LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 297

Search options

  1. Book ; Thesis: Einfluß von IGF-I, IGF-II und Bindungsprotein auf das Wachstum der Erythroleukämiezellen K-562

    Bernhardt, Jörg

    1991  

    Author's details vorgelegt von Jörg Bernhardt
    Size 94 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 1991
    HBZ-ID HT003975817
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    92 D 371 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online ; Thesis: Sustainable management of naturally disturbed forests

    Georgiev, Kostadin [Verfasser] / Müller, Jörg [Gutachter] / Bernhardt-Römermann, Markus [Gutachter]

    2021  

    Author's details Kostadin Georgiev ; Gutachter: Jörg Müller, Markus Bernhardt-Römermann
    Keywords Tiere (Zoologie) ; Animals (Zoology)
    Subject code sg590
    Language English
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Visual Communication in Urban Design and Planning

    Christmann, Gabriela / Singh, Ajit / Stollmann, Jörg / Bernhardt, Christoph

    The Impact of Mediatisation(s) on the Construction of Urban Futures

    2020  

    Abstract: This editorial introduces the subject matter of the thematic issue, which includes a diverse collection of contributions from authors in various disciplines including, history, architecture, planning, sociology and geography. Within the context of ... ...

    Abstract This editorial introduces the subject matter of the thematic issue, which includes a diverse collection of contributions from authors in various disciplines including, history, architecture, planning, sociology and geography. Within the context of mediatisation processes—and the increased use of ever-expanding I&C technologies—communication has undergone profound changes. As such, this thematic issue will discuss how far (digital) media tools and their social uses in urban design and planning have impacted the visualisation of urban imaginations and how urban futures are thereby communicatively produced. Referring to an approach originating from the media and communication sciences, the authors begin with an outline of the core concepts of mediatisation and digitalisation. They suggest how the term ‘visualisation’ can be conceived and, against this background, based upon the sociological approach of communicative constructivism, a proposal is offered, which diverges from traditional methods of conceptualising visualisations: Instead, it highlights the need for a greater consideration towards the active role of creators (e.g., planners) and recipients (e.g., stakeholders) as well as the distinctive techniques of communication involved (e.g., a specific digital planning tools). The authors in this issue illustrate how communicative construction, particularly the visual construction of urban futures, can be understood, depending upon the kind of social actors as well as the means of communication involved. The editorial concludes with a summary of the main arguments and core results presented.
    Keywords ddc:710 ; digital tools ; mediatisation ; urban planning and design ; visual communication ; visualisations
    Subject code 720
    Language English
    Publisher Lisbon: Cogitatio
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Inter-patient heterogeneity in the hepatic ischemia-reperfusion injury transcriptome: Implications for research and diagnostics.

    Groiss, Silvia / Viertler, Christian / Kap, Marcel / Bernhardt, Gerwin / Mischinger, Hans-Jörg / Sieuwerts, Anieta / Verhoef, Cees / Riegman, Peter / Kruhøffer, Mogens / Svec, David / Sjöback, Sjoback Robert / Becker, Karl-Friedrich / Zatloukal, Kurt

    New biotechnology

    2023  Volume 79, Page(s) 20–29

    Abstract: Cellular responses induced by surgical procedure or ischemia-reperfusion injury (IRI) may severely alter transcriptome profiles and complicate molecular diagnostics. To investigate this effect, we characterized such pre-analytical effects in 143 non- ... ...

    Abstract Cellular responses induced by surgical procedure or ischemia-reperfusion injury (IRI) may severely alter transcriptome profiles and complicate molecular diagnostics. To investigate this effect, we characterized such pre-analytical effects in 143 non-malignant liver samples obtained from 30 patients at different time points of ischemia during surgery from two individual cohorts treated either with the Pringle manoeuvre or total vascular exclusion. Transcriptomics profiles were analyzed by Affymetrix microarrays and expression of selected mRNAs was validated by RT-PCR. We found 179 mutually deregulated genes which point to elevated cytokine signaling with NFκB as a dominant pathway in ischemia responses. In contrast to ischemia, reperfusion induced pro-apoptotic and pro-inflammatory cascades involving TNF, NFκB and MAPK pathways. FOS and JUN were down-regulated in steatosis compared to their up-regulation in normal livers. Surprisingly, molecular signatures of underlying primary and secondary cancers were present in non-tumor tissue. The reported inter-patient variability might reflect differences in individual stress responses and impact of underlying disease conditions. Furthermore, we provide a set of 230 pre-analytically highly robust genes identified from histologically normal livers (<2% covariation across both cohorts) that might serve as reference genes and could be particularly suited for future diagnostic applications.
    MeSH term(s) Humans ; Transcriptome/genetics ; Gene Expression Regulation ; Liver/metabolism ; Reperfusion Injury/diagnosis ; Reperfusion Injury/genetics ; Ischemia/complications ; Ischemia/metabolism ; Ischemia/pathology
    Language English
    Publishing date 2023-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2400836-9
    ISSN 1876-4347 ; 1876-4347
    ISSN (online) 1876-4347
    ISSN 1876-4347
    DOI 10.1016/j.nbt.2023.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Trade-off for survival: Microbiome response to chemical exposure combines activation of intrinsic resistances and adapted metabolic activity.

    Adi Wicaksono, Wisnu / Braun, Maria / Bernhardt, Jörg / Riedel, Katharina / Cernava, Tomislav / Berg, Gabriele

    Environment international

    2022  Volume 168, Page(s) 107474

    Abstract: The environmental microbiota is increasingly exposed to chemical pollution. While the emergence of multi-resistant pathogens is recognized as a global challenge, our understanding of antimicrobial resistance (AMR) development from native microbiomes and ... ...

    Abstract The environmental microbiota is increasingly exposed to chemical pollution. While the emergence of multi-resistant pathogens is recognized as a global challenge, our understanding of antimicrobial resistance (AMR) development from native microbiomes and the risks associated with chemical exposure is limited. By implementing a lichen asa bioindicatororganism and model for a native microbiome, we systematically examined responses towards antimicrobials (colistin, tetracycline, glyphosate, and alkylpyrazine). Despite an unexpectedly high resilience, we identified potential evolutionary consequences of chemical exposure in terms of composition and functioning of native bacterial communities. Major shifts in bacterial composition were observed due to replacement of naturally abundant taxa; e.g. Chthoniobacterales by Pseudomonadales. A general response, which comprised activation of intrinsic resistance and parallel reduction of metabolic activity at RNA and protein levels was deciphered by a multi-omics approach. Targeted analyses of key taxa based on metagenome-assembled genomes reflected these responses but also revealed diversified strategies of their players. Chemical-specific responses were also observed, e.g., glyphosate enriched bacterial r-strategists and activated distinct ARGs. Our work demonstrates that the high resilience of the native microbiota toward antimicrobial exposure is not only explained by the presence of antibiotic resistance genes but also adapted metabolic activity as a trade-off for survival. Moreover, our results highlight the importance of native microbiomes as important but so far neglected AMR reservoirs. We expect that this phenomenon is representative for a wide range of environmental microbiota exposed to chemicals that potentially contribute to the emergence of antibiotic-resistant bacteria from natural environments.
    Language English
    Publishing date 2022-08-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2022.107474
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Abdominal wall hernias as complications of cirrhosis.

    Bernhardt, Gerwin A / Mischinger, Hans-Jörg

    Liver international : official journal of the International Association for the Study of the Liver

    2012  Volume 32, Issue 3, Page(s) 519–20; author reply 520

    MeSH term(s) Diabetes Mellitus/epidemiology ; Female ; Hepatopulmonary Syndrome/epidemiology ; Hepatorenal Syndrome/epidemiology ; Humans ; Liver Cirrhosis/complications ; Male ; Malnutrition/epidemiology ; Osteoporosis/epidemiology
    Language English
    Publishing date 2012-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/j.1478-3231.2011.02679.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online ; Thesis: Verteilungsmuster, Entwicklungsraten und Wirtsnachweis nekrophager Fliegenarten an menschlichen Leichen

    Bernhardt, Victoria [Verfasser] / Oehlmann, Jörg [Gutachter] / Amendt, Jens [Gutachter]

    2018  

    Author's details Victoria Bernhardt ; Gutachter: Jörg Oehlmann, Jens Amendt
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Proteomic profiling of antibiotic-resistant Escherichia coli GW-AmxH19 isolated from hospital wastewater treated with physical plasma.

    Hahn, Veronika / Zühlke, Daniela / Winter, Hauke / Landskron, Annchristin / Bernhardt, Jörg / Sievers, Susanne / Schmidt, Michael / von Woedtke, Thomas / Riedel, Katharina / Kolb, Juergen F

    Proteomics

    2024  , Page(s) e2300494

    Abstract: Microorganisms which are resistant to antibiotics are a global threat to the health of humans and animals. Wastewater treatment plants are known hotspots for the dissemination of antibiotic resistances. Therefore, novel methods for the inactivation of ... ...

    Abstract Microorganisms which are resistant to antibiotics are a global threat to the health of humans and animals. Wastewater treatment plants are known hotspots for the dissemination of antibiotic resistances. Therefore, novel methods for the inactivation of pathogens, and in particular antibiotic-resistant microorganisms (ARM), are of increasing interest. An especially promising method could be a water treatment by physical plasma which provides charged particles, electric fields, UV-radiation, and reactive species. The latter are foremost responsible for the antimicrobial properties of plasma. Thus, with plasma it might be possible to reduce the amount of ARM and to establish this technology as additional treatment stage for wastewater remediation. However, the impact of plasma on microorganisms beyond a mere inactivation was analyzed in more detail by a proteomic approach. Therefore, Escherichia coli GW-AmxH19, isolated from hospital wastewater in Germany, was used. The bacterial solution was treated by a plasma discharge ignited between each of four pins and the liquid surface. The growth of E. coli and the pH-value decreased during plasma treatment in comparison with the untreated control. Proteome and antibiotic resistance profile were analyzed. Concentrations of nitrite and nitrate were determined as long-lived indicative products of a transient chemistry associated with reactive nitrogen species (RNS). Conversely, hydrogen peroxide served as indicator for reactive oxygen species (ROS). Proteome analyses revealed an oxidative stress response as a result of plasma-generated RNS and ROS as well as a pH-balancing reaction as key responses to plasma treatment. Both, the generation of reactive species and a decreased pH-value is characteristic for plasma-treated solutions. The plasma-mediated changes of the proteome are discussed also in comparison with the Gram-positive bacterium Bacillus subtilis. Furthermore, no effect of the plasma treatment, on the antibiotic resistance of E. coli, was determined under the chosen conditions. The knowledge about the physiological changes of ARM in response to plasma is of fundamental interest to understand the molecular basis for the inactivation. This will be important for the further development and implementation of plasma in wastewater remediation.
    Language English
    Publishing date 2024-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.202300494
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 1868: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Trade-off for survival

    Wisnu Adi Wicaksono / Maria Braun / Jörg Bernhardt / Katharina Riedel / Tomislav Cernava / Gabriele Berg

    Environment International, Vol 168, Iss , Pp 107474- (2022)

    Microbiome response to chemical exposure combines activation of intrinsic resistances and adapted metabolic activity

    2022  

    Abstract: The environmental microbiota is increasingly exposed to chemical pollution. While the emergence of multi-resistant pathogens is recognized as a global challenge, our understanding of antimicrobial resistance (AMR) development from native microbiomes and ... ...

    Abstract The environmental microbiota is increasingly exposed to chemical pollution. While the emergence of multi-resistant pathogens is recognized as a global challenge, our understanding of antimicrobial resistance (AMR) development from native microbiomes and the risks associated with chemical exposure is limited. By implementing a lichen as a bioindicator organism and model for a native microbiome, we systematically examined responses towards antimicrobials (colistin, tetracycline, glyphosate, and alkylpyrazine). Despite an unexpectedly high resilience, we identified potential evolutionary consequences of chemical exposure in terms of composition and functioning of native bacterial communities. Major shifts in bacterial composition were observed due to replacement of naturally abundant taxa; e.g. Chthoniobacterales by Pseudomonadales. A general response, which comprised activation of intrinsic resistance and parallel reduction of metabolic activity at RNA and protein levels was deciphered by a multi-omics approach. Targeted analyses of key taxa based on metagenome-assembled genomes reflected these responses but also revealed diversified strategies of their players. Chemical-specific responses were also observed, e.g., glyphosate enriched bacterial r-strategists and activated distinct ARGs. Our work demonstrates that the high resilience of the native microbiota toward antimicrobial exposure is not only explained by the presence of antibiotic resistance genes but also adapted metabolic activity as a trade-off for survival. Moreover, our results highlight the importance of native microbiomes as important but so far neglected AMR reservoirs. We expect that this phenomenon is representative for a wide range of environmental microbiota exposed to chemicals that potentially contribute to the emergence of antibiotic-resistant bacteria from natural environments.
    Keywords Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Diagnostic evaluation and management of benign duodenal tumours (Re: ANZ J. Surg. 2010; 80: 526-30).

    Bernhardt, Gerwin A / Mischinger, Hans-Jörg

    ANZ journal of surgery

    2011  Volume 81, Issue 4, Page(s) 300–301

    MeSH term(s) Biopsy, Needle ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Diagnosis, Differential ; Duodenal Neoplasms/diagnosis ; Duodenal Neoplasms/surgery ; Duodenoscopy/methods ; Endosonography/methods ; Humans ; Pancreaticoduodenectomy/methods
    Language English
    Publishing date 2011-04
    Publishing country Australia
    Document type Comment ; Letter
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/j.1445-2197.2011.05683.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top