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  1. Article ; Online: Physical Activity in People With Dementia Living in Long-Term Care Facilities and the Connection With Environmental Factors and Behavior.

    Portegijs, Suzanne / van Beek, Sandra / van Tuyl, Lilian H D / Wagner, Cordula

    Journal of aging and physical activity

    2022  Volume 31, Issue 2, Page(s) 214–222

    Abstract: This study is conducted in order to gain a better understanding of the relationship between physical activity and agitated behavior among older people with dementia, and physical activity and characteristics of long-term care wards. Data were collected ... ...

    Abstract This study is conducted in order to gain a better understanding of the relationship between physical activity and agitated behavior among older people with dementia, and physical activity and characteristics of long-term care wards. Data were collected among people with dementia living in long-term care facilities (N = 76) by conducting observations at the wards and distributing questionnaires among professional caregivers. The results show that participants are largely inactive (82.8%) and a significant relation was found between the degree of physical activity and characteristics of the ward such as "taking sufficient time," which relates to the time caregivers take when interacting with residents. This study supports the existing knowledge about the degree of physical activity among people with dementia in long-term care and adds information about the potential influence of organizational factors that could be valuable for daily practice.
    MeSH term(s) Humans ; Aged ; Long-Term Care ; Dementia ; Caregivers ; Hospitals ; Exercise
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1543-267X
    ISSN (online) 1543-267X
    DOI 10.1123/japa.2021-0459
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  2. Article ; Online: The controversy of using PGA to define remission in RA.

    van Tuyl, Lilian H D / Boers, Maarten

    Nature reviews. Rheumatology

    2018  Volume 14, Issue 4, Page(s) 245

    MeSH term(s) Antirheumatic Agents ; Arthritis, Rheumatoid ; Humans ; Inflammation ; Prostaglandins A
    Chemical Substances Antirheumatic Agents ; Prostaglandins A
    Language English
    Publishing date 2018-03-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2018.36
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  3. Article ; Online: Mortality has improved in RA, but we must remain vigilant. Response to: 'Early intensive treatment normalises excess mortality in ACPA-negative RA but not in ACPA-positive RA' by Matthijssen

    Poppelaars, Pomme B M / van Tuyl, Lilian H D / Boers, Maarten

    Annals of the rheumatic diseases

    2019  Volume 79, Issue 10, Page(s) e125

    MeSH term(s) Anti-Citrullinated Protein Antibodies ; Arthritis, Rheumatoid/drug therapy ; Cohort Studies ; Follow-Up Studies ; Humans
    Chemical Substances Anti-Citrullinated Protein Antibodies
    Language English
    Publishing date 2019-07-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2019-215863
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  4. Article ; Online: Rheumatoid arthritis: Remission - keeping the patient experience front and centre.

    van Tuyl, Lilian H D / Boers, Maarten

    Nature reviews. Rheumatology

    2017  Volume 13, Issue 10, Page(s) 573–574

    MeSH term(s) Antirheumatic Agents ; Arthritis, Rheumatoid ; Humans ; Inflammation
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2017-08-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2017.139
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  5. Article ; Online: Normal mortality of the COBRA early rheumatoid arthritis trial cohort after 23 years of follow-up.

    Poppelaars, Pomme B M / van Tuyl, Lilian H D / Boers, Maarten

    Annals of the rheumatic diseases

    2019  Volume 78, Issue 5, Page(s) 586–589

    Abstract: Objectives: Mortality in patients with rheumatoid arthritis (RA) is higher than in the general population. We investigated mortality in the COBRA-trial cohort after 23 years follow-up, compared with a reference sample of the Dutch population.: Methods! ...

    Abstract Objectives: Mortality in patients with rheumatoid arthritis (RA) is higher than in the general population. We investigated mortality in the COBRA-trial cohort after 23 years follow-up, compared with a reference sample of the Dutch population.
    Methods: The COBRA-trial randomised patients with early RA to sulfasalazine monotherapy (SSZ, n=79) or a combination of SSZ, low-dose methotrexate and initially high, step-down prednisolone (COBRA, n=76). We compared the mortality in the COBRA-trial up to 2017 to a reference sample of the general population in the Netherlands (standardised mortality ratio, SMR), and its relation to early prognostic factors through stepwise Cox regression.
    Results: Duration of follow-up in patients alive was mean 23 (range 22-24) years. In total, 44 patients died (28%, SMR=0.80 [95% CI 0.59 to 1.06]); 20 of 75 COBRA patients (27%, SMR 0.75 [0.47 to 1.14]) and 24 of 79 SSZ patients (30%, SMR 0.85 [0.56 to 1.25]); p=0.61). In the reference sample of the general population, 55 people (36%) died. 5 factors were significantly associated with increased mortality hazard: damage progression at 28 weeks; high Health Assessment Questionnaire (HAQ) score and absence of HLA-DR 2 or 3; disease duration from start of complaints was also significant, but showed an uninterpretable pattern.
    Conclusions: This prospective trial cohort study of early RA is one of the first to show similar mortality compared with the general population after 23 years of follow-up. It confirms that early, intensive treatment of RA has long-term benefits and suggests that treating to target is especially important for patients with poor prognosis.
    MeSH term(s) Adult ; Aged ; Antirheumatic Agents/administration & dosage ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/mortality ; Disease Progression ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Male ; Methotrexate/administration & dosage ; Middle Aged ; Prednisolone/administration & dosage ; Prospective Studies ; Severity of Illness Index ; Sulfasalazine/administration & dosage ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Sulfasalazine (3XC8GUZ6CB) ; Prednisolone (9PHQ9Y1OLM) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2019-02-26
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2018-214618
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  6. Article ; Online: Patient-Reported Outcomes in Rheumatoid Arthritis.

    van Tuyl, Lilian H D / Michaud, Kaleb

    Rheumatic diseases clinics of North America

    2016  Volume 42, Issue 2, Page(s) 219–237

    Abstract: Patient-reported outcomes (PROs) and their measures have a long and important history for determining the status and treatment of patients with rheumatoid arthritis (RA). This article describes the history and evolution of PROs for RA and the current ... ...

    Abstract Patient-reported outcomes (PROs) and their measures have a long and important history for determining the status and treatment of patients with rheumatoid arthritis (RA). This article describes the history and evolution of PROs for RA and the current state of the field, with key examples of accepted and widely used measures, and offers some reflection on the roles of PROs for the study and management of RA.
    MeSH term(s) Activities of Daily Living ; Arthralgia/etiology ; Arthralgia/physiopathology ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/psychology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Depression/etiology ; Depression/psychology ; Fatigue/etiology ; Fatigue/physiopathology ; Humans ; Patient Reported Outcome Measures ; Quality Indicators, Health Care ; Quality of Life ; Severity of Illness Index ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/physiopathology
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2016.01.010
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  7. Article: Patient-reported remission in rheumatoid arthritis.

    van Tuyl, Lilian H D / Boers, Maarten

    The Journal of rheumatology

    2013  Volume 40, Issue 4, Page(s) 350–352

    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Disability Evaluation ; Female ; Humans ; Joints/physiopathology ; Male
    Language English
    Publishing date 2013-04
    Publishing country Canada
    Document type Comment ; Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.130098
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  8. Article: Evaluating quality of care in rheumatoid arthritis: the patient perspective.

    Mahmood, Sehrash / van Oosterhout, Marianne / de Jong, Sija / Landewé, Robert / van Riel, Piet / van Tuyl, Lilian H D

    RMD open

    2017  Volume 3, Issue 1, Page(s) e000411

    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2016-000411
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  9. Article ; Online: Patient-reported outcomes in core domain sets for rheumatic diseases.

    van Tuyl, Lilian H D / Boers, Maarten

    Nature reviews. Rheumatology

    2015  Volume 11, Issue 12, Page(s) 705–712

    Abstract: Patient-reported outcomes (PROs) are abundant in rheumatology and their numbers continue to increase. But which of the available measures are most important? Core outcome sets-including groups of domains and instruments for measuring them-have been ... ...

    Abstract Patient-reported outcomes (PROs) are abundant in rheumatology and their numbers continue to increase. But which of the available measures are most important? Core outcome sets-including groups of domains and instruments for measuring them-have been defined for many rheumatic diseases, with the aim that all these outcomes should be measured in every clinical trial. The subgroup of PROs included in these core sets is, therefore, undoubtedly important. This Review summarizes the PROs included in core outcome sets developed for use in clinical trials across a wide range of rheumatic diseases. Three PROs are commonly utilized across the majority of rheumatic conditions: pain, physical functioning and the patient global assessment of disease activity. However, additional research is needed to fully understand the role of the patient global assessment of disease activity, to distinguish specific domains within the broad concept of health-related quality of life, and to work towards consensus on the choice between generic and disease-specific instruments in various contexts.
    MeSH term(s) Diagnostic Self Evaluation ; Humans ; Rheumatic Diseases/diagnosis
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2015.116
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  10. Article ; Online: Favourable effect of a 'second hit' after 13 weeks in early RA non-responders: the Amsterdam COBRA treat-to-target randomized trial.

    Hartman, Linda / Rasch, Linda A / Turk, Samina A / Ter Wee, Marieke M / Kerstens, Pit J S M / van der Laken, Conny J / Nurmohamed, Michael T / van Schaardenburg, Dirkjan / van Tuyl, Lilian H D / Voskuyl, Alexandre E / Boers, Maarten / Lems, Willem F

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 6, Page(s) 2098–2105

    Abstract: Objective: The aim of this study was to investigate the effect of treat-to-target combination therapy with intensification at 13 weeks in early RA.: Methods: Early RA patients were classified as being at high or low risk of worsening RA based on ... ...

    Abstract Objective: The aim of this study was to investigate the effect of treat-to-target combination therapy with intensification at 13 weeks in early RA.
    Methods: Early RA patients were classified as being at high or low risk of worsening RA based on disease activity and prognostic factors. High-risk patients received COBRA-light (prednisolone 30 mg/day tapered to 7.5 mg/day, MTX increasing to 25 mg/week), and low-risk patients received MTX monotherapy increasing to 25 mg/week. The primary outcome (target) was DAS44 < 1.6 or EULAR good response at 26 weeks. At 13 weeks, non-responders were randomized to (open-label) intensification [high-risk patients: prednisolone 60 mg/day tapered to 7.5 mg/day, addition of SSZ (2 g/day) and HCQ (400 mg/day); low-risk patients: prednisolone 30 mg/day tapered to 7.5 mg/day] or continuation.
    Results: In the high-risk group (n = 150), 110 patients (73%) reached the target at 13 weeks, and 9 dropped out. Non-responders were randomized to intensification (n = 15) or continuation (n = 16), and after 26 weeks, 12 (80%) vs 7 (44%) of these, respectively, reached the target [difference: 36%, (95% CI 2%, 71%); P = 0.04]. In the low-risk group (n = 40), 17 (43%) reached the target. Non-responders were randomized to intensification (n = 8) or continuation (n = 7); 4 vs 3, respectively, reached the target.Adverse event rates were higher in the high-risk group, and higher in the intensification subgroup of that group. Serious adverse events were rare. Protocol violations were frequent and mostly led to mitigation of actual treatment intensification.
    Conclusion: Initial combination therapy was very successful in high-risk RA, and early intensification was beneficial in patients not reaching the strict target. The low-risk group was too small for drawing conclusions. In routine practice, adherence to early intensification based on strict targets is difficult.
    Trial registration: Netherlands Trial Register (NTR), NL4393, https://www.trialregister.nl/.
    MeSH term(s) Humans ; Antirheumatic Agents/adverse effects ; Sulfasalazine/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/chemically induced ; Methotrexate ; Prednisolone/therapeutic use ; Treatment Outcome ; Drug Therapy, Combination
    Chemical Substances Antirheumatic Agents ; Sulfasalazine (3XC8GUZ6CB) ; Methotrexate (YL5FZ2Y5U1) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac582
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