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  1. Book ; Thesis: Der kardiale Kv4.3 Kaliumkanal - Charakterisierung der neuen humanen Long-QT-Syndrom-Mutation Kv4.3-S490C und der pharmakologischen Effekte von Lidocain und Mexiletin

    Müller, Mara Elena / Thomas, Dierk

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Mara Elena Müler ; Doktorvater: Herr Prof. Dr. med. Dierk Thomas
    Language German
    Size XIII, 168 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    Note Im Titel ist das "v" tiefgestellt
    HBZ-ID HT021740367
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 477 order for loan Magazin

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  2. Book ; Online ; E-Book: Channelopathies in heart disease

    Thomas, Dierk / Remme, Carol Ann

    (Cardiac and vascular biology)

    2018  

    Author's details Dierk Thomas, Carol Ann Remme editors
    Series title Cardiac and vascular biology
    Keywords Biomedical engineering ; Cardiology ; Cardiovascular system ; Bioinformatics
    Subject code 610.28
    Language English
    Size 1 Online-Ressource (VI, 437 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019843620
    ISBN 978-3-319-77812-9 ; 9783319778112 ; 3-319-77812-9 ; 3319778110
    DOI 10.1007/978-3-319-77812-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Interpretation von Schrittmacher-EKGs durch die tragbare Defibrillatorweste : Fallstricke und Lösungen.

    Zylla, Maura M / Thomas, Dierk

    Herzschrittmachertherapie & Elektrophysiologie

    2021  Volume 32, Issue 4, Page(s) 500–503

    Abstract: The wearable cardioverter defibrillator (WCD) can protect patients against sudden cardiac death during temporarily increased or unknown risk of ventricular arrhythmias or in the situation of implantable cardioverter-defibrillator (ICD) explantation due ... ...

    Title translation Interpretation of paced ECGs by the wearable defibrillator : Pitfalls and solutions.
    Abstract The wearable cardioverter defibrillator (WCD) can protect patients against sudden cardiac death during temporarily increased or unknown risk of ventricular arrhythmias or in the situation of implantable cardioverter-defibrillator (ICD) explantation due to infection. In unusual cases, misinterpretation of the ECG by the tachycardia detection and discrimination algorithm of the WCD can occur which can lead to inappropriate acoustic alerts or inappropriate WCD therapy. We explain the mechanisms of inappropriate WCD therapy in two cases from daily clinical practice together with potential strategies to avoid such events in this special group of patients.
    MeSH term(s) Death, Sudden, Cardiac/prevention & control ; Defibrillators ; Defibrillators, Implantable ; Electric Countershock ; Electrocardiography ; Humans ; Wearable Electronic Devices
    Language German
    Publishing date 2021-10-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-021-00822-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3286: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Thesis: Der repolarisierende "Human-ether-a-go-go-related-gene"-Kaliumstrom im Herzen

    Thomas, Dierk

    2001  

    Author's details vorgelegt von Dierk Thomas
    Language German
    Size VI, 105 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2002
    HBZ-ID HT013419901
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: The Management of Atrial Fibrillation with Oral Anticoagulant Drugs.

    Zeymer, Uwe / Schneider, Steffen / Hochadel, Matthias / Kleemann, Thomas / Borggrefe, Martin / Akin, Ibrahim / Katus, Hugo / Thomas, Dierk / Werdan, Karl / Senges, Jochen

    Deutsches Arzteblatt international

    2023  Volume 120, Issue 18, Page(s) 324–325

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Anticoagulants/therapeutic use ; Administration, Oral ; Stroke
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-07-24
    Publishing country Germany
    Document type Letter
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2023.0009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Femoropopliteal Drug-coated Balloon Angioplasty: Long-term Results of the Randomized EffPac Trial.

    Teichgräber, Ulf / Lehmann, Thomas / Aschenbach, René / Thieme, Markus / Zeller, Thomas / Beschorner, Ulrich / Scheinert, Dierk

    Radiology

    2022  Volume 304, Issue 1, Page(s) 225–227

    MeSH term(s) Angioplasty, Balloon/methods ; Coated Materials, Biocompatible ; Femoral Artery/diagnostic imaging ; Humans ; Paclitaxel ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/surgery ; Treatment Outcome ; Vascular Patency
    Chemical Substances Coated Materials, Biocompatible ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.212622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Implementation of the multielectrode radiofrequency-balloon in real-world clinical practice-operator learning curve and procedural outcome at a high-volume center.

    Zylla, Maura M / Starrach, Lydia / Rahm, Ann-Kathrin / Thomas, Dierk / Frey, Norbert / Lugenbiel, Patrick

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1208250

    Abstract: Background: The novel multielectrode radiofrequency (RF) balloon catheter (HELIOSTAR™, Biosense Webster) is a new technology for pulmonary vein isolation (PVI) in atrial fibrillation (AF), combining RF-ablation and 3D-mapping visualization with the ... ...

    Abstract Background: The novel multielectrode radiofrequency (RF) balloon catheter (HELIOSTAR™, Biosense Webster) is a new technology for pulmonary vein isolation (PVI) in atrial fibrillation (AF), combining RF-ablation and 3D-mapping visualization with the concept of a "single-shot"-ablation device. This study evaluates the operator learning curve und procedural outcome during implementation of the multielectrode RF-balloon at a high-volume center.
    Methods: The first 40 patients undergoing PVI by multielectrode RF-balloon catheter at Heidelberg University Hospital were included in this prospective study. Procedural outcome was analyzed over the course of increasing experience with the device.
    Results: 157/157 pulmonary veins (PVs) were successfully isolated with the RF-balloon catheter, in 73.2% by a single RF-application. Median time to isolation (TTI) was 11.0 s (Q1 = 8.0 s; Q3 = 13.8 s). Median procedure time was 62.5 min (Q1 = 50.0 min; Q3 = 70.5 min). LA-dwell time was 28.5 min (Q1 = 23.3 min; Q3 = 36.5 min). Median fluoroscopy duration was 11.6 min (Q1 = 10.1 min; Q3 = 13.7 min). No serious procedure-related complications were observed, apart from one case of unclear, post-procedural acute-on-chronic kidney injury. With increasing operator experience, an additional reduction in procedure duration was observed.
    Conclusion: Rapid implementation of a "single shot"-ablation device combining RF-ablation and 3D-mapping can be achieved with high acute procedural efficacy and safety at a high-volume center. Previous experience with "single-shot" ablation devices may be advantageous for time-efficient introduction of the novel RF-balloon catheter into clinical practice.
    Clinical trial registration: ClinicalTrials.gov; Identifier NCT0560361.
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1208250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 5-Year Outcomes of Drug-Coated Balloons for Peripheral Artery In-Stent Restenosis, Long Lesions, and CTOs.

    Tepe, Gunnar / Brodmann, Marianne / Micari, Antonio / Scheinert, Dierk / Choi, Donghoon / Menk, Jeremiah / Zeller, Thomas

    JACC. Cardiovascular interventions

    2023  Volume 16, Issue 9, Page(s) 1065–1078

    Abstract: Background: Long-term data on drug-coated balloon (DCB) outcomes in complex femoropopliteal atherosclerotic lesions are limited.: Objectives: The authors sought to report 5-year safety and effectiveness outcomes of a paclitaxel DCB for the treatment ... ...

    Abstract Background: Long-term data on drug-coated balloon (DCB) outcomes in complex femoropopliteal atherosclerotic lesions are limited.
    Objectives: The authors sought to report 5-year safety and effectiveness outcomes of a paclitaxel DCB for the treatment of de novo in-stent restenosis (ISR), long lesions (LL), or chronic total occlusions (CTOs) in the prespecified imaging cohorts of the IN.PACT Global Study.
    Methods: The IN.PACT Global study was a prospective, international single-arm study. Assessments through 5 years included freedom from clinically driven target lesion revascularization (CD-TLR), a safety composite (freedom from device- and procedure-related death to 30 days, and freedom from major target limb amputation and freedom from clinically driven target vessel revascularization within 60 months), and major adverse events.
    Results: The prespecified imaging cohorts enrolled 132 de novo ISR, 158 LL, and 127 CTO participants. Kaplan-Meier estimates of freedom from CD-TLR through 5 years were 58.0% (ISR), 67.3% (LL), and 69.8% (CTO). The cumulative incidences of the composite safety endpoint were 56.0% (ISR), 65.7% (LL), and 69.8% (CTO). The 5-year freedom from all-cause mortality with vital status update were 81.4% (ISR), 75.2% (LL), and 78.2% (CTO). Within the ISR cohort, 15.9% of participants experienced 2 or more TLRs, compared with 9.5% and 5.5% in the LL and CTO groups, respectively.
    Conclusions: Results demonstrate long-term safety and effectiveness of this DCB in all 3 cohorts, with low reintervention rates in the LL and CTO cohorts and no safety issues. These results support the inclusion of this DCB into the treatment algorithm for complex femoropopliteal disease.
    MeSH term(s) Humans ; Popliteal Artery/diagnostic imaging ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/therapy ; Peripheral Arterial Disease/etiology ; Prospective Studies ; Coronary Restenosis/etiology ; Treatment Outcome ; Angioplasty, Balloon/adverse effects ; Limb Salvage ; Femoral Artery/diagnostic imaging ; Constriction, Pathologic/etiology ; Coated Materials, Biocompatible ; Vascular Patency
    Chemical Substances Coated Materials, Biocompatible
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.03.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6669: Show issues Location:
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  9. Article ; Online: Differential Effects of the Betablockers Carvedilol, Metoprolol and Bisoprolol on Cardiac K

    Rahm, Ann-Kathrin / Hackbarth, Juline / Müller, Mara E / Pfeiffer, Julia / Gampp, Heike / Petersenn, Finn / Rivinius, Rasmus / Frey, Norbert / Lugenbiel, Patrick / Thomas, Dierk

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: ... Cardiac ... ...

    Abstract Cardiac K
    MeSH term(s) Humans ; Metoprolol/pharmacology ; Bisoprolol/pharmacology ; Carvedilol/pharmacology ; Heart ; Heart Failure/drug therapy ; Protein Isoforms
    Chemical Substances Metoprolol (GEB06NHM23) ; Bisoprolol (Y41JS2NL6U) ; Carvedilol (0K47UL67F2) ; Protein Isoforms
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.

    Proske, Marcel / Janowski, Robert / Bacher, Sabrina / Kang, Hyun-Seo / Monecke, Thomas / Koehler, Tony / Hutten, Saskia / Tretter, Jana / Crois, Anna / Molitor, Lena / Varela-Rial, Alejandro / Fino, Roberto / Donati, Elisa / De Fabritiis, Gianni / Dormann, Dorothee / Sattler, Michael / Niessing, Dierk

    eLife

    2024  Volume 13

    Abstract: Mutations in the ... ...

    Abstract Mutations in the human
    MeSH term(s) Humans ; Mutation ; Molecular Dynamics Simulation ; Crystallography, X-Ray ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/chemistry ; Protein Domains ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/chemistry ; Protein Conformation ; Protein Multimerization
    Chemical Substances DNA-Binding Proteins ; RNA-Binding Proteins
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.93561
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