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Article ; Online: Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain.

Zilony-Hanin, Neta / Rosenberg, Michal / Richman, Michal / Yehuda, Ronen / Schori, Hadas / Motiei, Menachem / Rahimipour, Shai / Groisman, Alexander / Segal, Ester / Shefi, Orit

Small (Weinheim an der Bergstrasse, Germany)

2019 Volume 15, Issue 45, Page(s) e1904203

Abstract: Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon ( ... ...

Abstract	Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon (PSiO
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Cell Survival/drug effects ; Mice ; Microscopy, Confocal ; Microscopy, Fluorescence ; Nanostructures/chemistry ; Nanostructures/therapeutic use ; Nerve Growth Factor/chemistry ; Nerve Growth Factor/pharmacokinetics ; Nerve Growth Factor/therapeutic use ; PC12 Cells ; Porosity ; Rats ; Silicon/chemistry ; X-Ray Microtomography
Chemical Substances	Nerve Growth Factor (9061-61-4) ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2019-09-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1613-6829
ISSN (online)	1613-6829
DOI	10.1002/smll.201904203
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Article ; Online: Fertility outcomes after extended searches for ejaculated spermatozoa in men with virtual azoospermia.

Miller, Netanella / Biron-Shental, Tal / Pasternak, Yael / Belenky, Michael / Shefi, Shai / Itsykson, Pavel / Berkovitz, Arie

Fertility and sterility

2017 Volume 107, Issue 6, Page(s) 1305–1311

Abstract: Objective: To assess the fertility outcomes of extended searches for ejaculated spermatozoa in men with virtual azoospermia.: Design: A retrospective cohort of 242 couples whose male partner suffered from nonobstructive azoospermia and who were ... ...

Abstract	Objective: To assess the fertility outcomes of extended searches for ejaculated spermatozoa in men with virtual azoospermia. Design: A retrospective cohort of 242 couples whose male partner suffered from nonobstructive azoospermia and who were treated with the use of intracytoplasmic sperm injection (ICSI). Setting: Not applicable. Patient(s): One hundred forty patients were referred to an extended search in the ejaculate and 102 patients were referred to microsurgical testicular sperm extraction (microTESE). Intervention(s): None. Main outcome measure(s): Rates of sperm retrieval, fertilization, and pregnancy, take-home baby rate, and missed abortion rate were analyzed and compared. Result(s): In the ejaculated spermatozoa group, motile spermatozoa were retrieved in 91 cases (65%) and on oocyte pick-up day in 71 cases (78%), compared with 70 cases (68%) in the microTESE group, with a similar incidence of sperm retrieval between groups. No significant difference was found between groups regarding mean number of embryo transfer and fertilization and pregnancy rates. There was no significant difference between groups regarding take-home baby rate. A significantly higher first-trimester missed abortion rate was found in the ejaculated sperm group (n = 14; 52%) compared with the microTESE group (n = 3; 8.6%). Conclusion(s): Conducting an extended spermatozoa search in the ejaculate of men with virtual azoospermia can provide pregnancy rates similar to those obtained with the use of microTESE, with a higher rate of spontaneous abortions in the ejaculate group.
MeSH term(s)	Adult ; Azoospermia/epidemiology ; Azoospermia/therapy ; Cohort Studies ; Ejaculation ; Female ; Humans ; Israel/epidemiology ; Male ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy Rate ; Prevalence ; Retrospective Studies ; Sperm Injections, Intracytoplasmic/statistics & numerical data ; Sperm Retrieval/statistics & numerical data ; Treatment Outcome
Language	English
Publishing date	2017-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2017.04.005
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Article: Definition and current evaluation of subfertile men.

Shefi, Shai / Turek, Paul J

International braz j urol : official journal of the Brazilian Society of Urology

2006 Volume 32, Issue 4, Page(s) 385–397

Abstract: Male infertility affects 10% of reproductive aged couples worldwide and is treatable in many cases. In addition to other well-described etiologies, genetic causes of male infertility are now more commonly diagnosed. Using principles of evidence-based ... ...

Abstract	Male infertility affects 10% of reproductive aged couples worldwide and is treatable in many cases. In addition to other well-described etiologies, genetic causes of male infertility are now more commonly diagnosed. Using principles of evidence-based medicine, this review outlines diagnostic and treatments options to inform clinical management. In order of importance, randomized controlled clinical trials, basic scientific studies, meta-analyses, case-controlled cohort studies, best-practice policy recommendations and reviews from peer-reviewed literature were incorporated that provide organized and timely guidelines to the current management of male infertility. The strength of evidence for treatment recommendations is also classified when appropriate.
MeSH term(s)	Evidence-Based Medicine ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/etiology ; Infertility, Male/therapy ; Male
Language	English
Publishing date	2006-09-05
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2206649-4
ISSN	1677-5538
ISSN	1677-5538
DOI	10.1590/s1677-55382006000400002
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Article ; Online: Sexual dysfunction after radical prostatectomy: treatment failure or treatment delay?

Bronner, Gila / Shefi, Shai / Raviv, Gil

Journal of sex & marital therapy

2010 Volume 36, Issue 5, Page(s) 421–429

Abstract: This study defines characteristics of delayed help-seeking in men who fail phosphodiesterase-5 inhibitors (PDE5I) treatment for their post radical retropubic prostatectomy (RRP) erectile dysfunction (ED). Medical charts were reviewed retrospectively. All ...

Abstract	This study defines characteristics of delayed help-seeking in men who fail phosphodiesterase-5 inhibitors (PDE5I) treatment for their post radical retropubic prostatectomy (RRP) erectile dysfunction (ED). Medical charts were reviewed retrospectively. All men were offered second line treatment with vacuum devices or intracavernous injection (ICI) and sex therapy. This study included thirty one patients. Average age at surgery was 60 years (SD = 5.3, range 46-70). Average period for second line help-seeking was 25.9 months (SD = 12.9, range 3-111). All subjects believed that surgery would not affect their sexual function. Twenty men (65%) used ICI as a second line treatment. Eleven men (35%) declined treatment, waiting for spontaneous recovery. In ICI sub-group, 5 men (25%) regained spontaneous erection within 7-10 months after initial treatment (16-19 months post-surgery). Seven men (35%) responded positively to PDE5I 3-5 months after starting ICI. Three men (15%) used vacuum device. None regained spontaneous erection. All 7 men (23%) who met sex therapist with their partner reported improved sexual life, even if ED wasn't resolved. Patients should receive comprehensive information about sexual recovery, to encourage early ED treatment after RRP and to overcome unwanted misconceptions regarding spontaneous recovery.
MeSH term(s)	Adult ; Aged ; Coitus/psychology ; Combined Modality Therapy ; Erectile Dysfunction/etiology ; Erectile Dysfunction/therapy ; Humans ; Injections ; Israel ; Male ; Marital Therapy/methods ; Middle Aged ; Personal Satisfaction ; Phosphodiesterase Inhibitors/therapeutic use ; Prostatectomy/adverse effects ; Prostatic Neoplasms/surgery ; Quality of Life/psychology ; Treatment Outcome ; Vacuum ; Vasodilator Agents/therapeutic use
Chemical Substances	Phosphodiesterase Inhibitors ; Vasodilator Agents
Language	English
Publishing date	2010
Publishing country	England
Document type	Journal Article
ZDB-ID	752393-2
ISSN	1521-0715 ; 0092-623X
ISSN (online)	1521-0715
ISSN	0092-623X
DOI	10.1080/0092623X.2010.510777
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Article ; Online: Male infertility associated with adult dominant polycystic kidney disease: a case series.

Shefi, Shai / Levron, Jacob / Nadu, Andrei / Raviv, Gil

Archives of gynecology and obstetrics

2009 Volume 280, Issue 3, Page(s) 457–460

Abstract: Introduction: Although described earlier, the association of male infertility with adult dominant polycystic kidney disease (ADPKD) is quite rare and unfamiliar to some of the multidisciplinary team members caring for affected men.: Materials and ... ...

Abstract	Introduction: Although described earlier, the association of male infertility with adult dominant polycystic kidney disease (ADPKD) is quite rare and unfamiliar to some of the multidisciplinary team members caring for affected men. Materials and methods: Infertile men diagnosed to have ADPKD were evaluated by clinical characteristics including testis volume, as well as serum hormone levels, semen analysis, and transrectal ultrasonography (TRUS) because of low volume ejaculate. Results: Semen analysis revealed low-normal volume, normal pH, and azoospermia/virtual azoospermia. Serum hormones were within the normal range. Transrectal ultrasonography demonstrated cystic dilatation of the seminal vesicles in all three men. Conclusion: Patients should be referred for andrological evaluation of a presentation similar to obstructive azoospermia. Their potential to achieve paternity by surgical sperm retrieval combined with assisted reproductive technology is another example of cooperation between andrologists and gynecologists.
MeSH term(s)	Adult ; Azoospermia/complications ; Genitalia, Male/diagnostic imaging ; Humans ; Infertility, Male/complications ; Male ; Oligospermia/complications ; Organ Size ; Polycystic Kidney, Autosomal Dominant/complications ; Testis/pathology ; Ultrasonography
Language	English
Publishing date	2009-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-008-0916-9
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Article ; Online: Effect of craniosacral therapy on lower urinary tract signs and symptoms in multiple sclerosis.

Raviv, Gil / Shefi, Shai / Nizani, Dalia / Achiron, Anat

Complementary therapies in clinical practice

2009 Volume 15, Issue 2, Page(s) 72–75

Abstract: To examine whether craniosacral therapy improves lower urinary tract symptoms of multiple sclerosis (MS) patients. A prospective cohort study. Out-patient clinic of multiple sclerosis center in a referral medical center. Hands on craniosacral therapy ( ... ...

Abstract	To examine whether craniosacral therapy improves lower urinary tract symptoms of multiple sclerosis (MS) patients. A prospective cohort study. Out-patient clinic of multiple sclerosis center in a referral medical center. Hands on craniosacral therapy (CST). Change in lower urinary tract symptoms, post voiding residual volume and quality of life. Patients from our multiple sclerosis clinic were assessed before and after craniosacral therapy. Evaluation included neurological examination, disability status determination, ultrasonographic post voiding residual volume estimation and questionnaires regarding lower urinary tract symptoms and quality of life. Twenty eight patients met eligibility criteria and were included in this study. Comparison of post voiding residual volume, lower urinary tract symptoms and quality of life before and after craniosacral therapy revealed a significant improvement (0.001>p>0.0001). CST was found to be an effective means for treating lower urinary tract symptoms and improving quality of life in MS patients.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Massage ; Middle Aged ; Multiple Sclerosis/complications ; Prospective Studies ; Quality of Life ; Urinary Incontinence/etiology ; Urinary Incontinence/therapy
Language	English
Publishing date	2009-05
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2182834-9
ISSN	1873-6947 ; 1744-3881
ISSN (online)	1873-6947
ISSN	1744-3881
DOI	10.1016/j.ctcp.2008.12.006
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Article ; Online: Definition and current evaluation of subfertile men

Shai Shefi / Paul J. Turek

International Brazilian Journal of Urology, Vol 32, Iss 4, Pp 385-

2006 Volume 397

Abstract	Male infertility affects 10% of reproductive aged couples worldwide and is treatable in many cases. In addition to other well-described etiologies, genetic causes of male infertility are now more commonly diagnosed. Using principles of evidence-based medicine, this review outlines diagnostic and treatments options to inform clinical management. In order of importance, randomized controlled clinical trials, basic scientific studies, meta-analyses, case-controlled cohort studies, best-practice policy recommendations and reviews from peer-reviewed literature were incorporated that provide organized and timely guidelines to the current management of male infertility. The strength of evidence for treatment recommendations is also classified when appropriate.
Keywords	male infertility ; genetics ; semen ; spermatozoa ; oligospermia ; varicocele ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2006-08-01T00:00:00Z
Publisher	Sociedade Brasileira de Urologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PSA levels of 4.0 - 10 ng/mL and negative digital rectal examination. Antibiotic therapy versus immediate prostate biopsy.

Shtricker, Avraham / Shefi, Shai / Ringel, Avi / Gillon, Gabriel

International braz j urol : official journal of the Brazilian Society of Urology

2009 Volume 35, Issue 5, Page(s) 551–5; discussion 555–8

Abstract: Purpose: The management of mildly elevated (4.0-10.0 ng/ml) prostate specific antigen (PSA) is uncertain. Immediate prostate biopsy, antibiotic treatment, or short term monitoring PSA level for 1-3 months is still in controversy.: Materials and ... ...

Abstract	Purpose: The management of mildly elevated (4.0-10.0 ng/ml) prostate specific antigen (PSA) is uncertain. Immediate prostate biopsy, antibiotic treatment, or short term monitoring PSA level for 1-3 months is still in controversy. Materials and methods: We conducted a retrospective chart review of patients in a large community practice (2003 - 2007) who had PSA levels between 4.0-10 ng/mL without any further evidence of infection. Data was gathered regarding patient's age, whether standard antibiotic therapy (10-14 days of ofloxacin or ciprofloxacin) had been administered before the second PSA measurement, results of a second PSA test performed at 1- to 2-month intervals, whether a prostate biopsy was performed and its result. Results: One-hundred and thirty-five men met the study inclusion criteria with 65 (48.1%) having received antibiotics (group 1); the PSA levels decreased in 39 (60%) of which, sixteen underwent a biopsy which demonstrated prostate cancer in 4 (25%). Twenty-six (40%) patients of group 1 exhibited no decrease in PSA levels; seventeen of them underwent a biopsy that demonstrated cancer in 2 (12%). The other 70 (51.9%) patients were not treated with antibiotics (group 2); the PSA levels decreased in 42 (60%) of which, thirteen underwent a biopsy which demonstrated prostate cancer in 4 (31%). In the other 28 (40%) patients of group 2 there was no demonstrated decrease in PSA, nineteen of these subjects underwent a biopsy that demonstrated cancer in 8 (42%). Conclusions: There appears to be no advantage for administration of antibacterial therapy with initial PSA levels between 4-10 ng/mL without overt evidence of inflammation.
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Biopsy ; Ciprofloxacin/therapeutic use ; Digital Rectal Examination ; Humans ; Male ; Ofloxacin/therapeutic use ; Prostate-Specific Antigen/blood ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/drug therapy ; Prostatic Neoplasms/diagnosis ; Regression Analysis ; Retrospective Studies ; Sensitivity and Specificity
Chemical Substances	Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Ofloxacin (A4P49JAZ9H) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2009-10-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2206649-4
ISSN	1677-6119 ; 1677-5538
ISSN (online)	1677-6119
ISSN	1677-5538
DOI	10.1590/s1677-55382009000500006
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Article ; Online: PSA levels of 4.0 - 10 ng/ml and negative digital rectal examination

Avraham Shtricker / Shai Shefi / Avi Ringel / Gabriel Gillon

International Brazilian Journal of Urology, Vol 35, Iss 5, Pp 551-

antibiotic therapy versus immediate prostate biopsy

2009 Volume 558

Abstract	Purpose: The management of mildly elevated (4.0-10.0 ng/ml) prostate specific antigen (PSA) is uncertain. Immediate prostate biopsy, antibiotic treatment, or short term monitoring PSA level for 1-3 months is still in controversy. Material and Methods: We conducted a retrospective chart review of patients in a large community practice (2003 - 2007) who had PSA levels between 4.0-10 ng/mL without any further evidence of infection. Data was gathered regarding patient's age, whether standard antibiotic therapy (10-14 days of ofloxacin or ciprofloxacin) had been administered before the second PSA measurement, results of a second PSA test performed at 1- to 2-month intervals, whether a prostate biopsy was performed and its result. Results: One-hundred and thirty-five men met the study inclusion criteria with 65 (48.1%) having received antibiotics (group 1); the PSA levels decreased in 39 (60%) of which, sixteen underwent a biopsy which demonstrated prostate cancer in 4 (25%). Twenty-six (40%) patients of group 1 exhibited no decrease in PSA levels; seventeen of them underwent a biopsy that demonstrated cancer in 2 (12%). The other 70 (51.9%) patients were not treated with antibiotics (group 2); the PSA levels decreased in 42 (60%) of which, thirteen underwent a biopsy which demonstrated prostate cancer in 4 (31%). In the other 28 (40%) patients of group 2 there was no demonstrated decrease in PSA, nineteen of these subjects underwent a biopsy that demonstrated cancer in 8 (42%). Conclusions: There appears to be no advantage for administration of antibacterial therapy with initial PSA levels between 4-10 ng/mL without overt evidence of inflammation.
Keywords	PSA ; digital rectal examination ; antibiotics ; biopsy ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610 ; 616
Language	English
Publishing date	2009-10-01T00:00:00Z
Publisher	Sociedade Brasileira de Urologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The kinetics of the return of motile sperm to the ejaculate after vasectomy reversal.

Yang, Glen / Walsh, Thomas J / Shefi, Shai / Turek, Paul J

The Journal of urology

2007 Volume 177, Issue 6, Page(s) 2272–2276

Abstract: Purpose: In prior analyses we observed that the achievable patency rate after vasectomy reversal is a key factor in whether reversal surgery is more cost-effective than in vitro fertilization-intracytoplasmic sperm injection for fertility after ... ...

Abstract	Purpose: In prior analyses we observed that the achievable patency rate after vasectomy reversal is a key factor in whether reversal surgery is more cost-effective than in vitro fertilization-intracytoplasmic sperm injection for fertility after vasectomy. Because pregnancies will occur sooner with an earlier time to patency, this clinical parameter becomes important with advanced maternal age. We hypothesize that there are predictors of time to patency after reversal that are valuable for patient counseling and intraoperative decision making in cases of advanced maternal age. Materials and methods: We retrospectively reviewed a cohort of consecutive men who underwent vasectomy reversal. Data obtained included patient demographics, semen analyses, intraoperative findings, patency rates and time to achieve patency. Results: A total of 150 patients met the inclusion criteria. Mean patient age was 42.9 years (range 27 to 61) and mean followup was 12.5 months (range 1 to 90). The presence of motile sperm in vasa predicted faster patency rates postoperatively. Of patients with motile sperm 95% achieved patency by 6 months whereas 76% of patients without motile sperm achieved patency within 6 months (p = 0.04). An obstructive interval of 8 years or less and undergoing vasovasostomy instead of epididymovasostomy predicted faster time to patency within the first 3 months after reversal. Patient age was not associated with time to patency after bilateral vasovasostomy. Conclusions: Motile sperm found intraoperatively at the testicular vas, undergoing vasovasostomy and an obstructive interval of 8 years or less predict shorter time to patency after vasectomy reversal. Patient age does not appear to affect patency kinetics after reversal. Patient counseling regarding fertility after vasectomy may benefit from this information especially in the setting of advanced maternal age.
MeSH term(s)	Adult ; Cohort Studies ; Ejaculation/physiology ; Humans ; Kinetics ; Male ; Middle Aged ; Retrospective Studies ; Semen/cytology ; Sperm Motility/physiology ; Time Factors ; Treatment Outcome ; Vas Deferens/physiopathology ; Vasovasostomy
Language	English
Publishing date	2007-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2007.01.158
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