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Article ; Online: Changes in epidemiology of parainfluenza virus and respiratory syncytial virus infection during coronavirus disease 2019 pandemic in Korea.

Kim, Kyung-Ran / Park, Hwanhee / Kim, Doo Ri / Kim, Yae-Jean

Clinical and experimental pediatrics

2022 Volume 65, Issue 6, Page(s) 320–321

Language	English
Publishing date	2022-03-10
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2713-4148
ISSN (online)	2713-4148
DOI	10.3345/cep.2021.01823
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Article ; Online: COVID-19 Vaccination Status Among Korean Pediatric Population With Comorbidities.

Shin, Areum / Kim, Dong Wook / Kim, Young-Eun / Kim, Doo Ri / Jung, Jaehun / Kim, Yae-Jean

Journal of Korean medical science

2023 Volume 38, Issue 32, Page(s) e248

Abstract: The pediatric population with comorbidities is a high-risk group for severe coronavirus disease 2019 (COVID-19). As of January 2023, the COVID-19 vaccination rate for at least two doses among Korean children 5-11 years is low at 1.1%. We summarized the ... ...

Abstract	The pediatric population with comorbidities is a high-risk group for severe coronavirus disease 2019 (COVID-19). As of January 2023, the COVID-19 vaccination rate for at least two doses among Korean children 5-11 years is low at 1.1%. We summarized the COVID-19 vaccination status for the pediatric population (5-17 years) with comorbidities through July 2022 using the National Health Insurance Service database. Pediatric patients with comorbidities had higher vaccination rates than the general pediatric population (2.4% vs. 1.1% in 5-11-year-olds [
MeSH term(s)	Humans ; Child ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Comorbidity ; Vaccination ; Republic of Korea/epidemiology
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-08-14
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e248
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Article ; Online: The Changes in Respiratory and Enteric Adenovirus Epidemiology in Korea From 2017 to June 2022.

Kim, Kyung-Ran / Won, Jisu / Kim, Hyungjun / Kim, Bryan Inho / Kim, Mi Jin / Kim, Jae Young / Gwack, Jin / Kim, Yae-Jean

Journal of Korean medical science

2023 Volume 38, Issue 9, Page(s) e71

Abstract: Since October 2021, severe acute hepatitis of unknown etiology in pediatric patients has been observed in many countries around the world. Adenovirus (mainly enteric adenovirus) was detected in more than 50% of the cases. Nationwide surveillance on acute ...

Abstract	Since October 2021, severe acute hepatitis of unknown etiology in pediatric patients has been observed in many countries around the world. Adenovirus (mainly enteric adenovirus) was detected in more than 50% of the cases. Nationwide surveillance on acute hepatitis of unknown etiology in pediatric patients was started in May 2022 in Korea. Taking into account the severity of the illness and the urgency of the epidemiological situation worldwide, we report a summary of changes in adenovirus epidemiology during the past five years and six months in Korea.
MeSH term(s)	Humans ; Child ; Respiratory Rate ; Adenoviridae/genetics ; Republic of Korea/epidemiology
Language	English
Publishing date	2023-03-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e71
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Article ; Online: Effective vaccination strategies to control COVID-19 in Korea: a modeling study.

Ko, Youngsuk / Peck, Kyong Ran / Kim, Yae-Jean / Kim, Dong-Hyun / Jung, Eunok

Epidemiology and health

2023 Volume 45, Page(s) e2023084

Abstract: Objectives: In Korea, as immunity levels of the coronavirus disease 2019 (COVID-19) in the population acquired through previous infections and vaccinations have decreased, booster vaccinations have emerged as a necessary measure to control new outbreaks. ...

Abstract	Objectives: In Korea, as immunity levels of the coronavirus disease 2019 (COVID-19) in the population acquired through previous infections and vaccinations have decreased, booster vaccinations have emerged as a necessary measure to control new outbreaks. The objective of this study was to identify the most suitable vaccination strategy for controlling the surge in COVID-19 cases. Methods: A mathematical model was developed to concurrently evaluate the immunity levels induced by vaccines and infections. This model was then employed to investigate the potential for future resurgence and the possibility of control through the use of vaccines and antivirals. Results: As of May 11, 2023, if the current epidemic trend persists without further vaccination efforts, a peak in resurgence is anticipated to occur around mid-October of the same year. Under the most favorable circumstances, the peak number of severely hospitalized patients could be reduced by 43% (n=480) compared to the scenario without vaccine intervention (n=849). Depending on outbreak trends and vaccination strategies, the best timing for vaccination in terms of minimizing this peak varies from May 2023 to August 2023. Conclusions: Our findings suggest that if the epidemic persist, the best timing for administering vaccinations would need to be earlier than currently outlined in the Korean plan. It is imperative to continue monitoring outbreak trends, as this is key to determining the best vaccination timing in order to manage potential future surges.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination ; Vaccines ; Disease Outbreaks/prevention & control ; Republic of Korea/epidemiology
Chemical Substances	Vaccines
Language	English
Publishing date	2023-09-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590698-7
ISSN	2092-7193 ; 2092-7193
ISSN (online)	2092-7193
ISSN	2092-7193
DOI	10.4178/epih.e2023084
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Article ; Online: Updates on the coronavirus disease 2019 vaccine and consideration in children.

Kang, Hyun Mi / Choi, Eun Hwa / Kim, Yae-Jean

Clinical and experimental pediatrics

2021 Volume 64, Issue 7, Page(s) 328–338

Abstract: Humanity has been suffering from the global severe acute respiratory syndrome coronavirus 2 pandemic that began late in 2019. In 2020, for the first time in history, new vaccine platforms-including mRNA vaccines and viral vector-based DNA vaccines-have ... ...

Abstract	Humanity has been suffering from the global severe acute respiratory syndrome coronavirus 2 pandemic that began late in 2019. In 2020, for the first time in history, new vaccine platforms-including mRNA vaccines and viral vector-based DNA vaccines-have been given emergency use authorization, leading to mass vaccinations. The purpose of this article is to review the currently most widely used coronavirus disease 2019 vaccines, investigate their immunogenicity and efficacy data, and analyze the vaccine safety profiles that have been published, to date.
Language	English
Publishing date	2021-06-21
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2713-4148
ISSN (online)	2713-4148
DOI	10.3345/cep.2021.00696
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Article ; Online: Optimal Use and Need for Therapeutic Drug Monitoring of Teicoplanin in Children: A Systematic Review.

Choi, Joon-Sik / Yoon, Seo Hee / Park, Hyo Jung / Lee, Soo-Youn / Kim, Yae-Jean

Journal of Korean medical science

2023 Volume 38, Issue 7, Page(s) e62

Abstract: Background: Teicoplanin is a glycopeptide antimicrobial that treats serious invasive infections caused by gram-positive bacteria, such as the methicillin-resistant : Methods: The systematic review was performed in accordance with the preferred ... ...

Abstract	Background: Teicoplanin is a glycopeptide antimicrobial that treats serious invasive infections caused by gram-positive bacteria, such as the methicillin-resistant Methods: The systematic review was performed in accordance with the preferred reporting items for systematic reviews. Two authors (JSC and SHY) searched PubMed, Embase, and Cochrane Library databases using relevant terms independently. Results: Fourteen studies were finally included with a total of 1,380 patients. TDM was available in 2,739 samples collected in the nine studies. Dosing regimens varied widely, and eight studies used recommended dosing regimens. Timing for measuring TDM was mostly 72-96 hours or longer after the initiation of the first dose, which was expected to be a steady-state. The majority of studies had target trough levels of 10 µg/mL or above. Three studies reported that the clinical efficacy and treatment success rate of teicoplanin was 71.4%, 87.5%, and 88%. Adverse events associated with teicoplanin use were described in six studies with a focus on renal and/or hepatic impairment. Except for one study, no significant relation was noted between the incidence of adverse events and trough concentration. Conclusion: Current evidence on teicoplanin trough levels in pediatric populations is insufficient due to heterogeneity. However, target trough levels with favorable clinical efficacy are achievable by recommended dosing regimen in the majority of patients.
MeSH term(s)	Humans ; Child ; Teicoplanin ; Anti-Bacterial Agents/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Drug Monitoring ; Staphylococcal Infections/drug therapy
Chemical Substances	Teicoplanin (61036-62-2) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-20
Publishing country	Korea (South)
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e62
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Article: Genomic Analysis of Consecutive

Kim, Sun Ju / Kim, Yae-Jean / Ko, Kwan Soo

Frontiers in microbiology

2018 Volume 9, Page(s) 2840

Abstract: Acinetobacter ... ...

Abstract	Acinetobacter baumannii
Language	English
Publishing date	2018-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2018.02840
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Article ; Online: Performance evaluation of the SMG HHV-6 Q Real-Time PCR Kit for quantitative detection and differentiation of human herpesvirus 6A and 6B.

Kim, Tae Yeul / Park, Min-Seung / Yun, Sun Ae / Kang, Minhee / Kim, Doo Ri / Shin, Areum / Kim, Hyun-Young / Jang, Mi-Ae / Jang, Ja-Hyun / Kwon, Min-Jung / Huh, Hee Jae / Kim, Yae-Jean / Lee, Nam Yong

Microbiology spectrum

2024 Volume 12, Issue 4, Page(s) e0424923

Abstract: The aim of this study was to compare the performance of the newly developed SMG HHV-6 Q Real-Time PCR Kit (SMG assay) with the RealStar HHV-6 PCR Kit (RealStar assay). The analytical sensitivity and specificity, linearity, and precision of the SMG assay ... ...

Abstract	The aim of this study was to compare the performance of the newly developed SMG HHV-6 Q Real-Time PCR Kit (SMG assay) with the RealStar HHV-6 PCR Kit (RealStar assay). The analytical sensitivity and specificity, linearity, and precision of the SMG assay were evaluated. The clinical performance of the SMG assay was assessed and compared with that of the RealStar assay using 207 clinical specimens (HHV-6A positive,
MeSH term(s)	Humans ; Real-Time Polymerase Chain Reaction/methods ; Herpesvirus 6, Human/genetics ; DNA, Viral/genetics ; Sensitivity and Specificity ; Viral Load/methods ; Roseolovirus Infections/diagnosis
Chemical Substances	DNA, Viral
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04249-23
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Article ; Online: The impact of pre-transplant respiratory virus detection on post-transplant outcomes in children undergoing hematopoietic cell transplantation.

Kim, Sara Ruth / Nordlander, Anna / Xie, Hu / Kim, Yae-Jean / Ogimi, Chikara / Thakar, Monica S / Leisenring, Wendy / Englund, Janet A / Boeckh, Michael / Waghmare, Alpana

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: Background: Pre-transplant respiratory virus (RV) infections have been associated with negative transplant outcomes in adult hematopoietic cell transplantation (HCT) recipients. In the era of HCT delay due to high-risk RVs, we examined the impact of pre- ...

Abstract	Background: Pre-transplant respiratory virus (RV) infections have been associated with negative transplant outcomes in adult hematopoietic cell transplantation (HCT) recipients. In the era of HCT delay due to high-risk RVs, we examined the impact of pre-transplant RV detection on transplant outcomes in a pediatric HCT recipients. Methods: This retrospective cohort study included myeloablative allogeneic HCT recipients from 2010 to 2019. All patients were screened for RV at least once within 90 days before HCT using RT-PCR, regardless of symptoms. Post-transplant outcomes included days alive and out of hospital (DAOH) and progression to lower respiratory tract infection (LRTI). Results: Among 310 patients, 134 had a RV detected in the 90 days prior to HCT. In univariable analysis, transplant factors including younger age, total body irradiation, umbilical cord blood transplantation, lymphocyte count less than 100/mm3, and HCT comorbidity index score ≥3, and viral factors including symptomatic infection, human rhinovirus (HRV) as a virus type, and symptomatic pre-transplant upper respiratory tract infection (URTI) were associated with fewer DAOH. In multivariable analysis, transplant factors remained significant, but not viral factors. There was a higher incidence of progression to post-transplant LRTI with the same pre-transplant RV if the last positive PCR before HCT was ≤30 days compared to >30 days (p=0.007). Conclusion: In the setting of recommending HCT delay for high-risk RVs, symptomatic URTI, including HRV infections, may lead to increased duration of hospitalization and early progression to LRTI when transplantation is performed within 30 days of the last positive PCR test.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae216
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Article ; Online: Ruxolitinib Improves Immune-Dysregulation Features but not Epigenetic Abnormality in a Patient with STAT1 GOF.

Koh, June-Young / Kim, Doo Ri / Son, Sohee / Park, Hwanhee / Kim, Kyung-Ran / Min, Sunwoo / Lee, Ha Seok / Jhun, Byung Woo / Kang, Eun-Suk / Jung, Inkyung / Kang, Ji-Man / Kim, Yae-Jean / Shin, Eui-Cheol

Journal of clinical immunology

2024 Volume 44, Issue 4, Page(s) 84

Abstract: Purpose: Patients with STAT1 gain-of-function (GOF) mutations often exhibit autoimmune features. The JAK1/2 inhibitor ruxolitinib can be administered to alleviate autoimmune symptoms; however, it is unclear how immune cells are molecularly changed by ... ...

Abstract	Purpose: Patients with STAT1 gain-of-function (GOF) mutations often exhibit autoimmune features. The JAK1/2 inhibitor ruxolitinib can be administered to alleviate autoimmune symptoms; however, it is unclear how immune cells are molecularly changed by ruxolitinib treatment. Then, we aimed to investigate the trnscriptional and epigenetic status of immune cells before and after ruxolitinib treatment in a patient with STAT1 GOF. Methods: A patient with a heterozygous STAT1 GOF variant (p.Ala267Val), exhibiting autoimmune features, was treated with ruxolitinib, and peripheral blood mononuclear cells (PBMCs) were longitudinally collected. PBMCs were transcriptionally analyzed by single-cell cellular indexing of the transcriptomes and epitopes by sequencing (CITE-seq), and epigenetically analyzed by assay of transposase-accessible chromatin sequencing (ATAC-seq). Results: CITE-seq analysis revealed that before treatment, the patient's PBMCs exhibited aberrantly activated inflammatory features, especially IFN-related features. In particular, monocytes showed high expression levels of a subset of IFN-stimulated genes (ISGs). Ruxolitinib treatment substantially downregulated aberrantly overexpressed ISGs, and improved autoimmune features. However, epigenetic analysis demonstrated that genetic regions of ISGs-e.g., STAT1, IRF1, MX1, and OAS1-were highly accessible even after ruxolitinib treatment. When ruxolitinib was temporarily discontinued, the patient's autoimmune features were aggravated, which is in line with sustained epigenetic abnormality. Conclusions: In a patient with STAT1 GOF, ruxolitinib treatment improved autoimmune features and downregulated aberrantly overexpressed ISGs, but did not correct epigenetic abnormality of ISGs.
MeSH term(s)	Humans ; Gain of Function Mutation/genetics ; Leukocytes, Mononuclear/metabolism ; Nitriles/pharmacology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; STAT1 Transcription Factor/genetics
Chemical Substances	Nitriles ; Pyrazoles ; Pyrimidines ; ruxolitinib (82S8X8XX8H) ; STAT1 protein, human ; STAT1 Transcription Factor
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-024-01687-9
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