LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 53

Search options

  1. Article: [Application of Convolutional Neural Network for Evaluating CT Dose Using Image Noise Classification: A Phantom Study].

    Sugino, Masakazu / Shiraishi, Junji

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2020  Volume 76, Issue 11, Page(s) 1143–1151

    Abstract: Purpose: It is well known that there is a trade-off relationship between image noise and exposure dose in X-ray computed tomography (CT) examination. Therefore, CT dose level was evaluated by using the CT image noise property. Although noise power ... ...

    Abstract Purpose: It is well known that there is a trade-off relationship between image noise and exposure dose in X-ray computed tomography (CT) examination. Therefore, CT dose level was evaluated by using the CT image noise property. Although noise power spectrum (NPS) is a common measure for evaluating CT image noise property, it is difficult to evaluate noise performance directly on clinical CT images, because NPS requires CT image samples with uniform exposure area for the evaluation. In this study, various noise levels of CT phantom images were classified for estimating dose levels of CT images using convolutional neural network (CNN).
    Method: CT image samples of water phantom were obtained with a combination of mAs value (50, 100, 200 mAs) and X-ray tube voltage (80, 100, 120 kV). The CNN was trained and tested for classifying various noise levels of CT image samples by keeping 1) a constant kV and 2) a constant mAs. In addition, CT dose levels (CT dose index: CTDI) for all exposure conditions were estimated by using regression approach of the CNN.
    Result: Classification accuracies for various noise levels were very high (more than 99.9%). The CNN-estimated dose level of CT images was highly correlated (r=0.998) with the actual CTDI.
    Conclusion: CT image noise level classification using CNN can be useful for the estimation of CT radiation dose.
    MeSH term(s) Neural Networks, Computer ; Phantoms, Imaging ; Radiation Dosage ; Signal-To-Noise Ratio ; Tomography, X-Ray Computed
    Language Japanese
    Publishing date 2020-11-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2020_JSRT_76.11.1143
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: An Evaluation of the Efficacy of Machine Learning in Predicting Thyrotoxicosis and Hypothyroidism: A Comparative Assessment of Biochemical Test Parameters Used in Different Health Checkups.

    Yoshimura Noh, Jaeduk / Yoshihara, Ai / Hiruma, Shigenori / Ichikawa, Masahiro / Hirose, Rei / Koshibu, Masakazu / Imai, Hideyuki / Sankoda, Akiko / Suzuki, Nami / Fukushita, Miho / Matsumoto, Masako / Watanabe, Natsuko / Sugino, Kiminori / Ito, Koichi

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: Objective This study assessed the efficacy of machine learning in predicting thyrotoxicosis and hypothyroidism [thyroid-stimulating hormone (TSH) >10.0 mIU/L] by leveraging age and sex as variables and integrating biochemical test parameters used by the ... ...

    Abstract Objective This study assessed the efficacy of machine learning in predicting thyrotoxicosis and hypothyroidism [thyroid-stimulating hormone (TSH) >10.0 mIU/L] by leveraging age and sex as variables and integrating biochemical test parameters used by the Japan Society of Health Evaluation and Promotion (JHEP) and the Japan Society of Ningen Dock (JND). Subjects and Methods Our study included 20,653 untreated patients with Graves' disease, 3,435 untreated patients with painless thyroiditis, 4,266 healthy individuals, and 18,937 untreated patients with Hashimoto's thyroiditis. Machine learning was conducted using Prediction One on three distinct datasets: the Ito dataset (age, sex, and 30 blood tests and biochemical test data), the JHEP dataset (age, sex, and TP, T-Bil, AST, ALT, γGTP, ALP, CRE, UA, and T-Cho test data), and the JND dataset (age, sex, and AST, ALT, γGTP, CRE, and UA test data). Results The results for distinguishing thyrotoxicosis patients from the healthy control group showed that the JHEP dataset yielded substantial discriminative capacity with an area under the curve (AUC) of 0.966, sensitivity of 92.2%, specificity of 89.1%, and accuracy of 91.7%. The JND dataset displayed similar robustness, with an AUC of 0.948, sensitivity of 92.0%, specificity of 81.3%, and accuracy of 90.4%. Differentiating hypothyroid patients from the healthy control group yielded similarly robust performances, with the JHEP dataset yielding AUC, sensitivity, specificity, and accuracy values of 0.864, 84.2%, 72.1%, and 77.4%, respectively, and the JND dataset yielding values of 0.840, 83.2%, 67.2%, and 74.3%, respectively. Conclusions Machine learning is a potent screening tool for thyrotoxicosis and hypothyroidism.
    Language English
    Publishing date 2024-01-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2825-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Dehydroepiandrosterone sulfate (DHEAS) therapy for myotonic dystrophy type 1 and myotonia.

    Sugino, Masakazu

    Internal medicine (Tokyo, Japan)

    2006  Volume 44, Issue 12, Page(s) 1213–1214

    MeSH term(s) Adult ; Animals ; Dehydroepiandrosterone Sulfate/therapeutic use ; Humans ; Male ; Mice ; Myotonia/drug therapy ; Myotonic Dystrophy/drug therapy ; Rats ; Treatment Outcome
    Chemical Substances Dehydroepiandrosterone Sulfate (57B09Q7FJR)
    Language English
    Publishing date 2006-01-04
    Publishing country Japan
    Document type Comment ; Editorial
    ZDB-ID 32371-8
    ISSN 0918-2918 ; 0021-5120
    ISSN 0918-2918 ; 0021-5120
    DOI 10.2169/internalmedicine.44.1213
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review.

    Nakamura, Yoshitsugu / Sato, Hidenori / Miyano, Yuki / Murakami, Ryoko / Motoki, Mikiko / Shigekiyo, Taro / Sugino, Masakazu / Arawaka, Shigeki

    Clinical neurology and neurosurgery

    2021  Volume 208, Page(s) 106864

    Abstract: Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neurotransmission at the neuromuscular junction. MG is generally non-inherited but is rarely inherited. Here, we report two patients with MG in the same pedigree: a 62-year-old ... ...

    Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neurotransmission at the neuromuscular junction. MG is generally non-inherited but is rarely inherited. Here, we report two patients with MG in the same pedigree: a 62-year-old Japanese man and his 46-year-old daughter who were positive for anti-acetylcholine receptor antibodies and had thymoma. We performed whole-exome sequencing (WES) and human leukocyte antigen (HLA) analyses to investigate the genetic contribution to familial onset. WES analysis of both patients showed no known variations in candidate genes for familial MG, and HLA analysis failed to detect HLA haplotypes seen in early-onset and late-onset MG. These findings suggest the presence of an unknown genetic background. Previous genetic studies on familial MG have identified ENOX1 and IFNGR1 as candidate genes in patients without thymoma, whereas no studies have identified candidate genes in patients with thymoma. To explore causative genes, it may be necessary to consider whether the genetic background differs between patients with and without thymoma in familial autoimmune MG.
    MeSH term(s) Autoantibodies ; Female ; HLA Antigens/genetics ; Humans ; Male ; Middle Aged ; Myasthenia Gravis/genetics ; Myasthenia Gravis/immunology ; Myasthenia Gravis/pathology ; Pedigree ; Receptors, Cholinergic/immunology ; Thymoma/genetics ; Thymoma/immunology ; Thymoma/pathology ; Thymus Neoplasms/genetics ; Thymus Neoplasms/immunology ; Thymus Neoplasms/pathology ; Whole Exome Sequencing
    Chemical Substances Autoantibodies ; HLA Antigens ; Receptors, Cholinergic
    Language English
    Publishing date 2021-08-03
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2021.106864
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Time-series transcriptome analysis of peripheral blood mononuclear cells obtained from individuals who received the SARS-CoV-2 mRNA vaccine.

    Watanabe, Yoshiyuki / Yamamoto, Hiroyuki / Matsuba, Ikuro / Watanabe, Karin / Kunishima, Tomoyuki / Takechi, Yukako / Takuma, Tetsuo / Araki, Yasushi / Hirotsu, Nobuo / Sakai, Hiroyuki / Oikawa, Ritsuko / Danno, Hiroki / Fukuda, Masakazu / Sugino, Ryuichi / Futagami, Seiji / Wada, Kota / Itoh, Fumio / Tateishi, Keisuke / Oda, Ichiro /
    Hatori, Yutaka / Degawa, Hisakazu

    Journal of medical virology

    2023  Volume 95, Issue 6, Page(s) e28884

    Abstract: Messenger ribonucleic acid (mRNA) vaccination against coronavirus disease 2019 (COVID-19) is an effective prevention strategy, despite a limited understanding of the molecular mechanisms underlying the host immune system and individual heterogeneity of ... ...

    Abstract Messenger ribonucleic acid (mRNA) vaccination against coronavirus disease 2019 (COVID-19) is an effective prevention strategy, despite a limited understanding of the molecular mechanisms underlying the host immune system and individual heterogeneity of the variable effects of mRNA vaccination. We assessed the time-series changes in the comprehensive gene expression profiles of 200 vaccinated healthcare workers by performing bulk transcriptome and bioinformatics analyses, including dimensionality reduction utilizing the uniform manifold approximation and projection (UMAP) technique. For these analyses, blood samples, including peripheral blood mononuclear cells (PBMCs), were collected from 214 vaccine recipients before vaccination (T1) and on Days 22 (T2, after second dose), 90, 180 (T3, before a booster dose), and 360 (T4, after a booster dose) after receiving the first dose of BNT162b2 vaccine (UMIN000043851). UMAP successfully visualized the main cluster of gene expression at each time point in PBMC samples (T1-T4). Through differentially expressed gene (DEG) analysis, we identified genes that showed fluctuating expression levels and gradual increases in expression levels from T1 to T4, as well as genes with increased expression levels at T4 alone. We also succeeded in dividing these cases into five types based on the changes in gene expression levels. High-throughput and temporal bulk RNA-based transcriptome analysis is a useful approach for inclusive, diverse, and cost-effective large-scale clinical studies.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Transcriptome ; Leukocytes, Mononuclear ; SARS-CoV-2/genetics ; BNT162 Vaccine ; COVID-19/prevention & control ; RNA, Messenger/genetics ; Gene Expression Profiling ; Vaccination ; Antibodies, Viral ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine ; RNA, Messenger ; Antibodies, Viral
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28884
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Posterior reversible encephalopathy syndrome with extensive cytotoxic edema after blood transfusion: a case report and literature review.

    Nakamura, Yoshitsugu / Sugino, Masakazu / Tsukahara, Akihiro / Nakazawa, Hiroko / Yamamoto, Naomune / Arawaka, Shigeki

    BMC neurology

    2018  Volume 18, Issue 1, Page(s) 190

    Abstract: Background: Posterior reversible encephalopathy syndrome (PRES) is described as a clinical-radiological disease entity with good prognosis. In brain MRI, PRES generally presents with vasogenic edema. Although PRES is induced by various causes, a small ... ...

    Abstract Background: Posterior reversible encephalopathy syndrome (PRES) is described as a clinical-radiological disease entity with good prognosis. In brain MRI, PRES generally presents with vasogenic edema. Although PRES is induced by various causes, a small number of PRES cases have occurred after red cell blood transfusion. It is unclear whether there are characteristic features in PRES after blood transfusion.
    Case presentation: Here, we report a case of 75-year-old Japanese woman who had acute exacerbation of subacute anemia by bleeding from gastric ulcer. After receiving a red cell blood transfusion, she showed disturbance of consciousness with extensive cytotoxic and small vasogenic edema in the occipitoparietal area on brain MRI. She was diagnosed as PRES and suffered irreversible impairments of visual acuity and fields in both eyes. We summarized and discussed clinical features of cases with PRES after blood transfusion.
    Conclusions: A total of 21 cases including the present one have been reported as PRES after blood transfusion. Of the cases, 20 of 21 were female, and 15 of 17 developed PRES in the course of chronic anemia lasting over 1 month. Anemia was severe in 15 of 20 cases, with hemoglobin levels < 3.5 g/dl. In 14 of 17 cases, hemoglobin levels increased to 5 g/dl by red cell blood transfusion until the onset of PRES. On brain MRI, 2 of 21 cases showed cytotoxic edema and 3 of 21 cases showed irreversible neurological disturbance. In this patient, the occurrence of PRES in subacute anemia and the presence of extensive cytotoxic brain edema with irreversible neurological deficits were characteristic points. When treating severe anemia, even with a subacute progression, we should consider a possibility that PRES occurs after blood transfusion with extensive cytotoxic brain edema and irreversible neurological changes.
    MeSH term(s) Aged ; Anemia/therapy ; Brain Edema/etiology ; Erythrocyte Transfusion/adverse effects ; Female ; Humans ; Magnetic Resonance Imaging ; Posterior Leukoencephalopathy Syndrome/etiology ; Transfusion Reaction/complications
    Language English
    Publishing date 2018-11-12
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-018-1194-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Hypothyroidism-induced hypermagnesemia with a small dose of magnesium.

    Yamamoto, Naomune / Oh, Eriko / Yoshikawa, Ayaka / Takai, Masaaki / Yoshida, Mami / Saeki, Akio / Ishii, Hiroshi / Sugino, Masakazu

    Geriatrics & gerontology international

    2018  Volume 18, Issue 9, Page(s) 1420–1421

    MeSH term(s) Acute Kidney Injury/etiology ; Aged ; Female ; Humans ; Hypothyroidism/complications ; Magnesium Oxide/adverse effects ; Magnesium Oxide/blood
    Chemical Substances Magnesium Oxide (3A3U0GI71G)
    Language English
    Publishing date 2018-09-21
    Publishing country Japan
    Document type Case Reports ; Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.13485
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Case of insulinoma manifesting as hyperinsulinemia after discontinuing quetiapine in an elderly patient with delirium.

    Yamamoto, Naomune / Oh, Eriko / Nishiyama, Koji / Yoshida, Mami / Saeki, Akio / Ishii, Hiroshi / Takeda, Yoshi / Hamahata, Tetsuzo / Sugino, Masakazu

    Geriatrics & gerontology international

    2017  Volume 17, Issue 5, Page(s) 849–851

    MeSH term(s) Aged ; Delirium/drug therapy ; Humans ; Hyperinsulinism/etiology ; Insulinoma/complications ; Insulinoma/diagnosis ; Quetiapine Fumarate/therapeutic use
    Chemical Substances Quetiapine Fumarate (2S3PL1B6UJ)
    Language English
    Publishing date 2017-05-16
    Publishing country Japan
    Document type Case Reports ; Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.12967
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: h-prune affects anaplastic thyroid cancer invasion and metastasis.

    Nambu, Junko / Kobayashi, Tsuyoshi / Hashimoto, Masakazu / Tashiro, Hirotaka / Sugino, Keizo / Shimamoto, Fumio / Kikuchi, Akira / Ohdan, Hideki

    Oncology reports

    2016  Volume 35, Issue 6, Page(s) 3445–3452

    Abstract: Anaplastic thyroid cancer is one of the most aggressive human malignancies and is resistant to multimodal treatments. The expression of h-prune, the human homologue of Drosophila prune, has been reported to be correlated with progression and ... ...

    Abstract Anaplastic thyroid cancer is one of the most aggressive human malignancies and is resistant to multimodal treatments. The expression of h-prune, the human homologue of Drosophila prune, has been reported to be correlated with progression and aggressiveness in various cancers including breast, colorectal and pancreatic cancers. We examined the role of h-prune in anaplastic thyroid cancer cell migration, invasion and metastasis. Immunohistochemical analysis of h-prune was performed with 15 surgically resected specimens of anaplastic thyroid cancers. To investigate cell motility, Boyden chamber, wound healing and matrigel invasion assays were performed using cells from anaplastic thyroid cancer cell lines. A murine orthotopic thyroid cancer model was used to investigate metastatic ability. In the immunohistochemical analysis, only weak focal or no staining of h-prune was observed in non-tumor tissue. In contrast, diffuse staining of h-prune was observed in anaplastic thyroid cancer and lymph node metastasis samples. Both inhibition of h-prune phosphodiesterase activity with dipyridamole and small interfering RNA for h-prune suppressed 8505C and KTC-3 cell motility. In addition, treatment with dipyridamole and decreased expression of h-prune suppressed tumor invasion and pulmonary metastasis in a NOD/Shi-scid, IL-2Rγnull (NOG) mouse orthotopic thyroid cancer model. In conclusion, h-prune is frequently expressed in anaplastic thyroid cancer cells and lymph nodes metastasis, and promotes migration and invasion of anaplastic thyroid cancer cells and metastasis in an anaplastic thyroid cancer model. Thus, h-prune shows promise as a targeting candidate against anaplastic thyroid cancer.
    MeSH term(s) 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Animals ; Carrier Proteins/analysis ; Carrier Proteins/physiology ; Cell Line, Tumor ; Cell Movement ; Female ; Humans ; Lung Neoplasms/secondary ; Mice ; Neoplasm Invasiveness ; Thyroid Carcinoma, Anaplastic/pathology
    Chemical Substances Carrier Proteins ; PRUNE1 protein, human (EC 3.1.3.2) ; 3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17)
    Language English
    Publishing date 2016-04-20
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2016.4759
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Prenatal diagnosis of pentalogy of cantrell with craniorachischisis by three-dimensional ultrasonography in the first trimester.

    Murata, Susumu / Nakata, Masahiko / Sumie, Masahiro / Mastsuabra, Masakazu / Sugino, Norihiro

    Taiwanese journal of obstetrics & gynecology

    2009  Volume 48, Issue 3, Page(s) 317–318

    MeSH term(s) Abnormalities, Multiple/diagnostic imaging ; Abortion, Therapeutic ; Adult ; Female ; Humans ; Imaging, Three-Dimensional ; Neural Tube Defects/diagnostic imaging ; Pregnancy ; Pregnancy Trimester, First ; Ultrasonography, Prenatal
    Language English
    Publishing date 2009-09
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Letter
    ISSN 1875-6263
    ISSN (online) 1875-6263
    DOI 10.1016/S1028-4559(09)60315-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top