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  1. Article ; Online: A Personal Tribute to a Highly Inspiring Mentor, Professor Sir Peter J. Lachmann, 1931-2020.

    Würzner, Reinhard

    Viruses

    2021  Volume 13, Issue 2

    Abstract: With great sadness and sympathy for his family, especially for his wife and companion for many decades, Sylvia, I convey the news of the peaceful passing of Professor Sir Peter Lachmann on 26 December 2020, three days after his 89th birthday and after a ... ...

    Abstract With great sadness and sympathy for his family, especially for his wife and companion for many decades, Sylvia, I convey the news of the peaceful passing of Professor Sir Peter Lachmann on 26 December 2020, three days after his 89th birthday and after a Christmas celebration-as far as this was possible these days-in the heart of his family [...].
    MeSH term(s) Awards and Prizes ; Complement System Proteins/history ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Mentors
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13020206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In Memory of Two Pioneers in the Complement Field-Sir Peter J. Lachmann, 1931-2020 & Robert B. Sim, 1951-2021.

    Würzner, Reinhard

    Viruses

    2021  Volume 13, Issue 3

    Abstract: With deep sadness, we have to accept that two cornerstones, not just of British immunology, but also world-famous scientists in the field of complement research, passed away within the margin of a few weeks: Peter Julius Lachmann on 26 December 2020 ( ... ...

    Abstract With deep sadness, we have to accept that two cornerstones, not just of British immunology, but also world-famous scientists in the field of complement research, passed away within the margin of a few weeks: Peter Julius Lachmann on 26 December 2020 (Figure 1), and Robert Braidwood Sim (known to everyone as Bob) on 6 February 2021 (Figure 2) [...].
    MeSH term(s) Complement System Proteins ; History, 20th Century ; History, 21st Century ; Humans ; Laboratory Personnel/history ; Male ; Research/education ; Research/history ; United Kingdom
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-03-08
    Publishing country Switzerland
    Document type Editorial ; Historical Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13030431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: European Union funded project on the development of a whole complement deficiency screening ELISA-A story of success and an exceptional manager: Mohamed R. Daha.

    Würzner, Reinhard / Tedesco, Francesco / Garred, Peter / Mollnes, Tom Eirik / Truedsson, Lennart / Turner, Malcolm W / Sommarin, Yngve / Wieslander, Jörgen / Sim, Robert B

    Molecular immunology

    2015  Volume 68, Issue 1, Page(s) 63–66

    Abstract: ... The consortium was led by Prof. Mohamed R. Daha who had already guided a preceding European grant which prepared ...

    Abstract A whole complement ELISA-based assay kit, primarily designed to screen for deficiencies in components of the complement system was developed during a European Union grant involving more than a dozen European scientists and a small-medium enterprise company (Wieslab, which later merged into Eurodiagnostica). The consortium was led by Prof. Mohamed R. Daha who had already guided a preceding European grant which prepared the ground for this endeavor to create a novel and sophisticated complement measurement tool. The final result of the grant was a scientific publication (Seelen et al., 2005, J. Immunol. Methods 296, 187-198) and a commercially available complement deficiency screening kit, WIESLAB(®) Complement system Screen. Thereafter, the group decided to carry on with a grant, located at Innsbruck Medical University, and supported by royalties and unrestricted educational grants from Eurodiagnostica, Malmö, entitled "Search for Applications for WIESLAB(®) Complement system Screen (SAW)" with the aim to look for further applications of this assay. During the latter project the group organized several scientific meetings aimed at evaluating the use of the assay as well as developing further branches of its platform. A look back over almost two decades reveals a great story of excellent research which was also commercially successful, fulfilling the aims of European Union grants. It is also a story of ageless friendship, only possible due to the vision and guidance of an exceptional manager: Moh Daha.
    MeSH term(s) Allergy and Immunology/history ; Allergy and Immunology/manpower ; Biomedical Research/history ; Biomedical Research/manpower ; Complement System Proteins/analysis ; Complement System Proteins/deficiency ; Complement System Proteins/genetics ; Cooperative Behavior ; Enzyme-Linked Immunosorbent Assay/history ; Enzyme-Linked Immunosorbent Assay/methods ; European Union ; Gene Expression ; History, 20th Century ; History, 21st Century ; Humans
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2015-11
    Publishing country England
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2015.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
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  4. Article ; Online: Comprehensive Update and Revision of Nomenclature on Complement C6 and C7 Variants.

    Massri, Mariam / Foco, Luisa / Würzner, Reinhard

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 208, Issue 12, Page(s) 2597–2612

    Abstract: Complement genes encompass a wide array of variants, giving rise to numerous protein isoforms that have often been shown to exhibit clinical significance. Given that these variants have been discovered over a span of 50 y, one challenging consequence is ... ...

    Abstract Complement genes encompass a wide array of variants, giving rise to numerous protein isoforms that have often been shown to exhibit clinical significance. Given that these variants have been discovered over a span of 50 y, one challenging consequence is the inconsistency in the terminology used to classify them. This issue is prominently evident in the nomenclature used for complement C6 and C7 variants, for which we observed a great discrepancy between previously published works and variants described in current genome browsers. This report discusses the causes for the discrepancies in C6 and C7 nomenclature and seeks to establish a classification system that would unify existing and future variants. The inconsistency in the methods used to annotate amino acids and the modifications pinpointed in the C6 and C7 primers are some of the factors that contribute greatly to the discrepancy in the nomenclature. Several variants that were classified incorrectly are highlighted in this report, and we showcase first-hand how a unified classification system is important to match previous with current genetic information. Ultimately, we hope that the proposed classification system of nomenclature becomes an incentive for studies on complement variants and their physiological and/or pathological effects.
    MeSH term(s) Complement C5 ; Complement C6/genetics ; Complement C7/genetics ; Complement System Proteins
    Chemical Substances Complement C5 ; Complement C6 ; Complement C7 ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200045
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    Ud II Zs.37: Show issues Location:
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  5. Article ; Online: Ambient Availability of Amino Acids, Proteins, and Iron Impacts Copper Resistance of

    Yap, Annie / Talasz, Heribert / Lindner, Herbert / Würzner, Reinhard / Haas, Hubertus

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 847846

    Abstract: The transition metals iron and copper are required by virtually all organisms but are toxic in excess. Acquisition of both metals and resistance to copper excess have previously been shown to be important for virulence of the most common airborne human ... ...

    Abstract The transition metals iron and copper are required by virtually all organisms but are toxic in excess. Acquisition of both metals and resistance to copper excess have previously been shown to be important for virulence of the most common airborne human mold pathogen,
    MeSH term(s) Amino Acids/metabolism ; Aspergillus fumigatus ; Copper/metabolism ; Gene Expression Regulation, Fungal ; Histidine/genetics ; Histidine/metabolism ; Humans ; Iron/metabolism
    Chemical Substances Amino Acids ; Histidine (4QD397987E) ; Copper (789U1901C5) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-04-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.847846
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  6. Article ; Online: Multidisciplinary expert group: communication measures to increase vaccine compliance in adults.

    Hastall, Matthias R / Koinig, Isabell / Kunze, Ursula / Meixner, Oliver / Sachse, Katharina / Würzner, Reinhard

    Wiener medizinische Wochenschrift (1946)

    2022  

    Abstract: The WHO categorized vaccine hesitancy as one of the greatest threats to global health worldwide. Vaccination of elderly persons is of increasing relevance, given that they represent a growing segment in the population and considering the burden diseases ... ...

    Title translation Multidisziplinäre Expertengruppe: Kommunikationsmaßnahmen zur Erhöhung der Impfbereitschaft bei Erwachsenen.
    Abstract The WHO categorized vaccine hesitancy as one of the greatest threats to global health worldwide. Vaccination of elderly persons is of increasing relevance, given that they represent a growing segment in the population and considering the burden diseases pose to them. Many factors leading to vaccine hesitancy are related to inadequate communication. In the present report, experts from various academic fields present recommendations to support communication strategies that may help to initiate targeted communication measures to enhance vaccination compliance in adults.
    Language English
    Publishing date 2022-07-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-022-00946-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 903: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Book ; Thesis: Zur Beeinflussung des Gerinnungssystems durch ein niedermolekulares Heparin bei gesunden Personen

    Würzner, Reinhard

    1986  

    Size 135 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1986
    HBZ-ID HT003245212
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    87 E 1170 order for loan Magazin

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  8. Article ; Online: Editorial: The Role of Complement in Microbial Infections.

    Stoiber, Heribert / Thielens, Nicole / Würzner, Reinhard / De Messias Reason, Iara

    Frontiers in immunology

    2021  Volume 12, Page(s) 640092

    Language English
    Publishing date 2021-03-04
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.640092
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  9. Article ; Online: The Complex Role of Regulatory T Cells in Immunity and Aging.

    Rocamora-Reverte, Lourdes / Melzer, Franz Leonard / Würzner, Reinhard / Weinberger, Birgit

    Frontiers in immunology

    2021  Volume 11, Page(s) 616949

    Abstract: The immune system is a tightly regulated network which allows the development of defense mechanisms against foreign antigens and tolerance toward self-antigens. Regulatory T cells (Treg) contribute to immune homeostasis by maintaining unresponsiveness to ...

    Abstract The immune system is a tightly regulated network which allows the development of defense mechanisms against foreign antigens and tolerance toward self-antigens. Regulatory T cells (Treg) contribute to immune homeostasis by maintaining unresponsiveness to self-antigens and suppressing exaggerated immune responses. Dysregulation of any of these processes can lead to serious consequences. Classically, Treg cell functions have been described in CD4
    MeSH term(s) Aging/immunology ; Animals ; Humans ; Immunity, Cellular/immunology ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.616949
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  10. Article ; Online: MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis.

    Rosbjerg, Anne / Würzner, Reinhard / Garred, Peter / Skjoedt, Mikkel-Ole

    Journal of innate immunity

    2021  Volume 13, Issue 4, Page(s) 211–224

    Abstract: Activation of the complement system is mediated by the interaction between pathogens and pattern recognition molecules (PRMs); mannose-binding lectin (MBL), ficolins, and collectin-10/-11 from the lectin pathway and C1q from the classical pathway. Lectin ...

    Abstract Activation of the complement system is mediated by the interaction between pathogens and pattern recognition molecules (PRMs); mannose-binding lectin (MBL), ficolins, and collectin-10/-11 from the lectin pathway and C1q from the classical pathway. Lectin pathway activation specifically depends on proteases named MBL-associated serine proteases (MASPs) that are found in complexes with PRMs. In this study, we hypothesize that MASPs can recognize selected pathogens independently of PRMs. Using different clinical strains of opportunistic fungi, we have observed that MASPs directly recognize certain fungal pathogens in a way that can facilitate complement activation. Among these were Aspergillus fumigatus - a dangerous pathogen, especially for immunocompromised patients. In flow cytometry and fluorescence microscopy, we found that MASP-1 and -3 bound to all A. fumigatus growth stages (conidia, germ tubes, and hyphae), whereas rMASP-2 and the nonproteolytic rMAP-1 did not. Bound rMASPs could recruit rMBL and rficolin-3 to A. fumigatus conidia in a nonclassical manner and activate complement via rMASP-2. In experiments using recombinant and purified components, rMASP-1 increased the neutrophilic phagocytosis of conidia. In serum where known complement activation pathways were blocked, phagocytosis could be mediated by rMASP-3. We have encountered an unknown pathway for complement activation and found that MASP-1 and MASP-3 have dual functions as enzymes and as PRMs.
    MeSH term(s) Aspergillus fumigatus ; Complement Activation ; Complement Pathway, Mannose-Binding Lectin ; Complement System Proteins ; Humans ; Mannose-Binding Lectin ; Mannose-Binding Protein-Associated Serine Proteases ; Phagocytosis
    Chemical Substances Mannose-Binding Lectin ; Complement System Proteins (9007-36-7) ; MASP1 protein, human (EC 3.4.21.-) ; Mannose-Binding Protein-Associated Serine Proteases (EC 3.4.21.-)
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000514546
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    Zs.A 6727: Show issues Location:
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