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Article ; Online: Trans-superior ophthalmic vein approach for treatment of carotid-cavernous fistula.

Srinivasan, Visish M / Sen, Anish N / Kan, Peter

2019 Volume 46, Issue Suppl_2, Page(s) V4

Abstract: The authors present a case of a patient with a Barrow Type B carotid-cavernous fistula (CCF) who presented with severe symptoms of eye redness, diplopia, and proptosis. Due to the tortuosity and size of her angular vein and the lack of good flow/access ... ...

Abstract	The authors present a case of a patient with a Barrow Type B carotid-cavernous fistula (CCF) who presented with severe symptoms of eye redness, diplopia, and proptosis. Due to the tortuosity and size of her angular vein and the lack of good flow/access via the inferior petrosal sinus, she was treated with a transvenous approach via a large, dilated superior ophthalmic vein for coil embolization of the CCF. The patient had a full angiographic and symptomatic cure. The authors present the treatment plan and strategy and the fluoroscopic recording of the treatment. Nuances of the technique are discussed.The video can be found here: https://youtu.be/ABkGm17-cBU.
MeSH term(s)	Carotid-Cavernous Sinus Fistula/surgery ; Cavernous Sinus/surgery ; Embolization, Therapeutic/methods ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Veins/surgery
Language	English
Publishing date	2019-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2019.4.FocusVid.18496
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Article ; Online: Letter to the Editor: The role of neurosurgeons in mild traumatic brain injury.

Srinivasan, Visish M / Karas, Patrick J / Sen, Anish N / Fridley, Jared S

Journal of neurosurgery

2016 Volume 125, Issue 1, Page(s) 233

Language	English
Publishing date	2016-05-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2015.12.JNS152964
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Article: Laryngotracheal Resection in Thyroid Cancer - Experience from a Single Centre Series of 22 Cases.

Chakravarthy, N Siddhartha / Thomas, Varghese / Sam, Thomas Shawn / Sen, Supriya / Cherian, Anish Jacob / Abraham, Deepak Thomas / Jacob, Paul Mazhuvanchary

Indian journal of surgical oncology

2021 Volume 13, Issue 1, Page(s) 51–60

Abstract: Involvement of the aerodigestive tract is reported in one-third of patients with locally invasive thyroid cancer. It is associated with significant morbidity and mortality, with airway obstruction being the immediate cause of death in 50% of patients who ...

Abstract	Involvement of the aerodigestive tract is reported in one-third of patients with locally invasive thyroid cancer. It is associated with significant morbidity and mortality, with airway obstruction being the immediate cause of death in 50% of patients who die of thyroid cancer. Management is challenging and includes the risks of extensive surgery as well as decisions regarding the type of surgery and adjuvant therapy. Retrospective cohort study, reporting institutional experience with patients who underwent laryngotracheal resection for invasive thyroid cancer over the past 10 years. Twenty-two patients were included in the study. All patients had Shin stage 4 disease. The median follow-up was 18 months. Five patients had systemic metastasis at diagnosis. Nineteen patients underwent tracheal resection and end to end anastomosis, and 3 underwent laryngectomy. The mean length of the resected trachea was 2.94 cm. Tracheal releasing manoeuvres were utilized in 11 patients. Three patients required a tracheostomy postoperatively. Other complications included a temporary vocal cord palsy in 5 patients, temporary hypocalcemia in 6 and permanent hypocalcemia in 1 patient. Adjuvant radiotherapy was utilized in 9 patients and I-131 therapy in 13 patients. Three patients died during follow-up. Two patients developed thyroid bed recurrence, two patients developed systemic metastasis on follow-up. Most patients survived for a prolonged period with only biochemical evidence of disease persistence and three with no evidence of disease. Laryngotracheal resection with primary anastomosis is a safe and effective option, providing adequate symptomatic relief as well as prolonged survival in carefully selected patients with invasive Shin stage 4 disease.
Language	English
Publishing date	2021-08-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-021-01407-4
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Article: Clinical application of near-infrared spectroscopy in patients with traumatic brain injury: a review of the progress of the field.

Sen, Anish N / Gopinath, Shankar P / Robertson, Claudia S

Neurophotonics

2016 Volume 3, Issue 3, Page(s) 31409

Abstract: Near-infrared spectroscopy (NIRS) is a technique by which the interaction between light in the near-infrared spectrum and matter can be quantitatively measured to provide information about the particular chromophore. Study into the clinical application ... ...

Abstract	Near-infrared spectroscopy (NIRS) is a technique by which the interaction between light in the near-infrared spectrum and matter can be quantitatively measured to provide information about the particular chromophore. Study into the clinical application of NIRS for traumatic brain injury (TBI) began in the 1990s with early reports of the ability to detect intracranial hematomas using NIRS. We highlight the advances in clinical applications of NIRS over the past two decades as they relate to TBI. We discuss recent studies evaluating NIRS techniques for intracranial hematoma detection, followed by the clinical application of NIRS in intracranial pressure and brain oxygenation measurement, and conclude with a summary of potential future uses of NIRS in TBI patient management.
Language	English
Publishing date	2016-04-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2781943-7
ISSN	2329-4248 ; 2329-423X
ISSN (online)	2329-4248
ISSN	2329-423X
DOI	10.1117/1.NPh.3.3.031409
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Article ; Online: Intraoperative Computed Tomography Angiography: A Novel Completion Imaging Modality for Carotid Endarterectomy.

Sen, Anish N / Fridley, Jared / Sebastian, Sherly / Duckworth, Edward A M

Operative neurosurgery (Hagerstown, Md.)

2017 Volume 13, Issue 6, Page(s) 739–745

Abstract: Background: Intraoperative computed tomography angiography (ICTA) is a novel completion imaging modality for carotid endarterectomy (CEA). No studies exist in the literature describing ICTA use in CEA.: Objective: To evaluate the feasibility and ... ...

Abstract	Background: Intraoperative computed tomography angiography (ICTA) is a novel completion imaging modality for carotid endarterectomy (CEA). No studies exist in the literature describing ICTA use in CEA. Objective: To evaluate the feasibility and efficacy of ICTA as a method of immediately evaluating the technical results of CEA. Methods: Twenty-three consecutive CEAs were performed by a single neurosurgeon over an 8-month period. Of this series, 12 utilized ICTA for completion imaging, 10 utilized duplex ultrasonography (US), and 1 utilized no intraoperative completion imaging. Electronic medical records were reviewed to assess demographics, CTA results, US results, and need for revisions. Results: Patients included 13 men (62%) and 8 women (38%). All patients had symptomatic internal carotid artery stenosis. Polytetrafluoroethylene (PTFE) patch angioplasty was used in 16 cases (70%). Average operative times were comparable between cases that utilized CTA and US, 180 and 175 min, respectively. Major technical defects were identified in one of the 12 cases utilizing ICTA and none of the 10 cases utilizing intraoperative US. The technical defect was revised without subsequent neurological complication. One patient had a postoperative intracerebral hemorrhage requiring surgical evacuation. Fifteen patients were followed for up to 3 months with no postoperative stroke or transient ischemic attacks. Conclusion: ICTA is a potentially safe and effective completion imaging modality compared to traditional alternatives, enabling the identification of technical deficits intraoperatively. While no statistically significant difference in operative times were noted between intraoperative CTA and US use, numerous steps must be taken to maximize the efficiency of ICTA.
MeSH term(s)	Aged ; Angiography, Digital Subtraction ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Computed Tomography Angiography ; Endarterectomy, Carotid/methods ; Female ; Humans ; Magnetic Resonance Angiography ; Male ; Middle Aged ; Monitoring, Intraoperative/instrumentation ; Monitoring, Intraoperative/methods
Language	English
Publishing date	2017-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1093/ons/opw036
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Article ; Online: Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 18

Abstract: Poor antitumor response of pancreatic cancer to immunotherapies is a major barrier to effective disease management. Herein we show that pancreatic cancers overexpress vasoactive intestinal peptide, and pharmacological inhibition of its signaling ... ...

Abstract	Poor antitumor response of pancreatic cancer to immunotherapies is a major barrier to effective disease management. Herein we show that pancreatic cancers overexpress vasoactive intestinal peptide, and pharmacological inhibition of its signaling significantly enhances responsiveness of pancreatic ductal adenocarcinoma to immune checkpoint therapy, thus improving overall survival in mouse models.
Keywords	Science ; Q
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma.

Nature communications

2022 Volume 13, Issue 1, Page(s) 6418

Abstract: A paucity of effector T cells within tumors renders pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint therapies. While several under-development approaches target immune-suppressive cells in the tumor microenvironment, there is less ... ...

Abstract	A paucity of effector T cells within tumors renders pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint therapies. While several under-development approaches target immune-suppressive cells in the tumor microenvironment, there is less focus on improving T cell function. Here we show that inhibiting vasoactive intestinal peptide receptor (VIP-R) signaling enhances anti-tumor immunity in murine PDAC models. In silico data mining and immunohistochemistry analysis of primary tumors indicate overexpression of the neuropeptide vasoactive intestinal peptide (VIP) in human PDAC tumors. Elevated VIP levels are also present in PDAC patient plasma and supernatants of cultured PDAC cells. Furthermore, T cells up-regulate VIP receptors after activation, identifying the VIP signaling pathway as a potential target to enhance T cell function. In mouse PDAC models, VIP-R antagonist peptides synergize with anti-PD-1 antibody treatment in improving T cell recruitment into the tumors, activation of tumor-antigen-specific T cells, and inhibition of T cell exhaustion. In contrast to the limited single-agent activity of anti-PD1 antibodies or VIP-R antagonist peptides, combining both therapies eliminate tumors in up to 40% of animals. Furthermore, tumor-free mice resist tumor re-challenge, indicating anti-cancer immunological memory generation. VIP-R signaling thus represents a tumor-protective immune-modulatory pathway that is targetable in PDAC.
MeSH term(s)	Humans ; Mice ; Animals ; Vasoactive Intestinal Peptide/pharmacology ; Carcinoma, Pancreatic Ductal/drug therapy ; Pancreatic Neoplasms/drug therapy ; Receptors, Vasoactive Intestinal Peptide ; Signal Transduction ; Tumor Microenvironment ; Pancreatic Neoplasms
Chemical Substances	Vasoactive Intestinal Peptide (37221-79-7) ; Receptors, Vasoactive Intestinal Peptide
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-34242-4
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Article ; Online: Intracranial Hypertension Caused by Occipital Calvarial Hemangioma: Case Report.

Srinivasan, Visish M / Karas, Patrick J / Sen, Anish N / Fridley, Jared S / Gopinath, Shankar P

World neurosurgery

2016 Volume 91, Page(s) 672.e1–3

Abstract: Background: Primary intraosseous calvarial hemangiomas (PICHs) are generally rare and predominate (3:1) in women. Occurrence in the frontal and parietal bones is most common, but involvement of the occipital bone is exceedingly rare, representing 3 of ... ...

Abstract	Background: Primary intraosseous calvarial hemangiomas (PICHs) are generally rare and predominate (3:1) in women. Occurrence in the frontal and parietal bones is most common, but involvement of the occipital bone is exceedingly rare, representing 3 of 125 cases in a series of PICHs studied by Heckl et al. in 2000. Histopathology establishes the diagnosis of cavernous hemangioma, which represents the most common subtype of intraosseous hemangiomas. Others include sclerosing, cellular, and capillary. When they do occur in the calvarium, they are most often asymptomatic and discovered incidentally or due to a palpable defect in the skull. Case description: In this case, a calvarial hemangioma was found to be the cause of elevated intracranial pressure in a 35-year-old woman. Resection of the hemangioma and reconstruction of the calvarium provided a complete cure for her symptoms. Conclusions: Primary intraosseous hemangiomas are rarely symptomatic but must be considered in the differential for calvarial lesions as part of safe surgical planning. Formulating an accurate differential diagnosis by acquiring proper imaging studies and specifically recognizing the classical "starburst" appearance, as well as considering the highly vascular pathology to avoid excess blood loss, is important. This unique case of a hemangioma-induced venous sinus compression and subsequent elevated intracranial pressure illustrates that hemangiomas can arise from any part of the calvarium and cause a wide variety of clinical symptoms.
MeSH term(s)	Adult ; Female ; Hemangioma, Cavernous/complications ; Hemangioma, Cavernous/diagnostic imaging ; Hemangioma, Cavernous/surgery ; Humans ; Intracranial Hypertension/diagnostic imaging ; Intracranial Hypertension/etiology ; Intracranial Hypertension/surgery ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Obesity/complications ; Occipital Bone/diagnostic imaging ; Occipital Bone/pathology ; Skull Neoplasms/complications ; Skull Neoplasms/diagnostic imaging ; Skull Neoplasms/surgery ; Tomography Scanners, X-Ray Computed
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2016.04.009
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Article ; Online: Anticancer activity and other biomedical properties of β-sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches.

Nandi, Sudeshna / Nag, Anish / Khatua, Somanjana / Sen, Surjit / Chakraborty, Nilanjan / Naskar, Arghya / Acharya, Krishnendu / Calina, Daniela / Sharifi-Rad, Javad

Phytotherapy research : PTR

2023 Volume 38, Issue 2, Page(s) 592–619

Abstract: Sterols, including β-sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of β-sitosterol and ... ...

Abstract	Sterols, including β-sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of β-sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. β-sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of β-sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of β-sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of β-sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of β-sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of β-sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. β-sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of β-sitosterol have also shown anti-cancer effects. However, research in the field of drug delivery and the detailed mode of action of β-sitosterol-mediated anticancer activities remains limited. β-sitosterol, as a non-toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, β-sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of β-sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on β-sitosterol as a potent superfood in combating cancer.
MeSH term(s)	Humans ; Male ; Animals ; Plant Extracts/pharmacology ; Sitosterols/pharmacology ; Sitosterols/therapeutic use ; Prostatic Neoplasms ; Leukemia ; Phytosterols ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Ethnopharmacology
Chemical Substances	gamma-sitosterol (5LI01C78DD) ; Plant Extracts ; Sitosterols ; Phytosterols ; Phytochemicals
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8061
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Article ; Online: Occipital Artery Pseudoaneurysm After Posterior Fossa Craniotomy.

Srinivasan, Visish M / Karas, Patrick J / Sen, Anish N / Fridley, Jared S / Chen, Stephen R / Gopinath, Shankar P

World neurosurgery

2017 Volume 98, Page(s) 868.e1–868.e4

Abstract: Background: Pseudoaneurysms of scalp arteries have been reported in rare cases after iatrogenic injury; however, they are far more commonly seen after traumatic injuries. They are usually associated with the superficial temporal artery; however, there ... ...

Abstract	Background: Pseudoaneurysms of scalp arteries have been reported in rare cases after iatrogenic injury; however, they are far more commonly seen after traumatic injuries. They are usually associated with the superficial temporal artery; however, there have been a few reports of psuedoaneurysms of the occipital artery (OA). Case description: We present a unique case of an OA pseudoaneurysm presenting with delayed postoperative hemorrhage after a retrosigmoid craniotomy. The pseudoaneurysm was treated by coil embolization. Conclusions: The patient recovered fully after endovascular embolization. Other treatment options for pseudoaneurysms of facial, temporal, and scalp arteries include surgical clipping/trapping with excision, Hunterian ligation, or direct compression. Pseudoaneurysms of extracranial scalp arteries are rare and most often caused by traumatic compression of the artery against a bony ridge. Despite their rarity, pseudoaneurysms secondary to iatrogenic injury to extracranial arteries should be considered in the differential diagnosis in patients presenting with delayed incisional pain, redness, and swelling.
MeSH term(s)	Aneurysm, False/etiology ; Aneurysm, False/surgery ; Cerebral Arterial Diseases/etiology ; Cerebral Arterial Diseases/surgery ; Craniotomy/adverse effects ; Embolization, Therapeutic/methods ; Endovascular Procedures/methods ; Humans ; Middle Aged ; Occipital Lobe/blood supply ; Postoperative Complications/etiology ; Postoperative Complications/surgery
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2016.12.050
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