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  1. Article ; Online: A series of narrative reviews on air pollution and respiratory health for Pulmonology: Why it is important and who should read it.

    Viegi, G / Taborda-Barata, L

    Pulmonology

    2022  Volume 28, Issue 4, Page(s) 243–244

    MeSH term(s) Air Pollution/adverse effects ; Air Pollution/analysis ; Environmental Exposure ; Humans ; Pulmonary Medicine
    Language English
    Publishing date 2022-02-01
    Publishing country Spain
    Document type Editorial ; Review
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2021.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Esposizione ambientale e occupazionale: utilità di un’analisi integrata dei determinanti di salute.

    Maio, Sara / Gariazzo, Claudio / Massari, Stefania / Marinaccio, Alessandro / Viegi, Giovanni / Annesi-Maesano, Isabella

    Epidemiologia e prevenzione

    2024  Volume 47, Issue 6, Page(s) 5–7

    Title translation Environmental and occupational exposure: usefulness of an integrated analysis of health determinants.
    MeSH term(s) Humans ; Italy ; Environmental Exposure/adverse effects ; Occupational Exposure/adverse effects ; Occupational Health
    Language Italian
    Publishing date 2024-04-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    DOI 10.19191/EP23.6.S3.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Esposizione ambientale e occupazionale: utilità di un’analisi integrata dei determinanti di salute.

    Maio, Sara / Gariazzo, Claudio / Massari, Stefania / Marinaccio, Alessandro / Viegi, Giovanni / Annesi-Maesano, Isabella

    Epidemiologia e prevenzione

    2024  Volume 47, Issue 6, Page(s) 5–7

    Title translation Environmental and occupational exposure: usefulness of an integrated analysis of health determinants.
    MeSH term(s) Humans ; Italy ; Environmental Exposure/adverse effects ; Occupational Exposure/adverse effects ; Occupational Health
    Language Italian
    Publishing date 2024-04-19
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    DOI 10.19191/EP23.6.S3.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outdoor air pollution and respiratory health.

    Maio, S / Sarno, G / Tagliaferro, S / Pirona, F / Stanisci, I / Baldacci, S / Viegi, G

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2023  Volume 27, Issue 1, Page(s) 7–12

    Abstract: The need to address the impact of air pollution on health is reinforced by recent scientific evidence and the 2021 WHO Air Quality Guidelines (AQG). Air pollution is an avoidable risk factor causing a high burden for society with elevated deaths, health ... ...

    Abstract The need to address the impact of air pollution on health is reinforced by recent scientific evidence and the 2021 WHO Air Quality Guidelines (AQG). Air pollution is an avoidable risk factor causing a high burden for society with elevated deaths, health disorders, disabilities and huge socio-economic costs, especially in low- and middle-income countries. We have evaluated recent evidence from international reports, systematic reviews and official websites of international agencies. Growing evidence shows a causal relationship between air pollution exposure and acute lower respiratory infections, chronic obstructive pulmonary disease, asthma and lung cancer. Exposure to air pollution in both the short- and long-term has a serious impact on respiratory health. Harmful effects occur even at very low pollutant concentration levels, and there are no detectable thresholds below which exposure may be considered safe. The adverse respiratory health effects of air pollutants, even at low levels, are confirmed by recent epidemiological studies. Scientific respiratory societies and patient associations, along with other stakeholders in the health sector, should increase their engagement and advocacy to raise awareness of clean air policies and the latest WHO AQG.
    MeSH term(s) Humans ; Air Pollution/adverse effects ; Air Pollutants/adverse effects ; Asthma ; Drug-Related Side Effects and Adverse Reactions ; Lung Neoplasms
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2023-03-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.22.0249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The severe asthma registries: a way to better know and fight the disease.

    Maio, S / Baldacci, S / Cecchi, L / Viegi, G

    European annals of allergy and clinical immunology

    2021  Volume 53, Issue 3, Page(s) 99–102

    MeSH term(s) Asthma/diagnosis ; Asthma/epidemiology ; Humans ; Registries
    Language English
    Publishing date 2021-04-01
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2105540-3
    ISSN 1764-1489 ; 0397-9148
    ISSN 1764-1489 ; 0397-9148
    DOI 10.23822/EurAnnACI.1764-1489.203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COPD treatment - a conceptual review based on critical endpoints.

    Roque, A / Taborda-Barata, L / Cruz, Á A / Viegi, G / Maricoto, T

    Pulmonology

    2023  Volume 29, Issue 5, Page(s) 410–420

    Abstract: Introduction: Chronic obstructive pulmonary disease (COPD) is one of the main causes of death and disability worldwide. Many treatment options are now available, but criteria for choosing inhaled bronchodilators and inhaled corticosteroids have been ... ...

    Abstract Introduction: Chronic obstructive pulmonary disease (COPD) is one of the main causes of death and disability worldwide. Many treatment options are now available, but criteria for choosing inhaled bronchodilators and inhaled corticosteroids have been under discussion. New trials have highlighted the role of patient`s characteristics, such as eosinophil count and exacerbation history, in selecting the most effective personalised treatment option.
    Methods: In this conceptual review, an in-depth rationale is developed with an integrative approach to COPD treatment, gathering data from the main clinical trials performed so far and that may provide support for actual GOLD 2023 recommendations.
    Results: According to the patient's characteristics and profile, different treatment options, including mono, dual and triple therapies, are presented in a diagram matrix, comparing their efficacy in terms of reduction of exacerbations and mortality risk.
    Discussion and conclusion: Eosinophil counts and past exacerbation profile may play equally relevant roles to predict the individual risk and the potential response to inhaled corticosteroids. Thus, a comprehensive approach considering these two predictors is needed to aid clinicians decide preventative actions and choice of a first-line or step-up treatment.
    MeSH term(s) Humans ; Eosinophils ; Administration, Inhalation ; Leukocyte Count ; Adrenal Cortex Hormones/therapeutic use ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2023-04-06
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2023.02.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Different greenness exposure in Europe and respiratory outcomes in youths. A systematic review and meta-analysis.

    Squillacioti, Giulia / Fasola, Salvatore / Ghelli, Federica / Colombi, Nicoletta / Pandolfo, Alessandra / La Grutta, Stefania / Viegi, Giovanni / Bono, Roberto

    Environmental research

    2024  Volume 247, Page(s) 118166

    Abstract: The existing evidence on the association between greenness and respiratory outcomes remains inconclusive. We aimed at systematically summarizing existing literature on greenness exposure and respiratory outcomes in European children and adolescents, with ...

    Abstract The existing evidence on the association between greenness and respiratory outcomes remains inconclusive. We aimed at systematically summarizing existing literature on greenness exposure and respiratory outcomes in European children and adolescents, with a preliminary attempt to qualify the distribution of dominant tree species across different geographical areas and bioclimatic regions. Overall, 4049 studies were firstly identified by searching PubMed/MEDLINE, EMBASE, Scopus, Web of Science, GreenFile and CAB direct, up to 29 August 2023. Eighteen primary studies were included in the systematic review and six were meta-analyzed. No overall significant association was observed between the Normalized Difference Vegetation Index, assessed within 500-m buffers (i.e. NDVI-500), and the odds of asthma for 0.3-increase in the exposure (OR: 0.97, 95% CI from 0.53 to 1.78). Similarly, an overall exposure to the NDVI-300 highest tertile, as compared to the lowest tertile, was not significantly associated with asthma (OR: 0.65, 95% CI from 0.22 to 1.91): heterogeneity among studies was significant (p = 0.021). We delineated some key elements that might have mostly contributed to the lack of scientific consensus on this topic, starting from the urgent need of harmonized approaches for the operational definition of greenness. Additionally, the complex interplay between greenness and respiratory health may vary across different geographical regions and climatic conditions. At last, the inconsistent findings may reflect the heterogeneity and complexity of this relationship, rather than a lack of scientific consensus itself. Future research should compare geographical areas with similar bioclimatic parameters and dominant or potentially present vegetation species, in order to achieve a higher inter-study comparability.
    MeSH term(s) Child ; Humans ; Adolescent ; Asthma/epidemiology ; Environment ; Europe/epidemiology ; Trees ; Research Design
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effetti acuti dell’inquinamento atmosferico e delle temperature estreme sulla mortalità causa-specifica in Italia. Risultati del progetto BIGEPI.

    Stafoggia, Massimo / De' Donato, Francesca / Michelozzi, Paola / Viegi, Giovanni / Maio, Sara / Gariazzo, Claudio

    Recenti progressi in medicina

    2023  Volume 114, Issue 7, Page(s) 441–446

    Abstract: Introduction: Air pollution and extreme temperatures have been associated with multiple adverse health effects, especially on the cardiovascular and respiratory systems. The evidence of a relationship between daily exposures and mortality from metabolic, ...

    Title translation Acute effects of air pollution and extreme temperatures on cause-specific mortality in Italy. Results of the BIGEPI project.
    Abstract Introduction: Air pollution and extreme temperatures have been associated with multiple adverse health effects, especially on the cardiovascular and respiratory systems. The evidence of a relationship between daily exposures and mortality from metabolic, nervous and mental causes needs to be strengthened. The aim of this study is to investigate the association between daily exposure to fine particulate matter (PM2.5) and extreme temperatures (heat and cold) with cause-specific mortality in the entire Italian population.
    Methods: The daily counts of deaths from natural, cardiovascular, respiratory, metabolic, diabetes, nervous and mental causes were provided by Istat at the municipal level for the period 2006-2015. Through the application of machine-learning models based on satellite data and spatiotemporal variables, population-weighted exposures to daily mean PM2.5 (2013-2015) and air temperature (2006-2015) were estimated at municipality level. Time-series models adjusted for seasonal and long-term trends were applied, and associations between the above exposures and different causes of death at the national level were estimated.
    Results: The study found a marked effect of PM2.5 on deaths from nervous causes, with a % increase of risk (IR%) of 6.55% (95% confidence interval: 3.38%-9.81%) per PM2.5 increases of 10 µg/m3. The study also highlighted significant effects of low and high temperatures on all study outcomes. The effects were greater for high temperatures. In particular, the effects of heat, expressed as a % increase in risk per temperature increase from the 75th to the 99th percentile, show the highest associations with mortality from nervous causes (58.3%; 95%CI: 49.7%-67.5%), mental causes (48.4%; 95%CI: 40.4%-56.9%), respiratory causes 45.8%; 95%CI: 39.7%-52.1%) and metabolic causes (36.9%; 95%CI: 30.6%-43.5%).
    Discussion: The study showed a strong association between daily exposure to PM2.5 and extreme temperatures, especially heat, with mortality outcomes, especially those under-investigated, such as diabetes, metabolic, nervous and mental causes.
    MeSH term(s) Humans ; Hot Temperature ; Temperature ; Cause of Death ; Air Pollution/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Italy/epidemiology ; Particulate Matter/adverse effects
    Chemical Substances Particulate Matter
    Language Italian
    Publishing date 2023-06-30
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/4062.40463
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  9. Article ; Online: Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health.

    Ferrante, Giuliana / Fasola, Salvatore / Cilluffo, Giovanna / Piacentini, Giorgio / Viegi, Giovanni / La Grutta, Stefania

    Frontiers in public health

    2022  Volume 10, Page(s) 871140

    Abstract: Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure-health effect relationships. The exposome is an ... ...

    Abstract Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure-health effect relationships. The exposome is an emerging concept in epidemiology, encompassing the totality of the exposures experienced by an individual throughout life and their changes over time. This innovative approach provides a risk profile instead of individual predictors. Exposome research may contribute to better understand the complex relationships between environmental exposures and childhood respiratory health, in order to implement prevention strategies and mitigate adverse health outcomes across the life span. Indeed, an accurate assessment of the exposome needs several measurements as well as different technologies. High-throughput "omics" technologies may be promising tools to integrate a wide range of exposures. However, analyzing large and complex datasets requires the development of advanced statistical tools. This narrative review summarizes the current knowledge on exposome-based approaches in pediatric respiratory health. Further, it explores practical implementation, associated evidence gaps, research limitations and future research perspectives.
    MeSH term(s) Child ; Environmental Exposure/adverse effects ; Exposome ; Humans
    Language English
    Publishing date 2022-06-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.871140
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  10. Article ; Online: Global Burden of Chronic Respiratory Diseases.

    Viegi, Giovanni / Maio, Sara / Fasola, Salvatore / Baldacci, Sandra

    Journal of aerosol medicine and pulmonary drug delivery

    2020  Volume 33, Issue 4, Page(s) 171–177

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Asthma/epidemiology ; Asthma/etiology ; Chronic Disease ; Global Burden of Disease ; Humans ; Incidence ; Prevalence ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/etiology ; Quality-Adjusted Life Years ; Risk Factors
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2417924-3
    ISSN 1941-2703 ; 1941-2711
    ISSN (online) 1941-2703
    ISSN 1941-2711
    DOI 10.1089/jamp.2019.1576
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