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  1. Book: Tobacco and Cancer

    Dorothy K Hatsukami / Stephen S Hecht

    The Science and the Story

    2022  

    Keywords Tobacco Carcinogenesis ; Tobacco Use History
    Language English
    Size 450 p.
    Publisher WSPC
    Document type Book
    Note PDA Manuell_15
    Format 157 x 235 x 29
    ISBN 9789811239526 ; 9811239525
    Database PDA

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  2. Article ; Online: An Update on the Formation in Tobacco, Toxicity, and Carcinogenicity of N'-Nitrosonornicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.

    Peterson, Lisa A / Stanfill, Stephen B / Hecht, Stephen S

    Carcinogenesis

    2024  

    Abstract: The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered "carcinogenic to humans" by the International Agency for Research on Cancer (IARC) and are believed to be important in ... ...

    Abstract The tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are considered "carcinogenic to humans" by the International Agency for Research on Cancer (IARC) and are believed to be important in the carcinogenic effects of both smokeless tobacco and combusted tobacco products. This short review focuses on the results of recent studies on the formation of NNN and NNK in tobacco, and their carcinogenicity and toxicity in laboratory animals. New mechanistic insights are presented regarding the role of dissimilatory nitrate reductases in certain microorganisms involved in the conversion of nitrate to nitrite that leads to the formation of NNN and NNK during curing and processing of tobacco. Carcinogenicity studies of the enantiomers of the major NNK metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and the enantiomers of NNN are reviewed. Recent toxicity studies of inhaled NNK and co-administration studies of NNK with formaldehyde, acetaldehyde, acrolein, and CO2, all of which occur in high concentrations in cigarette smoke, are discussed.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgae018
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  3. Article ; Online: Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention.

    Gupta, Prakash C / Hecht, Stephen S

    Chemical research in toxicology

    2023  Volume 36, Issue 4, Page(s) 561–562

    MeSH term(s) Smoking ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.3c00085
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  4. Article ; Online: Metabolism and DNA Adduct Formation of Tobacco-Specific

    Li, Yupeng / Hecht, Stephen S

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: The tobacco- ... ...

    Abstract The tobacco-specific
    MeSH term(s) Carcinogens/metabolism ; Carcinogens/toxicity ; DNA Adducts ; Humans ; Nitrosamines/toxicity ; Nicotiana/metabolism ; Tobacco Products
    Chemical Substances Carcinogens ; DNA Adducts ; Nitrosamines
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23095109
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  5. Article ; Online: Metabolic Activation and DNA Interactions of Carcinogenic

    Li, Yupeng / Hecht, Stephen S

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: ... ...

    Abstract Carcinogenic
    MeSH term(s) Activation, Metabolic ; Animals ; Carcinogens/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; DNA/metabolism ; DNA Adducts ; Humans ; Nitrosamines/toxicity
    Chemical Substances Carcinogens ; DNA Adducts ; Nitrosamines ; DNA (9007-49-2) ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23094559
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  6. Article ; Online: Mass Spectrometric Quantitation of

    Li, Yupeng / Hecht, Stephen S

    Chemical research in toxicology

    2022  Volume 35, Issue 9, Page(s) 1579–1588

    Abstract: ... ...

    Abstract N
    MeSH term(s) Biomarkers/urine ; Carcinogens/metabolism ; Glucuronides/urine ; Humans ; Neoplasms ; Nitrosamines/chemistry ; Oxides ; Pyridines/urine ; Smokers ; Nicotiana/metabolism ; Tobacco Products ; Tobacco, Smokeless
    Chemical Substances Biomarkers ; Carcinogens ; Glucuronides ; Nitrosamines ; Oxides ; Pyridines ; N'-nitrosonornicotine (X656TZ86DX)
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.2c00195
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  7. Article ; Online: Carcinogenic components of tobacco and tobacco smoke: A 2022 update.

    Li, Yupeng / Hecht, Stephen S

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2022  Volume 165, Page(s) 113179

    Abstract: ... many of which have been recognized as hazardous to human health by regulatory agencies. In 2012, the U.S ...

    Abstract Tobacco and tobacco smoke contain a complex mixture of over 9500 chemical compounds, many of which have been recognized as hazardous to human health by regulatory agencies. In 2012, the U.S. Food and Drug Administration established a list of harmful and potentially harmful constituents in unburned tobacco and tobacco smoke, 79 of which are considered as carcinogens. Over the past 10 years, with advancing analytical technology, significant amounts of new data have been published, increasing our understanding of levels of carcinogens in tobacco products. The International Agency for Research on Cancer (IARC) has released 35 monographs since 2012, with an increasing number of compounds in unburned tobacco and tobacco smoke classified as carcinogens. In this paper, we provide an updated list of IARC-classified carcinogens in unburned tobacco and tobacco mainstream smoke. A total of 83 carcinogens has been identified - 37 in unburned tobacco and 80 in tobacco smoke - with their occurrence levels reported since 2012. No clear decreasing trends were observed for any of these carcinogens in recent years. Surveillance of the levels of tobacco carcinogens as well as regulatory actions are needed to ensure control of their levels so that potential reduced risks of cancer and other diseases may be achieved.
    MeSH term(s) Carcinogens/analysis ; Carcinogens/toxicity ; Humans ; Smoke/adverse effects ; Smoke/analysis ; Nicotiana/chemistry ; Tobacco Products/toxicity ; Tobacco Smoke Pollution/analysis
    Chemical Substances Carcinogens ; Smoke ; Tobacco Smoke Pollution
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2022.113179
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    Zs.A 529: Show issues Location:
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  8. Article ; Online: Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention.

    Hecht, Stephen S / Hatsukami, Dorothy K

    Nature reviews. Cancer

    2022  Volume 22, Issue 3, Page(s) 143–155

    Abstract: Tobacco products present a deadly combination of nicotine addiction and carcinogen exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless tobacco products lead to unacceptable exposure to multiple carcinogens, ... ...

    Abstract Tobacco products present a deadly combination of nicotine addiction and carcinogen exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless tobacco products lead to unacceptable exposure to multiple carcinogens, including the tobacco-specific nitrosamine N'-nitrosonornicotine, a likely cause of the commonly occurring oral cavity cancers observed particularly in South-East Asian countries. Cigarettes continue to deliver a large number of carcinogens, including tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons and volatile organic compounds. The multiple carcinogens in cigarette smoke are responsible for the complex mutations observed in critical cancer genes. The exposure of smokeless tobacco users and smokers to carcinogens and toxicants can now be monitored by urinary and DNA adduct biomarkers that may be able to identify those individuals at highest risk of cancer so that effective cancer prevention interventions can be initiated. Regulation of the levels of carcinogens, toxicants and nicotine in tobacco products and evidence-based tobacco control efforts are now recognized as established pathways to preventing tobacco related cancer.
    MeSH term(s) Carcinogens/toxicity ; Cigarette Smoking ; Humans ; Mouth Neoplasms/etiology ; Mouth Neoplasms/prevention & control ; Nicotiana/metabolism ; Tobacco, Smokeless/adverse effects
    Chemical Substances Carcinogens
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-021-00423-4
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  9. Article ; Online: DNA damage in human oral cells induced by use of e-cigarettes.

    Guo, Jiehong / Hecht, Stephen S

    Drug testing and analysis

    2022  Volume 15, Issue 10, Page(s) 1189–1197

    Abstract: The use of electronic cigarettes (e-cigarettes) has increased rapidly in the United States, especially among high school students. e-Cigarettes contain some recognized carcinogens and may induce DNA damage in oral cells. The aim of this review is to ... ...

    Abstract The use of electronic cigarettes (e-cigarettes) has increased rapidly in the United States, especially among high school students. e-Cigarettes contain some recognized carcinogens and may induce DNA damage in oral cells. The aim of this review is to summarize studies reporting DNA adducts or other types of DNA damage in oral cells in vitro or in vivo upon exposure to e-cigarette vapor and to evaluate the possible connections between e-cigarette exposure and oral cancer. Three databases including PubMed, Scopus, and EMBASE and gray literature were searched for articles published up to April 24, 2022. After screening 321 articles, we extracted 27 for further investigation. Based on the inclusion criteria, 22 articles were eligible for this review. The in vitro studies demonstrate that e-cigarette liquid or vapor can induce DNA damage, oxidative stress, DNA double-stranded breaks, apoptosis, cytotoxicity, and genotoxicity in different types of oral cells. The clinical studies showed that e-cigarette users have significantly higher levels of N'-nitrosonornicotine, acrolein DNA adducts, metanuclear anomalies, gene regulation, and lactate dehydrogenase enzyme expression and significantly lower levels of apurinic/apyrimidinic sites than non-users. Comparison of micronuclei levels between e-cigarette users and non-users gave inconsistent results. e-Cigarettes are implicated in DNA damage to oral cells, but publications to date present limited evidence. Future studies with larger sample sizes are required to investigate the long-term consequences of e-cigarette use.
    MeSH term(s) Humans ; United States ; Electronic Nicotine Delivery Systems ; DNA Adducts ; Tobacco Products ; DNA Damage
    Chemical Substances DNA Adducts ; N'-nitrosonornicotine (X656TZ86DX)
    Language English
    Publishing date 2022-10-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3375
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  10. Article ; Online: Metabolism and DNA Adduct Formation of Tobacco-Specific N -Nitrosamines

    Yupeng Li / Stephen S. Hecht

    International Journal of Molecular Sciences, Vol 23, Iss 5109, p

    2022  Volume 5109

    Abstract: The tobacco-specific N -nitrosamines 4-( N -nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N ′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke. They have been ... ...

    Abstract The tobacco-specific N -nitrosamines 4-( N -nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N ′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke. They have been classified as “carcinogenic to humans” by the International Agency for Research on Cancer. In 1998, we published a review of the biochemistry, biology and carcinogenicity of tobacco-specific nitrosamines. Over the past 20 years, considerable progress has been made in our understanding of the mechanisms of metabolism and DNA adduct formation by these two important carcinogens, along with progress on their carcinogenicity and mutagenicity. In this review, we aim to provide an update on the carcinogenicity and mechanisms of the metabolism and DNA interactions of NNK and NNN.
    Keywords metabolism ; DNA adducts ; tobacco-specific N -nitrosamines ; NNK ; NNN ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 580
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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