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  1. Article: Editorial: Comorbidity in bipolar disorder, volume II.

    De Berardis, Domenico / Fornaro, Michele / Carmassi, Claudia

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1115357

    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1115357
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  2. Article ; Online: Plasma and Platelet Brain-Derived Neurotrophic Factor (BDNF) Levels in Bipolar Disorder Patients with Post-Traumatic Stress Disorder (PTSD) or in a Major Depressive Episode Compared to Healthy Controls.

    Dell'Oste, Valerio / Palego, Lionella / Betti, Laura / Fantasia, Sara / Gravina, Davide / Bordacchini, Andrea / Pedrinelli, Virginia / Giannaccini, Gino / Carmassi, Claudia

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Post-traumatic stress disorder (PTSD) is a highly disabling mental disorder arising after traumatism exposure, often revealing critical and complex courses when comorbidity with bipolar disorder (BD) occurs. To search for PTSD or depression biomarkers ... ...

    Abstract Post-traumatic stress disorder (PTSD) is a highly disabling mental disorder arising after traumatism exposure, often revealing critical and complex courses when comorbidity with bipolar disorder (BD) occurs. To search for PTSD or depression biomarkers that would help clinicians define BD presentations, this study aimed at preliminarily evaluating circulating brain-derived-neurotrophic factor (BDNF) levels in BD subjects with PTSD or experiencing a major depressive episode versus controls. Two bloodstream BDNF components were specifically investigated, the storage (intraplatelet) and the released (plasma) ones, both as adaptogenic/repair signals during neuroendocrine stress response dynamics. Bipolar patients with PTSD (
    MeSH term(s) Humans ; Biomarkers ; Bipolar Disorder ; Brain-Derived Neurotrophic Factor ; Depressive Disorder, Major ; Stress Disorders, Post-Traumatic
    Chemical Substances Biomarkers ; Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063529
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  3. Article ; Online: Post-traumatic Stress and Depressive Symptoms in Women With Ovarian Cancer 3-6 Months After Diagnosis.

    Carmassi, Claudia / Pedrinelli, Virginia / Fantasia, Sara / Andreoli, Debora / Giovannoni, Federico / Massimetti, Enrico / Cosio, Stefania / Dell'osso, Liliana / Gadducci, Angiolo

    Anticancer research

    2024  Volume 44, Issue 2, Page(s) 829–838

    Abstract: Background/aim: The potentially traumatic role of severe life-threatening medical conditions is still debated in psychiatry and not yet recognized, particularly among post-traumatic stress disorders. However, increasing evidence suggests the ... ...

    Abstract Background/aim: The potentially traumatic role of severe life-threatening medical conditions is still debated in psychiatry and not yet recognized, particularly among post-traumatic stress disorders. However, increasing evidence suggests the psychopathological impact of severe medical conditions related to their poor prognosis, high lethality, treatments heaviness and invasiveness. Ovarian cancer (OC) is one of the malignancies with the highest mortality and the aim of this study was to investigate post-traumatic stress and depressive symptoms in women 3 to 6 months after diagnosis.
    Patients and methods: A sample of 83 women diagnosed with OC at different stages (from AI to IV) was recruited and assessed by means of the: Structural Clinical Interview for Mental Disorders according to DSM-5 (SCID-5), Trauma and Loss Spectrum Self-Report (TALS-SR), Impact Event Scale-Revised (IES-R), Hamilton Rating Scale for Depression (HAM-D), Mood Spectrum-Self Report (MOOD-SR), Work and Social Adjustment Scale (WSAS).
    Results: Full data on the psychiatric assessments were available for 45 patients: 13 (28.9%) patients reported a diagnosis of PTSD. Patients with PTSD reported statistically significant higher depressive symptoms and more severe impact on work and social functioning compared to those without PTSD.
    Conclusion: Our results highlight the need to carefully assess the potentially traumatic burden of a diagnosis of OC and its association with depressive symptoms for their impact on patients' global functioning, in order to provide appropriate preventive and therapeutic interventions.
    MeSH term(s) Humans ; Female ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/etiology ; Stress Disorders, Post-Traumatic/psychology ; Depression/diagnosis ; Depression/etiology ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/diagnosis
    Language English
    Publishing date 2024-02-02
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16875
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  4. Article: Emotional Dysregulation and Post-Traumatic Stress Symptoms: Which Interaction in Adolescents and Young Adults? A Systematic Review.

    Conti, Lorenzo / Fantasia, Sara / Violi, Miriam / Dell'Oste, Valerio / Pedrinelli, Virginia / Carmassi, Claudia

    Brain sciences

    2023  Volume 13, Issue 12

    Abstract: Emotional dysregulation (ED) has recently been conceptualized as a transnosographic entity in major mental disorders, and increasing evidence has suggested association between ED and post-traumatic stress symptoms (PTSS), though the nature of this ... ...

    Abstract Emotional dysregulation (ED) has recently been conceptualized as a transnosographic entity in major mental disorders, and increasing evidence has suggested association between ED and post-traumatic stress symptoms (PTSS), though the nature of this association is unclear. The aim of the present review was to examine the possible interplay between ED and trauma exposure in the literature, as well as a possible role for the comorbidity of PTSD or PTSS in adolescents and young adults. In particular, we explored whether ED may represent a risk factor for PTSD or, conversely, a consequence of traumatic exposure. This systematic review was conducted according to PRISMA 2020 guidelines in three databases (PubMed, Scopus, and Embase). The 34 studies included showed a wide heterogeneity in terms of the populations selected and outcomes examined. Most studies used the Difficulties in Emotion Regulation Scale (DERS) and examined the relationship between ED, trauma, and psychopathological manifestations after the occurrence of trauma, with a focus on child abuse. Although current data in the literature are heterogeneous and inconclusive, this research highlights the role of ED as a mechanism that may mediate vulnerability to PTSD, but also as a predictor of severity and maintenance of typical, atypical, or associated PTSD symptoms, suggesting prevention programs for PTSD and other mental disorders should support the development of emotion regulation strategies.
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13121730
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  5. Article: The relationship between peritraumatic distress, mental health symptoms and functioning impairment in healthcare workers during the COVID-19 emergency.

    Carmassi, Claudia / Bertelloni, Carlo Antonio / Dell'Oste, Valerio / Pedrinelli, Virginia / Fantasia, Sara / Atti, Anna-Rita / Goracci, Arianna / Nanni, Maria Giulia / Massimetti, Enrico / Dell'Osso, Lilliana / Bui, Eric

    CNS spectrums

    2024  , Page(s) 1–23

    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852923006338
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  6. Article: A case of catatonia in the aftermath of the COVID-19 pandemic: does autism spectrum matter?

    Dell'Osso, Liliana / Amatori, Giulia / Gesi, Camilla / Carmassi, Claudia

    Annals of general psychiatry

    2021  Volume 20, Issue 1, Page(s) 54

    Abstract: Background: There is growing concern about the psychopathological consequences of the COVID-19 pandemic. The prolonged stress due to the spreading fear of the contagion and to the enforced containment measures are deemed to trigger recurrences of ... ...

    Abstract Background: There is growing concern about the psychopathological consequences of the COVID-19 pandemic. The prolonged stress due to the spreading fear of the contagion and to the enforced containment measures are deemed to trigger recurrences of preexisting mental disorders as well as the onset of new ones. From such perspective, clinical cases may be of primary ground to identify individual features and pandemic-related factors predisposing to the development of serious psychiatric symptoms.
    Case presentation: Mr. R. is a 64-year-old, married, unemployed man, whose premorbid personality was characterized by relevant autistic traits. The patient developed catatonia in the context of the COVID-19 pandemic. We aimed at discussing the role of both preexisting and precipitating factors.
    Conclusions: Autism spectrum could represent a predisposing factor for severe psychopathological outcome and catatonia. Furthermore, the present clinical case highlights the role of COVID-19 pandemic in influencing physical and mental health.
    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Journal Article
    ISSN 1744-859X
    ISSN 1744-859X
    DOI 10.1186/s12991-021-00377-9
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  7. Article ; Online: Lutto: dalla reazione fisiologica al disturbo da lutto prolungato.

    Carmassi, Claudia / Amatori, Giulia / Cappelli, Andrea / Brosio, Enrico / Chauvel, Hélène / Dell'Osso, Liliana / Bui, Eric

    Rivista di psichiatria

    2023  Volume 58, Issue 4, Page(s) 154–159

    Abstract: The death of a loved one is a universal experience, and marker of the human condition. Grief, the cognitive, emotional, and behavioral responses to bereavement, is both a ubiquitous and a unique psychological process. Thus, health providers often find ... ...

    Title translation Grief: from the physiological reaction to the psychopathology.
    Abstract The death of a loved one is a universal experience, and marker of the human condition. Grief, the cognitive, emotional, and behavioral responses to bereavement, is both a ubiquitous and a unique psychological process. Thus, health providers often find themselves in a dilemma, caught between the need to alleviate an individual's distress and impairment, and the danger of overly "pathologizing" their grief reaction. This chapter reviews how acute grief reactions generally evolve over time, the clinical presentation of complicated grief, and finally, other psychiatric disorders that might develop or be precipitated in the aftermath of the death of a loved one, particularly prolonged grief disorder.
    MeSH term(s) Humans ; Grief ; Bereavement ; Mental Disorders/etiology ; Psychopathology
    Language Italian
    Publishing date 2023-04-30
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 205570-3
    ISSN 2038-2502 ; 0035-6484
    ISSN (online) 2038-2502
    ISSN 0035-6484
    DOI 10.1708/4064.40477
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    Zs.B 1521: Show issues Location:
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  8. Article: Emotional dysregulation as trans-nosographic psychopathological dimension in adulthood: A systematic review.

    Carmassi, Claudia / Conti, Lorenzo / Gravina, Davide / Nardi, Benedetta / Dell'Osso, Liliana

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 900277

    Abstract: Introduction: Emotional dysregulation (ED) is characterized by inappropriate emotional reactions related to environmental or cognitive stimuli. In most recent years, increasing interest has been devoted to its definition and detection across mental ... ...

    Abstract Introduction: Emotional dysregulation (ED) is characterized by inappropriate emotional reactions related to environmental or cognitive stimuli. In most recent years, increasing interest has been devoted to its definition and detection across mental disorders for its detrimental role progressively highlighted in both neurodevelopment and adult mental disorders, with implications on the severity of clinical manifestations. The aim of this systematic review was to evaluate and gather the scientific evidence about ED in adult psychiatric population to elucidate the concept of ED as trans-nosographic entity.
    Methods: The electronics databases PubMed, Scopus and Web of Science was reviewed to identify studies in accordance with the PRISMA guidelines; at the end of the selection process a total of 29 studies (
    Results: Our results suggest ED as a trans-diagnostic factor across multiple mental disorders, such as bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, personality disorders; a better definition of this concept could be helpful to interpret and clarify many clinical cases and improve their diagnostic and therapeutic management.
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.900277
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  9. Article: Biological correlates of altered circadian rhythms, autonomic functions and sleep problems in autism spectrum disorder.

    Dell'Osso, Liliana / Massoni, Leonardo / Battaglini, Simone / Cremone, Ivan Mirko / Carmassi, Claudia / Carpita, Barbara

    Annals of general psychiatry

    2022  Volume 21, Issue 1, Page(s) 13

    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a complex and multifaceted neurobehavioral syndrome. In the last decades, several studies highlighted an increased prevalence of sleep problems in ASD, which would be ... ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by a complex and multifaceted neurobehavioral syndrome. In the last decades, several studies highlighted an increased prevalence of sleep problems in ASD, which would be associated with autonomic system and circadian rhythm disruption. The present review aimed to summarize the available literature about sleep problems in ASD subjects and about the possible biological factors implicated in circadian rhythm and autonomic system deregulation in this population, as well as possible therapeutic approaches. Shared biological underpinnings between ASD symptoms and altered circadian rhythms/autonomic functions are also discussed. Studies on sleep showed how ASD subjects typically report more problems regarding insufficient sleep time, bedtime resistance and reduced sleep pressure. A link between sleep difficulties and irritability, deficits in social skills and behavioral problems was also highlighted. Among the mechanisms implicated, alteration in genes related to circadian rhythms, such as CLOCK genes, and in melatonin levels were reported. ASD subjects also showed altered hypothalamic pituitary adrenal (HPA) axis and autonomic functions, generally with a tendency towards hyperarousal and hyper sympathetic state. Intriguingly, some of these biological alterations in ASD individuals were not associated only with sleep problems but also with more autism-specific clusters of symptoms, such as communication impairment or repetitive behaviors Although among the available treatments melatonin showed promising results, pharmacological studies for sleep problems in ASD need to follow more standardized protocols to reach more repeatable and reliable results. Further research should investigate the issue of sleep problems in ASD in a broader perspective, taking into account shared pathophysiological mechanisms for core and associated symptoms of ASD.
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2090401-0
    ISSN 1744-859X ; 1475-2832
    ISSN 1744-859X ; 1475-2832
    DOI 10.1186/s12991-022-00390-6
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  10. Article ; Online: Melatonin as a Chronobiotic with Sleep-promoting Properties.

    Cruz-Sanabria, Francy / Carmassi, Claudia / Bruno, Simone / Bazzani, Andrea / Carli, Marco / Scarselli, Marco / Faraguna, Ugo

    Current neuropharmacology

    2023  Volume 21, Issue 4, Page(s) 951–987

    Abstract: The use of exogenous melatonin (exo-MEL) as a sleep-promoting drug has been under extensive debate due to the lack of consistency of its described effects. In this study, we conduct a systematic and comprehensive review of the literature on the ... ...

    Abstract The use of exogenous melatonin (exo-MEL) as a sleep-promoting drug has been under extensive debate due to the lack of consistency of its described effects. In this study, we conduct a systematic and comprehensive review of the literature on the chronobiotic, sleep-inducing, and overall sleep-promoting properties of exo-MEL. To this aim, we first describe the possible pharmacological mechanisms involved in the sleep-promoting properties and then report the corresponding effects of exo-MEL administration on clinical outcomes in: a) healthy subjects, b) circadian rhythm sleep disorders, c) primary insomnia. Timing of administration and doses of exo-MEL received particular attention in this work. The exo-MEL pharmacological effects are hereby interpreted in view of changes in the physiological properties and rhythmicity of endogenous melatonin. Finally, we discuss some translational implications for the personalized use of exo-MEL in the clinical practice.
    MeSH term(s) Humans ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Circadian Rhythm ; Sleep/physiology
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2023-10-05
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X20666220217152617
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