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Article ; Online: Performance of an adjustable compression wrap in occupational leg swelling.

Taha, Wassila / Benigni, Jean Patrick / Uhl, Jean François / Carpentier, Patrick H / Filori, Pascal / Bishara, Rashad

2024 , Page(s) 2683555231226385

Abstract: ... Material and methods: An adjustable compression wrap was tried on volunteers for 5 h and volumes measured ...

Abstract	Background: Edema in some subjects worsens over time and wraps help to reduce the leg volume. Material and methods: An adjustable compression wrap was tried on volunteers for 5 h and volumes measured in each limb before and after wrapping using a 3D surface scanner (HandySCAN 3D®) to estimate the volume of the leg. The contralateral leg was used as control. Results: We observed a significant decrease in volume in the wrap legs and an increase in the control legs ( Conclusions: Using the Readywrap® for 5 hours significantly reduces the leg volume. This study enables Readywrap to be studied in a population that is easy to observe in the context of a research program. The Handyscan3D® was shown accurate and reproducible to assess leg volume in future studies.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	645172-x
ISSN	1758-1125 ; 0268-3555
ISSN (online)	1758-1125
ISSN	0268-3555
DOI	10.1177/02683555231226385
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Article: La vis-plaque B.H.P. dans l'ostéosynthèse des fractures de l'extrémité supérieure du fémur. A propos de 241 ostéosynthèses (100 fractures cervicales vraies et 141 fractures du massif trochantérien).

Saragaglia, D / Benammar, N / Sartorius, C / Faure, C / Butel, J / Carpentier, E / Dayez, J / Merloz, P / Gordeeff, A / Legrand, J J

Journal de chirurgie

1986 Volume 123, Issue 3, Page(s) 171–177

Abstract: Butel's hip plate was used for osteosynthesis of 241 fractures of upper end of femur (100 true cervical - 141 trochanteric and subtrochanteric fractures). Results for true cervical fractures were assessed as satisfactory in 89.5% of cases, with only 3 ... ...

Title translation	Butel's hip screw-plate in osteosynthesis of fractures of the upper end of the femur. Apropos of 241 osteosyntheses (100 true cervical fractures and 141 fractures of the trochanter).
Abstract	Butel's hip plate was used for osteosynthesis of 241 fractures of upper end of femur (100 true cervical - 141 trochanteric and subtrochanteric fractures). Results for true cervical fractures were assessed as satisfactory in 89.5% of cases, with only 3 pseudarthroses and 4 cases of femoral head necrosis (2 septic, 2 aseptic), a total complication rate of 7.5%. These clinical results confirm the value of screw fixation at several cephalic anchorage sites (demonstrated biomechanically) in true cervical fractures. Results in trochanteric and subtrochanteric fractures were rated as satisfactory in 86.9% of cases, complications including 2 ruptures of plate, 1 sepsis and 4 early loosening of plate. The latter sequela was avoided by an improved choice of indication for the procedure and by substitution of this compound material (screw-plate) for a monobloc piece ("anti-loosening cervicocephalic screw apparatus"), in compound fractures of trochanter.
MeSH term(s)	Adult ; Aged ; Biomechanical Phenomena ; Bone Plates/adverse effects ; Bone Screws/adverse effects ; Female ; Femoral Neck Fractures/surgery ; Femur Head Necrosis/etiology ; Follow-Up Studies ; Fracture Fixation, Internal/adverse effects ; Fracture Fixation, Internal/instrumentation ; Hip Fractures/surgery ; Humans ; Male ; Middle Aged ; Pseudarthrosis/etiology ; Reoperation
Language	French
Publishing date	1986-03
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	218138-1
ISSN	1773-0422 ; 0021-7697
ISSN (online)	1773-0422
ISSN	0021-7697
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Article ; Online: Type II metacaspase mediates light-dependent programmed cell death in Chlamydomonas reinhardtii.

Lambert, Lou / de Carpentier, Félix / André, Phuc / Marchand, Christophe H / Danon, Antoine

Plant physiology

2023 Volume 194, Issue 4, Page(s) 2648–2662

Abstract: Among the crucial processes that preside over the destiny of cells from any type of organism are those involving their self-destruction. This process is well characterized and conceptually logical to understand in multicellular organisms; however, the ... ...

Abstract	Among the crucial processes that preside over the destiny of cells from any type of organism are those involving their self-destruction. This process is well characterized and conceptually logical to understand in multicellular organisms; however, the levels of knowledge and comprehension of its existence are still quite enigmatic in unicellular organisms. We use Chlamydomonas (Chlamydomonas reinhardtii) to lay the foundation for understanding the mechanisms of programmed cell death (PCD) in a unicellular photosynthetic organism. In this paper, we show that while PCD induces the death of a proportion of cells, it allows the survival of the remaining population. A quantitative proteomic analysis aiming at unveiling the proteome of PCD in Chlamydomonas allowed us to identify key proteins that led to the discovery of essential mechanisms. We show that in Chlamydomonas, PCD relies on the light dependence of a photosynthetic organism to generate reactive oxygen species and induce cell death. Finally, we obtained and characterized mutants for the 2 metacaspase genes in Chlamydomonas and showed that a type II metacaspase is essential for PCD execution.
MeSH term(s)	Chlamydomonas reinhardtii/genetics ; Proteomics ; Apoptosis/genetics ; Cell Death/genetics ; Chlamydomonas/genetics
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiad618
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Book ; Online: Goodness-of-Fit Testing for H\"older-Continuous Densities

Chhor, Julien / Carpentier, Alexandra

Sharp Local Minimax Rates

2021

Abstract: ... alternative of all H\"older-smooth densities $p$ such that $\|p-p_0\|_t \geq \rho$ where $t \in [1,2 ... We consider the goodness-of fit testing problem for H\"older smooth densities over $\mathbb{R}^d$ ... large $\rho$ should be to distinguish, with high probability, the case $p=p_0$ from the composite ...

Abstract	We consider the goodness-of fit testing problem for H\"older smooth densities over $\mathbb{R}^d$: given $n$ iid observations with unknown density $p$ and given a known density $p_0$, we investigate how large $\rho$ should be to distinguish, with high probability, the case $p=p_0$ from the composite alternative of all H\"older-smooth densities $p$ such that $\\|p-p_0\\|_t \geq \rho$ where $t \in [1,2]$. The densities are assumed to be defined over $\mathbb{R}^d$ and to have H\"older smoothness parameter $\alpha>0$. In the present work, we solve the case $\alpha \leq 1$ and handle the case $\alpha>1$ using an additional technical restriction on the densities. We identify matching upper and lower bounds on the local minimax rates of testing, given explicitly in terms of $p_0$. We propose novel test statistics which we believe could be of independent interest. We also establish the first definition of an explicit cutoff $u_B$ allowing us to split $\mathbb{R}^d$ into a bulk part (defined as the subset of $\mathbb{R}^d$ where $p_0$ takes only values greater than or equal to $u_B$) and a tail part (defined as the complementary of the bulk), each part involving fundamentally different contributions to the local minimax rates of testing. Comment: 76 pages
Keywords	Mathematics - Statistics Theory ; Computer Science - Information Theory ; 62G10 (Primary) ; 62B10 ; 62C20 (Secondary)
Publishing date	2021-09-09
Publishing country	us
Document type	Book ; Online
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Article ; Online: Patient Education in Spa Resorts

Patrick H. Carpentier / Bernadette Satger / Brigitte Sandrin

International Journal of Environmental Research and Public Health, Vol 19, Iss 1176, p

Experience from a French National Program for Patients with Chronic Venous Insufficiency

2022 Volume 1176

Abstract: ... p = 0.0024) and 9 months ( p = 0.018). These results demonstrate the feasibility of a TEP for CVI ...

Abstract	The prognosis of chronic venous insufficiency (CVI) is greatly depending upon the ability of the patients to optimize their health-related behaviors (mainly compliance to compression stockings, physical activity and diet). As this is usually challenging for the patients, we developed a therapeutic education program (TEP) aiming at helping them to achieve these optimizations. We report here the preliminary results obtained with this program. This structured TEP was developed by a working group of 15 health professionals to be used during the regular French spa 3-week treatment course for CVI patients. The program included three interactive workshops aiming at improving the patients’ knowledge, skills and motivation, two educational consultations allowing to set and follow-up their personal action plans and a built-in evaluation. It was implemented in spa resorts specialized in CVI. Among the first 150 patients (116 women and 34 men, mean age 69 years old (SD 8 years), 49% had post-thrombotic disease. Compliance to the education workshops was 98%. After a 3-month follow-up, 83% of the patients fully achieved at least one behavioral objective. Quality of life, as assessed by the CIVIQ 2 auto-questionnaire, improved at 3 months ( p = 0.0024) and 9 months ( p = 0.018). These results demonstrate the feasibility of a TEP for CVI patients and its ability to improve their health-related behaviors, opening the way for the development of similar programs for other chronic diseases in the setting of spa resorts.
Keywords	venous insufficiency ; therapeutic education ; patient education ; balneotherapy ; spa resort ; health resort ; Medicine ; R
Subject code	027
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Des anomalies cutanées diffuses.

Zenati, N / Carpentier, P H / Blaise, S

La Revue de medecine interne

2017 Volume 39, Issue 11, Page(s) 896–897

Title translation	Diffuse cutaneous abnormality.
MeSH term(s)	Humans ; Male ; Middle Aged ; Skin Diseases, Vascular/pathology ; Telangiectasis/pathology
Language	French
Publishing date	2017-07-06
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2017.06.008
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Article ; Online: Dilated cardiomyopathy and rhabdomyolysis caused by hypopituitarism: a challenging diagnosis.

Verhoestraete, Pauwelijn / Carpentier, Marijn / Donck, Jan / Vandekerckhove, Hans

Acta cardiologica

2019 Volume 75, Issue 7, Page(s) 593–597

Language	English
Publishing date	2019-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2019.1665848
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Article ; Online: Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization.

Prangé, Thierry / Carpentier, Philippe / Dhaussy, Anne Claire / van der Linden, Peter / Girard, Eric / Colloc'h, Nathalie

Acta crystallographica. Section D, Structural biology

2022 Volume 78, Issue Pt 2, Page(s) 162–173

Abstract: The stability of the tetrameric enzyme urate oxidase in complex with excess of 8-azaxanthine was investigated either under high hydrostatic pressure per se or under a high pressure of argon. The active site is located at the interface of two subunits, ... ...

Abstract	The stability of the tetrameric enzyme urate oxidase in complex with excess of 8-azaxanthine was investigated either under high hydrostatic pressure per se or under a high pressure of argon. The active site is located at the interface of two subunits, and the catalytic activity is directly related to the integrity of the tetramer. This study demonstrates that applying pressure to a protein-ligand complex drives the thermodynamic equilibrium towards ligand saturation of the complex, revealing a new binding site. A transient dimeric intermediate that occurs during the pressure-induced dissociation process was characterized under argon pressure and excited substates of the enzyme that occur during the catalytic cycle can be trapped by pressure. Comparison of the different structures under pressure infers an allosteric role of the internal hydrophobic cavity in which argon is bound, since this cavity provides the necessary flexibility for the active site to function.
MeSH term(s)	Argon ; Binding Sites ; Hydrostatic Pressure ; Ligands ; Urate Oxidase/chemistry ; Urate Oxidase/metabolism
Chemical Substances	Ligands ; Argon (67XQY1V3KH) ; Urate Oxidase (EC 1.7.3.3)
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2968623-4
ISSN	2059-7983 ; 0907-4449
ISSN (online)	2059-7983
ISSN	0907-4449
DOI	10.1107/S2059798321012134
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Article ; Online: Repeated blood-brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial.

Carpentier, Alexandre / Stupp, Roger / Sonabend, Adam M / Dufour, Henry / Chinot, Olivier / Mathon, Bertrand / Ducray, François / Guyotat, Jacques / Baize, Nathalie / Menei, Philippe / de Groot, John / Weinberg, Jeffrey S / Liu, Benjamin P / Guemas, Eric / Desseaux, Carole / Schmitt, Charlotte / Bouchoux, Guillaume / Canney, Michael / Idbaih, Ahmed

Nature communications

2024 Volume 15, Issue 1, Page(s) 1650

Abstract: Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in recurrent glioblastoma patients receiving carboplatin are reported. A nine- ... ...

Abstract	Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in recurrent glioblastoma patients receiving carboplatin are reported. A nine-emitter ultrasound implant was placed at the end of tumor resection replacing the bone flap. After surgery, activation to disrupt the BBB was performed every four weeks either before or after carboplatin infusion. The primary objective of the Phase 1 was to evaluate the safety of escalating numbers of ultrasound emitters using a standard 3 + 3 dose escalation. The primary objective of the Phase 2 was to evaluate the efficacy of BBB opening using magnetic resonance imaging (MRI). The secondary objectives included safety and clinical efficacy. Thirty-three patients received a total of 90 monthly sonications with carboplatin administration and up to nine emitters activated without observed DLT. Grade 3 procedure-related adverse events consisted of pre syncope (n = 3), fatigue (n = 1), wound infection (n = 2), and pain at time of device connection (n = 7). BBB opening endpoint was met with 90% of emitters showing BBB disruption on MRI after sonication. In the 12 patients who received carboplatin just prior to sonication, the progression-free survival was 3.1 months, the 1-year overall survival rate was 58% and median overall survival was 14.0 months from surgery.
MeSH term(s)	Humans ; Carboplatin/adverse effects ; Blood-Brain Barrier/pathology ; Glioblastoma/diagnostic imaging ; Glioblastoma/drug therapy ; Ultrasonography ; Biological Transport ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
Chemical Substances	Carboplatin (BG3F62OND5)
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Clinical Trial, Phase II ; Clinical Trial, Phase I ; Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45818-7
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Article ; Online: How abiotic stress-induced socialization leads to the formation of massive aggregates in Chlamydomonas.

de Carpentier, Félix / Maes, Alexandre / Marchand, Christophe H / Chung, Céline / Durand, Cyrielle / Crozet, Pierre / Lemaire, Stéphane D / Danon, Antoine

Plant physiology

2022 Volume 190, Issue 3, Page(s) 1927–1940

Abstract: Multicellular organisms implement a set of reactions involving signaling and cooperation between different types of cells. Unicellular organisms, on the other hand, activate defense systems that involve collective behaviors between individual organisms. ... ...

Abstract	Multicellular organisms implement a set of reactions involving signaling and cooperation between different types of cells. Unicellular organisms, on the other hand, activate defense systems that involve collective behaviors between individual organisms. In the unicellular model alga Chlamydomonas (Chlamydomonas reinhardtii), the existence and the function of collective behaviors mechanisms in response to stress remain mostly at the level of the formation of small structures called palmelloids. Here, we report the characterization of a mechanism of abiotic stress response that Chlamydomonas can trigger to form massive multicellular structures. We showed that these aggregates constitute an effective bulwark within which the cells are efficiently protected from the toxic environment. We generated a family of mutants that aggregate spontaneously, the socializer (saz) mutants, of which saz1 is described here in detail. We took advantage of the saz mutants to implement a large-scale multiomics approach that allowed us to show that aggregation is not the result of passive agglutination, but rather genetic reprogramming and substantial modification of the secretome. The reverse genetic analysis we conducted allowed us to identify positive and negative regulators of aggregation and to make hypotheses on how this process is controlled in Chlamydomonas.
MeSH term(s)	Chlamydomonas/genetics ; Socialization ; Chlamydomonas reinhardtii/genetics ; Stress, Physiological ; Signal Transduction
Language	English
Publishing date	2022-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiac321
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