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  1. Article ; Online: Nanodrug delivery systems for metabolic chronic liver diseases: advances and perspectives.

    Athanasopoulou, Foteini / Manolakakis, Michail / Vernia, Santiago / Kamaly, Nazila

    Nanomedicine (London, England)

    2023  Volume 18, Issue 1, Page(s) 67–84

    Abstract: Nanomedicines are revolutionizing healthcare as recently demonstrated by the Pfizer/BioNTech and Moderna COVID-2019 vaccines, with billions of doses administered worldwide in a safe manner. Nonalcoholic fatty liver disease is the most common ... ...

    Abstract Nanomedicines are revolutionizing healthcare as recently demonstrated by the Pfizer/BioNTech and Moderna COVID-2019 vaccines, with billions of doses administered worldwide in a safe manner. Nonalcoholic fatty liver disease is the most common noncommunicable chronic liver disease, posing a major growing challenge to global public health. However, due to unmet diagnostic and therapeutic needs, there is great interest in the development of novel translational approaches. Nanoparticle-based approaches offer novel opportunities for efficient and specific drug delivery to liver cells, as a step toward precision medicines. In this review, the authors highlight recent advances in nanomedicines for the generation of novel diagnostic and therapeutic tools for nonalcoholic fatty liver disease and related liver diseases.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/diagnosis ; COVID-19 ; Nanomedicine ; Drug Delivery Systems ; Nanoparticles/therapeutic use
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2022-0261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Nanoparticle protein corona evolution: from biological impact to biomarker discovery.

    Kamaly, Nazila / Farokhzad, Omid C / Corbo, Claudia

    Nanoscale

    2022  Volume 14, Issue 5, Page(s) 1606–1620

    Abstract: Nanoparticles exposed to biological fluids such as blood, quickly interact with their surrounding milieu resulting in a biological coating that results in large part as a function of the physicochemical properties of the nanomaterial. The large ... ...

    Abstract Nanoparticles exposed to biological fluids such as blood, quickly interact with their surrounding milieu resulting in a biological coating that results in large part as a function of the physicochemical properties of the nanomaterial. The large nanoparticle surface area-to-volume ratio further augments binding of biological molecules and the resulting biomolecular or protein corona, once thought of as problematic biofouling, is now viewed as a rich source of biological information that can guide the development of nanomedicines. This review gives an overview of the utility of the protein corona in proteomic profiling and discusses how a better understanding of nano-bio interactions can accelerate the clinical translation of nanomedicines and facilitate the identification of disease-specific biomarkers. With the FDA requirement of the protein corona analysis of nanoparticles in place, it is envisaged that analyzing the protein corona of nanoparticles on a case-by-case basis can provide highly valuable nano-bio interface information that can aid and improve their clinical translation.
    MeSH term(s) Biomarkers ; Nanomedicine ; Nanoparticles ; Protein Corona ; Proteomics
    Chemical Substances Biomarkers ; Protein Corona
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d1nr06580g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nanoconfined anti-oxidizing RAFT nitroxide radical polymer for reduction of low-density lipoprotein oxidation and foam cell formation.

    Basak, Suman / Khare, Harshvardhan Ajay / Kempen, Paul J / Kamaly, Nazila / Almdal, Kristoffer

    Nanoscale advances

    2022  Volume 4, Issue 3, Page(s) 742–753

    Abstract: Atherosclerosis is a leading cause of death worldwide. Antioxidant therapy has been considered a promising treatment modality for atherosclerosis, since reactive oxygen species (ROS) play a major role in the pathogenesis of atherosclerosis. We developed ... ...

    Abstract Atherosclerosis is a leading cause of death worldwide. Antioxidant therapy has been considered a promising treatment modality for atherosclerosis, since reactive oxygen species (ROS) play a major role in the pathogenesis of atherosclerosis. We developed ROS-scavenging antioxidant nanoparticles (NPs) that can serve as an effective therapy for atherosclerosis. The newly developed novel antioxidant ROS-eliminating NPs were synthesized
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d1na00631b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm.

    Morgulchik, Nelli / Athanasopoulou, Foteini / Chu, Edmund / Lam, Yoriko / Kamaly, Nazila

    Interface focus

    2021  Volume 12, Issue 1, Page(s) 20210006

    Abstract: Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early 2020 and severely threatened people's livelihoods and health. Patients with pre- ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early 2020 and severely threatened people's livelihoods and health. Patients with pre-diagnosed conditions admitted to hospital often develop complications leading to mortality due to acute respiratory distress syndrome (ARDS) and associated multiorgan failure and blood clots. ARDS is associated with a cytokine storm. Cytokine storms arise due to elevated levels of circulating cytokines and are associated with infections. Targeting various pro-inflammatory cytokines in a specific manner can result in a potent therapeutic approach with minimal host collateral damage. Immunoregulatory therapies are now of interest in order to regulate the cytokine storm, and this review will summarize and discuss advances in targeted therapies against cytokine storms induced by COVID-19.
    Language English
    Publishing date 2021-12-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2021.0006
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  5. Article ; Online: Annexin A1 based inflammation resolving mediators and nanomedicines for inflammatory bowel disease therapy.

    Xu, Runxin / Weber, Marie-Christin / Hu, Xinkai / Neumann, Philipp-Alexander / Kamaly, Nazila

    Seminars in immunology

    2022  Volume 61-64, Page(s) 101664

    Abstract: Inflammatory bowel diseases (IBD) such as Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic, progressive, and relapsing disorders of the gastrointestinal tract (GIT), characterised by intestinal epithelial injury and inflammation. Current ... ...

    Abstract Inflammatory bowel diseases (IBD) such as Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic, progressive, and relapsing disorders of the gastrointestinal tract (GIT), characterised by intestinal epithelial injury and inflammation. Current research shows that in addition to traditional anti-inflammatory therapy, resolution of inflammation and repair of the epithelial barrier are key biological requirements in combating IBD. Resolution mediators include endogenous lipids that are generated during inflammation, e.g., lipoxins, resolvins, protectins, maresins; and proteins such as Annexin A1 (ANXA1). Nanoparticles can specifically deliver these potent inflammation resolving mediators in a spatiotemporal manner to IBD lesions, effectively resolve inflammation, and promote a return to homoeostasis with minimal collateral damage. We discuss these exciting and timely concepts in this review.
    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Advancements in nanomedicines for the detection and treatment of diabetic kidney disease.

    Tillman, Luke / Tabish, Tanveer A / Kamaly, Nazila / Moss, Primrose / El-Briri, Amal / Thiemermann, Christoph / Pranjol, Md Zahidul I / Yaqoob, Muhammad M

    Biomaterials and biosystems

    2022  Volume 6, Page(s) 100047

    Abstract: In the diabetic kidneys, morbidities such as accelerated ageing, hypertension and hyperglycaemia create a pro-inflammatory microenvironment characterised by extensive fibrogenesis. Radiological techniques are not yet optimised generating inconsistent and ...

    Abstract In the diabetic kidneys, morbidities such as accelerated ageing, hypertension and hyperglycaemia create a pro-inflammatory microenvironment characterised by extensive fibrogenesis. Radiological techniques are not yet optimised generating inconsistent and non-reproducible data. The gold standard procedure to assess renal fibrosis is kidney biopsy, followed by histopathological assessment. However, this method is risky, invasive, subjective and examines less than 0.01% of kidney tissue resulting in diagnostic errors. As such, less than 10% of patients undergo kidney biopsy, limiting the accuracy of the current diabetic kidney disease (DKD) staging method. Standard treatments suppress the renin-angiotensin system to control hypertension and use of pharmaceuticals aimed at controlling diabetes have shown promise but can cause hypoglycaemia, diuresis and malnutrition as a result of low caloric intake. New approaches to both diagnosis and treatment are required. Nanoparticles (NPs) are an attractive candidate for managing DKD due to their ability to act as theranostic tools that can carry drugs and enhance image contrast. NP-based point-of-care systems can provide physiological information previously considered unattainable and provide control over the rate and location of drug release. Here we discuss the use of nanotechnology in renal disease, its application to both the treatment and diagnosis of DKD. Finally, we propose a new method of NP-based DKD classification that overcomes the current systems limitations.
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-5344
    ISSN (online) 2666-5344
    DOI 10.1016/j.bbiosy.2022.100047
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  7. Article ; Online: Improved Targeting of Cancers with Nanotherapeutics.

    Foster, Christian / Watson, Andre / Kaplinsky, Joseph / Kamaly, Nazila

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1530, Page(s) 13–37

    Abstract: Targeted cancer nanotherapeutics offers numerous opportunities for the selective uptake of toxic chemotherapies within tumors and cancer cells. The unique properties of nanoparticles, such as their small size, large surface-to-volume ratios, and the ... ...

    Abstract Targeted cancer nanotherapeutics offers numerous opportunities for the selective uptake of toxic chemotherapies within tumors and cancer cells. The unique properties of nanoparticles, such as their small size, large surface-to-volume ratios, and the ability to achieve multivalency of targeting ligands on their surface, provide superior advantages for nanoparticle-based drug delivery to a variety of cancers. This review highlights various key concepts in the design of targeted nanotherapeutics for cancer therapy, and discusses physicochemical parameters affecting nanoparticle targeting, along with recent developments for cancer-targeted nanomedicines.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6646-2_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Active targeted delivery of immune therapeutics to lymph nodes.

    Bahmani, Baharak / Vohra, Ishaan / Kamaly, Nazila / Abdi, Reza

    Current opinion in organ transplantation

    2017  Volume 23, Issue 1, Page(s) 8–14

    Abstract: Purpose of review: Organ transplantation is a life-saving procedure and the only option for patients with end-organ failure. Immune therapeutics have been key to the success of organ transplantation. However, immune therapeutics are still unable to ... ...

    Abstract Purpose of review: Organ transplantation is a life-saving procedure and the only option for patients with end-organ failure. Immune therapeutics have been key to the success of organ transplantation. However, immune therapeutics are still unable to eliminate graft rejection and their toxicity has been implicated in poorer long-term transplant outcomes. Targeted nanodelivery has the potential to enhance not only the therapeutic index but also the bioavailability of the immune therapeutics. One of the key sites of immune therapeutics delivery is lymph node where the priming of immune cells occur. The focus of this review is on nanomedicine research to develop the targeted delivery of immune therapeutics to lymph nodes for controlling immune activation.
    Recent findings: As nanomedicine creates its niche in clinical care, it provides novel immunotherapy platforms for transplant recipients. Draining lymph nodes are the primary loci of immune activation and represent a formidable site for delivery of wide variety of immune therapeutics. There have been relentless efforts to improve the properties of nanomedicines, to have in-depth knowledge of antigen and drug loading, and, finally, to explore various routes of passive and active targeted delivery to lymph nodes.
    Summary: The application of nanotechnology principles in the delivery of immune therapeutics to the lymph node has created enormous excitement as a paradigm shifting approach that enables targeted delivery of a gamut of molecules to achieve a desired immune response. Therefore, innovative strategies that improve their efficacy while reducing their toxicity are among the highest unmet needs in transplantation.
    MeSH term(s) Animals ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunologic Factors/immunology ; Lymph Nodes/immunology ; Nanomedicine
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery.

    Habibi, Neda / Kamaly, Nazila / Memic, Adnan / Shafiee, Hadi

    Nano today

    2016  Volume 11, Issue 1, Page(s) 41–60

    Abstract: Self-assembly of peptides can yield an array of well-defined nanostructures that are highly attractive nanomaterials for many biomedical applications such as drug delivery. Some of the advantages of self-assembled peptide nanostructures over other ... ...

    Abstract Self-assembly of peptides can yield an array of well-defined nanostructures that are highly attractive nanomaterials for many biomedical applications such as drug delivery. Some of the advantages of self-assembled peptide nanostructures over other delivery platforms include their chemical diversity, biocompatibility, high loading capacity for both hydrophobic and hydrophilic drugs, and their ability to target molecular recognition sites. Furthermore, these self-assembled nanostructures could be designed with novel peptide motifs, making them stimuli-responsive and achieving triggered drug delivery at disease sites. The goal of this work is to present a comprehensive review of the most recent studies on self-assembled peptides with a focus on their "smart" activity for formation of targeted and responsive drug-delivery carriers.
    Language English
    Publishing date 2016-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2224882-1
    ISSN 1878-044X ; 1748-0132
    ISSN (online) 1878-044X
    ISSN 1748-0132
    DOI 10.1016/j.nantod.2016.02.004
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  10. Article ; Online: Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.

    Kamaly, Nazila / Yameen, Basit / Wu, Jun / Farokhzad, Omid C

    Chemical reviews

    2016  Volume 116, Issue 4, Page(s) 2602–2663

    MeSH term(s) Drug Delivery Systems ; Drug Liberation ; Nanoparticles/chemistry ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Polymers/chemistry ; Polymers/metabolism
    Chemical Substances Pharmaceutical Preparations ; Polymers
    Language English
    Publishing date 2016-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.5b00346
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/78: Show issues
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