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  1. Article ; Online: QueryTrack: Joint-Modality Query Fusion Network for RGBT Tracking.

    Fan, Huijie / Yu, Zhencheng / Wang, Qiang / Fan, Baojie / Tang, Yandong

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2024  Volume 33, Page(s) 3187–3199

    Abstract: Existing RGB-Thermal trackers usually treat intra-modal feature extraction and inter-modal feature fusion as two separate processes, therefore the mutual promotion of extraction and fusion is neglected. Then, the complementary advantages of RGB-T fusion ... ...

    Abstract Existing RGB-Thermal trackers usually treat intra-modal feature extraction and inter-modal feature fusion as two separate processes, therefore the mutual promotion of extraction and fusion is neglected. Then, the complementary advantages of RGB-T fusion are not fully exploited, and the independent feature extraction is not adaptive to modal quality fluctuation during tracking. To address the limitations, we design a joint-modality query fusion network, in which the intra-modal feature extraction and the inter-modal fusion are coupled together and promote each other via joint-modality queries. The queries are initialized based on the multimodal features of the current frame, making the subsequent fusion adaptive to modal quality fluctuation during tracking. Then the joint-modality query fusion (JQF) utilizes the queries to interact with RGB-T features, allowing the intra-modal enhancement and the inter-modal interactions to be unified for mutual promotion. In this way, JQF can distinguish and enhance the complementary modality features, while filtering out redundant information. For real-time tracking, we propose regional cross-attention for cross-modal interactions to reduce computational cost. Our end-to-end tracker sets a new state-of-the-art performance on multiple RGBT tracking benchmarks including LasHeR, VTUAV, RGBT234 and GTOT, while running at a real-time speed.
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2024.3393298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: miR-HCC2 suppresses hepatitis B virus replication by inhibiting the activity of the enhancer I/X promoter.

    Gao, Huijie / Fan, Hongxia / Xie, Hong

    Archives of virology

    2023  Volume 168, Issue 11, Page(s) 282

    Abstract: miR-HCC2 has been reported to markedly promote the growth, metastasis, and stemness of hepatocellular carcinoma (HCC) cells in vitro and in vivo. Deep sequencing showed that miR-HCC2 was significantly upregulated in hepatitis B virus (HBV)-positive ( ... ...

    Abstract miR-HCC2 has been reported to markedly promote the growth, metastasis, and stemness of hepatocellular carcinoma (HCC) cells in vitro and in vivo. Deep sequencing showed that miR-HCC2 was significantly upregulated in hepatitis B virus (HBV)-positive (HBV
    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Hep G2 Cells ; Hepatitis B/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Virus Replication/genetics ; Gene Expression Regulation, Neoplastic
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-10-27
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05899-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The regulatory effect of the YY1/miR‑HCC2/BAMBI axis on the stemness of liver cancer cells.

    Gao, Huijie / Fan, Hongxia / Xie, Hong

    International journal of oncology

    2023  Volume 62, Issue 5

    Abstract: Cancer stem cells serve key roles in liver cancer recurrence and metastasis. Therefore, the present study evaluated novel regulators of stem cell factor expression to identify novel therapeutic strategies that could target liver cancer stem cells. Deep ... ...

    Abstract Cancer stem cells serve key roles in liver cancer recurrence and metastasis. Therefore, the present study evaluated novel regulators of stem cell factor expression to identify novel therapeutic strategies that could target liver cancer stem cells. Deep sequencing was performed to identify novel microRNAs (miRNAs) that were specifically altered in liver cancer tissues. The expression levels of stem cell markers were investigated by reverse transcription‑quantitative PCR and western blotting. Sphere formation assays and flow cytometry were used to assess tumor sphere‑forming ability and evaluate the population of cluster of differentiation 90
    MeSH term(s) Humans ; Cell Line, Tumor ; MicroRNAs/metabolism ; Liver Neoplasms/pathology ; Wnt Signaling Pathway/genetics ; Heterografts ; Neoplastic Stem Cells/pathology ; Gene Expression Regulation, Neoplastic ; Cell Proliferation/genetics ; Membrane Proteins/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
    Chemical Substances MicroRNAs ; BAMBI protein, human ; Membrane Proteins ; YY1 protein, human ; YY1 Transcription Factor
    Language English
    Publishing date 2023-03-31
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1154403-x
    ISSN 1791-2423 ; 1019-6439
    ISSN (online) 1791-2423
    ISSN 1019-6439
    DOI 10.3892/ijo.2023.5507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acid-Activated TAT Peptide-Modified Biomimetic Boron Nitride Nanoparticles for Enhanced Targeted Codelivery of Doxorubicin and Indocyanine Green: A Synergistic Cancer Photothermal and Chemotherapeutic Approach.

    Li, Hui / Fan, Yuan / Shen, Yizhe / Xu, Huashan / Zhang, Huijie / Chen, Fuxue / Feng, Shini

    ACS applied materials & interfaces

    2024  

    Abstract: The evolution of nano-drug delivery systems addresses the limitations of conventional cancer treatments with stimulus-responsive nanomaterial-based delivery systems presenting temporal and spatial advantages. Among various nanomaterials, boron nitride ... ...

    Abstract The evolution of nano-drug delivery systems addresses the limitations of conventional cancer treatments with stimulus-responsive nanomaterial-based delivery systems presenting temporal and spatial advantages. Among various nanomaterials, boron nitride nanoparticles (BNNs) demonstrate significant potential in drug delivery and cancer treatment, providing a high drug loading capacity, multifunctionality, and low toxicity. However, the challenge lies in augmenting nanomaterial accumulation exclusively within tumors while preserving healthy tissues. To address this, we introduce a novel approach involving cancer cell membrane-functionalized BNNs (CM-BID
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c01622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Measurements of the Thickness and Area of Thick Oil Slicks Using Ultrasonic and Image Processing Methods

    Hualong Du / Huijie Fan / Qifeng Zhang / Shuo Li

    Remote Sensing, Vol 15, Iss 2977, p

    2023  Volume 2977

    Abstract: The in situ measurement of thick oil slick thickness (>0.5 mm) and area in real time in order to estimate the volume of an oil spill is very important for determining the oil spill response strategy and evaluating the oil spill disposal efficiency. In ... ...

    Abstract The in situ measurement of thick oil slick thickness (>0.5 mm) and area in real time in order to estimate the volume of an oil spill is very important for determining the oil spill response strategy and evaluating the oil spill disposal efficiency. In this article, a method is proposed to assess the volume of oil slicks by simultaneously measuring the thick oil slick thickness and area using ultrasonic inspection and image processing methods, respectively. A remotely operated vehicle (ROV), integrating two ultrasonic immersion transducers, was implemented as a platform to receive ultrasonic reflections from an oil slick. The oil slick thickness was determined by multiplying the speed of sound by the ultrasonic traveling time within the oil slick, which was calculated using the cross-correlation method. Images of the oil slick were captured by an optical camera using an airborne drone. The oil slick area was calculated by conducting image processing on images of the oil slick using the proposed image processing algorithms. Multiple measurements were performed to verify the proposed method in the laboratory experiments. The results show that the thickness, area and volume of a thick oil slick can be accurately measured with the proposed method. The method could potentially be used as an applicable tool for measuring the volume of an oil slick during an oil spill response.
    Keywords ultrasonic measurement ; optical image processing ; oil slick thickness and area ; remotely operated vehicle (ROV) ; six-rotor airborne drone ; Science ; Q
    Subject code 620
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: DILS: depth incremental learning strategy.

    Wang, Yanmei / Han, Zhi / Yu, Siquan / Zhang, Shaojie / Liu, Baichen / Fan, Huijie

    Frontiers in neurorobotics

    2024  Volume 17, Page(s) 1337130

    Abstract: There exist various methods for transferring knowledge between neural networks, such as parameter transfer, feature sharing, and knowledge distillation. However, these methods are typically applied when transferring knowledge between networks of equal ... ...

    Abstract There exist various methods for transferring knowledge between neural networks, such as parameter transfer, feature sharing, and knowledge distillation. However, these methods are typically applied when transferring knowledge between networks of equal size or from larger networks to smaller ones. Currently, there is a lack of methods for transferring knowledge from shallower networks to deeper ones, which is crucial in real-world scenarios such as system upgrades where network size increases for better performance. End-to-end training is the commonly used method for network training. However, in this training strategy, the deeper network cannot inherit the knowledge from the existing shallower network. As a result, not only is the flexibility of the network limited but there is also a significant waste of computing power and time. Therefore, it is imperative to develop new methods that enable the transfer of knowledge from shallower to deeper networks. To address the aforementioned issue, we propose an depth incremental learning strategy (DILS). It starts from a shallower net and deepens the net gradually by inserting new layers each time until reaching requested performance. We also derive an analytical method and a network approximation method for training new added parameters to guarantee the new deeper net can inherit the knowledge learned by the old shallower net. It enables knowledge transfer from smaller to larger networks and provides good initialization of layers in the larger network to stabilize the performance of large models and accelerate their training process. Its reasonability can be guaranteed by information projection theory and is verified by a series of synthetic and real-data experiments.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453002-5
    ISSN 1662-5218
    ISSN 1662-5218
    DOI 10.3389/fnbot.2023.1337130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Effect of portulaca (Portulaca oleracea L.) extract on the quality and physicochemical attributes of vacuum-packed seasoned steaks during chilled storage.

    Zhao, Zhengshan / Deng, Qiuhao / Wang, Xin / Xiao, Huijie / Fan, Xiaojing / Chen, Lin / Feng, Xianchao

    Journal of the science of food and agriculture

    2024  

    Abstract: Background: Vacuum packaging has the ability to reduce oxidative deterioration and microbial-induced spoilage of meat. However, in an oxygen-free environment, it can lead to the development of an unappealing purplish-red color and a decrease in the ... ...

    Abstract Background: Vacuum packaging has the ability to reduce oxidative deterioration and microbial-induced spoilage of meat. However, in an oxygen-free environment, it can lead to the development of an unappealing purplish-red color and a decrease in the water-holding capacity of meat, thereby impacting the overall meat quality. Portulaca oleracea L. (POL) is a homology of medicine and food known for its exceptional antioxidant and antimicrobial properties.
    Results: The aim of our present study was to investigate the antioxidant and antimicrobial ability of n-butanol phase extract of POL and the effect of POL extract incorporation on the quality (water-holding capacity, shear force, color, and texture) and physicochemical (pH, total volatile base nitrogen, and total viable counts) attributes of vacuum-packed seasoned steaks at 4 °C over a 15-day period. Results showed that the POL extract had excellent antioxidant and antimicrobial capacity. Furthermore, the addition of POL extract significantly inhibited protein oxidation and microbial growth of steaks (P < 0.05), and improved the water-holding capacity, color properties, and tenderness (P < 0.05). Moreover, there were no significant differences (P > 0.05) in the color, water-holding capacity, or tenderness between the 0.5 and 1 g kg
    Conclusion: These results indicate that POL extract had the potential to replace sodium nitrite due to its ability to hinder protein oxidation and microbial growth of vacuum-packed seasoned steaks, while enhancing the color, water-holding capacity, and tenderness of seasoned steaks. © 2024 Society of Chemical Industry.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The important role of surface charge on a new mechanism of nitrogen reduction.

    Wu, Shuang / Liu, Huijie / Qu, Mengnan / Du, Aijun / Fan, Jianfen / Sun, Qiao

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 11, Page(s) 7986–7993

    Abstract: The electrocatalytic nitrogen reduction reaction (NRR) is a green and sustainable approach for producing ammonia. Low-cost carbon-based materials are promising catalysts for the electrochemical NRR. Among them, Cu- ... ...

    Abstract The electrocatalytic nitrogen reduction reaction (NRR) is a green and sustainable approach for producing ammonia. Low-cost carbon-based materials are promising catalysts for the electrochemical NRR. Among them, Cu-N
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp05485j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.

    Xiao, Guodong / Lu, Weiping / Yuan, Jing / Liu, Zuyue / Wang, Peili / Fan, Huijie

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 99

    Abstract: Background: Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-box and WD repeat domain- ... ...

    Abstract Background: Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-box and WD repeat domain-containing 7 (FBXW7) as a tumor suppressor in Triple-negative breast cancer (TNBC). However, few studies have focused on the function of FBXW7 in cancer stemness in TNBC and the related mechanism.
    Methods: We detected FBXW7 by immunohistochemistry (IHC) in 80 TNBC patients. FBXW7 knockdown and overexpression in MD-MBA-231 and HCC1937 cell models were constructed. The effect of FBXW7 on malignant phenotype and stemness was assessed by colony assays, flow cytometry, transwell assays, western blot, and sphere formation assays. Immunoprecipitation-Mass Spectrometry (IP-MS) and ubiquitination experiments were used to find and verify potential downstream substrate proteins of FBXW7. Animal experiments were constructed to examine the effect of FBXW7 on tumorigenic potential and cancer stemness of TNBC cells in vivo.
    Results: The results showed that FBXW7 was expressed at low levels in TNBC tissues and positively correlated with prognosis of TNBC patients. In vitro, FBXW7 significantly inhibited colony formation, cell cycle progression, cell migration, EMT process, cancer stemness and promotes apoptosis. Further experiments confirmed that chromodomain-helicase-DNA-binding protein 4 (CHD4) is a novel downstream target of FBXW7 and is downregulated by FBXW7 via proteasomal degradation. Moreover, CHD4 could promote the nuclear translocation of β-catenin and reverse the inhibitory effect of FBXW7 on β-catenin, and ultimately activate the Wnt/β-catenin pathway. Rescue experiments confirmed that the FBXW7-CHD4-Wnt/β-catenin axis was involved in regulating the maintenance of CSC in TNBC cells. In animal experiments, FBXW7 reduced CSC marker expression and suppressed TNBC cell tumorigenesis in vivo.
    Conclusions: Taken together, these results highlight that FBXW7 degrades CHD4 protein through ubiquitination, thereby blocking the activation of the Wnt/β-catenin pathway to inhibit the stemness of TNBC cells. Thus, targeting FBXW7 may be a promising strategy for therapeutic intervention against TNBC.
    MeSH term(s) Animals ; Humans ; beta Catenin ; Carcinogenesis ; Cell Transformation, Neoplastic ; F-Box-WD Repeat-Containing Protein 7/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex ; Triple Negative Breast Neoplasms/genetics
    Chemical Substances beta Catenin ; CHD4 protein, human ; F-Box-WD Repeat-Containing Protein 7 ; Mi-2 Nucleosome Remodeling and Deacetylase Complex (EC 3.5.1.98) ; FBXW7 protein, human
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04897-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mask Guidance Pyramid Network for Overlapping Cervical Cell Edge Detection

    Wei Zhang / Huijie Fan / Xuanhua Xie / Qiang Wang / Yandong Tang

    Applied Sciences, Vol 13, Iss 7526, p

    2023  Volume 7526

    Abstract: An important indicator of cervical cancer diagnosis is to calculate the proportion of diseased cells and cancer cells, so it is necessary to segment cells and judge the cell status. The existing methods are difficult to deal with the segmentation of ... ...

    Abstract An important indicator of cervical cancer diagnosis is to calculate the proportion of diseased cells and cancer cells, so it is necessary to segment cells and judge the cell status. The existing methods are difficult to deal with the segmentation of overlapping cells. In order to solve this problem, we put forward such a hypothesis by reading a large number of literature, that is, image segmentation and edge measurement tasks have unity in high-level features. To prove this hypothesis, in this paper, we focus on the complementary between overlapping cervical cell edge information and cell object information to get higher accuracy cell edge detection results. Specifically, we present a joint multi-task learning framework for overlapping cell edge detection by the mask guidance pyramid network. The main component of the framework is the Mask Guidance Module (MGM), which integrates two tasks and stores the shared latent semantics to interact in the two tasks. For semantic edge detection, we propose the novel Refinement Aggregated Module (RAM) fusion to promote semantic edges. Finally, to improve the edge pixel accuracy, the edge consistency constraint loss function is introduced to our model training. Our extensive experiments have proved that our method outperforms other edge detection efforts.
    Keywords edge detection ; medical image segmentation ; overlapping cervical cell ; mask guidance ; pyramid network ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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