning. Methods We applied the Global Burden of Disease (GBD) method created by WHO. YLL rate per 1,000 were calculated from medical death certificates in 2003 in Shilin Yi Nationality Autonomous County (Shilin county). Results The male had greater YLL rate per 1,000 than did the female almost in each age group. It demonstrated a higher premature mortality burden due to injuries in Shilin county. Among the top non-communicable diseases, respiratory diseases are the most common mortality burden. Yi people are still suffering from maternal conditions, with two times the burden rates of Han people. For Yi people, while malignant neoplasm was one of the least burden of disease for male, it was the greatest for female, which is the opposite to Han people. Conclusion Strategies of economic development should be reviewed to enhance the prevention and treatment of injuries, maternal conditions and respiratory diseases for Yi people.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	390
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: MS4A1 as a Potential Independent Prognostic Factor of Breast Cancer Related to Lipid Metabolism and Immune Microenvironment Based on TCGA Database Analysis.

Li, Shilin / Fang, Yi

Medical science monitor : international medical journal of experimental and clinical research

2022 Volume 28, Page(s) e934597

Abstract: BACKGROUND Lipid metabolism has been proved to be related to the prognosis of breast cancer patients in previous studies, and the tumor immune microenvironment (TIME) plays an important role in tumorigenesis and development, but the dynamic regulation of ...

Abstract	BACKGROUND Lipid metabolism has been proved to be related to the prognosis of breast cancer patients in previous studies, and the tumor immune microenvironment (TIME) plays an important role in tumorigenesis and development, but the dynamic regulation of these is still a challenge. MATERIAL AND METHODS This study used lipid metabolism-related pathways to score the gene expression of 980 breast cancer patients in the TCGA database. We used 4 pathways in HALLMARK related to lipid metabolism to score the genes in the database. The differentially expressed genes (DEGs) were further analyzed through survival analysis and Cox regression analysis, and MS4A1, which is associated with better prognosis, was finally determined to be a predictor. In-depth analysis found that MS4A1 was negatively correlated with patient age, clinical stage, tumor size, and distant metastasis. In the MS4A1 high-expression group, most genes were enriched in immune-related pathways, and CIBERSORT analysis found that MS4A1 expression was positively correlated with the abundance of 10 kinds of immune cells, such as CD8+T cells, which are related to the active immune status. RESULTS Our results suggest that MS4A1 expression can indicate the situation of lipid metabolism in breast cancer patients and reflect the status of the immune microenvironment. CONCLUSIONS MS4A1 has the potential to be an independent indicator of prognosis. Since the expression of MS4A1 is also related to the immune checkpoint mutation burden, detecting its expression level can also provide guidance for choosing treatment options.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Databases, Genetic ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genome/genetics ; Genome/immunology ; Glycoproteins/genetics ; Humans ; Lipid Metabolism/genetics ; Lymphocytes, Tumor-Infiltrating/immunology ; Prognosis ; Tumor Microenvironment/immunology
Chemical Substances	Biomarkers, Tumor ; Glycoproteins ; MS4A1 protein, human
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.934597
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Article ; Online: The excitatory effect of 5-HT

Jiang, Pengxin / Fang, Shilin / Huang, Nini / Lu, Weiqun

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

2023 Volume 283, Page(s) 111457

Abstract: The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) plays an essential role in the regulation of neural activity via multiple receptors. Here, we investigated the functional role of serotoninergic input on the Dahlgren cell population in the ... ...

Abstract	The neurotransmitter 5-hydroxytryptamine (5-HT, serotonin) plays an essential role in the regulation of neural activity via multiple receptors. Here, we investigated the functional role of serotoninergic input on the Dahlgren cell population in the caudal neurosecretory system (CNSS) of olive flounder. In this study, the effect of 5-HT on the firing activity of Dahlgren cells was explored in terms of changes in firing frequency and firing pattern using multicellular recording electrophysiology ex vivo, and the role of several 5-HT receptor subtypes in the regulation was determined. The results revealed that 5-HT increased the firing frequency in a concentration-dependent manner and altered the firing pattern of Dahlgren cells. The effect of 5-HT on the firing activity of Dahlgren cells was mediated through the 5-HT
MeSH term(s)	Animals ; Serotonin/pharmacology ; Flounder/physiology ; Neurosecretory Systems/physiology ; Neurotransmitter Agents
Chemical Substances	Serotonin (333DO1RDJY) ; Neurotransmitter Agents
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121246-1
ISSN	1531-4332 ; 0300-9629 ; 1095-6433
ISSN (online)	1531-4332
ISSN	0300-9629 ; 1095-6433
DOI	10.1016/j.cbpa.2023.111457
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Article ; Online: Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders.

Jia, Shilin / Yang, Hui / Huang, Fang / Fan, Wenguo

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2023 Volume 72, Issue 9, Page(s) 1895–1907

Abstract: Perioperative neurocognitive disorder (PND) is a common disorder following anesthesia and surgery, especially in the elderly. The complex cellular and molecular processes are involved in PND, but the underlying pathogenesis of which remains inconclusive ... ...

Abstract	Perioperative neurocognitive disorder (PND) is a common disorder following anesthesia and surgery, especially in the elderly. The complex cellular and molecular processes are involved in PND, but the underlying pathogenesis of which remains inconclusive due to conflicting data. A growing body of evidence has been shown that perioperative systemic inflammation plays important roles in the development of PND. We reviewed the relevant literature retrieved by a search in the PubMed database (on July 20, 2023). The search terms used were "delirium", "post operative cognitive dysfunction", "perioperative neurocognitive disorder", "inflammation" and "systemic", alone and in combination. All articles identified were English-language, full-text papers. The ones cited in the review are those that make a substantial contribution to the knowledge about systemic inflammation and PNDs. The aim of this review is to bring together the latest evidence for the understanding of how perioperative systemic inflammation mediates neuroinflammation and brain injury, how the inflammation is regulated and how we can translate these findings into prevention and/or treatment for PND.
MeSH term(s)	Humans ; Aged ; Neuroinflammatory Diseases ; Neurocognitive Disorders/etiology ; Neurocognitive Disorders/pathology ; Neurocognitive Disorders/prevention & control ; Inflammation/prevention & control
Language	English
Publishing date	2023-09-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-023-01792-2
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Zs.A 675: Show issues

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Article ; Online: Design, synthesis, and activity evaluation of novel multitargeted l-tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease.

Zeng, Xianghao / Cheng, Shaobing / Li, Huilan / Yu, Haiyang / Cui, Yushun / Fang, Yuanying / Yang, Shilin / Feng, Yulin

Archiv der Pharmazie

2024 , Page(s) e2300603

Abstract: Alzheimer's disease (AD) is a multifactorial neurological disease, and the multitarget directed ligand (MTDL) strategy may be an effective approach to delay its progression. Based on this strategy, 27 derivatives of l-tryptophan, 3a-1-3d-1, were designed, ...

Abstract	Alzheimer's disease (AD) is a multifactorial neurological disease, and the multitarget directed ligand (MTDL) strategy may be an effective approach to delay its progression. Based on this strategy, 27 derivatives of l-tryptophan, 3a-1-3d-1, were designed, synthesized, and evaluated for their biological activity. Among them, IC
Language	English
Publishing date	2024-01-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300603
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Article ; Online: The soil emergence-related transcription factor PIF3 controls root penetration by interacting with the receptor kinase FER.

Xu, Fan / Chen, Jia / Li, Yingbin / Ouyang, Shilin / Yu, Mengting / Wang, Yirong / Fang, Xianming / He, Kai / Yu, Feng

Developmental cell

2024 Volume 59, Issue 4, Page(s) 434–447.e8

Abstract: The cotyledons of etiolated seedlings from terrestrial flowering plants must emerge from the soil surface, while roots must penetrate the soil to ensure plant survival. We show here that the soil emergence-related transcription factor PHYTOCHROME- ... ...

Abstract	The cotyledons of etiolated seedlings from terrestrial flowering plants must emerge from the soil surface, while roots must penetrate the soil to ensure plant survival. We show here that the soil emergence-related transcription factor PHYTOCHROME-INTERACTING FACTOR 3 (PIF3) controls root penetration via transducing external signals perceived by the receptor kinase FERONIA (FER) in Arabidopsis thaliana. The loss of FER function in Arabidopsis and soybean (Glycine max) mutants resulted in a severe defect in root penetration into agar medium or hard soil. Single-cell RNA sequencing (scRNA-seq) profiling of Arabidopsis roots identified a distinct cell clustering pattern, especially for root cap cells, and identified PIF3 as a FER-regulated transcription factor. Biochemical, imaging, and genetic experiments confirmed that PIF3 is required for root penetration into soil. Moreover, FER interacted with and stabilized PIF3 to modulate the expression of mechanosensitive ion channel PIEZO and the sloughing of outer root cap cells.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Phosphotransferases/metabolism ; Phytochrome/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Arabidopsis Proteins ; Basic Helix-Loop-Helix Transcription Factors ; Phosphotransferases (EC 2.7.-) ; Phytochrome (11121-56-5) ; PIF3 protein, Arabidopsis ; Transcription Factors ; At3g51550 protein, Arabidopsis (EC 2.7.-)
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2024.01.001
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A comparison of pregnancy outcomes and congenital malformations in offspring between patients undergoing intracytoplasmic sperm injection and conventional in vitro fertilization: a retrospective cohort study.

Zhang, Nan / Tian, Tian / Li, Jia / Zhu, Xiaxuan / Jiesisibieke, Dina / Fang, Shilin / Liu, Ping / Li, Rong / Qiao, Jie / Yang, Rui

Fertility and sterility

2024

Abstract: Objective: To explore whether intracytoplasmic sperm injection (ICSI) would increase the malformation risk in fetuses and live births compared with conventional in vitro fertilization (IVF).: Design: Retrospective cohort study.: Patient(s): Data ... ...

Abstract	Objective: To explore whether intracytoplasmic sperm injection (ICSI) would increase the malformation risk in fetuses and live births compared with conventional in vitro fertilization (IVF). Design: Retrospective cohort study. Patient(s): Data were collected from couples who underwent conventional IVF or ICSI from January 2009 to December 2019 at the Center for Reproductive Medicine of Peking University Third Hospital in the People's Republic of China. A total of 46,167 conventional IVF fresh transfer cycles and 33,247 ICSI fresh transfer cycles were included. Intervention(s): Intracytoplasmic sperm injection and conventional IVF. Main outcome measure(s): The primary outcomes were congenital abnormalities in live births. The secondary outcomes included the pregnancy outcomes, the malformations among the miscarriages, specific types of malformations in live births, birth weight, and sex. Result(s): The rates of congenital malformations in conventional IVF and ICSI were 5.44‰ and 5.78‰, respectively. There was no statistically significant difference between the two groups, as indicated by the adjusted odds ratio of 1.098 (95% confidence interval 0.787, 1.532). The rates of specific malformations were comparable between ICSI and IVF. Additionally, no discernible disparities were noted in pregnancy outcomes, the malformations among the miscarriages,birth weight between the two groups. Conclusion: Our study suggested the safety of ICSI and provided novel evidence by comparing pregnancy outcomes and congenital malformations in offspring between patients undergoing conventional IVF and ICSI.
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2024.01.025
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Article ; Online: Understanding gene regulation during the development of the sea cucumber Apostichopus japonicus using comparative transcriptomics

Fang Su / Shilin Liu / Lili Xing / Da Huo / Hongsheng Yang / Lina Sun

Frontiers in Marine Science, Vol

2023 Volume 10

Abstract: Embryonic development, especially metamorphosis and settlement, has a major impact on the life history of marine invertebrates. Apostichopus japonicus is an economically important species of sea cucumber. In this study, we performed RNA sequencing on six ...

Abstract	Embryonic development, especially metamorphosis and settlement, has a major impact on the life history of marine invertebrates. Apostichopus japonicus is an economically important species of sea cucumber. In this study, we performed RNA sequencing on six key stages of A. japonicas development: fertilized eggs, blastula, gastrula, auricularia, doliolaria, and pentactula. A total of 32,353 genes were identified and annotated as a reference gene set for subsequent pairwise comparison analysis. After filtering out low-quality genes, the dynamic molecular responses to development were revealed by WGCNA. The results showed that of the 20 modules, genes in the blue, yellow, and darkslateblue modules were highly correlated with the gastrula, auricularia, and blastula stages, respectively. GO terms for “RNA” and “proteasome complex” were most significantly enriched in the blue module. In the darkslateblue and yellow module, receptors of signaling pathways and metabolic processes were significantly enriched, respectively. All DEGs were categorized into 34 terms, mainly associated with signal transduction and cellular immunity. The expression pattern of genes associated with adhesion, cell cycle, signal, transcription factor, extracellular matrix (ECM), and cytoskeleton was analyzed according to gene function. The results of this study facilitated a more comprehensive understanding of the molecular characteristics of sea cucumber embryonic development and will provide theoretical guidance for larva rearing in sea cucumber culture.
Keywords	Apostichopus japonicus ; development ; metamorphosis ; RNA-Seq ; WGCNA ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	572
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article: Peripheral role of glutamate in orofacial pain.

Liu, Jinyue / Jia, Shilin / Huang, Fang / He, Hongwen / Fan, Wenguo

Frontiers in neuroscience

2022 Volume 16, Page(s) 929136

Abstract: Glutamate is the principal excitatory neurotransmitter in the central nervous system. In the periphery, glutamate acts as a transmitter and involves in the signaling and processing of sensory input. Glutamate acts at several types of receptors and also ... ...

Abstract	Glutamate is the principal excitatory neurotransmitter in the central nervous system. In the periphery, glutamate acts as a transmitter and involves in the signaling and processing of sensory input. Glutamate acts at several types of receptors and also interacts with other transmitters/mediators under various physiological and pathophysiological conditions including chronic pain. The increasing amount of evidence suggests that glutamate may play a role through multiple mechanisms in orofacial pain processing. In this study, we reviewed the current understanding of how peripheral glutamate mediates orofacial pain, how glutamate is regulated in the periphery, and how these findings are translated into therapies for pain conditions.
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.929136
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