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Article ; Online: Effect of electron beam irradiation in gas atmosphere during ETEM.

Tokunaga, Tomoharu / Kawakami, Takumi / Higuchi, Kimitaka / Yamamoto, Yuta / Yamamoto, Takahisa

Micron (Oxford, England : 1993)

2022 Volume 158, Page(s) 103289

Abstract: Transmission electron microscopy (TEM) is used to observe the atomic structures of materials. Environmental TEM (ETEM) is a method wherein a gas can be evaluated and it has been used to observe the dynamic reaction between materials and gases at the ... ...

Abstract	Transmission electron microscopy (TEM) is used to observe the atomic structures of materials. Environmental TEM (ETEM) is a method wherein a gas can be evaluated and it has been used to observe the dynamic reaction between materials and gases at the atomic level. An electron beam (EB), which has a sufficiently high energy (exceeding a few tens of kilovolts), can be used to ionize gas molecules. Subsequently, the ionized molecules might react with the materials during ETEM. Therefore, the current generated by the ions and electrons were measured to verify the presence of ions generated due to the ionization of the N
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	207808-9
ISSN	1878-4291 ; 0047-7206 ; 0968-4328
ISSN (online)	1878-4291
ISSN	0047-7206 ; 0968-4328
DOI	10.1016/j.micron.2022.103289
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Article ; Online: Plasmapheresis for systemic vasculitis.

Fukuoka, Kazuhito / Kishimoto, Mitsumasa / Kawakami, Takahisa / Komagata, Yosinori / Kaname, Shinya

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2022 Volume 26, Issue 3, Page(s) 493–506

Abstract: Systemic vasculitides include a variety of, and numerous diseases. In 2012, the International CHAPEL HILL Consensus Conference (CHCC2012) led to a major reorganization of the classification of vasculitis, and this is still in wide use today. Although the ...

Abstract	Systemic vasculitides include a variety of, and numerous diseases. In 2012, the International CHAPEL HILL Consensus Conference (CHCC2012) led to a major reorganization of the classification of vasculitis, and this is still in wide use today. Although the results of plasmapheresis for individual diseases have been sometimes shown, there are few systematic reviews that discuss the effects along with vasculitis classification. Therefore, we will discuss the efficacy and the latest evidence for each vasculitis according to the CHCC 2012 classification in this review. This review provides a comprehensive overview of the estimation of plasmapheresis in each of the vasculitides, with a particular focus on small vasculitides, which have recently discussed frequently. For some time now, plasma exchange therapy (PEX) has been frequently used and is expected to be effective in some diseases, most of which are included in small vessel vasculitides. In particular, data showing efficacy have been accumulated for immune complex vasculitis, and the recommendation seems to be high. For instance, anti-GBM nephritis, concomitant use of PEX is essential and strongly recommended. On the other hand, for ANCA-related vasculitis among small vessel vasculitis, RCTs have recently shown negative results. In particular, the PEXIVAS trial statistically showed that PEX has no potential to reduce the mortality and renal death in AAV, but the ASFA, ACR, and KDIGO guidelines following this trial all regard PEX as salvage therapy or selective treatment for severe cases. As plasmapheresis is often performed in combination with other therapies, it is difficult to evaluate to clarify its efficacy on its own, and this predisposition may be pronounced in vasculitis, a rare disease. Although statistically significant differences are not apparent, the diseases that show a trend toward efficacy may possibly include treatment-sensitive subgroups. Further analysis is expected in the future.
MeSH term(s)	Consensus ; Humans ; Plasma Exchange ; Plasmapheresis ; Systemic Vasculitis/therapy ; Vasculitis/therapy
Language	English
Publishing date	2022-03-16
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.13829
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Zs.A 5208: Show issues

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Article ; Online: Minute oscillation stretching: A novel modality for reducing musculo-tendinous stiffness and maintaining muscle strength.

Ikeda, Naoki / Yonezu, Takahisa / Kawakami, Yasuo

Scandinavian journal of medicine & science in sports

2020 Volume 31, Issue 1, Page(s) 104–114

Abstract: A novel stretching modality was developed to provide repetitive small length changes to the plantar flexors undergoing passive stretch defined as "minute oscillation stretching" (MOS). This study investigated the effects of MOS on neuromuscular activity ... ...

Abstract	A novel stretching modality was developed to provide repetitive small length changes to the plantar flexors undergoing passive stretch defined as "minute oscillation stretching" (MOS). This study investigated the effects of MOS on neuromuscular activity during force production, the rate of torque development (RTD), and the elastic properties of the plantar flexors and Achilles tendon. Ten healthy males participated in this study. The neuromuscular activity of the triceps surae and tibialis anterior muscles during maximal voluntary plantar flexion torque [MVT], RTD of plantar flexion, Achilles tendon stiffness, and muscle stiffness were measured before and after two types of interventions for a total of 5 minutes: static stretching (SS) and MOS at 15 Hz and without intervention (control). Achilles tendon stiffness was calculated from the tendon elongation measuring by ultrasonography. Muscle stiffness was determined for the medial gastrocnemius [MG] using shear wave elastography. The MVT, mean electromyographic amplitudes [mEMG] of MG and lateral gastrocnemius [LG], and RTD were significantly decreased following SS (MVT: -7.2 ± 7.9%; mEMG of MG: -8.7 ± 10.2%; mEMG of LG: -12.4 ± 10.5%; RTD: -6.6 ± 6.8%), but not after MOS. Achilles tendon stiffness significantly decreased after SS (-13.4 ± 12.3%) and MOS (-9.7 ± 11.5%), with no significant differences between them. Muscle stiffness significantly decreased in SS and MOS, with relative changes being significantly greater for MOS (-7.9 ± 8.3%) than SS (-2.3 ± 2.9%) interventions. All variables remained unchanged in the controls. In conclusion, MOS changed muscle-tendon compliance without loss of muscle function.
MeSH term(s)	Achilles Tendon/diagnostic imaging ; Achilles Tendon/physiology ; Adult ; Ankle/diagnostic imaging ; Ankle/physiology ; Elasticity ; Elasticity Imaging Techniques ; Humans ; Male ; Muscle Strength ; Muscle Stretching Exercises ; Muscle, Skeletal/physiology ; Torque ; Ultrasonography ; Young Adult
Language	English
Publishing date	2020-10-07
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1077418-x
ISSN	1600-0838 ; 0905-7188
ISSN (online)	1600-0838
ISSN	0905-7188
DOI	10.1111/sms.13830
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Zs.A 3247: Show issues

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Article: Effect of electron beam irradiation in gas atmosphere during ETEM

Tokunaga, Tomoharu / Kawakami, Takumi / Higuchi, Kimitaka / Yamamoto, Yuta / Yamamoto, Takahisa

Micron. 2022 July, v. 158

2022

Abstract	Transmission electron microscopy (TEM) is used to observe the atomic structures of materials. Environmental TEM (ETEM) is a method wherein a gas can be evaluated and it has been used to observe the dynamic reaction between materials and gases at the atomic level. An electron beam (EB), which has a sufficiently high energy (exceeding a few tens of kilovolts), can be used to ionize gas molecules. Subsequently, the ionized molecules might react with the materials during ETEM. Therefore, the current generated by the ions and electrons were measured to verify the presence of ions generated due to the ionization of the N₂ gas atmosphere during EB irradiation in ETEM. The electron energy loss spectra (EELS) were acquired from the N₂ gas atmosphere to estimate the types of ions generated. The results demonstrated that ions and electrons were generated in the N₂ atmosphere during ETEM and EB irradiation. Moreover, the EELS analysis indicated that the generated ion was N₂⁺. The material observation conducted using gas ETEM can detect the reaction between gases, ions, and materials.
Keywords	energy ; ionization ; irradiation
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	207808-9
ISSN	1878-4291 ; 0047-7206 ; 0968-4328
ISSN (online)	1878-4291
ISSN	0047-7206 ; 0968-4328
DOI	10.1016/j.micron.2022.103289
Database	NAL-Catalogue (AGRICOLA)

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Recanalization of an obstructive pancreaticojejunal anastomosis with direct visualization by using antegrade peroral pancreatoscopy.

Kawakami, Yujiro / Koshita, Shinsuke / Kanno, Yoshihide / Ogawa, Takahisa / Murabayashi, Toji / Nakase, Hiroshi / Ito, Kei

Endoscopy

2020 Volume 52, Issue 10, Page(s) E376–E377

MeSH term(s)	Cholangiopancreatography, Endoscopic Retrograde ; Humans ; Pancreatic Ducts/surgery ; Pancreaticojejunostomy
Language	English
Publishing date	2020-03-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1133-4304
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of wearing surgical masks on fraction of inspired oxygen in spontaneously breathing patients: improving safety for frontline healthcare professionals under pandemic situations.

Minoguchi, Kazuhiro / Isii, Akira / Nakamura, Toshiki / Sato, Hitoshi / Abe, Takeru / Kawakami, Hiromasa / Nakamura, Kyota / Goto, Takahisa

BMC anesthesiology

2022 Volume 22, Issue 1, Page(s) 108

Abstract: Background: During pandemic situations, many guidelines recommend that surgical masks be worn by both healthcare professionals and infected patients in healthcare settings. The purpose of this study was to clarify the levels and changes of oxygen ... ...

Abstract	Background: During pandemic situations, many guidelines recommend that surgical masks be worn by both healthcare professionals and infected patients in healthcare settings. The purpose of this study was to clarify the levels and changes of oxygen concentration over time while oxygen was administered over a surgical mask. Methods: Patients scheduled to undergo general anesthesia (n = 99) were enrolled in this study. First, patients were administered oxygen at 6 L/min via an oxygen mask over a surgical mask for 5 min. The patients removed the surgical mask and then took a 3-min break; thereafter, the same amount of oxygen was administered for another 5 min via the oxygen mask. We measured the fraction of inspired oxygen (FiO Results: The FiO Conclusion: The FiO
MeSH term(s)	Delivery of Health Care ; Humans ; Masks ; Oxygen ; Pandemics ; Respiration
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-022-01649-x
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Article ; Online: Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients: A systematic review and meta-analysis.

Nakajima, Daisuke / Kawakami, Hiromasa / Mihara, Takahiro / Sato, Hitoshi / Goto, Takahisa

PloS one

2020 Volume 15, Issue 1, Page(s) e0227904

Abstract: Background: Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect of lidocaine in pediatric patients ... ...

Abstract	Background: Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect of lidocaine in pediatric patients remains unclear. We conducted a systematic review and meta-analysis with Trial Sequential Analysis to evaluate the effect of intravenous lidocaine on prevention of POV/PONV. Methods: Six databases including trial registration sites were searched. Randomized clinical trials evaluating the incidence of POV/PONV after intravenous lidocaine compared with control were included. The primary outcome was the incidence of POV within 24 hours after general anesthesia. The incidence of POV was combined as a risk ratio with 95% confidence interval using a random-effect model. We used the I2 to assess heterogeneity. We evaluated the quality of trials using the Cochrane methodology, and we assessed quality of evidence using the Grading of Recommendation Assessment, Development, and Evaluation approach. We also assessed adverse events. Results and discussion: Six trials with 849 patients were included, of whom 433 received intravenous lidocaine. Three trials evaluated the incidence of POV, and 3 evaluated the incidence of PONV. The overall incidence of POV within 24 hours after anesthesia was 45.9% in the lidocaine group and 63.4% in the control group (risk ratio, 0.73; 95% confidence interval, 0.53-1.00; I2 = 32%; p = 0.05). The incidence of PONV within 24 hours after anesthesia was 3.73% in the lidocaine group and 4.87% in the control group (RR, 0.76; 95% CI, 0.36-1.59; I2 = 0%; p = 0.47). The quality of evidence was downgraded to "very low" due to the study designs, inconsistency, imprecision, and possible publication bias. Conclusion: Our meta-analysis suggests that intravenous lidocaine infusion may reduce the incidence of POV, however, the evidence quality was "very low." Further trials with a low risk of bias are necessary.
MeSH term(s)	Administration, Intravenous ; Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Lidocaine/therapeutic use ; Male ; Pediatrics ; Postoperative Complications/drug therapy ; Postoperative Complications/physiopathology ; Postoperative Nausea and Vomiting/drug therapy ; Postoperative Nausea and Vomiting/pathology ; Randomized Controlled Trials as Topic
Chemical Substances	Lidocaine (98PI200987)
Language	English
Publishing date	2020-01-28
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0227904
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of anesthetic agents on the amount of bleeding during dilatation and evacuation: A systematic review and meta-analysis.

Lee, Hyun Ah / Kawakami, Hiromasa / Mihara, Takahiro / Sato, Hitoshi / Goto, Takahisa

PloS one

2021 Volume 16, Issue 12, Page(s) e0261494

Abstract: Purpose: Patients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is ... ...

Abstract	Purpose: Patients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is lacking. Therefore, we conducted a systematic review and meta-analysis to compare the effects of volatile anesthetics and propofol on the amount of bleeding in patients undergoing dilatation and evacuation. Methods: We conducted a systematic search of four databases, namely PubMed, Embase, Cochrane Central Register of Controlled Trials databases, and Web of Science (Clarivate Analytics), from their respective inception to April 2021. Moreover, we searched two trial registration sites. The inclusion criterion was randomized controlled trials of patients who underwent dilatation and evacuation under general anesthesia using volatile anesthetics or propofol. The primary outcome was the amount of perioperative bleeding. The mean difference of the bleeding was combined using a random-effects model. The I2 statistic was used to assess heterogeneity. We assessed risk of bias with Cochrane domains. We controlled type I and II errors due to sparse data and repetitive testing with Trial Sequential Analysis. We assessed the quality of evidence with GRADE. Results: Five studies were included in the systematic review. The amount of bleeding was compared in four studies and was higher in the volatile anesthetic group, with a mean difference of 164.7 ml (95% confidence interval, 43.6 to 285.7; p = 0.04). Heterogeneity was considerable, with an I2 value of 97%. Two studies evaluated the incidence of significant bleeding, which was significantly higher in the volatile anesthetic group (RR, 2.42; 95% confidence interval, 1.04-5.63; p = 0.04). Conclusion: Choosing propofol over volatile anesthetics during dilatation and evacuation might reduce bleeding and the incidence of excessive bleeding. However, the quality of the evidence was very low. This necessitates further trials with a low risk of bias. Trial registration: PROSPERO (CRD42019120873).
MeSH term(s)	Abortion, Induced/adverse effects ; Abortion, Induced/methods ; Abortion, Spontaneous/surgery ; Anesthetics, Inhalation/adverse effects ; Anesthetics, Inhalation/therapeutic use ; Anesthetics, Intravenous/adverse effects ; Anesthetics, Intravenous/therapeutic use ; Dilatation and Curettage/adverse effects ; Dilatation and Curettage/methods ; Female ; Hemorrhage/chemically induced ; Humans ; Incidence ; Pregnancy ; Propofol/adverse effects ; Propofol/therapeutic use
Chemical Substances	Anesthetics, Inhalation ; Anesthetics, Intravenous ; Propofol (YI7VU623SF)
Language	English
Publishing date	2021-12-22
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0261494
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients

Daisuke Nakajima / Hiromasa Kawakami / Takahiro Mihara / Hitoshi Sato / Takahisa Goto

PLoS ONE, Vol 15, Iss 1, p e

A systematic review and meta-analysis.

2020 Volume 0227904

Abstract: BACKGROUND:Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect of lidocaine in pediatric patients remains ... ...

Abstract	BACKGROUND:Intravenous lidocaine in adults undergoing general anesthesia has been shown to reduce the incidence of postoperative nausea and vomiting (PONV). However, the anti-postoperative vomiting (POV) effect of lidocaine in pediatric patients remains unclear. We conducted a systematic review and meta-analysis with Trial Sequential Analysis to evaluate the effect of intravenous lidocaine on prevention of POV/PONV. METHODS:Six databases including trial registration sites were searched. Randomized clinical trials evaluating the incidence of POV/PONV after intravenous lidocaine compared with control were included. The primary outcome was the incidence of POV within 24 hours after general anesthesia. The incidence of POV was combined as a risk ratio with 95% confidence interval using a random-effect model. We used the I2 to assess heterogeneity. We evaluated the quality of trials using the Cochrane methodology, and we assessed quality of evidence using the Grading of Recommendation Assessment, Development, and Evaluation approach. We also assessed adverse events. RESULTS AND DISCUSSION:Six trials with 849 patients were included, of whom 433 received intravenous lidocaine. Three trials evaluated the incidence of POV, and 3 evaluated the incidence of PONV. The overall incidence of POV within 24 hours after anesthesia was 45.9% in the lidocaine group and 63.4% in the control group (risk ratio, 0.73; 95% confidence interval, 0.53-1.00; I2 = 32%; p = 0.05). The incidence of PONV within 24 hours after anesthesia was 3.73% in the lidocaine group and 4.87% in the control group (RR, 0.76; 95% CI, 0.36-1.59; I2 = 0%; p = 0.47). The quality of evidence was downgraded to "very low" due to the study designs, inconsistency, imprecision, and possible publication bias. CONCLUSION:Our meta-analysis suggests that intravenous lidocaine infusion may reduce the incidence of POV, however, the evidence quality was "very low." Further trials with a low risk of bias are necessary.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of anesthetic agents on the amount of bleeding during dilatation and evacuation

Hyun Ah Lee / Hiromasa Kawakami / Takahiro Mihara / Hitoshi Sato / Takahisa Goto

PLoS ONE, Vol 16, Iss 12, p e

A systematic review and meta-analysis.

2021 Volume 0261494

Abstract: Purpose Patients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is ... ...

Abstract	Purpose Patients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is lacking. Therefore, we conducted a systematic review and meta-analysis to compare the effects of volatile anesthetics and propofol on the amount of bleeding in patients undergoing dilatation and evacuation. Methods We conducted a systematic search of four databases, namely PubMed, Embase, Cochrane Central Register of Controlled Trials databases, and Web of Science (Clarivate Analytics), from their respective inception to April 2021. Moreover, we searched two trial registration sites. The inclusion criterion was randomized controlled trials of patients who underwent dilatation and evacuation under general anesthesia using volatile anesthetics or propofol. The primary outcome was the amount of perioperative bleeding. The mean difference of the bleeding was combined using a random-effects model. The I2 statistic was used to assess heterogeneity. We assessed risk of bias with Cochrane domains. We controlled type I and II errors due to sparse data and repetitive testing with Trial Sequential Analysis. We assessed the quality of evidence with GRADE. Results Five studies were included in the systematic review. The amount of bleeding was compared in four studies and was higher in the volatile anesthetic group, with a mean difference of 164.7 ml (95% confidence interval, 43.6 to 285.7; p = 0.04). Heterogeneity was considerable, with an I2 value of 97%. Two studies evaluated the incidence of significant bleeding, which was significantly higher in the volatile anesthetic group (RR, 2.42; 95% confidence interval, 1.04-5.63; p = 0.04). Conclusion Choosing propofol over volatile anesthetics during dilatation and evacuation might reduce bleeding and the incidence of excessive bleeding. However, the quality of the evidence was very low. This necessitates further trials with a low ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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