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Article: Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis.

Swart, Alexander / Hamouda, Abdelrahman / Pennington, Zach / Lakomkin, Nikita / Mikula, Anthony L / Martini, Michael L / Shafi, Mahnoor / Subramaniam, Thirusivapragasam / Sebastian, Arjun S / Freedman, Brett A / Nassr, Ahmad N / Fogelson, Jeremy L / Elder, Benjamin D

Journal of clinical medicine

2024 Volume 13, Issue 5

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13051430
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Article ; Online: Staat statt Stadt

Lilla Kammermann / Sebastian Johann Rudolf Martini / Enikő Charlotte Zöller

Sub\urban, Vol 11, Iss 3/

2023 Volume 4

Abstract: Die „Investitionen von herausgehobener volkswirtschaftlicher Bedeutung“ haben einen großen Einfluss auf die ungarische Stadtplanung. Als planungsbeschleunigendes Instrument können diese von der nationalen Regierung Ungarns eingesetzt werden, um Fristen ... ...

Abstract	Die „Investitionen von herausgehobener volkswirtschaftlicher Bedeutung“ haben einen großen Einfluss auf die ungarische Stadtplanung. Als planungsbeschleunigendes Instrument können diese von der nationalen Regierung Ungarns eingesetzt werden, um Fristen für Genehmigungen zu verkürzen und rechtliche Vorgaben zu umgehen. Seit geraumer Zeit wird dieses Instrument zudem eingesetzt, um in oppositionell regierten Kommunen – wie der Hauptstadt Budapest – eine Stadtentwicklung durchzusetzen, die mit den Zielen der nationalen Regierung übereinstimmt. Dabei kann sehr weitreichend die kommunale Bauleitplanung auf entsprechend ausgewiesenen Flächen außer Kraft gesetzt werden, auch ohne Einvernehmen mit den betroffenen Kommunen. Dieses Vorgehen ist im Kontext des kontinuierlichen Rückbaus der Demokratie in Ungarn durch die Orbán-Regierungen zu betrachten, welcher auch geordnete demokratische Planungsverfahren unterminiert. Am Beispiel des Budapester Südens wird deutlich, wie die Eingriffe der Regierung in die kommunale Planungshoheit Budapests regierungsnahen Investor_innen entgegenkommen, während Belange unberücksichtigt bleiben, die für eine sozialverträgliche, ökologisch sowie denkmalpflegerisch ausgewogene Stadtentwicklungspolitik unerlässlich sind.
Keywords	Autokratie ; Budapest ; kommunale Planungshoheit ; politische Planungspraxis ; Stadtentwicklungspolitik ; Städtebau ; Cities. Urban geography ; GF125 ; Urban groups. The city. Urban sociology ; HT101-395
Subject code	350
Language	German
Publishing date	2023-11-01T00:00:00Z
Publisher	sub\urban. zeitschrift für kritische stadtforschung
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Growth hormone treatment in aged patients with comorbidities: A systematic review.

Tausendfreund, Olivia / Bidlingmaier, Martin / Martini, Sebastian / Müller, Katharina / Rippl, Michaela / Schilbach, Katharina / Schmidmaier, Ralf / Drey, Michael

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

2024 Volume 75, Page(s) 101584

Abstract: Objective: Hormonal substitution with growth hormone in aged patients remains a debated research topic and is rarely initiated in clinical practice. This reluctance may originate from concerns about adverse effects and the uncritical use as an anti- ... ...

Abstract	Objective: Hormonal substitution with growth hormone in aged patients remains a debated research topic and is rarely initiated in clinical practice. This reluctance may originate from concerns about adverse effects and the uncritical use as an anti-aging agent. Nevertheless, beneficial effects for selected patients suffering from certain acute and chronic illnesses could justify its use at an advanced age. This systematic review analyzes randomized controlled studies of GH interventions in older patients with different comorbidities to assess both, beneficial and harmful effects. Design: A systematic search strategy was implemented to identify relevant studies from PubMed, MEDLINE, and The Cochrane Library. Inclusion criteria: participants aged over 65 years, randomized controlled trials involving human growth hormone (GH) and presence of at least one additional comorbidity independent of a flawed somatotropic axis. Results: The eight eligible studies encompassed various comorbidities including osteoporosis, frailty, chronic heart failure, hip fracture, amyotrophic lateral sclerosis and hemodialysis. Outcomes varied, including changes in body composition, physical performance, strength, bone mineral density, cardiovascular parameters, quality of life and housing situation. Study protocols differed greatly in GH application frequency (daily, 2nd day or 3×/week), doses (0.41 mg-2.6 mg; mean 1.3 mg per 60 kg patient) and duration (1-12 months; mean 7 months). Mild dose-related side effects were reported, alongside noticeable positive impacts particularly on body composition, functionality, and quality of life. Conclusion: Despite limited evidence, GH treatment might offer diverse benefits with few adverse effects. Further research with IGF-I dependent indication and clear outcomes, incorporating IGF-I dependent GH titration in older adults is warranted.
MeSH term(s)	Aged ; Humans ; Comorbidity ; Growth Hormone ; Human Growth Hormone/adverse effects ; Human Growth Hormone/therapeutic use ; Insulin-Like Growth Factor I ; Quality of Life ; Randomized Controlled Trials as Topic ; Aging/pathology
Chemical Substances	Growth Hormone (9002-72-6) ; Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2024-03-09
Publishing country	Scotland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1436781-6
ISSN	1532-2238 ; 1096-6374
ISSN (online)	1532-2238
ISSN	1096-6374
DOI	10.1016/j.ghir.2024.101584
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Article: The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity.

Hamouda, Abdelrahman M / Pennington, Zach / Astudillo Potes, Maria / Mikula, Anthony L / Lakomkin, Nikita / Martini, Michael L / Abode-Iyamah, Kingsley O / Freedman, Brett A / McClendon, Jamal / Nassr, Ahmad N / Sebastian, Arjun S / Fogelson, Jeremy L / Elder, Benjamin D

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020340
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Article ; Online: Diagnostisches und therapeutisches Vorgehen bei Sarkopenie.

Schaupp, Anna / Martini, Sebastian / Schmidmaier, Ralf / Drey, Michael

Zeitschrift fur Gerontologie und Geriatrie

2021 Volume 54, Issue 7, Page(s) 717–724

Abstract: Sarcopenia describes a generalized loss of muscle power, mass and function. It is marked by an impaired quality of life and an increased mortality rate. The SARC‑F questionnaire was developed as a screening tool to identify patients at risk of impairment ...

Title translation	Diagnostic and therapeutic approach to sarcopenia.
Abstract	Sarcopenia describes a generalized loss of muscle power, mass and function. It is marked by an impaired quality of life and an increased mortality rate. The SARC‑F questionnaire was developed as a screening tool to identify patients at risk of impairment in primary care. It addresses five functional areas of physical activity in daily life. In case of a relevant impairment this is to be followed by measurement of hand grip strength using a dynamometer and/or of leg muscle strength by the chair rising test. Patients with pathological results should undergo a measurement of the skeletal muscle index, e.g. by Dual-energy X‑ray Absorptiometry. If this lies below the gender-specific threshold, the diagnostic criteria for sarcopenia are met. Cases with normal lean muscle mass are coined as probable sarcopenia. In both cases, causes must be clarified and treatment should be initiated. To differentiate between acute and chronic sarcopenia it is necessary to assess disease progress after a certain period of time.
MeSH term(s)	Absorptiometry, Photon ; Hand Strength ; Humans ; Muscle Strength ; Muscle, Skeletal ; Quality of Life ; Sarcopenia/diagnosis ; Sarcopenia/pathology ; Sarcopenia/therapy
Language	German
Publishing date	2021-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1227032-5
ISSN	1435-1269 ; 0044-281X ; 0948-6704
ISSN (online)	1435-1269
ISSN	0044-281X ; 0948-6704
DOI	10.1007/s00391-021-01968-7
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Article ; Online: Reduced Bone Density Based on Hounsfield Units After Long-Segment Spinal Fusion with Harrington Rods.

Swart, Alexander / Hamouda, Abdelrahman M / Pennington, Zach / Mikula, Anthony L / Martini, Michael / Lakomkin, Nikita / Shafi, Mahnoor / Nassr, Ahmad N / Sebastian, Arjun S / Fogelson, Jeremy L / Freedman, Brett A / Elder, Benjamin D

World neurosurgery

2024

Abstract: Background: Long-segment instrumentation, such as Harrington rods, offloads vertebrae within the construct, which may result in significant stress shielding of the fused segments. The present study aimed to determine the effects of spinal fusion on bone ...

Abstract	Background: Long-segment instrumentation, such as Harrington rods, offloads vertebrae within the construct, which may result in significant stress shielding of the fused segments. The present study aimed to determine the effects of spinal fusion on bone density by measuring Hounsfield units (HUs) throughout the spine in patients with a history of Harrington rod fusion. Methods: Patients with a history of Harrington rod fusion treated at a single academic institution were identified. Mean HUs were calculated at 5 spinal segments for each patient: cranial adjacent mobile segment, cranial fused segment, midconstruct fused segment, caudal fused segment, and caudal adjacent mobile segment. Mean HUs for each level were compared using a paired-sample t test, with statistical significance defined by P < 0.05. Hierarchic multiple regression, including age, gender, body mass index, and time since original fusion, was used to determine predictors of midfused segment HUs. Results: One hundred patients were included (mean age, 55 ± 12 years; 62% female). Mean HUs for the midconstruct fused segment (110; 95% confidence interval [CI], 100-121) were significantly lower than both the cranial and caudal fused segments (150 and 118, respectively; both P < 0.05), as well as both the cranial and caudal adjacent mobile segments (210 and 130, respectively; both P < 0.001). Multivariable regression showed midconstruct HUs were predicted only by patient age (-2.6 HU/year; 95% CI, -3.4 to -1.9; P < 0.001) and time since original surgery (-1.4 HU/year; 95% CI, -2.6 to -0.2; P = 0.02). Conclusions: HUs were significantly decreased in the middle of previous long-segment fusion constructs, suggesting that multilevel fusion constructs lead to vertebral bone density loss within the construct, potentially from stress shielding.
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.02.063
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Article: Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?

Gross, Colin F / Jungblut, Lisa / Schindera, Sebastian / Messerli, Michael / Fretz, Valentin / Frauenfelder, Thomas / Martini, Katharina

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 4

Abstract: Background: To assess the impact of the lung cancer screening protocol recommended by the European Society of Thoracic Imaging (ESTI) on nodule diameter, volume, and density throughout different computed tomography (CT) scanners.: Methods: An ... ...

Abstract	Background: To assess the impact of the lung cancer screening protocol recommended by the European Society of Thoracic Imaging (ESTI) on nodule diameter, volume, and density throughout different computed tomography (CT) scanners. Methods: An anthropomorphic chest phantom containing fourteen different-sized (range 3-12 mm) and CT-attenuated (100 HU, -630 HU and -800 HU, termed as solid, GG1 and GG2) pulmonary nodules was imaged on five CT scanners with institute-specific standard protocols (P Results: Using P Conclusion: Considering radiation dose, image noise, nodule size, and density measurements, we fully endorse the ESTI screening protocol including the use of REC. For size measurements, volume should be preferred over diameter.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13040631
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Article ; Online: Resistance training-induced improvement in physical function is not associated to changes in endocrine somatotropic activity in prefrail older adults.

Schaupp, Anna / Bidlingmaier, Martin / Martini, Sebastian / Reincke, Martin / Schluessel, Sabine / Schmidmaier, Ralf / Drey, Michael

Archives of gerontology and geriatrics

2022 Volume 103, Page(s) 104792

Abstract: Context: Resistance training improves muscle function in prefrail and frail elderly. The role of the somatotropic axis in this physiologic process remains unclear. Insulin-like growth factor I (IGF-I) and its associated proteins Insulin-like growth ... ...

Abstract	Context: Resistance training improves muscle function in prefrail and frail elderly. The role of the somatotropic axis in this physiologic process remains unclear. Insulin-like growth factor I (IGF-I) and its associated proteins Insulin-like growth factor binding protein 3 (IGFBP3) and acid labile subunit (ALS) build a circulating ternary complex that mediates growth hormone (GH) effects on peripheral organs and can serve as a measure of endocrine somatotropic activity. Objective: The aim of this study was to assess the association between resistance training-induced changes in physical performance and basal levels of IGF-I, IGFBP-3 and ALS in prefrail older adults. Methods: 69 prefrail community-dwelling older adults, aged 65 to 94 years, were randomly assigned to a 12-week period of strength or power training or to a control group. The study was registered at clinicaltrials.gov as NCT00783159. Serum concentrations of IGF-I, IGFBP-3 and ALS were measured at rest before and after the intervention. Hormonal differences were examined in relation to changes in physical performance assessed by the Short Physical Performance Battery (SPPB). Results: While resistance training led to significant improvements in SPPB score it did not induce significant differences in somatotropic hormone concentrations. Pre- and post-intervention changes in IGF-I, IGFBP-3, ALS or IGF/IGFBP-3 molar ratio were not related to the intervention mode, even after adjustment for age, sex, nutritional status, as well as SPPB and hormone concentrations at baseline. Conclusion: Training-induced improvements in physical performance in prefrail older adults were not associated with significant changes in endocrine somatotropic activity.
Language	English
Publishing date	2022-08-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2022.104792
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Article ; Online: Bone Quality as Measured by Hounsfield Units More Accurately Predicts Proximal Junctional Kyphosis than Vertebral Bone Quality Following Long-Segment Thoracolumbar Fusion.

Pennington, Zach / Mikula, Anthony L / Lakomkin, Nikita / Martini, Michael / Pinter, Zachariah W / Shafi, Mahnoor / Hamouda, Abdelrahman / Bydon, Mohamad / Clarke, Michelle J / Freedman, Brett A / Krauss, William E / Nassr, Ahmad N / Sebastian, Arjun S / Fogelson, Jeremy L / Elder, Benjamin D

World neurosurgery

2024

Abstract: Objective: To compare the prognostic power of Hounsfield units and VBQ score for predicting proximal junctional kyphosis (PJK) following long-segment thoracolumbar fusion to the upper thoracic spine (T1-T6) METHODS: Vertebral bone quality around the ... ...

Abstract	Objective: To compare the prognostic power of Hounsfield units and VBQ score for predicting proximal junctional kyphosis (PJK) following long-segment thoracolumbar fusion to the upper thoracic spine (T1-T6) METHODS: Vertebral bone quality around the upper instrumented vertebrae (UIV) was measured using HU on preoperative CT and VBQ on preoperative MRI. Spinopelvic parameters were also categorized according to the SRS-Schwab classification. Univariable analysis to identify predictors of the occurrence of PJK and survival analyses with Kaplan-Meier method and Cox regression were performed to identify predictors of time to PJK (defined as ≥10° change in Cobb angle of UIV+2 and UIV). Sensitivity analyses showed thresholds of HU<164 and VBQ>2.7 to be most predictive for PJK. Results: Seventy-six patients (mean age 66.0±7.0yr; 27.6% male) were identified, of whom 15 suffered PJK. Significant predictors of PJK were high postoperative pelvic tilt (p=0.038), high postoperative T1-pelvic angle (p=0.041), and high postoperative PI-LL mismatch (p=0.028). On survival analyses, bone quality, as assessed by the average Hounsfield units of the UIV and UIV+1 was the only significant predictor of time to PJK (OR=3.053; 95%CI [1.032, 9.032]; p=0.044). VBQ measured using the UIV, UIV+1, UIV+2, and UIV-1 vertebrae approached, but did not reach significance (2.913; [0.797, 10.646]; 0.106). Conclusion: In larger cohorts, VBQ may prove to be a significant predictor of PJK following long-segment thoracolumbar fusion. However, Hounsfield units on CT have greater predictive power, suggesting preoperative workup for long-segment thoracolumbar fusion benefits from CT versus MRI alone to identify those at increased risk of PJK.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.04.003
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Article ; Online: Hypogonadism is frequent in very old men with multimorbidity and is associated with anemia and sarcopenia.

Schluessel, Sabine / Bidlingmaier, Martin / Martini, Sebastian / Reincke, Martin / Reisch, Nicole / Schaupp, Anna / Stalla, Günter / Teupser, Daniel / Schmidmaier, Ralf / Drey, Michael

Zeitschrift fur Gerontologie und Geriatrie

2023 Volume 57, Issue 1, Page(s) 43–49

Abstract: Background: Clinical data regarding hypogonadism in very old men with multimorbidity are rare. Hypogonadism can contribute to osteoporosis, anemia and sarcopenia and is therefore a relevant problem for geriatric patients.: Methods: A total of 167 men ...

Title translation	Hypogonadismus ist bei sehr alten multimorbiden Männern häufig und ist mit Anämie und Sarkopenie assoziiert.
Abstract	Background: Clinical data regarding hypogonadism in very old men with multimorbidity are rare. Hypogonadism can contribute to osteoporosis, anemia and sarcopenia and is therefore a relevant problem for geriatric patients. Methods: A total of 167 men aged 65-96 years (mean 81 ± 7 years) admitted to an acute geriatric ward were included in a cross-sectional study. Body composition derived from dual-energy X‑ray absorptiometry, bone mineral density, handgrip strength, multimorbidity, polypharmacy and laboratory values were obtained from the routine electronic clinical patient file. Results: Hypogonadism was present in 62% (n = 104) of the study participants, of whom 83% showed clinical manifestation of hypogonadism (hypogonadism in combination with anemia, sarcopenia and/or low T‑score). The subgroups showed a distribution of 52% primary and 48% secondary hypogonadism. Compared to the eugonadal patients, hypogonadal patients had reduced handgrip strength (p = 0.031) and lower hemoglobin levels (p = 0.043), even after adjustment for age, body mass index and glomerular filtration rate. Conclusion: Hypogonadism is common in geriatric patients. If chronic anemia, sarcopenia, or osteoporosis are diagnosed, testosterone levels should be determined in geriatric settings.
MeSH term(s)	Male ; Humans ; Aged ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Sarcopenia/complications ; Hand Strength ; Cross-Sectional Studies ; Multimorbidity ; Hypogonadism/diagnosis ; Hypogonadism/epidemiology ; Hypogonadism/complications ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Osteoporosis/complications ; Anemia/diagnosis ; Anemia/epidemiology ; Anemia/complications ; Testosterone
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1227032-5
ISSN	1435-1269 ; 0044-281X ; 0948-6704
ISSN (online)	1435-1269
ISSN	0044-281X ; 0948-6704
DOI	10.1007/s00391-023-02235-7
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