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  1. Article: Focal cross transformer: multi-view brain tumor segmentation model based on cross window and focal self-attention.

    Zongren, Li / Silamu, Wushouer / Shurui, Feng / Guanghui, Yan

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1192867

    Abstract: Introduction: Recently, the Transformer model and its variants have been a great success in terms of computer vision, and have surpassed the performance of convolutional neural networks (CNN). The key to the success of Transformer vision is the ... ...

    Abstract Introduction: Recently, the Transformer model and its variants have been a great success in terms of computer vision, and have surpassed the performance of convolutional neural networks (CNN). The key to the success of Transformer vision is the acquisition of short-term and long-term visual dependencies through self-attention mechanisms; this technology can efficiently learn global and remote semantic information interactions. However, there are certain challenges associated with the use of Transformers. The computational cost of the global self-attention mechanism increases quadratically, thus hindering the application of Transformers for high-resolution images.
    Methods: In view of this, this paper proposes a multi-view brain tumor segmentation model based on cross windows and focal self-attention which represents a novel mechanism to enlarge the receptive field by parallel cross windows and improve global dependence by using local fine-grained and global coarse-grained interactions. First, the receiving field is increased by parallelizing the self-attention of horizontal and vertical fringes in the cross window, thus achieving strong modeling capability while limiting the computational cost. Second, the focus on self-attention with regards to local fine-grained and global coarse-grained interactions enables the model to capture short-term and long-term visual dependencies in an efficient manner.
    Results: Finally, the performance of the model on Brats2021 verification set is as follows: dice Similarity Score of 87.28, 87.35 and 93.28%; Hausdorff Distance (95%) of 4.58 mm, 5.26 mm, 3.78 mm for the enhancing tumor, tumor core and whole tumor, respectively.
    Discussion: In summary, the model proposed in this paper has achieved excellent performance while limiting the computational cost.
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1192867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: New insights into

    Li, Tianxiao / Zhang, Huabing / Tan, Xiang / Zhang, Rui / Wu, Fasi / Yu, Zongren / Su, Bomin

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1261205

    Abstract: Our previous study reported ... ...

    Abstract Our previous study reported that
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1261205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gut microbiota associated with appetite suppression in high-temperature and high-humidity environmentsResearch in context

    Yalan Wu / Xiangrong Feng / Mengjun Li / Zongren Hu / Yuhua Zheng / Song Chen / Huanhuan Luo

    EBioMedicine, Vol 99, Iss , Pp 104918- (2024)

    1481  

    Abstract: Summary: Background: Food is crucial for maintaining vital human and animal activities. Disorders in appetite control can lead to various metabolic disturbances. Alterations in the gut microbial composition can affect appetite and energy metabolism. ... ...

    Abstract Summary: Background: Food is crucial for maintaining vital human and animal activities. Disorders in appetite control can lead to various metabolic disturbances. Alterations in the gut microbial composition can affect appetite and energy metabolism. While alterations in the gut microbiota have been observed in high-temperature and high-humidity (HTH) environments, the relationship between the gut microbiota during HTH and appetite remains unclear. Methods: We utilised an artificial climate box to mimic HTH environments, and established a faecal bacteria transplantation (FMT) mouse model. Mendelian randomisation (MR) analysis was used to further confirm the causal relationship between gut microbiota and appetite or appetite-related hormones. Findings: We found that, in the eighth week of exposure to HTH environments, mice showed a decrease in food intake and body weight, and there were significant changes in the intestinal microbiota compared to the control group. After FMT, we observed similar changes in food intake, body weight, and gut bacteria. Appetite-related hormones, including ghrelin, glucagon-like peptide-1, and insulin, were reduced in DH (mice exposed to HTH conditions) and DHF (FMT from mice exposed to HTH environments for 8 weeks), while the level of peptide YY initially increased and then decreased in DH and increased after FMT. Moreover, MR analysis further confirmed that these changes in the intestinal microbiota could affect appetite or appetite-related hormones. Interpretation: Together, our data suggest that the gut microbiota is closely associated with appetite suppression in HTH. These findings provide novel insights into the effects of HTH on appetite. Funding: This work was supported by the National Natural Science Foundation of China and Guangzhou University of Chinese Medicine.
    Keywords Gut microbiota ; Appetite suppression ; High-temperature and high-humidity environments ; Mendelian randomization analyses ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 630
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: [No title information]

    Liu, Jiangyi / Liao, Xingyun / Li, Na / Xu, Zongren / Yang, Wang / Zhou, Hongxiu / Liu, Yusen / Zhang, Zhi / Wang, Guoqing / Hou, Shengping

    MedComm

    2024  Volume 5, Issue 4, Page(s) e534

    Abstract: Autoimmune uveitis (AU) is a kind of immune-mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and progression of AU ...

    Title translation Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
    Abstract Autoimmune uveitis (AU) is a kind of immune-mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to disease initiation and progression of AU remains unclear. Here, we induced an experimental AU (EAU) model with IRBP
    Language Italian
    Publishing date 2024-04-07
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gut microbiota associated with appetite suppression in high-temperature and high-humidity environments.

    Wu, Yalan / Feng, Xiangrong / Li, Mengjun / Hu, Zongren / Zheng, Yuhua / Chen, Song / Luo, Huanhuan

    EBioMedicine

    2023  Volume 99, Page(s) 104918

    Abstract: Background: Food is crucial for maintaining vital human and animal activities. Disorders in appetite control can lead to various metabolic disturbances. Alterations in the gut microbial composition can affect appetite and energy metabolism. While ... ...

    Abstract Background: Food is crucial for maintaining vital human and animal activities. Disorders in appetite control can lead to various metabolic disturbances. Alterations in the gut microbial composition can affect appetite and energy metabolism. While alterations in the gut microbiota have been observed in high-temperature and high-humidity (HTH) environments, the relationship between the gut microbiota during HTH and appetite remains unclear.
    Methods: We utilised an artificial climate box to mimic HTH environments, and established a faecal bacteria transplantation (FMT) mouse model. Mendelian randomisation (MR) analysis was used to further confirm the causal relationship between gut microbiota and appetite or appetite-related hormones.
    Findings: We found that, in the eighth week of exposure to HTH environments, mice showed a decrease in food intake and body weight, and there were significant changes in the intestinal microbiota compared to the control group. After FMT, we observed similar changes in food intake, body weight, and gut bacteria. Appetite-related hormones, including ghrelin, glucagon-like peptide-1, and insulin, were reduced in DH (mice exposed to HTH conditions) and DHF (FMT from mice exposed to HTH environments for 8 weeks), while the level of peptide YY initially increased and then decreased in DH and increased after FMT. Moreover, MR analysis further confirmed that these changes in the intestinal microbiota could affect appetite or appetite-related hormones.
    Interpretation: Together, our data suggest that the gut microbiota is closely associated with appetite suppression in HTH. These findings provide novel insights into the effects of HTH on appetite.
    Funding: This work was supported by the National Natural Science Foundation of China and Guangzhou University of Chinese Medicine.
    MeSH term(s) Humans ; Animals ; Mice ; Gastrointestinal Microbiome ; Appetite ; Humidity ; Temperature ; Body Weight
    Language English
    Publishing date 2023-12-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Guhan Yangsheng Jing mitigates hippocampal neuronal pyroptotic injury and manifies learning and memory capabilities in sleep deprived mice via the NLRP3/Caspase1/GSDMD signaling pathway.

    Fu, Xinying / Yan, Siyang / Hu, Zongren / Sheng, Wen / Li, Wanyu / Kuang, Shida / Feng, Xue / Liu, Lumei / Zhang, Wei / He, Qinghu

    Journal of ethnopharmacology

    2024  Volume 326, Page(s) 117972

    Abstract: Ethnopharmacological relevance: Guhan Yangsheng Jing (GHYSJ) is a traditional Chinese patent medicine, that has the function of nourishing the kidney and replenishing the essence, invigorating the brain and calming the mind. It is often used to treat ... ...

    Abstract Ethnopharmacological relevance: Guhan Yangsheng Jing (GHYSJ) is a traditional Chinese patent medicine, that has the function of nourishing the kidney and replenishing the essence, invigorating the brain and calming the mind. It is often used to treat dizziness, memory loss, sleep disorders, fatigue, and weakness, etc. However, its mechanism for improving sleep has not yet been determined.
    Aim of the study: This study aims to explore the effects of GHYSJ on Sleep Deprivation (SD)-induced hippocampal neuronal pyroptotic injury, learning and cognitive abilities, and sleep quality in mice.
    Methods: In this study, a PCPA-induced SD mouse model was established. We assessed the influence of GHYSJ on sleep quality and mood by using the pentobarbital-induced sleep test (PIST) and sucrose preference test (SPT). The pharmacological effects of GHYSJ on learning and memory impairment were evaluated by the Morris Water Maze (MWM) and Open Field Test (OFT). Pathological changes in the hippocampal tissue of the SD rats were observed via HE staining and Nissl staining. The severity of neuronal damage was evaluated by detecting the expression of the neuronal marker Microtubule-associated protein 2 (MAP2), via immunohistochemistry and immunofluorescence. Furthermore, the levels of neurotransmitter 5-hydroxytryptophan (5-HTP), 5-hydroxy tryptamine (5-HT), γ-aminobutyric acid (GABA), and Glutamic acid (Glu) in hippocampal tissues, as well as the expression of inflammatory factors Interleukin-1β (IL-1β) and Interleukin-18 (IL-18) in serum, were determined by ELISA. The expressions of mRNA and protein NOD-like receptor thermal protein domain associated protein 3 (NLRP3), Gasdermin D (GSDMD), Cysteinyl aspartate specific proteinase1 (Caspase1), High mobility group box-1 protein (HMGB1) and Apoptosis-associated speck-like protein containing CARD (ASC) related to the cellular ferroptosis pathway were tested and analyzed by RT-PCR and WB respectively.
    Results: PCPA significantly diminishes the sleep span of experimental animals by expediting the expenditure of 5-HT, consequently establishing an essentially direct SD model. The intervention of GHYSJ displays remarkable efficacy in mitigating insomnia symptoms, encompassing difficulties in initiating sleep and insufficient sleep duration. Likewise, it ameliorates memory function impairments induced by sleep deprivation, along with symptoms such as fatigue and depletion of vitality. GHYSJ exerts a protective influence on hippocampal neurons facilitated by inhibiting the down regulation of MAP2 and maintaining the equilibrium of neurotransmitters (5-HTP, 5-HT, GABA, and Glu). It diminishes the expression of intracellular pyroptosis-associated inflammatory factors (IL-1β and IL-18) and curbs the activation of the NLRP3/Caspase1/GSDMD pyroptosis-related signaling pathways, thereby alleviating the damage caused by hippocampal neuronal pyroptosis.
    MeSH term(s) Mice ; Animals ; Rats ; Aspartic Acid ; Interleukin-18 ; Sleep Deprivation ; NLR Family, Pyrin Domain-Containing 3 Protein ; 5-Hydroxytryptophan ; Serotonin ; Sleep ; Signal Transduction ; Neurons ; Memory Disorders/drug therapy ; gamma-Aminobutyric Acid ; Caspase 1
    Chemical Substances Aspartic Acid (30KYC7MIAI) ; Interleukin-18 ; NLR Family, Pyrin Domain-Containing 3 Protein ; 5-Hydroxytryptophan (C1LJO185Q9) ; Serotonin (333DO1RDJY) ; gamma-Aminobutyric Acid (56-12-2) ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2024-02-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2

    Wan Zongren / Wang Jipeng / Liu Qing / Yang Dan / Li Pengling / Wang Lixin

    Open Life Sciences, Vol 18, Iss 1, Pp 47-

    2023  Volume 50

    Abstract: Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases and is considered as the most common type of cancer. DLX4 was originally identified as a β-globin gene suppressor in red blood cells, which plays critical roles in several types ...

    Abstract Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases and is considered as the most common type of cancer. DLX4 was originally identified as a β-globin gene suppressor in red blood cells, which plays critical roles in several types of cancers. However, the role and related mechanism of DLX4 in NSCLC are still unclear. The study aimed to uncover the expression of DLX4 in human NSCLC cells and tissues, reveal its possible role in NSCLC, and investigate the underlying mechanisms. Immunoblot and TCGA database were used to detect the expression of DLX4 in human NSCLC cells and tissues. CCK-8, colony formation, and FCM assays were conducted to detect the effects of DLX4 on the viability and cell cycle of NCI-H2170 and A549 cells. Immunoblot assays were further performed to investigate the possible mechanism underlying DLX4 affecting the growth of NSCLC. We revealed that knockdown of DLX4 inhibited NSCLC cell proliferation. We further revealed that DLX4 knockdown induced the NSCLC cell cycle arrest. Our results further showed that downregulation of DLX4 suppressed YB-1 expression, which further suppressed CKS2 expression, thereby suppressing tumor growth of NSCLC. In conclusion, DLX4 has the potential to serve as a promising drug for NSCLC treatment.
    Keywords non-small cell lung cancer ; dlx4 ; yb-1 ; cks2 ; cell cycle ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Impact of body mass index on long-term outcomes in patients undergoing percutaneous coronary intervention stratified by diabetes mellitus: a retrospective cohort study.

    Rao, Chongyou / Zhong, Qin / Wu, Rilige / Li, Zongren / Duan, Yongjie / Zhou, You / Wang, Chi / Chen, Xu / Wang, Ruiqing / He, Kunlun

    BMC cardiovascular disorders

    2024  Volume 24, Issue 1, Page(s) 113

    Abstract: Background: Patients with diabetes mellitus (DM) caused by obesity have increased in recent years. The impact of obesity on long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) with or without DM remains unclear.: Methods! ...

    Abstract Background: Patients with diabetes mellitus (DM) caused by obesity have increased in recent years. The impact of obesity on long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) with or without DM remains unclear.
    Methods: We retrospectively analysed data from 1918 patients who underwent PCI. Patients were categorized into four groups based on body mass index (BMI, normal weight: BMI < 25 kg/m
    Results: During a median follow-up of 7.0 years, no significant differences in MACCE, myocardial infarction, or stroke were observed among the four groups. Overweight and obese individuals exhibited lower all-cause mortality rates compared with normal-weight patients (without DM: hazard ratio [HR]: 0.54, 95% confidence interval [CI]: 0.37 to 0.78; with DM: HR: 0.57, 95% CI: 0.38 to 0.86). In non-diabetic patients, the overweight and obese group demonstrated a higher risk of unplanned repeat revascularization than the normal-weight group (HR:1.23, 95% CI:1.03 to 1.46). After multivariable adjustment, overweight and obesity were not significantly associated with MACCE, all-cause death, myocardial infarction, stroke, or unplanned repeat revascularization in patients with and without diabetes undergoing PCI.
    Conclusion: Overweight and obesity did not demonstrate a significant protective effect on long-term outcomes in patients with and without diabetes undergoing PCI.
    MeSH term(s) Humans ; Overweight ; Retrospective Studies ; Body Mass Index ; Percutaneous Coronary Intervention/adverse effects ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Myocardial Infarction/etiology ; Obesity/complications ; Obesity/diagnosis ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/complications ; Treatment Outcome ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Artery Disease/complications
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-024-03770-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A satellite-derived, ground-measurement-independent monthly PM2.5 mass concentration dataset over China during 2000 - 2015

    Ying Zhang / Zhengqiang Li / Yuanyuan Wei / Zongren Peng

    Big Earth Data, Vol 0, Iss 0, Pp 1-

    2021  Volume 17

    Abstract: Following the accelerated development of urbanization and industrialization, atmospheric particulate matter has become a significant threat to public health globally. Environmental health studies usually use the mass concentration of fine particles (PM2 ... ...

    Abstract Following the accelerated development of urbanization and industrialization, atmospheric particulate matter has become a significant threat to public health globally. Environmental health studies usually use the mass concentration of fine particles (PM2.5) as a base data to predict the health risks of particulate exposure. However, PM2.5 data from ground monitoring stations in China has not been provided until January 2013 by the Ministry of Environmental Protection of China. Hence, an alternative dataset of PM2.5 spatiotemporal distributions extending to years earlier than 2013 is urgently needed, which is of great significance to atmospheric environment assessment and pollution prevention and control. Atmospheric aerosol products by the moderate-resolution imaging spectroradiometer (MODIS) have been released since 2000, which provides the possibility to reconstruct historical PM2.5. However, most current methods do not have the ability to estimate PM2.5 mass concentration independently of ground observations. The PM2.5 mass concentration data set produced by PM2.5 remote sensing (PMRS) model based on physical processes does not depend on the ground observations, and also is not affected by the uncertainty of model emission sources or the completeness of chemical reaction mechanism. These ensure that the point-by-point validation for PM2.5 mass concentration data is more convincing, and the dataset can also be further used for model assimilation and artificial intelligence training to improve their predictions. In this study, we calculate the monthly PM2.5 mass concentration near the ground over land of China using aerosol inversion products (aerosol optical depth and fine-mode fraction) of MODIS and meteorological data (boundary layer height & relative humidity) provided by the Modern-Era Retrospective Analysis for Research and Applications Version 2 (MERRA-2) data set. The results show that, in China, 6 pollution centers mainly concentrated in the central and eastern regions. The highest PM2.5 mass ...
    Keywords pm2.5 ; data set ; satellite-derived ; china ; monthly ; Geography. Anthropology. Recreation ; G ; Geology ; QE1-996.5
    Subject code 333
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2.

    Wan, Zongren / Wang, Jipeng / Liu, Qing / Yang, Dan / Li, Pengling / Wang, Lixin

    Open life sciences

    2023  Volume 18, Issue 1, Page(s) 20220720

    Abstract: Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases and is considered as the most common type of cancer. DLX4 was originally identified as a β-globin gene suppressor in red blood cells, which plays critical roles in several types ...

    Abstract Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases and is considered as the most common type of cancer. DLX4 was originally identified as a β-globin gene suppressor in red blood cells, which plays critical roles in several types of cancers. However, the role and related mechanism of DLX4 in NSCLC are still unclear. The study aimed to uncover the expression of DLX4 in human NSCLC cells and tissues, reveal its possible role in NSCLC, and investigate the underlying mechanisms. Immunoblot and TCGA database were used to detect the expression of DLX4 in human NSCLC cells and tissues. CCK-8, colony formation, and FCM assays were conducted to detect the effects of DLX4 on the viability and cell cycle of NCI-H2170 and A549 cells. Immunoblot assays were further performed to investigate the possible mechanism underlying DLX4 affecting the growth of NSCLC. We revealed that knockdown of DLX4 inhibited NSCLC cell proliferation. We further revealed that DLX4 knockdown induced the NSCLC cell cycle arrest. Our results further showed that downregulation of DLX4 suppressed YB-1 expression, which further suppressed CKS2 expression, thereby suppressing tumor growth of NSCLC. In conclusion, DLX4 has the potential to serve as a promising drug for NSCLC treatment.
    Language English
    Publishing date 2023-09-19
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2817958-4
    ISSN 2391-5412 ; 2391-5412
    ISSN (online) 2391-5412
    ISSN 2391-5412
    DOI 10.1515/biol-2022-0720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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