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  1. Article ; Online: Il Sistema Sanitario Nazionale e la pandemia da SARS-CoV-2: un disastro annunciato? Riflessioni per un cambiamento.

    Gristina, Giuseppe R / Piccinni, Mariassunta

    Recenti progressi in medicina

    2022  Volume 113, Issue 1, Page(s) 41–53

    Abstract: Almost two years after the first official report from World Health Organization (WHO), the SARS-CoV-2 pandemic (covid-19) outreached 200 mln of cases around the world with an overall mortality equal to 2% (more than 4.5 mln of cases). In many countries, ... ...

    Title translation The Italian National Healthcare System and the SARS-CoV-2 pandemic: a foretold debacle? Reflections for changing.
    Abstract Almost two years after the first official report from World Health Organization (WHO), the SARS-CoV-2 pandemic (covid-19) outreached 200 mln of cases around the world with an overall mortality equal to 2% (more than 4.5 mln of cases). In many countries, when the surge in cases of severe covid-19 respiratory failure has exceeded the availability of intensive healthcare resources (intensive care beds, respirators, human resources) clinicians were forced to triage intensive care unit (ICU) admissions. In order to support these difficult decisions, many scientific societies and national regulatory bodies developed guidelines to prioritize patients entitled to receive mechanical ventilation and other life support treatments. From an ethical point of view two main theoretical approaches - the egalitarian and the utilitarian one - have been suggested to identify the criteria to be adopted for triaging the ICU patients. In regard, there is a limited consensus until now and in many cases these different theoretical approaches gave rise to a clash of opinions contributing to additional difficulties for doctors. In Italy, the National Committee for Bioethics is the only public institution that, through an official document, has expressly taken a position on the issue of triage and rationing of resources, admitting its lawfulness in particular conditions as long as it is based on common clinical criteria of clinical appropriateness and ethical proportionality, underlining however the fundamental role of "preparedness". As the covid-19 crisis seems slowing down, the need to debate the triage criteria and the allocation of the scarce ICU resources it seems less pressing. Instead, it seems more useful to dwell on two aspects with respect to the choice of regulatory criteria for allocating resources: 1) the necessary interconnection between macro- and micro-allocation choices which ends up conditioning the decision-making processes relating to individual patients; 2) the opportunity for decision-makers and healthcare professionals to maintain a right level of "honesty" towards citizens and patients regarding the causes of the lack of resources and the decision-making processes that involve the need to make "tragic choices" at both levels.
    MeSH term(s) COVID-19 ; Critical Care ; Delivery of Health Care ; Humans ; Pandemics ; SARS-CoV-2 ; Triage
    Language Italian
    Publishing date 2022-01-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3733.37184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 pandemic in ICU. Limited resources for many patients: approaches and criteria for triaging.

    Gristina, Giuseppe R / Piccinni, Mariassunta

    Minerva anestesiologica

    2021  Volume 87, Issue 12, Page(s) 1367–1379

    Abstract: The COVID-19 pandemic has shattered the illusion that healthcare resource shortages that require rationing are problems restricted to low- and middle-income countries. During the pandemic surges, many high-income countries have been confronted with ... ...

    Abstract The COVID-19 pandemic has shattered the illusion that healthcare resource shortages that require rationing are problems restricted to low- and middle-income countries. During the pandemic surges, many high-income countries have been confronted with unprecedented demands for healthcare systems that dramatically exceeded available resources. Hospitals capacities were overwhelmed, and physicians working in intensive care units (ICUs) were often forced to deny admissions to patients in desperate need of intensive care. To support these difficult decisions, many scientific societies and governmental bodies have developed guidelines on the triage of patients in need of mechanical ventilation and other life-support treatments. The ethical approaches underlying these guidelines were grounded on egalitarian or utilitarian principles. Thus far, however, consensus on the approaches used, and, above all, on the solutions adopted have been limited, giving rise to a clash of opinions that has further complicated health professionals' ability to respond optimally to their patients' needs. As the COVID-19 crisis moves toward a phase of what some have called "pandemic normalcy," the need to debate the merits and demerits of the individual decisions made in the allocation of ICU resources seems less pressing. Instead, the aims of the authors are: 1) to critically review the approaches and criteria used for triaging patients to be admitted in ICU; 2) to clarify how macro- and micro-allocation choices, in their interdependance, can condition decision-making processes regarding the care of individual patients; 3) to reflect on the need for decision-makers and professionals working in ICUs to maintain a proper degree of "honesty" towards citizens and patients regarding the causes of the resource shortages and the decision-making processes, which, in different ways routinely and in crisis times, involve the need to make "tragic choices" at both levels.
    MeSH term(s) COVID-19 ; Humans ; Intensive Care Units ; Pandemics ; SARS-CoV-2 ; Triage
    Language English
    Publishing date 2021-10-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.21.15736-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Do more targets allow more cancer treatments, or not?

    Marchetti, Paolo / Curigliano, Giuseppe / Calabria, Silvia / Piccinni, Carlo / Botticelli, Andrea / Martini, Nello

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 187, Page(s) 99–104

    Abstract: The three current oncology models (histological, agnostic and mutational) mainly differ in clinical, technological and organisational aspects, leading to different regulatory procedures and implications in antineoplastic therapy access by patients. ... ...

    Abstract The three current oncology models (histological, agnostic and mutational) mainly differ in clinical, technological and organisational aspects, leading to different regulatory procedures and implications in antineoplastic therapy access by patients. Within the histological and agnostic models, Regulatory Agencies authorise target therapies and define their price, reimbursement, prescription and access based on results from clinical trials including patients affected by the same tumour (histological) or subjects with specific genetic mutations regardless of the tumour site or the histology (agnostic). The mutational model has been developed to identify specific actionable molecular alterations found by next-generation sequencing test-based large platforms on solid and liquid biopsies. Nevertheless, due to the highly uncertain efficacy and possible toxicity of drugs tested within this model, regulatory procedures based on histological or agnostic oncology cannot be followed. Multidisciplinary skills are required (e.g. the molecular tumour board's (MTB) representatives) to identify the best association between the genomic profile and the drug planned to be used, but quality requirements, practices and procedures of these discussions still need to be standardised. Real-world evidence from clinical practice (i.e. genomic findings, clinical data and MTBs' choices) lacks, therefore, it is urgently needed as opposed to limited findings from clinical trials. A potential solution for an appropriate access to the therapy chosen by the mutational model can be the indication-value-based sub iudice procedure of authorisation. The access to therapies suggested by extensive molecular profiling could be easily implementable within the Italian national health system, thanks to the existing regulatory procedures, i.e. the managed-entry agreements and the antineoplastic drug monitoring registries, alongside those granted by conventional studies (phase I, II, III, IV) conducted according to the histological and agnostic models.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Antineoplastic Agents/therapeutic use ; Genomics ; Medical Oncology ; Mutation
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.03.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Applicazioni della digital medicine ai PDTA: tassonomia, metodologia, impatto sul paziente e barriere da superare.

    Calabria, Silvia / Piccinni, Carlo / Recchia, Giuseppe / Santoro, Eugenio / Grigolo, Sabrina / Martini, Nello

    Recenti progressi in medicina

    2022  Volume 113, Issue 2, Page(s) 105–113

    Abstract: Digital health represents an important step in the management of chronic diseases also in light of the reform of proximity care that is intended to be implemented as part of the Recovery Plan (PNRR). For this purpose, the inclusion of digital health ... ...

    Title translation Applications of digital medicine to care pathways: taxonomy, methods, impact on patients, barriers to overcome.
    Abstract Digital health represents an important step in the management of chronic diseases also in light of the reform of proximity care that is intended to be implemented as part of the Recovery Plan (PNRR). For this purpose, the inclusion of digital health tools in the care pathways is strategic. A specific Working Group of the MaCroScopio Project defined a taxonomic, methodological and cultural framework within which the development of digital health can be promoted. This would ensure that the introduction of this type of technological innovation addresses not only the need for a more efficient health system but also the real patients' healthcare requirements. At the same time it fosters the reduction of healthcare access inequalities, instead of their exacerbation.
    MeSH term(s) Chronic Disease ; Critical Pathways ; Health Services Accessibility ; Humans ; Medicine
    Language Italian
    Publishing date 2022-02-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3748.37314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The use of CEEA 34 in stapled hemorrhoidectomy: suggested modifications in technique.

    Piccinni, Giuseppe

    World journal of surgery

    2009  Volume 33, Issue 1, Page(s) 154–5; author reply 156

    MeSH term(s) Equipment Design ; Hemorrhoids/surgery ; Humans ; Surgical Staplers/supply & distribution
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-008-9753-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multimodal ocular imaging in Proteus syndrome.

    Salerni, Annabella / Scartozzi, Luca / Piccinni, Fabrizio / Mosca, Luigi / Mattei, Roberta / Leoni, Chiara / Onesimo, Roberta / Zampino, Giuseppe / Rizzo, Stanislao

    European journal of ophthalmology

    2022  Volume 33, Issue 5, Page(s) NP5–NP10

    Abstract: In this report we illustrate the ophthalmologic assessment of two patients affected by Proteus Syndrome (PS), an extremely rare genetic disorder. Case #1 describes a 26 year old male patient followed for multiple ophthalmic anomalies: a limbal dermoid ... ...

    Abstract In this report we illustrate the ophthalmologic assessment of two patients affected by Proteus Syndrome (PS), an extremely rare genetic disorder. Case #1 describes a 26 year old male patient followed for multiple ophthalmic anomalies: a limbal dermoid cyst, a unilateral cataract, bilateral nystagmus, severe myopia and unilateral optic nerve head drusen. Case #2 describes a 20 year old female patient referred to our Ophthalmology Department for a routine ophthalmologic evaluation after being treated for 3 years with Miransertib (an experimental AKT-pathway inhibitor). Both patients underwent a complete ophthalmologic examination and a multimodal imaging evaluation. The multimodal imaging approach has revealed useful to evaluate both cases in detail and to keep track of disease evolution over time, moreover providing helpful features to further characterize this rare syndrome.
    MeSH term(s) Male ; Female ; Humans ; Young Adult ; Adult ; Proteus Syndrome/diagnosis ; Eye Abnormalities ; Nystagmus, Pathologic/diagnosis ; Diagnostic Imaging ; Myopia ; Abnormalities, Multiple
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721221125852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Italian law on informed consent and advance directives: its impact on intensive care units and the European legal framework.

    Gristina, Giuseppe R / Busatta, Lucia / Piccinni, Mariassunta

    Minerva anestesiologica

    2018  Volume 85, Issue 4, Page(s) 401–411

    Abstract: The Italian Parliament has recently approved a law on informed consent, advance directives and advance care planning. The law also deals with health care proxy and health care decisions for minors and adults who are not able to give consent. The Italian ... ...

    Abstract The Italian Parliament has recently approved a law on informed consent, advance directives and advance care planning. The law also deals with health care proxy and health care decisions for minors and adults who are not able to give consent. The Italian law arrived quite late in comparison with other European countries. After several years of debate on the need to approve such a law, the focus has now shifted to the assessment of the legislative provisions and their impact on clinical practice. In this article, the authors firstly offer an overview of the findings from the empirical research regarding the use of the different legal tools in the field of intensive care medicine; secondly, they present the tools now provided by law no. 219/2017 particularly with regard to the decision-making processes in the Intensive Care Unit (ICU); thirdly, the authors offer a comparison between the new Italian law and other European legal orders, with special reference to France, Spain, Germany and England. The aim of the article is to assess the degree of innovation of the law vis-à-vis the previous framework.
    MeSH term(s) Advance Directives/legislation & jurisprudence ; Europe ; Humans ; Informed Consent/legislation & jurisprudence ; Intensive Care Units ; Italy
    Language English
    Publishing date 2018-11-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.18.13179-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Radiomics applications in cardiac imaging: a comprehensive review.

    Polidori, Tiziano / De Santis, Domenico / Rucci, Carlotta / Tremamunno, Giuseppe / Piccinni, Giulia / Pugliese, Luca / Zerunian, Marta / Guido, Gisella / Pucciarelli, Francesco / Bracci, Benedetta / Polici, Michela / Laghi, Andrea / Caruso, Damiano

    La Radiologia medica

    2023  Volume 128, Issue 8, Page(s) 922–933

    Abstract: Radiomics is a new emerging field that includes extraction of metrics and quantification of so-called radiomic features from medical images. The growing importance of radiomics applied to oncology in improving diagnosis, cancer staging and grading, and ... ...

    Abstract Radiomics is a new emerging field that includes extraction of metrics and quantification of so-called radiomic features from medical images. The growing importance of radiomics applied to oncology in improving diagnosis, cancer staging and grading, and improved personalized treatment, has been well established; yet, this new analysis technique has still few applications in cardiovascular imaging. Several studies have shown promising results describing how radiomics principles could improve the diagnostic accuracy of coronary computed tomography angiography (CCTA) and magnetic resonance imaging (MRI) in diagnosis, risk stratification, and follow-up of patients with coronary heart disease (CAD), ischemic heart disease (IHD), hypertrophic cardiomyopathy (HCM), hypertensive heart disease (HHD), and many other cardiovascular diseases. Such quantitative approach could be useful to overcome the main limitations of CCTA and MRI in the evaluation of cardiovascular diseases, such as readers' subjectiveness and lack of repeatability. Moreover, this new discipline could potentially overcome some technical problems, namely the need of contrast administration or invasive examinations. Despite such advantages, radiomics is still not applied in clinical routine, due to lack of standardized parameters acquisition, inconsistent radiomic methods, lack of external validation, and different knowledge and experience among the readers. The purpose of this manuscript is to provide a recent update on the status of radiomics clinical applications in cardiovascular imaging.
    MeSH term(s) Humans ; Cardiomyopathy, Hypertrophic ; Magnetic Resonance Imaging ; Heart Diseases/diagnostic imaging ; Tomography, X-Ray Computed ; Computed Tomography Angiography
    Language English
    Publishing date 2023-06-16
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-023-01658-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Deep learning image reconstruction algorithm: impact on image quality in coronary computed tomography angiography.

    De Santis, Domenico / Polidori, Tiziano / Tremamunno, Giuseppe / Rucci, Carlotta / Piccinni, Giulia / Zerunian, Marta / Pugliese, Luca / Del Gaudio, Antonella / Guido, Gisella / Barbato, Luca / Laghi, Andrea / Caruso, Damiano

    La Radiologia medica

    2023  Volume 128, Issue 4, Page(s) 434–444

    Abstract: Purpose: To perform a comprehensive intraindividual objective and subjective image quality evaluation of coronary CT angiography (CCTA) reconstructed with deep learning image reconstruction (DLIR) and to assess correlation with routinely applied hybrid ... ...

    Abstract Purpose: To perform a comprehensive intraindividual objective and subjective image quality evaluation of coronary CT angiography (CCTA) reconstructed with deep learning image reconstruction (DLIR) and to assess correlation with routinely applied hybrid iterative reconstruction algorithm (ASiR-V).
    Material and methods: Fifty-one patients (29 males) undergoing clinically indicated CCTA from April to December 2021 were prospectively enrolled. Fourteen datasets were reconstructed for each patient: three DLIR strength levels (DLIR_L, DLIR_M, and DLIR_H), ASiR-V from 10% to 100% in 10%-increment, and filtered back-projection (FBP). Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) determined objective image quality. Subjective image quality was assessed with a 4-point Likert scale. Concordance between reconstruction algorithms was assessed by Pearson correlation coefficient.
    Results: DLIR algorithm did not impact vascular attenuation (P ≥ 0.374). DLIR_H showed the lowest noise, comparable with ASiR-V 100% (P = 1) and significantly lower than other reconstructions (P ≤ 0.021). DLIR_H achieved the highest objective quality, with SNR and CNR comparable to ASiR-V 100% (P = 0.139 and 0.075, respectively). DLIR_M obtained comparable objective image quality with ASiR-V 80% and 90% (P ≥ 0.281), while achieved the highest subjective image quality (4, IQR: 4-4; P ≤ 0.001). DLIR and ASiR-V datasets returned a very strong correlation in the assessment of CAD (r = 0.874, P = 0.001).
    Conclusion: DLIR_M significantly improves CCTA image quality and has very strong correlation with routinely applied ASiR-V 50% dataset in the diagnosis of CAD.
    MeSH term(s) Male ; Humans ; Computed Tomography Angiography/methods ; Deep Learning ; Radiographic Image Interpretation, Computer-Assisted/methods ; Coronary Angiography/methods ; Algorithms ; Radiation Dosage ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2023-02-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-023-01607-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acute myeloid leukemia: Incidence, transplantation and survival through Italian administrative healthcare data.

    Calabria, Silvia / Ronconi, Giulia / Dondi, Letizia / Piccinni, Carlo / Pedrini, Antonella / Esposito, Immacolata / Addesi, Alice / Rossi, Giuseppe / Ferrara, Felicetto / Venditti, Adriano / Martini, Nello

    Tumori

    2023  Volume 109, Issue 5, Page(s) 496–503

    Abstract: Objective: To identify newly diagnosed patients with acute myeloid leukemia in 2017 treated with intensive chemotherapy or unfit for intensive chemotherapy, and to assess their probability of receiving allogeneic stem cell transplantation and survival, ... ...

    Abstract Objective: To identify newly diagnosed patients with acute myeloid leukemia in 2017 treated with intensive chemotherapy or unfit for intensive chemotherapy, and to assess their probability of receiving allogeneic stem cell transplantation and survival, from the Italian National Health Service perspective.
    Patients and methods: From the Ricerca e Salute database, adults with an in-hospital diagnosis of acute myeloid leukemia (International Classification of Disease-9th version-Clinical Modification code 205.0x) in 2017 (index date), without any identifying acute myeloid leukemia criteria within the preceding year, were selected. Among them, subjects treated with intensive chemotherapy (chemotherapy during an overnight hospitalization) within one year after index date were identified. The remaining were considered unfit for intensive chemotherapy. Gender, age and comorbidities were described. Within the follow-up period, probabilities of in-hospital allogeneic stem cell transplantation and overall survival were assessed through Kaplan Meier analyses.
    Results: From 4,840,063 beneficiaries of the Italian National Health Service, 368 newly acute myeloid leukemia diagnosed adults (9.0 *100,000) were selected. Males comprised 57%. Mean age was 68±15. There were 197 patients treated with intensive chemotherapy. The remaining 171 unfit for intensive chemotherapy were older (72±14) and with more comorbidities (e.g. hypertension, chronic lung diseases and chronic kidney disease). Only patients treated with intensive chemotherapy underwent an allogeneic stem cell transplantation (41; 33%) during the one year after the index date. Within the first and second follow-up year, respectively: 41.1% and 26.9% of subjects treated with intensive chemotherapy (144) survived (median survival time: 7.8 months); 25.7% and 18.7% of those unfit for intensive chemotherapy (139) survived (1.2 months). Difference was significant (p<0.0001). Within one and two years after transplantation (41 patients), 73.5% and 67.3% of subjects survived, respectively.
    Conclusion: This study, by showing the incidence of acute myeloid leukemia in Italy in 2017, the proportion of patients treated with intensive chemotherapy from the new diagnosis, the use of allogeneic stem cell transplantation and two-year survival, integrated evidence on large and unselected populations and may help to improve treatment strategies of older acute myeloid leukemia patients.
    MeSH term(s) Adult ; Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Incidence ; State Medicine ; Transplantation, Homologous ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Delivery of Health Care ; Retrospective Studies
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.1177/03008916231153698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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