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  1. Article ; Online: Infectious complications and vaccines.

    Ljungman, Per

    Hematology. American Society of Hematology. Education Program

    2022  Volume 2021, Issue 1, Page(s) 587–591

    Abstract: Infections are a major cause of morbidity and can result in mortality in long-term survivors after allogeneic hematopoietic cell transplantation. Chronic graft-versus-host disease and delayed immune reconstitution are recognized risk factors. Different ... ...

    Abstract Infections are a major cause of morbidity and can result in mortality in long-term survivors after allogeneic hematopoietic cell transplantation. Chronic graft-versus-host disease and delayed immune reconstitution are recognized risk factors. Different strategies must be utilized depending on the individual patient's situation but include prolonged antimicrobial prophylaxis and vaccination. Some important infections due to pathogens preventable by vaccination are pneumococci, influenza, varicella-zoster virus, and SARS-CoV-2. Despite the fact that such recommendations have been in place for decades, implementation of these recommendations has been reported to be poor.
    MeSH term(s) Aged ; Bacterial Infections/etiology ; Bacterial Infections/prevention & control ; COVID-19/etiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Infections/etiology ; Male ; Mycoses/etiology ; Mycoses/prevention & control ; Transplantation, Homologous/adverse effects ; Transplantation, Homologous/methods ; Vaccination/adverse effects ; Vaccination/methods ; Vaccines/adverse effects ; Vaccines/therapeutic use ; Virus Diseases/etiology ; Virus Diseases/prevention & control
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2021000294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Is antiviral therapy against HHV-6B beneficial?

    Ljungman, Per

    Blood

    2020  Volume 135, Issue 17, Page(s) 1413–1414

    MeSH term(s) Antiviral Agents/therapeutic use ; Cytosine/analogs & derivatives ; Hematopoietic Stem Cell Transplantation ; Herpesvirus 6, Human ; Humans ; Incidence ; Organophosphonates ; Roseolovirus Infections/drug therapy ; Viremia/drug therapy
    Chemical Substances Antiviral Agents ; Organophosphonates ; brincidofovir (6794O900AX) ; Cytosine (8J337D1HZY)
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020005448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Varicella zoster virus vaccine in patients with haematological malignancies.

    Ljungman, Per

    The Lancet. Infectious diseases

    2019  Volume 19, Issue 9, Page(s) 921–922

    MeSH term(s) Adult ; Chickenpox Vaccine ; Hematologic Neoplasms ; Herpes Zoster ; Herpes Zoster Vaccine ; Herpesvirus 3, Human/immunology ; Humans
    Chemical Substances Chickenpox Vaccine ; Herpes Zoster Vaccine
    Language English
    Publishing date 2019-08-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(19)30400-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chromosomally integrated HHV-6: a new piece of the puzzle.

    Ljungman, Per

    Blood

    2017  Volume 130, Issue 8, Page(s) 961–962

    MeSH term(s) DNA, Viral ; Herpesvirus 6, Human/genetics ; Humans ; Roseolovirus Infections ; Virus Integration
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-06-790410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: One step at a time.

    Schoemans, Hélène / Ljungman, Per

    Blood

    2021  Volume 138, Issue 14, Page(s) 1208–1209

    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013434
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  6. Article ; Online: Does cytomegalovirus viral load in stem-cell transplant recipients matter?

    Ljungman, Per

    The Lancet. Haematology

    2016  Volume 3, Issue 3, Page(s) e102

    MeSH term(s) Cytomegalovirus/genetics ; Cytomegalovirus Infections/virology ; DNA, Viral ; Humans ; Transplant Recipients ; Viral Load
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Comment ; Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(16)00022-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enterovirus D68: a new threat to hematology patients?

    Ljungman, Per

    Blood

    2015  Volume 125, Issue 11, Page(s) 1683–1684

    MeSH term(s) Enterovirus D, Human ; Enterovirus Infections/complications ; Enterovirus Infections/diagnosis ; Female ; Hematologic Neoplasms/complications ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/diagnosis
    Language English
    Publishing date 2015-03-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-01-623785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of cytomegalovirus serostatus on outcome of hematopoietic stem cell transplantation.

    Ljungman, Per

    Current opinion in hematology

    2014  Volume 21, Issue 6, Page(s) 466–469

    Abstract: Purpose of review: The aim of this review is to discuss recent developments regarding the impact of cytomegalovirus (CMV) serological status of hematopoietic stem cell transplantation recipients and their donors on transplant outcome.: Recent findings! ...

    Abstract Purpose of review: The aim of this review is to discuss recent developments regarding the impact of cytomegalovirus (CMV) serological status of hematopoietic stem cell transplantation recipients and their donors on transplant outcome.
    Recent findings: CMV seropositivity of the recipient is still a negative factor for transplant outcome. The use of a CMV seropositive donor has a negative impact on survival in patients receiving unrelated but not human leukocyte antigen-identical sibling grafts. In CMV seropositive patients, the donor serological status influences outcome in patients receiving unrelated donor grafts after myeloablative but not reduced-intensity conditioning. Early CMV replication reduces the risk for leukemia relapse but does not improve survival. The use of leukocyte depleted blood products is sufficient to prevent primary CMV infection.
    Summary: Despite major advances in management of CMV infections, CMV serologic status remains an important risk factor for transplant-related complications and mortality after allogeneic hematopoietic stem cell transplantation.
    MeSH term(s) Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/transmission ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Leukemia/complications ; Leukemia/mortality ; Leukemia/therapy ; Leukemia/virology ; Treatment Outcome
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3703: Show issues Location:
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  9. Article ; Online: Respiratory syncytial virus in hematopoietic cell transplant recipients: factors determining progression to lower respiratory tract disease.

    Ljungman, Per

    The Journal of infectious diseases

    2014  Volume 209, Issue 8, Page(s) 1151–1152

    MeSH term(s) Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Viruses/pathogenicity ; Respiratory Tract Diseases/diagnosis
    Language English
    Publishing date 2014-04-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jit833
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  10. Article ; Online: Different recovery patterns of CMV-specific and WT1-specific T cells in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: Impact of CMV infection and leukemia relapse.

    Luo, Xiao-Hua / Poiret, Thomas / Liu, Zhenjiang / Meng, Qingda / Nagchowdhury, Anurupa / Ljungman, Per

    Frontiers in immunology

    2023  Volume 13, Page(s) 1027593

    Abstract: In allogeneic hematopoietic cell transplantation (allo-HSCT), both virus-specific T cells and leukemia-specific T cells need to be reconstituted to protect patients from virus infections and primary disease relapse. Cytomegalovirus (CMV) infection ... ...

    Abstract In allogeneic hematopoietic cell transplantation (allo-HSCT), both virus-specific T cells and leukemia-specific T cells need to be reconstituted to protect patients from virus infections and primary disease relapse. Cytomegalovirus (CMV) infection remains an important cause of morbidity and mortality after allo-HSCT. Emerging data indicate that CMV reactivation is associated with reduced risk of leukemia relapse in patients with acute myeloid leukemia (AML) undergoing allo-HSCT. In a cohort of 24 WT1+ AML patients during the first year following HSCT, CMV specific CD8+ T cells (CMV-CTL) reconstituted much faster than WT1-specific CD8+ T cell (WT1-CTL) after allo-SCT. Moreover, CMV-CTL expressed lower levels of exhaustion markers and were more functional as identified by production of IFN-γ/TNF-α and expression of Eomes/T-bet. Interestingly, our patients with CMV reactivation presented higher frequency of CMV-CTL, lower levels of Eomes+T-bet- and higher levels of Eomes+T-bet+ expression in response to WT1 and CMV pp65 antigen during the first year after transplantation as compared to patients without CMV reactivation. Kinetics of CMV-CTL and WT1-CTL after transplantation might be associated with measurable residual disease and later leukemia relapse. Our results support that CMV reactivation, aside from the CMV-CTL reconstitution, could influence WT1-CTL reconstitution after allo-HSCT, thus potentially contributing to the remission/relapse of AML.
    MeSH term(s) Humans ; Chronic Disease ; Cytomegalovirus ; Cytomegalovirus Infections ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/therapy ; Recurrence ; Transplantation, Homologous ; WT1 Proteins
    Chemical Substances WT1 protein, human ; WT1 Proteins
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1027593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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