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  1. Article: Navigating Now and Next: Recent Advances and Future Horizons in Robotic Radical Prostatectomy.

    Mian, Abrar H / Tollefson, Matthew K / Shah, Paras / Sharma, Vidit / Mian, Ahmed / Thompson, R Houston / Boorjian, Stephen A / Frank, Igor / Khanna, Abhinav

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Robotic-assisted radical prostatectomy (RARP) has become the leading approach for radical prostatectomy driven by innovations aimed at improving functional and oncological outcomes. The initial advancement in this field was transperitoneal multiport ... ...

    Abstract Robotic-assisted radical prostatectomy (RARP) has become the leading approach for radical prostatectomy driven by innovations aimed at improving functional and oncological outcomes. The initial advancement in this field was transperitoneal multiport robotics, which has since undergone numerous technical modifications. These enhancements include the development of extraperitoneal, transperineal, and transvesical approaches to radical prostatectomy, greatly facilitated by the advent of the Single Port (SP) robot. This review offers a comprehensive analysis of these evolving techniques and their impact on RARP. Additionally, we explore the transformative role of artificial intelligence (AI) in digitizing robotic prostatectomy. AI advancements, particularly in automated surgical video analysis using computer vision technology, are unprecedented in their scope. These developments hold the potential to revolutionize surgeon feedback and assessment and transform surgical documentation, and they could lay the groundwork for real-time AI decision support during surgical procedures in the future. Furthermore, we discuss future robotic platforms and their potential to further enhance the field of RARP. Overall, the field of minimally invasive radical prostatectomy for prostate cancer has been an incubator of innovation over the last two decades. This review focuses on some recent developments in robotic prostatectomy, provides an overview of the next frontier in AI innovation during prostate cancer surgery, and highlights novel robotic platforms that may play an increasing role in prostate cancer surgery in the future.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differential Assessment of Internal Jugular Vein Stenosis in Patients Undergoing CT and MRI with Contrast.

    Abdalkader, Mohamad / Miller, Matthew I / Klein, Piers / Hui, Ferdinand K / Siracuse, Jeffrey J / Mian, Asim Z / Sakai, Osamu / Nguyen, Thanh N / Setty, Bindu N

    Tomography (Ann Arbor, Mich.)

    2024  Volume 10, Issue 2, Page(s) 266–276

    Abstract: Objective: Internal Jugular Vein Stenosis (IJVS) is hypothesized to play a role in the pathogenesis of diverse neurological diseases. We sought to evaluate differences in IJVS assessment between CT and MRI in a retrospective patient cohort.: Methods: ...

    Abstract Objective: Internal Jugular Vein Stenosis (IJVS) is hypothesized to play a role in the pathogenesis of diverse neurological diseases. We sought to evaluate differences in IJVS assessment between CT and MRI in a retrospective patient cohort.
    Methods: We included consecutive patients who had both MRI of the brain and CT of the head and neck with contrast from 1 June 2021 to 30 June 2022 within the same admission. The degree of IJVS was categorized into five grades (0-IV).
    Results: A total of 35 patients with a total of 70 internal jugular (IJ) veins were included in our analysis. There was fair intermodality agreement in stenosis grades (κ = 0.220, 95% C.I. = [0.029, 0.410]), though categorical stenosis grades were significantly discordant between imaging modalities, with higher grades more frequent in MRI (χ
    Conclusion: MRI with contrast overestimates the degree of IJVS compared to CT with contrast. Consideration of this discrepancy should be considered in diagnosis and treatment planning in patients with potential IJVS-related symptoms.
    MeSH term(s) Humans ; Constriction, Pathologic/diagnostic imaging ; Constriction, Pathologic/pathology ; Jugular Veins/diagnostic imaging ; Jugular Veins/pathology ; Retrospective Studies ; Magnetic Resonance Imaging ; Vascular Diseases/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography10020021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Prognostic Survival Model Incorporating Patient-Reported Outcomes for Transplant-Ineligible Patients With Multiple Myeloma.

    Mian, Hira / Seow, Hsien / Balitsky, Amaris K / Cheung, Matthew C / Gayowsky, Anastasia / Tay, Jason / Wildes, Tanya M / McCurdy, Arleigh / Visram, Alissa / Sandhu, Irwindeep / Sutradhar, Rinku

    The oncologist

    2024  

    Abstract: Developing prognostic tools specifically for patients themselves represents an important step in empowering patients to engage in shared decision-making. Incorporating patient-reported outcomes may improve the accuracy of these prognostic tools. We ... ...

    Abstract Developing prognostic tools specifically for patients themselves represents an important step in empowering patients to engage in shared decision-making. Incorporating patient-reported outcomes may improve the accuracy of these prognostic tools. We conducted a retrospective population-based study of transplant-ineligible (TIE) patients with multiple myeloma (MM) diagnosed between January 2007 and December 2018. A multivariable Cox regression model was developed to predict the risk of death within 1-year period from the index date. We identified 2356 patients with TIE MM. The following factors were associated with an increased risk of death within 1 year: age > 80 (HR 1.11), history of heart failure (HR 1.52), "CRAB" at diagnosis (HR 1.61), distance to cancer center (HR 1.25), prior radiation (HR 1.48), no proteosome inhibitor/immunomodulatory therapy usage (HR 1.36), recent emergency department (HR 1.55) or hospitalization (HR 2.13), poor performance status (ECOG 3-4 HR 1.76), and increasing number of severe symptoms (HR 1.56). Model discrimination was high with C-statistic of 0.74, and calibration was very good. To our knowledge, this represents one of the first prognostic models developed in MM incorporating patient-reported outcomes. This survival prognostic tool may improve communication regarding prognosis and shared decision-making among older adults with MM and their health care providers.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyae041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biodegradation in oil sands process-affected water: A comprehensive laboratory analysis of the in situ biodegradation of dissolved organic acids.

    Asiedu, Evelyn / Zhao, Kankan / Anwar, Mian Nabeel / Ross, Matthew / Balaberda, Amy-Lynne / Ulrich, Ania C

    Chemosphere

    2023  Volume 349, Page(s) 141018

    Abstract: Oil sands process-affected water (OSPW) is a by-product of the extraction of bitumen, and volumes of OSPW have accumulated across the Alberta oil sands region due to the governments zero-discharge policy. Some dissolved organics in OSPW, including toxic ... ...

    Abstract Oil sands process-affected water (OSPW) is a by-product of the extraction of bitumen, and volumes of OSPW have accumulated across the Alberta oil sands region due to the governments zero-discharge policy. Some dissolved organics in OSPW, including toxic naphthenic acids (NAs), can be biodegraded in oxic conditions, thereby reducing the toxicity of OSPW. While there has been much focus on degradation of NAs, the biodegradation of other dissolved organic chemicals by endogenous organisms remains understudied. Here, using the HPLC-ultrahigh resolution Orbitrap mass spectrometry, we examined the microbial biodegradation of dissolved organic acids in OSPW. Non-targeted analysis enabled the estimation of biodegradation rates for unique heteroatomic chemical classes detected in negative ion mode. The microcosm experiments were conducted with and without nutrient supplementation, and the changes in the microbial community over time were investigated. Without added nutrients, internal standard-adjusted intensities of all organics, including NAs, were largely unchanged. The addition of nutrients increased the biodegradation rate of O
    MeSH term(s) Oil and Gas Fields ; Water Pollutants, Chemical/analysis ; Organic Chemicals ; Carboxylic Acids/chemistry ; Oxygen/analysis
    Chemical Substances Water Pollutants, Chemical ; Organic Chemicals ; naphthenic acid (YNM5U6B7A4) ; Carboxylic Acids ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.141018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sulfated Zirconium Metal-Organic Frameworks as Well-Defined Supports for Enhancing Organometallic Catalysis.

    Syed, Zoha H / Mian, Mohammad Rasel / Patel, Roshan / Xie, Haomiao / Pengmei, Zihan / Chen, Zhihengyu / Son, Florencia A / Goetjen, Timothy A / Chapovetsky, Alon / Fahy, Kira M / Sha, Fanrui / Wang, Xingjie / Alayoglu, Selim / Kaphan, David M / Chapman, Karena W / Neurock, Matthew / Gagliardi, Laura / Delferro, Massimiliano / Farha, Omar K

    Journal of the American Chemical Society

    2022  Volume 144, Issue 37, Page(s) 16883–16897

    Abstract: Understanding heterogeneous catalysts is a challenging pursuit due to surface site nonuniformity and aperiodicity in traditionally used materials. One example is sulfated metal oxides, which function as highly active catalysts and as supports for ... ...

    Abstract Understanding heterogeneous catalysts is a challenging pursuit due to surface site nonuniformity and aperiodicity in traditionally used materials. One example is sulfated metal oxides, which function as highly active catalysts and as supports for organometallic complexes. These applications are due to traits such as acidity, ability to act as a weakly coordinating ligand, and aptitude for promoting transformations via radical cation intermediates. Research is ongoing about the structural features of sulfated metal oxides that imbue the aforementioned properties, such as sulfate geometry and coordination. To better understand these materials, metal-organic frameworks (MOFs) have been targeted as structurally defined analogues. Composed of inorganic nodes and organic linkers, MOFs possess features such as high porosity and crystallinity, which make them attractive for mechanistic studies of heterogeneous catalysts. In this work, Zr
    MeSH term(s) Ammonia ; Benzene ; Catalysis ; Ligands ; Metal-Organic Frameworks/chemistry ; Oxides/chemistry ; Sulfates ; Sulfur Oxides ; Toluene ; Zirconium/chemistry
    Chemical Substances Ligands ; Metal-Organic Frameworks ; Oxides ; Sulfates ; Sulfur Oxides ; Toluene (3FPU23BG52) ; Ammonia (7664-41-7) ; Zirconium (C6V6S92N3C) ; Benzene (J64922108F)
    Language English
    Publishing date 2022-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c05290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Workaholism on Job Burnout: A Comparison Between American and Chinese Employees.

    Cheung, Francis / Tang, Catherine S K / Lim, Matthew Sheng Mian / Koh, Jie Min

    Frontiers in psychology

    2018  Volume 9, Page(s) 2546

    Abstract: Past research frequently reports significant relation between workaholism and job burnout, and some studies further indicate workaholism varies across countries. Surprisingly, there is no study that directly examines whether country moderates the ... ...

    Abstract Past research frequently reports significant relation between workaholism and job burnout, and some studies further indicate workaholism varies across countries. Surprisingly, there is no study that directly examines whether country moderates the workaholism-burnout association. To address this research question, we have collected independent work samples from two culturally diverse countries, namely the People's Republic of China and the United States. A total of 2243 participants (1243 American respondents and 1000 Chinese respondents) were recruited. Preliminary group comparison suggested that there were statistical differences among participants from different industries on the key variables, including workaholism, job demands, autonomy and emotional exhaustion. Therefore, we have divided our participants into three subsamples [i.e., (1) natural resources, mining and construction industry, (2) manufacturing industry, and (3) service industry] and separate analyses were conducted. In the moderated regression analyses, workaholism significantly predicted two dimensions of job burnout, namely emotional exhaustion and depersonalization, even when job demand and job autonomy were controlled. Finally, although two significant moderating effects were found, there was a lack of consistent empirical support to the hypothesized moderating effect of country on workaholism-burnout association. Implications and limitations were discussed.
    Language English
    Publishing date 2018-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2018.02546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Serine/threonine kinase PpkA coordinates the interplay between T6SS2 activation and quorum sensing in the marine pathogen Vibrio alginolyticus

    Yang, Zhen / Zhou, Xiaohui / Ma, Yue / Zhou, Mian / Waldor, Matthew K / Zhang, Yuanxing / Wang, Qiyao

    Environmental microbiology. 2018 Feb., v. 20, no. 2

    2018  

    Abstract: Type VI secretion systems (T6SS) are multiprotein secretion machines that can mediate killing of bacterial cells and thereby modify the composition of bacterial communities. The mechanisms that control the production of and secretion of these killing ... ...

    Abstract Type VI secretion systems (T6SS) are multiprotein secretion machines that can mediate killing of bacterial cells and thereby modify the composition of bacterial communities. The mechanisms that control the production of and secretion of these killing machines are incompletely understood, although quorum sensing (QS) and the PpkA kinase modulate T6SS activity in some organisms. Here we investigated control the T6S in the marine organism Vibrio alginolyticus EPGS, which encodes two T6SS systems (T6SS1 and T6SS2). We found that the organism principally relies on T6SS2 for interbacterial competition. We further carried out a phosphoproteomic screen to identify substrates of the T6SS2‐linked PpkA2 kinase. Substrates of PpkA2 encoded within the T6SS2 cluster as well proteins that are apparently not linked to T6SS‐related processes were identified. Similar to other organisms, PpkA2 autophosphorylation was critical for T6SS2 function. Notably, phosphorylation of a polypeptide encoded outside of the T6SS2 cluster, VtsR, was critical for T6SS2 expression and function because it augments the expression of luxR, a key regulator of QS that also promotes T6SS2 gene expression. Thus, PpkA2 controls a phosphorylation cascade that mediates a positive regulatory loop entwining T6SS and QS, thereby coordinating these pathways to enhance the competitive fitness of V. alginolyticus.
    Keywords Vibrio alginolyticus ; aquatic organisms ; bacteria ; bacterial communities ; equipment ; gene expression ; pathogens ; polypeptides ; protein phosphorylation ; protein-serine-threonine kinases ; quorum sensing ; secretion ; type VI secretion system
    Language English
    Dates of publication 2018-02
    Size p. 903-919.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2020213-1
    ISSN 1462-2920 ; 1462-2912
    ISSN (online) 1462-2920
    ISSN 1462-2912
    DOI 10.1111/1462-2920.14039
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Intraspinal migration of a clavicular Steinmann pin: case report and management strategy.

    Mian, Matthew K / Nahed, Brian V / Walcott, Brian P / Coumans, Jean-Valery

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2012  Volume 19, Issue 2, Page(s) 310–313

    Abstract: Spine injury resulting from migration of previously implanted appendicular skeleton fixation hardware is rare. We present a 41-year-old man who had Steinmann fixation pins placed for a left clavicular fracture 2 years prior. He presented with a burning ... ...

    Abstract Spine injury resulting from migration of previously implanted appendicular skeleton fixation hardware is rare. We present a 41-year-old man who had Steinmann fixation pins placed for a left clavicular fracture 2 years prior. He presented with a burning sensation over his biceps bilaterally and numbness over the left anterior chest and abdomen following a significant blunt traumatic injury. A CT scan revealed migration of a fractured Steinmann pin entering the left C8 neural foramen, traversing anterior to the spinal cord. The patient underwent a left C7 hemilaminectomy, foraminal decompression, and first rib resection to identify the extraforaminal portion of the pin and remove it under direct vision. He recovered uneventfully. We conclude that a principle of safe surgical removal includes adequate exposure to allow for direct visualization of the pin and neural structures. We review the evaluation and management strategies of this unusual condition.
    MeSH term(s) Adult ; Bone Nails/adverse effects ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Foreign-Body Migration/diagnostic imaging ; Foreign-Body Migration/surgery ; Humans ; Internal Fixators/adverse effects ; Male ; Neurosurgical Procedures/methods ; Radiography ; Spinal Cord/diagnostic imaging ; Spinal Cord/surgery
    Language English
    Publishing date 2012-02
    Publishing country Scotland
    Document type Case Reports ; Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2011.05.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas.

    Ding, Xiaofan / He, Mian / Chan, Anthony W H / Song, Qi Xiu / Sze, Siu Ching / Chen, Hui / Man, Matthew K H / Man, Kwan / Chan, Stephen L / Lai, Paul B S / Wang, Xin / Wong, Nathalie

    Gastroenterology

    2020  

    Abstract: Background & aims: Intratumor heterogeneity and divergent clonal lineages within and among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic and epigenetic variations within liver ... ...

    Abstract Background & aims: Intratumor heterogeneity and divergent clonal lineages within and among primary and recurrent hepatocellular carcinomas (HCCs) produce challenges to patient management. We investigated genetic and epigenetic variations within liver tumors, among hepatic lesions, and between primary and relapsing tumors.
    Methods: Tumor and matched nontumor liver specimens were collected from 113 patients who underwent partial hepatectomy for primary or recurrent HCC at 2 hospitals in Hong Kong. We performed whole-genome, whole-exome, or targeted capture sequencing analyses of 356 HCC specimens collected from multiple tumor regions and matched initial and recurrent tumors. We performed parallel DNA methylation profiling analyses of 95 specimens. Genomes and epigenomes of nontumor tissues that contained areas of cirrhosis or fibrosis were analyzed. We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity. Cells were analyzed by immunoblotting and chromatin immunoprecipitation with quantitative polymerase chain reaction.
    Results: We determined the monoclonal origins of individual tumors using a single-sample collection approach that captured more than 90% of mutations that are detected in all regions of tumors. Phylogenetic and phyloepigenetic analyses showed interactions and codependence between the genomic and epigenomic features of HCCs. Methylation analysis showed a field effect in cirrhotic liver tissues that predisposes them to tumor development. Comparisons of genetic features showed that 52% of recurrent HCCs derive from the clonal lineage of the initial tumor. The clonal origin of recurrent HCCs allowed construction of a temporal map of genetic alterations that were associated with tumor recurrence. Activation of JAK signaling to STAT was a characteristic of HCC progression via mutations that are associated with response to drug sensitivity. The combination of a mutation that increases the function of TP53 and the 17p chromosome deletion might provide liver cancer cells with a replicative advantage. Chromatin immunoprecipitation analysis of TP53 with the R249S substitution showed its interaction with genes that encode chromatin regulators (MLL1 and MLL2). We validated MLL1 and MLL2 as direct targets of TP53
    Conclusions: We performed a systematic evaluation of intra- and intertumor genetic heterogeneity in HCC samples and identified genetic and epigenetic changes that are associated with tumor progression and recurrence. We identified chromatin regulators that are up-regulated by mutant TP53 in HCC cells and inhibitors that reduce proliferation of these cells. DNA methylation patterns in cirrhotic or fibrotic liver tissues might be used to identify those at risk of HCC development.
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2019.09.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sulfated Zirconium Metal–Organic Frameworks as Well-Defined Supports for Enhancing Organometallic Catalysis

    Syed, Zoha H. / Mian, Mohammad Rasel / Patel, Roshan / Xie, Haomiao / Pengmei, Zihan / Chen, Zhihengyu / Son, Florencia A. / Goetjen, Timothy A. / Chapovetsky, Alon / Fahy, Kira M. / Sha, Fanrui / Wang, Xingjie / Alayoglu, Selim / Kaphan, David M. / Chapman, Karena W. / Neurock, Matthew / Gagliardi, Laura / Delferro, Massimiliano / Farha, Omar K.

    Journal of the American Chemical Society. 2022 Sept. 12, v. 144, no. 37

    2022  

    Abstract: Understanding heterogeneous catalysts is a challenging pursuit due to surface site nonuniformity and aperiodicity in traditionally used materials. One example is sulfated metal oxides, which function as highly active catalysts and as supports for ... ...

    Abstract Understanding heterogeneous catalysts is a challenging pursuit due to surface site nonuniformity and aperiodicity in traditionally used materials. One example is sulfated metal oxides, which function as highly active catalysts and as supports for organometallic complexes. These applications are due to traits such as acidity, ability to act as a weakly coordinating ligand, and aptitude for promoting transformations via radical cation intermediates. Research is ongoing about the structural features of sulfated metal oxides that imbue the aforementioned properties, such as sulfate geometry and coordination. To better understand these materials, metal–organic frameworks (MOFs) have been targeted as structurally defined analogues. Composed of inorganic nodes and organic linkers, MOFs possess features such as high porosity and crystallinity, which make them attractive for mechanistic studies of heterogeneous catalysts. In this work, Zr₆-based MOF NU-1000 is sulfated and characterized using techniques such as single crystal X-ray diffraction in addition to diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). The dynamic nature of the sulfate binding motif is found to transition from monodentate, to bidentate, to tridentate depending on the degree of hydration, as supported by density functional theory (DFT) calculations. Heightened Brønsted acidity compared to the parent MOF was observed upon sulfation and probed through trimethylphosphine oxide physisorption, ammonia sorption, in situ ammonia DRIFTS, and DFT studies. With the support structure benchmarked, an organoiridium complex was chemisorbed onto the sulfated MOF node, and the efficacy of this supported catalyst was demonstrated for stoichiometric and catalytic activation of benzene-d₆ and toluene with structure–activity relationships derived.
    Keywords Fourier transform infrared spectroscopy ; X-ray diffraction ; acidity ; ammonia ; catalysts ; catalytic activity ; cations ; crystal structure ; density functional theory ; geometry ; ligands ; porosity ; sorption ; stoichiometry ; sulfates ; toluene ; zirconium
    Language English
    Dates of publication 2022-0912
    Size p. 16883-16897.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c05290
    Database NAL-Catalogue (AGRICOLA)

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