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  1. Article: Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review.

    Alito, Angelo / Fontana, Jacopo Maria / Franzini Tibaldeo, Eleonora / Verme, Federica / Piterà, Paolo / Miller, Elzbieta / Cremascoli, Riccardo / Brioschi, Andrea / Capodaglio, Paolo

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: Multiple sclerosis (MS) is the most common cause of non-traumatic long-term disability in young adults. Whole-body cryostimulation (WBC) is a cold-based physical therapy known to induce physiological exercise-mimicking changes in the cardiovascular, ... ...

    Abstract Multiple sclerosis (MS) is the most common cause of non-traumatic long-term disability in young adults. Whole-body cryostimulation (WBC) is a cold-based physical therapy known to induce physiological exercise-mimicking changes in the cardiovascular, neuromuscular, immune, and endocrine systems and to influence functional and psychological parameters by exposing the human body to cryogenic temperatures (≤-110 °C) for 2-3 min. The purpose of this scoping review is to present an overall view on the potential role of WBC as an adjuvant therapy in the treatment of MS. PubMed, ScienceDirect, Embase, and Web of Science were searched up to 30 November 2023, and a total of 13 articles were included. WBC may have beneficial antioxidant effects as a short-term adjuvant treatment in MS. There were no significant changes in antioxidant enzymes, nitric oxide levels, metalloproteinase levels, blood counts, rheology, and biochemistry. WBC can lead to a reduction in fatigue and an improvement in functional status, with a significant effect on both mental and physical well-being. There were no reported adverse effects. The results suggest that WBC may complement therapeutic options for patients with MS, as the effects of cryogenic cold stimulation have been shown to activate antioxidant processes and improve functional status, mood, anxiety, and fatigue.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13072003
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  2. Article ; Online: Deep brain stimulation for trigeminal autonomic cephalalgias.

    Messina, Giuseppe / Broggi, Giovanni / Levi, Vincenzo / Franzini, Angelo

    Expert review of neurotherapeutics

    2018  Volume 18, Issue 5, Page(s) 421–426

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2018-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2018.1462702
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  3. Article ; Online: An unusual surgical indication for cerebral tuberculosis: status dystonicus. Case report.

    Franzini, Andrea / Franzini, Angelo / Levi, Vincenzo / Cordella, Roberto / Messina, Giuseppe

    Acta neurochirurgica

    2018  Volume 160, Issue 7, Page(s) 1355–1358

    Abstract: Actual indications for surgery in tuberculosis are limited to obtaining a diagnosis, acquiring tissue for culture studies, treating hydrocephalus, aspiring a brain abscess, and reducing intracranial pressure in patients with multiple tuberculomas. ... ...

    Abstract Actual indications for surgery in tuberculosis are limited to obtaining a diagnosis, acquiring tissue for culture studies, treating hydrocephalus, aspiring a brain abscess, and reducing intracranial pressure in patients with multiple tuberculomas. Tuberculosis-related movement disorders are usually treated pharmacologically. We report on a child affected by post-tubercular generalized dystonia, who progressed to status dystonicus (SD) and underwent stereotactic bilateral pallidotomy. After surgery, SD resolved, and drugs were rapidly tapered. The successful reversal of SD and the motor improvement observed in our patient demonstrate the safety, feasibility, and clinical efficacy of pallidotomy in post-tuberculous-meningoencephalitis dystonia and SD.
    MeSH term(s) Child ; Dystonia/etiology ; Dystonia/pathology ; Dystonia/surgery ; Female ; Globus Pallidus/surgery ; Humans ; Pallidotomy/adverse effects ; Pallidotomy/methods ; Postoperative Complications/prevention & control ; Tuberculosis, Meningeal/complications ; Tuberculosis, Meningeal/pathology ; Tuberculosis, Meningeal/surgery
    Language English
    Publishing date 2018-05-15
    Publishing country Austria
    Document type Case Reports ; Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-018-3561-5
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  4. Article ; Online: Is Deep Brain Stimulation still an option for tremor recurrence after Focused Ultrasound thalamotomy? A case report.

    Levi, Vincenzo / Eleopra, Roberto / Franzini, Angelo / Romito, Luigi

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2019  Volume 68, Page(s) 344–346

    Abstract: With the development of MRI-guided focused ultrasound (FUS), there is an ongoing renewal of interest for ablative procedures as a surgical option for tremor disorders. One of the main criticisms regarding FUS thalamotomy is the potential recurrence of ... ...

    Abstract With the development of MRI-guided focused ultrasound (FUS), there is an ongoing renewal of interest for ablative procedures as a surgical option for tremor disorders. One of the main criticisms regarding FUS thalamotomy is the potential recurrence of tremor symptoms during follow-up. In case of tremor reappearance, repeating the ultrasound ablation may represent a reasonable option. However, tremor is often perceived as a highly disabling condition and patients may be reluctant to undergo the same unsuccessful treatment again. In this context, few data are available about the feasibility of Deep Brain Stimulation (DBS) in case of tremor recurrence after FUS. Moreover, concerns exist that FUS lesioning could preclude or limit the effectiveness of future DBS. Here we present the case of a 73-year-old right-handed man with a disabling, right-hand, mixed tremor recurring after initial successful FUS thalamotomy and that was properly managed in the end with thalamic Deep Brain Stimulation. Our case suggests that DBS and FUS thalamotomy are not mutually exclusive, but rather they represent complementary tools in the surgical approach to tremor.
    MeSH term(s) Aged ; Deep Brain Stimulation/methods ; Essential Tremor/therapy ; Hand ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Recurrence ; Thalamus/physiopathology ; Thalamus/surgery ; Treatment Outcome ; Ultrasonic Therapy/methods
    Language English
    Publishing date 2019-07-18
    Publishing country Scotland
    Document type Case Reports ; Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2019.07.035
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  5. Article: Characteristics of Patients Returning to Work After Brain Tumor Surgery.

    Schiavolin, Silvia / Mariniello, Arianna / Broggi, Morgan / Acerbi, Francesco / Schiariti, Marco / Franzini, Angelo / Di Meco, Francesco / Ferroli, Paolo / Leonardi, Matilde

    Frontiers in human neuroscience

    2021  Volume 14, Page(s) 609080

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2020.609080
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  6. Article ; Online: Correction to:"Careful" reprogramming of baclofen intrathecal programmable synchromed infusion pumps at their replacement in a series of 156 patients.

    Dones, Ivano / Messina, Giuseppe / Franzini, Angelo

    Acta neurochirurgica

    2017  Volume 159, Issue 12, Page(s) 2449

    Abstract: The original version of this article unfortunately contained mistakes. The names of all authors are inadvertently inverted and are now corrected in the authorgroup of this article. ...

    Abstract The original version of this article unfortunately contained mistakes. The names of all authors are inadvertently inverted and are now corrected in the authorgroup of this article.
    Language English
    Publishing date 2017-10-17
    Publishing country Austria
    Document type Journal Article ; Published Erratum
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-017-3364-0
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  7. Article ; Online: Conservative treatment for bilateral subdural hematomas.

    Perin, Alessandro / Messina, Giuseppe / Di Meco, Francesco / Franzini, Angelo

    Journal of neurosurgical sciences

    2018  Volume 64, Issue 1, Page(s) 124–125

    MeSH term(s) Adult ; Blood Patch, Epidural/methods ; Conservative Treatment/methods ; Female ; Hematoma, Subdural, Intracranial/complications ; Hematoma, Subdural, Intracranial/therapy ; Humans ; Intracranial Hypotension/etiology
    Language English
    Publishing date 2018-02-23
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.18.04332-1
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  8. Article ; Online: Surgery for treatment of refractory chronic cluster headache: toward standard procedures.

    Franzini, Angelo / Messina, Giuseppe

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2015  Volume 36 Suppl 1, Page(s) 131–135

    Abstract: The degree of disability due to chronic cluster headache refractory to conservative treatments justifies surgical procedures as second-line treatments. Many studies and reports nowadays confirm the efficacy of the two mostly used surgical techniques in ... ...

    Abstract The degree of disability due to chronic cluster headache refractory to conservative treatments justifies surgical procedures as second-line treatments. Many studies and reports nowadays confirm the efficacy of the two mostly used surgical techniques in such cases. Both deep brain stimulation and occipital nerve stimulation are in fact currently utilized for this purpose but the surgical technique has not yet been standardized. We describe the surgical steps of both procedures.
    MeSH term(s) Brain/physiology ; Cluster Headache/therapy ; Electric Stimulation Therapy/methods ; Electrodes, Implanted ; Female ; Humans ; Male ; Neuroimaging ; Peripheral Nerves/physiology
    Language English
    Publishing date 2015-05
    Publishing country Italy
    Document type News
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-015-2179-0
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  9. Article ; Online: Posterior hypothalamic deep brain stimulation. The impact on cluster headache control and other indications.

    Broggi, Giovanni / Franzini, Angelo

    World neurosurgery

    2014  Volume 82, Issue 1-2, Page(s) 68–69

    MeSH term(s) Cluster Headache/drug therapy ; Cluster Headache/surgery ; Deep Brain Stimulation/methods ; Humans ; Hypothalamus, Posterior/surgery ; Male
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2013.02.091
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    Zs.A 1159: Show issues Location:
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  10. Article ; Online: Staged pallidotomy: MRI and clinical follow-up in status dystonicus.

    Franzini, Angelo / Levi, Vincenzo / Franzini, Andrea / Dones, Ivano / Messina, Giuseppe

    British journal of neurosurgery

    2017  Volume 33, Issue 2, Page(s) 184–187

    Abstract: Purpose: We report on a patient affected by Status Distonicus who was treated with Deep Brain Stimulation electrodes implanted in the Globus Pallidus internus (Gpi) and used for serial radiofrequency lesions.: Materials and methods: The evolution of ... ...

    Abstract Purpose: We report on a patient affected by Status Distonicus who was treated with Deep Brain Stimulation electrodes implanted in the Globus Pallidus internus (Gpi) and used for serial radiofrequency lesions.
    Materials and methods: The evolution of radiofrequency lesions was monitored by post-operative and late Magnetic Resonance Imaging (MRI). After the first lesion the patient did improve, though not in a significant fashion. Therefore, three further radiofrequency lesions were delivered 2, 4 and 6 days respectively after surgery with subsequent improvement of dystonic movements.
    Results: MRI scans performed at 8 days, 3 months, and 6 months after surgery showed a diffuse T2-hyperintense and T1-hypointense GPi signal alteration which progressively decreased over time.
    Conclusion: We confirm that the possibility to stage pallidotomies over time using a couple of new contacts is a safe and efficacious procedure in treating SD patients where the lesions themselves are limited by the appearance of side effects, or in patients showing a poor response to a single lesion. As far as we know, this is the first description of MRI evolution and monitoring of a staged pallidotomy.
    MeSH term(s) Child ; Conservative Treatment/methods ; Deep Brain Stimulation/methods ; Dystonia/surgery ; Follow-Up Studies ; Globus Pallidus/surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Pallidotomy/methods ; Postoperative Care ; Treatment Outcome
    Language English
    Publishing date 2017-11-28
    Publishing country England
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2017.1409875
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