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Article ; Online: Characterization of intestinal O-glycome in reactive oxygen species deficiency.

Saldova, Radka / Thomsson, Kristina A / Wilkinson, Hayden / Chatterjee, Maitrayee / Singh, Ashish K / Karlsson, Niclas G / Knaus, Ulla G

PloS one

2024 Volume 19, Issue 3, Page(s) e0297292

Abstract: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation resulting from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Reactive oxygen species (ROS) generated by NADPH oxidases ...

Abstract	Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation resulting from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Reactive oxygen species (ROS) generated by NADPH oxidases (NOX) provide antimicrobial defense, redox signaling and gut barrier maintenance. NADPH oxidase mutations have been identified in IBD patients, and mucus layer disruption, a critical aspect in IBD pathogenesis, was connected to NOX inactivation. To gain insight into ROS-dependent modification of epithelial glycosylation the colonic and ileal mucin O-glycome of mice with genetic NOX inactivation (Cyba mutant) was analyzed. O-glycans were released from purified murine mucins and analyzed by hydrophilic interaction ultra-performance liquid chromatography in combination with exoglycosidase digestion and mass spectrometry. We identified five novel glycans in ileum and found minor changes in O-glycans in the colon and ileum of Cyba mutant mice. Changes included an increase in glycans with terminal HexNAc and in core 2 glycans with Fuc-Gal- on C3 branch, and a decrease in core 3 glycans in the colon, while the ileum showed increased sialylation and a decrease in sulfated glycans. Our data suggest that NADPH oxidase activity alters the intestinal mucin O-glycans that may contribute to intestinal dysbiosis and chronic inflammation.
MeSH term(s)	Humans ; Mice ; Animals ; Reactive Oxygen Species ; Mucins/chemistry ; Inflammation ; Polysaccharides/chemistry ; Inflammatory Bowel Diseases ; NADPH Oxidases/genetics ; Intestinal Mucosa/chemistry
Chemical Substances	Reactive Oxygen Species ; Mucins ; Polysaccharides ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2.

Chatterjee, Maitrayee / van Putten, Jos P M / Strijbis, Karin

mBio

2020 Volume 11, Issue 6

Abstract: Mucus plays a pivotal role in protecting the respiratory tract against microbial infections. It acts as a primary contact site to entrap microbes and facilitates their removal from the respiratory tract via the coordinated beating of motile cilia. The ... ...

Abstract	Mucus plays a pivotal role in protecting the respiratory tract against microbial infections. It acts as a primary contact site to entrap microbes and facilitates their removal from the respiratory tract via the coordinated beating of motile cilia. The major components of airway mucus are heavily
MeSH term(s)	Bacterial Infections/metabolism ; COVID-19/virology ; Glycoproteins/metabolism ; Glycosylation ; Humans ; Mucin 5AC/metabolism ; Mucin-1/metabolism ; Mucin-5B/metabolism ; Mucins/metabolism ; Respiratory Tract Infections/microbiology ; Respiratory Tract Infections/prevention & control ; Respiratory Tract Infections/virology ; SARS-CoV-2/pathogenicity ; Virus Diseases/metabolism
Chemical Substances	Glycoproteins ; MUC1 protein, human ; MUC5AC protein, human ; MUC5B protein, human ; Mucin 5AC ; Mucin-1 ; Mucin-5B ; Mucins
Keywords	covid19
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.02374-20
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Article ; Online: Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface.

Chatterjee, Maitrayee / Huang, Liane Z X / Mykytyn, Anna Z / Wang, Chunyan / Lamers, Mart M / Westendorp, Bart / Wubbolts, Richard W / van Putten, Jos P M / Bosch, Berend-Jan / Haagmans, Bart L / Strijbis, Karin

PLoS pathogens

2023 Volume 19, Issue 8, Page(s) e1011571

Abstract: Mucins play an essential role in protecting the respiratory tract against microbial infections while also acting as binding sites for bacterial and viral adhesins. The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by ... ...

Abstract	Mucins play an essential role in protecting the respiratory tract against microbial infections while also acting as binding sites for bacterial and viral adhesins. The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by mucociliary clearance. Transmembrane mucins MUC1, MUC4, and MUC16 can restrict microbial invasion at the apical surface of the epithelium. In this study, we determined the impact of host mucins and mucin glycans on epithelial entry of SARS-CoV-2. Human lung epithelial Calu-3 cells express the SARS-CoV-2 entry receptor ACE2 and high levels of glycosylated MUC1, but not MUC4 and MUC16, on their cell surface. The O-glycan-specific mucinase StcE specifically removed the glycosylated part of the MUC1 extracellular domain while leaving the underlying SEA domain and cytoplasmic tail intact. StcE treatment of Calu-3 cells significantly enhanced infection with SARS-CoV-2 pseudovirus and authentic virus, while removal of terminal mucin glycans sialic acid and fucose from the epithelial surface did not impact viral entry. In Calu-3 cells, the transmembrane mucin MUC1 and ACE2 are located to the apical surface in close proximity and StcE treatment results in enhanced binding of purified spike protein. Both MUC1 and MUC16 are expressed on the surface of human organoid-derived air-liquid interface (ALI) differentiated airway cultures and StcE treatment led to mucin removal and increased levels of SARS-CoV-2 replication. In these cultures, MUC1 was highly expressed in non-ciliated cells while MUC16 was enriched in goblet cells. In conclusion, the glycosylated extracellular domains of different transmembrane mucins might have similar protective functions in different respiratory cell types by restricting SARS-CoV-2 binding and entry.
MeSH term(s)	Humans ; Mucins/metabolism ; Angiotensin-Converting Enzyme 2 ; COVID-19 ; SARS-CoV-2/metabolism ; CA-125 Antigen/metabolism ; Lung/metabolism ; Polysaccharides
Chemical Substances	Mucins ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; CA-125 Antigen ; Polysaccharides
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011571
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Article ; Online: Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface.

Maitrayee Chatterjee / Liane Z X Huang / Anna Z Mykytyn / Chunyan Wang / Mart M Lamers / Bart Westendorp / Richard W Wubbolts / Jos P M van Putten / Berend-Jan Bosch / Bart L Haagmans / Karin Strijbis

PLoS Pathogens, Vol 19, Iss 8, p e

2023 Volume 1011571

Abstract	Mucins play an essential role in protecting the respiratory tract against microbial infections while also acting as binding sites for bacterial and viral adhesins. The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by mucociliary clearance. Transmembrane mucins MUC1, MUC4, and MUC16 can restrict microbial invasion at the apical surface of the epithelium. In this study, we determined the impact of host mucins and mucin glycans on epithelial entry of SARS-CoV-2. Human lung epithelial Calu-3 cells express the SARS-CoV-2 entry receptor ACE2 and high levels of glycosylated MUC1, but not MUC4 and MUC16, on their cell surface. The O-glycan-specific mucinase StcE specifically removed the glycosylated part of the MUC1 extracellular domain while leaving the underlying SEA domain and cytoplasmic tail intact. StcE treatment of Calu-3 cells significantly enhanced infection with SARS-CoV-2 pseudovirus and authentic virus, while removal of terminal mucin glycans sialic acid and fucose from the epithelial surface did not impact viral entry. In Calu-3 cells, the transmembrane mucin MUC1 and ACE2 are located to the apical surface in close proximity and StcE treatment results in enhanced binding of purified spike protein. Both MUC1 and MUC16 are expressed on the surface of human organoid-derived air-liquid interface (ALI) differentiated airway cultures and StcE treatment led to mucin removal and increased levels of SARS-CoV-2 replication. In these cultures, MUC1 was highly expressed in non-ciliated cells while MUC16 was enriched in goblet cells. In conclusion, the glycosylated extracellular domains of different transmembrane mucins might have similar protective functions in different respiratory cell types by restricting SARS-CoV-2 binding and entry.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Phytochemical composition analysis and evaluation of

Ghosh, Pranabesh / Das, Chandrima / Biswas, Swagata / Nag, Sudip Kumar / Dutta, Alolika / Biswas, Maitrayee / Sil, Sayantan / Hazra, Labani / Ghosh, Chandreyi / Das, Shaktijit / Saha, Moumita / Mondal, Nasim / Mandal, Suprodip / Ghosh, Anirban / Karmakar, Srabani / Chatterjee, Sirshendu

F1000Research

2020 Volume 9, Page(s) 493

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Antioxidants/pharmacology ; Asteraceae/chemistry ; Cells, Cultured ; Cleome/chemistry ; Commelina/chemistry ; Euphorbia/chemistry ; Heliotropium/chemistry ; Humans ; India ; Leukocytes, Mononuclear/drug effects ; Phytochemicals/pharmacology ; Plant Extracts/pharmacology ; Plant Weeds/chemistry
Chemical Substances	Antioxidants ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2020-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.22966.1
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Article ; Online: Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion.

Chatterjee, Maitrayee / Pushkaran, Anju Choorakottayil / Vasudevan, Anil Kumar / Menon, Krishna Kumar N / Biswas, Raja / Mohan, Chethampadi Gopi

International journal of biological macromolecules

2017 Volume 110, Page(s) 598–607

Abstract: Lactobacillus species possesses surface exposed Mucin Binding Protein (MucBP) which plays a role in adhesion to gastrointestinal mucin. MucBP contains one or more mucin binding domain (MBD), the functionality of which has yet not been characterized ... ...

Abstract	Lactobacillus species possesses surface exposed Mucin Binding Protein (MucBP) which plays a role in adhesion to gastrointestinal mucin. MucBP contains one or more mucin binding domain (MBD), the functionality of which has yet not been characterized thoroughly. Here, we have characterized a 93-amino acid MBD (MBD
MeSH term(s)	Adhesins, Bacterial/chemistry ; Adhesins, Bacterial/genetics ; Adhesins, Bacterial/metabolism ; Adhesins, Bacterial/pharmacology ; Animals ; Bacterial Adhesion/drug effects ; Enteropathogenic Escherichia coli/metabolism ; Enteropathogenic Escherichia coli/pathogenicity ; Lactobacillus fermentum/chemistry ; Lactobacillus fermentum/genetics ; Lactobacillus fermentum/metabolism ; Mucins/metabolism ; Protein Domains ; Proteus vulgaris/metabolism ; Proteus vulgaris/pathogenicity ; Salmonella paratyphi A/metabolism ; Salmonella paratyphi A/pathogenicity ; Shigella sonnei/metabolism ; Shigella sonnei/pathogenicity ; Swine
Chemical Substances	Adhesins, Bacterial ; Mucins
Language	English
Publishing date	2017-10-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2017.10.107
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Article: Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion

Chatterjee, Maitrayee / Anil Kumar Vasudevan / Anju Choorakottayil Pushkaran / Chethampadi Gopi Mohan / Krishna Kumar N. Menon / Raja Biswas

International journal of biological macromolecules. 2017,

2017

Abstract	Lactobacillus species possesses surface exposed Mucin Binding Protein (MucBP) which plays a role in adhesion to gastrointestinal mucin. MucBP contains one or more mucin binding domain (MBD), the functionality of which has yet not been characterized thoroughly. Here, we have characterized a 93-amino acid MBD (MBD93) of MucBP (LAF_0673) from Lactobacillus fermentum. Multiple sequence alignment of L. fermentum MBD93 exhibited â¼60% sequence homology with MBDs from other Lactobacillus species. Further, we cloned, expressed and purified MBD93 from Escherichia coli as N-terminal histidine-tagged protein (6X His-MBD93). The purified MBD93 was able to bind to mucin and showed strong affinity towards the terminally expressed mucin glycans viz. N-acetylgalactosamine (GalNAc), N-acetylglucosamine (GlcNAc), Galactose (Gal), and Sialic acid (N-acetylneuraminic acid; Neu5Ac). In silico experiments further confirmed the interaction between homology modeled MBD93 to mucin glycans through hydrogen-bonding with its surface amino acid residues Ser57, Pro58, Ile60, Tyr63 and Ala65. We also have demonstrated that MBD93 was able to inhibit the adhesion of enteric pathogens, including E. coli, Salmonella Paratyphi A, Shigella sonnei and Proteus vulgaris to mucin. Our results suggested that L. fermentum MBD93 is a functionally sufficient unit to act as an adhesin and to protect from invading enteric pathogens.
Keywords	adhesins ; adhesion ; amino acids ; binding proteins ; enteropathogens ; Escherichia coli ; galactose ; gastrointestinal system ; hydrogen bonding ; Lactobacillus fermentum ; mucins ; N-acetylglucosamine ; polysaccharides ; Proteus vulgaris ; Salmonella Paratyphi A ; sequence alignment ; sequence homology ; Shigella sonnei ; sialic acid
Language	English
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2017.10.107
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Article ; Online: Phytochemical composition analysis and evaluation of in vitro medicinal properties and cytotoxicity of five wild weeds

Pranabesh Ghosh / Chandrima Das / Swagata Biswas / Sudip Kumar Nag / Alolika Dutta / Maitrayee Biswas / Sayantan Sil / Labani Hazra / Chandreyi Ghosh / Shaktijit Das / Moumita Saha / Nasim Mondal / Suprodip Mandal / Anirban Ghosh / Srabani Karmakar / Sirshendu Chatterjee

F1000Research, Vol

A comparative study [version 1; peer review: 1 approved, 2 approved with reservations]

2020 Volume 9

Abstract: Background: Medicinal plants are a source of phytochemicals and they are used for the treatment of several oxidative stress-related or other diseases for their effectiveness, low toxicity and easy availability. Five traditionally used and less ... ...

Abstract	Background: Medicinal plants are a source of phytochemicals and they are used for the treatment of several oxidative stress-related or other diseases for their effectiveness, low toxicity and easy availability. Five traditionally used and less characterized herbaceous weeds of West Bengal, India, namely, Heliotropium indicum, Tridax procumbens, Cleome rutidosperma, Commelina benghalensis and Euphorbia hirta, were investigated for the current research study. Methods: Aqueous and 70% ethanolic extracts of the leaves were analyzed for estimation of essential phytochemicals and to evaluate their in vitro antioxidant status, medicinal properties and cytotoxic effects. To the best of our knowledge, several assays and comparative evaluations using these herbs are reported for the first time. For quantitative study, UV-vis spectrophotometry and high-performance liquid chromatography with diode array detector HPLC-DAD techniques were used. Antibacterial properties were investigated using the Kirby-Bauer disc diffusion method. For in vitro anti-lithiatic study, a titration method was used. The cell viability assay was done using peripheral blood mononuclear cells. Results: The aqueous extract exhibits higher content of polyphenols, flavonoids, tannins and inhibition percentage values for free radical scavenging assays, whereas the 70% ethanolic extract exhibits higher content of alkaloids and cardiac glycosides. HPLC-DAD analysis of 70% ethanolic extracts led us to identify 10 predominant phenolic constituents. Euphorbia hirta extracts showed minimum cytotoxicity (cell death ~2.5% and 4% in water and 70% ethanolic extract, respectively), whereas Cleome rutidosperma and Tridax procumbens’ 70% ethanolic extracts showed higher cell death (~13% and 28%, respectively), compared with the control (cell death ~10-12%). Conclusions: The study concluded that of all the medicinal weeds selected for the current study, Euphorbia hirta possesses the highest amount of bioactive compounds and hence exhibits the highest in vitro antioxidant activity and promising in vitro medicinal properties.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
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Article ; Online: Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options.

Chatterjee, Maitrayee / Anju, C P / Biswas, Lalitha / Anil Kumar, V / Gopi Mohan, C / Biswas, Raja

International journal of medical microbiology : IJMM

2016 Volume 306, Issue 1, Page(s) 48–58

Abstract: Pseudomonas aeruginosa is a leading cause of nosocomial infections and is responsible for ∼10% of all hospital-acquired infections worldwide. It continues to pose a therapeutic challenge because of the high rate of morbidity and mortality associated with ...

Abstract	Pseudomonas aeruginosa is a leading cause of nosocomial infections and is responsible for ∼10% of all hospital-acquired infections worldwide. It continues to pose a therapeutic challenge because of the high rate of morbidity and mortality associated with it and the possibility of development of drug resistance during therapy. Standard antibiotic regimes against P. aeruginosa are increasingly becoming ineffective due to the rise in drug resistance. With the scope for developing new antibiotics being limited, alternative treatment options are gaining more and more attention. A number of recent studies reported complementary and alternative treatment options to combat P. aeruginosa infections. Quorum sensing inhibitors, phages, probiotics, anti-microbial peptides, vaccine antigens and antimicrobial nanoparticles have the potential to act against drug resistant strains. Unfortunately, most studies considering alternative treatment options are still confined in the pre-clinical stages, although some of these findings have tremendous potential to be turned into valuable therapeutics. This review is intended to raise awareness of several novel approaches that can be considered further for combating drug resistant P. aeruginosa infections.
MeSH term(s)	Biological Products/pharmacology ; Biological Products/therapeutic use ; Biological Therapy/methods ; Drug Resistance, Bacterial ; Humans ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/therapy ; Pseudomonas aeruginosa/drug effects
Chemical Substances	Biological Products
Language	English
Publishing date	2016-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2015.11.004
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Article ; Online: Antimicrobial activity of plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans.

Nair, Sweatha V / Baranwal, Gaurav / Chatterjee, Maitrayee / Sachu, Arun / Vasudevan, Anil Kumar / Bose, Chinchu / Banerji, Asoke / Biswas, Raja

International journal of medical microbiology : IJMM

2016 Volume 306, Issue 4, Page(s) 237–248

Abstract: Candida albicans and Staphylococcus aureus are opportunistic pathogens. Despite causing a number of independent infections, both pathogens can co-infect to cause urinary tract infections, skin infections, biofilm associated infections, sepsis and ... ...

Abstract	Candida albicans and Staphylococcus aureus are opportunistic pathogens. Despite causing a number of independent infections, both pathogens can co-infect to cause urinary tract infections, skin infections, biofilm associated infections, sepsis and pneumonia. Infections of these two pathogens especially their biofilm associated infections are often difficult to treat using currently available anti-bacterial and anti-fungal agents. In order to identify a common anti-microbial agent which could confer a broad range of protection against their infections, we screened several phytochemicals and identified plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a phytochemical from Plumbago species as a potent antimicrobial agent against S. aureus and C. albicans, with a minimum inhibitory concentration of 5μg/ml. Antimicrobial activity of plumbagin was validated using an ex-vivo porcine skin model. For better understanding of the antimicrobial activity of plumbagin, a Drosophila melanogaster infection model was used, where D. melanogaster was infected using S. aureus and C. albicans, or with both organisms. The fly's survival rate was dramatically increased when infected flies were treated using plumbagin. Further, plumbagin was effective in preventing and dispersing catheter associated biofilms formed by these pathogens. The overall results of this work provides evidence that plumbagin, possesses an excellent antimicrobial activity which should be explored further for the treatment of S. aureus and C. albicans infections.
MeSH term(s)	Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification ; Anti-Infective Agents/pharmacology ; Biofilms/drug effects ; Candida albicans/drug effects ; Candida albicans/physiology ; Candidiasis/drug therapy ; Disease Models, Animal ; Drosophila melanogaster ; Female ; Microbial Sensitivity Tests ; Naphthoquinones/chemistry ; Naphthoquinones/isolation & purification ; Naphthoquinones/pharmacology ; Phytochemicals/chemistry ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plumbaginaceae/chemistry ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology ; Survival Analysis ; Treatment Outcome
Chemical Substances	Anti-Infective Agents ; Naphthoquinones ; Phytochemicals ; plumbagin (YAS4TBQ4OQ)
Language	English
Publishing date	2016-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2016.05.004
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