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  1. Article ; Online: Comment from professor Andreas Schulze-Bonhage on: Lesion-focused stereotactic thermo-coagulation of focal cortical dysplasia II-B: a new approach to epilepsy surgery?

    Schulze-Bonhage, Andreas

    Seizure

    2014  Volume 23, Issue 6, Page(s) 478

    MeSH term(s) Electrocoagulation ; Epilepsy/surgery ; Humans ; Malformations of Cortical Development, Group I/surgery ; Stereotaxic Techniques
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2014.02.013
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    Zs.A 3573: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: A realistic and patient-specific perspective on EEG-based seizure detection.

    Schulze-Bonhage, Andreas

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2022  Volume 138, Page(s) 191–192

    MeSH term(s) Algorithms ; Electroencephalography ; Humans ; Seizures/diagnosis ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2022-03-17
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2022.03.006
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  3. Article ; Online: Seizure prediction: Time for new, multimodal and ultra-long-term approaches.

    Schulze-Bonhage, Andreas

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Volume 133, Page(s) 152–153

    MeSH term(s) Electroencephalography ; Humans ; Seizures/diagnosis
    Language English
    Publishing date 2021-11-05
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.10.006
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  4. Article ; Online: Malformations of cortical development as models of altered brain excitability.

    Schulze-Bonhage, Andreas

    The Lancet. Neurology

    2021  Volume 20, Issue 11, Page(s) 882–883

    MeSH term(s) Brain ; Humans ; Malformations of Cortical Development ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2021-10-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(21)00342-2
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    Zs.A 5955: Show issues Location:
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  5. Article ; Online: Termination of seizures by ictal transcranial focal cortex stimulation.

    Hirsch, Martin / Coenen, Volker Arnd / Schulze-Bonhage, Andreas

    Epilepsia open

    2023  Volume 8, Issue 2, Page(s) 673–677

    Abstract: Whereas high-level evidence exists on chronic neuromodulatory effects of different brain stimulation approaches in reducing seizure frequency, evidence for acute antiseizure effects of electrical brain stimulation during seizures is sparse. As part of an ...

    Abstract Whereas high-level evidence exists on chronic neuromodulatory effects of different brain stimulation approaches in reducing seizure frequency, evidence for acute antiseizure effects of electrical brain stimulation during seizures is sparse. As part of an ongoing trial, we implanted a patient with a novel focal cortex stimulation (FCS) device with a Laplacian electrode placed over a precentral focal cortical dysplasia. The baseline seizure frequency was 125 per month, consisting of (i) focal aware sensory seizures that invariably progressed to uni- or bilateral tonic contraction and clonic jerking, and (ii) primary motor seizures. Besides an overall reduction in seizure frequency, on-demand stimulation had an immediate effect on seizures with a sensory phase, whereby 63%-86% of these seizures were terminated by ictal stimulation. These observations provide the first evidence that ictal self-triggered transcranial focal cortex stimulation can significantly interfere with the progression of seizure semiology.
    MeSH term(s) Humans ; Brain ; Cerebral Cortex ; Deep Brain Stimulation ; Electric Stimulation ; Seizures/therapy ; Male ; Adult
    Language English
    Publishing date 2023-03-26
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12728
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  6. Article ; Online: Value of ultralong-term subcutaneous EEG monitoring for treatment decisions in temporal lobe epilepsy: A case report.

    Hirsch, Martin / Novitskaya, Yulia / Schulze-Bonhage, Andreas

    Epilepsia open

    2023  Volume 8, Issue 4, Page(s) 1616–1621

    Abstract: Treatment decisions in epilepsy critically depend on information on the course of the disease, its severity and options for specific local interventions. We here report a patient with pharmaco-resistant non-lesional temporal lobe epilepsy with evidence ... ...

    Abstract Treatment decisions in epilepsy critically depend on information on the course of the disease, its severity and options for specific local interventions. We here report a patient with pharmaco-resistant non-lesional temporal lobe epilepsy with evidence for predominant right temporal epileptogenesis. While seizure frequency had been grossly underestimated for many years, ultralong-term monitoring with a subcutaneous EEG device revealed actual seizure frequency (66 over 11 months vs four patient-documented seizures), providing objective data on treatment efficacy and additional supportive lateralizing information that played a decisive role for the choice of surgical treatment, which had been rejected by the patient prior to this information.
    MeSH term(s) Humans ; Epilepsy, Temporal Lobe/diagnosis ; Epilepsy, Temporal Lobe/surgery ; Electroencephalography ; Seizures ; Epilepsy ; Monitoring, Physiologic
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12844
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  7. Article ; Online: Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.

    Novitskaya, Yulia / Dümpelmann, Matthias / Schulze-Bonhage, Andreas

    Frontiers in network physiology

    2023  Volume 3, Page(s) 1297345

    Abstract: Over the past decades, studies of human brain networks have received growing attention as the assessment and modelling of connectivity in the brain is a topic of high impact with potential application in the understanding of human brain organization ... ...

    Abstract Over the past decades, studies of human brain networks have received growing attention as the assessment and modelling of connectivity in the brain is a topic of high impact with potential application in the understanding of human brain organization under both physiological as well as various pathological conditions. Under specific diagnostic settings, human neuronal signal can be obtained from intracranial EEG (iEEG) recording in epilepsy patients that allows gaining insight into the functional organisation of living human brain. There are two approaches to assess brain connectivity in the iEEG-based signal: evaluation of spontaneous neuronal oscillations during ongoing physiological and pathological brain activity, and analysis of the electrophysiological cortico-cortical neuronal responses, evoked by single pulse electrical stimulation (SPES). Both methods have their own advantages and limitations. The paper outlines available methodological approaches and provides an overview of current findings in studies of physiological and pathological human brain networks, based on intracranial EEG recordings.
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2674-0109
    ISSN (online) 2674-0109
    DOI 10.3389/fnetp.2023.1297345
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  8. Article ; Online: Neurostimulation targeting the epileptic focus: Current understanding and perspectives for treatment.

    Schulze-Bonhage, Andreas / Nitsche, Michael A / Rotter, Stefan / Focke, Niels K / Rao, Vikram R

    Seizure

    2024  Volume 117, Page(s) 183–192

    Abstract: For the one third of people with epilepsy whose seizures are not controlled with medications, targeting the seizure focus with neurostimulation can be an effective therapeutic strategy. In this focused review, we summarize a discussion of targeted ... ...

    Abstract For the one third of people with epilepsy whose seizures are not controlled with medications, targeting the seizure focus with neurostimulation can be an effective therapeutic strategy. In this focused review, we summarize a discussion of targeted neurostimulation modalities during a workshop held in Frankfurt, Germany in September 2023. Topics covered include: available devices for seizure focus stimulation; alternating current (AC) and direct current (DC) stimulation to reduce focal cortical excitability; modeling approaches to simulate DC stimulation; reconciling the efficacy of focal stimulation with the network theory of epilepsy; and the emerging concept of 'neurostimulation zones,' which are defined as cortical regions where focal stimulation is most effective for reducing seizures and which may or may not directly involve the seizure onset zone. By combining experimental data, modeling results, and clinical outcome analysis, rational selection of target regions and stimulation parameters is increasingly feasible, paving the way for a broader use of neurostimulation for epilepsy in the future.
    MeSH term(s) Humans ; Epilepsy/therapy ; Electric Stimulation Therapy/methods
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2024.03.001
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    Zs.A 3573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Add-on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study.

    Novitskaya, Yulia / Schütz, Elisa / Metternich, Birgitta / Schulze-Bonhage, Andreas / Hirsch, Martin

    Epilepsia

    2024  Volume 65, Issue 3, Page(s) 630–640

    Abstract: Objective: Cenobamate, a novel antiseizure medication with a dual mechanism of action, has been shown in pivotal trials to significantly improve seizure control in treatment-resistant focal epilepsy. We aimed to evaluate whether these promising results ... ...

    Abstract Objective: Cenobamate, a novel antiseizure medication with a dual mechanism of action, has been shown in pivotal trials to significantly improve seizure control in treatment-resistant focal epilepsy. We aimed to evaluate whether these promising results could be confirmed in a real-world setting with a follow-up period of up to 12 months.
    Methods: Patients from a tertiary epilepsy center who received cenobamate add-on between June 2021 and October 2023 were followed up prospectively at 3, 6, and 12 months after treatment initiation for assessment of seizure outcomes and treatment-related adverse events.
    Results: The clinical cohort included 112 adult patients with 30% nonlesional cases and a wide spectrum of epileptogenic lesions underlying refractory focal epilepsy. We observed a significant reduction in monthly seizure frequency of all seizure types already after 3 months of treatment at a median cenobamate dose of 100 mg/day. Forty-six percent of patients were responders with a ≥50% seizure reduction, 26% had a ≥75% seizure reduction, and 9% became seizure-free. Among the 74 patients with available follow-up of 12 months, the responder rates reached 55%, 35%, and 19% for ≥50%, ≥75%, and 100% seizure reduction, respectively. After 3 months of treatment, 38% of patients reported adverse effects, mainly (84%) mild to moderate in intensity. Adjustment of comedication allowed successful management of adverse effects in 32% of patients. At a group level, there was no correlation between the cenobamate daily dose and the incidence of adverse events.
    Significance: We found a clinically relevant response to cenobamate already at a low daily dose of 100 mg also in a patient cohort with a higher degree of drug resistance than in pivotal trials. Our prospectively collected data provide real-world evidence for high efficacy and good tolerability of the drug, although no standardized treatment protocol or comparison with a control group was applied.
    MeSH term(s) Adult ; Humans ; Anticonvulsants/therapeutic use ; Drug Therapy, Combination ; Epilepsies, Partial/drug therapy ; Seizures/drug therapy ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/chemically induced ; Drug-Related Side Effects and Adverse Reactions ; Treatment Outcome ; Carbamates ; Chlorophenols ; Tetrazoles
    Chemical Substances Anticonvulsants ; Cenobamate (P85X70RZWS) ; Carbamates ; Chlorophenols ; Tetrazoles
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17874
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    Zs.MO 475: Show issues

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  10. Book ; Online ; Thesis: <dc:title>Vergleichende Analyse des Erfolges und der Sicherheit subduraler und Tiefen- Elektrodenregistrierungen bei der invasiven prächirurgischen Epilepsiediagnostik</dc:title>

    Männlin, Julia [Verfasser] / Schulze-Bonhage, Andreas [Akademischer Betreuer] / Schulze-Bonhage, Andreas [Sonstige] / Steinhoff, Bernhard J. [Sonstige]

    2023  

    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität
    Publishing place Freiburg
    Document type Book ; Online ; Thesis
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