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Article: [Rezension von: Goodwin, Richard M., ..., The dynamics of a capitalist economy]

Mainwaring, Lynn / Goodwin, Richard M

The economic journal : the journal of the Royal Economic Society 98 ,September = No. 392, S. 866-867

1988

Author's details	Lynn Mainwaring
Keywords	40;49
Language	English
Publisher	Wiley-Blackwell
Publishing place	Oxford [u.a.]
Document type	Article
ZDB-ID	3025-9 ; 1473822-3
ISSN	1468-0297 ; 0013-0133
ISSN (online)	1468-0297
ISSN	0013-0133
Database	ECONomics Information System

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Book: Bates' guide to physical examination and history taking

Bickley, Lynn S. / Szilagyi, Peter G. / Hoffman, Richard M. / Bates, Barbara / Soriano, Rainier P.

2021

Title variant	Guide to physical examination and history taking ; Physical examination and history taking
Author's details	Lynn S. Bickley, MD, FACP, Peter G. Szilagyi, MD, MPH, Richard M. Hoffman, MD, MPH, FACP ; guest editor Rainier P. Soriano, MD
Keywords	Physical diagnosis ; Medical history taking
Subject code	616.0754
Language	English
Size	xxxviii, 1201 Seiten, Illustrationen, Diagramme, 28 cm
Edition	Thirteenth edition, international edition
Publisher	Wolters Kluwer
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index. Zugang zur Online-Ausgabe über Code
Old title	Vorangegangen ist
HBZ-ID	HT020808453
ISBN	978-1-975109-91-2 ; 9781496398178 ; 1-975109-91-0 ; 1496398173
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2021 A 286	available for loan (reading room)	Lesesaal EG
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Article: Effect of bilberry juice on indices of muscle damage and inflammation in runners completing a half-marathon: a randomised, placebo-controlled trial

Lynn, Anthony

Journal of the International Society of Sports Nutrition, 15:22

2018

Abstract: ... 30.9 ± 10.4 y; mass 71.6 ± 11.0 kg; M = 16; F = 5) were recruited to a single blind, randomised ... BACKGROUND: Emerging evidence indicates that fruits rich in polyphenols may attenuate exercise ... to determine whether bilberry juice (BJ), which is particularly rich in polyphenols, reduces markers of muscle ...

Abstract	BACKGROUND: Emerging evidence indicates that fruits rich in polyphenols may attenuate exercise-induced muscle damage and associated markers of inflammation and soreness. This study was conducted to determine whether bilberry juice (BJ), which is particularly rich in polyphenols, reduces markers of muscle damage in runners completing a half marathon. METHODS: A total of 21 recreationally trained runners (age 30.9 ± 10.4 y; mass 71.6 ± 11.0 kg; M = 16; F = 5) were recruited to a single blind, randomised, placebo-controlled, parallel study. Participants were block randomised to consume 2 × 200 ml of BJ or energy-matched control drink (PLA) for 5 d before the Sheffield Half Marathon, on race day, and for 2 days post-race. Measurements of delayed onset muscle soreness (DOMS), muscle damage (creatine kinase; CK) and inflammation (c-reactive protein; CRP) were taken at baseline, pre-race, post-race, 24 h post-race and 48 h post-race. The effect of treatment on outcome measures was analysed using magnitude-based inferences based on data from 19 participants; 2 participants were excluded from the analyses because they did not provide samples for all time points. RESULTS: The half marathon caused elevations in DOMS, CRP and CK. BJ had a possibly harmful effect on DOMS from pre-race to immediately post-race (11.6%, 90% CI ± 14.7%), a likely harmful effect on CRP from pre-race to 24 h post-race (mean difference ES 0.56, 90% CI ± 0.72) and a possibly harmful effect on CRP from pre-race to 48 h post-race (ES 0.12, 90% CI ± 0.69). At other time points, the differences between the BJ and PLA groups in DOMS and CRP were unclear, possibly trivial or likely trivial. Differences in the changes in CK between BJ and PLA were unclear at every time point other than from baseline to pre-race, where BJ had a possibly harmful effect on reducing muscle damage (ES 0.23, 90% CI ± 0.57). CONCLUSION: Despite being a rich source of antioxidant and anti-inflammatory phytochemicals, BJ evoked small to moderate increases in exercise-induced DOMS and CRP. Further larger studies are required to confirm these unexpected preliminary results.
Keywords	Bilberry ; Inflammation ; Muscle damage ; Polyphenols
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article ; Online: Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study.

Quaye, Aurora N / Hisey, William M / Mackenzie, Todd A / Robinson, Christina M / Richard, Janelle M / Anderson, Joseph C / Warters, Robert D / Butterly, Lynn F

Anesthesiology

2024

Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004955
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Article ; Online: Case ascertainment in active paediatric surveillance systems: a report from the British Paediatric Surveillance Unit Ascertainment Group.

Lynn, Richard M / Reading, Richard

Archives of disease in childhood

2019 Volume 105, Issue 1, Page(s) 62–68

Abstract: The British Paediatric Surveillance Unit (BPSU) conducts surveillance of rare paediatric conditions using active, or prospective, case finding. The reliability of estimates of incidence, which is the primary outcome of public health importance, depends ... ...

Abstract	The British Paediatric Surveillance Unit (BPSU) conducts surveillance of rare paediatric conditions using active, or prospective, case finding. The reliability of estimates of incidence, which is the primary outcome of public health importance, depends on ascertainment being as near complete as possible. This paper reviews evidence of the completeness of ascertainment in recent surveillance studies run through the BPSU. Ascertainment varied between 49% and 94% depending on the study. These are upper estimates. This was the basis of a discussion on barriers and facilitators of ascertainment which we have separated into factors related to the condition, factors related to the study methods, factors related to the study team and factors related to the surveillance system infrastructure. This leads to a series of recommendations to ensure continuing high levels of ascertainment in active surveillance studies.
MeSH term(s)	Child ; Humans ; Incidence ; Pediatrics/methods ; Population Surveillance ; Rare Diseases/epidemiology ; Surveys and Questionnaires ; United Kingdom/epidemiology
Language	English
Publishing date	2019-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2019-317401
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Article ; Online: Subtypes of avoidant/restrictive food intake disorder in children and adolescents: a latent class analysis.

Sanchez-Cerezo, Javier / Neale, Josephine / Julius, Nikita / Croudace, Tim / Lynn, Richard M / Hudson, Lee D / Nicholls, Dasha

EClinicalMedicine

2024 Volume 68, Page(s) 102440

Abstract: Background: The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) describes three primary avoidant/restrictive food intake disorder (ARFID) subtypes including sensory sensitivity, lack of interest in food or eating, and fear ... ...

Abstract	Background: The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) describes three primary avoidant/restrictive food intake disorder (ARFID) subtypes including sensory sensitivity, lack of interest in food or eating, and fear of aversive consequences. Studies exploring these subtypes have yielded varying results. We used latent class analysis (LCA) based on the psychopathology of ARFID in a sample of children and adolescents to empirically identify classes. Methods: We carried out a surveillance study of ARFID in collaboration with the British Paediatric Surveillance Unit (BPSU) and the Child and Adolescent Psychiatry Surveillance System (CAPSS) in the United Kingdom and the Republic of Ireland from 1st of March 2021 to 31st of March 2022. Paediatricians and child and adolescent psychiatrists were contacted monthly to report newly diagnosed cases of ARFID electronically and complete a detailed clinical questionnaire. Cases aged 5-18 years were included. LCA was performed specifying 1-6 classes and likelihood-based tests for model selection. The Bayesian Information Criterion (BIC), the Akaike Information Criterion (AIC) and the Sample-Size Adjusted BIC were used to determine the most parsimonious model. Analysis of variance (ANOVA) and χ2 tests were used to compare the characteristics of the identified classes. A multinomial logistic regression (MLR) was performed to investigate predicting factors for the latent classes. Findings: We identified 319 children and adolescents with ARFID. LCA revealed four distinct classes which were labelled as Interpretation: LCA identified four different classes in a sample of children and adolescents with ARFID. The Funding: This study was funded by the Former EMS Ltd (charity number 1098725, registered October 9th 2017).
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2024.102440
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fetal alcohol syndrome in the UK.

Burleigh, Charlotte Rebecca / Lynn, Richard M / Verity, Chris / Winstone, Anne Marie / White, Simon R / Johnson, Kathryn

Archives of disease in childhood

2023 Volume 108, Issue 10, Page(s) 852–856

Abstract: Objective: To determine the incidence of fetal alcohol syndrome (FAS) in the UK in children aged 0-16 years.: Design: Active surveillance was undertaken through the British Paediatric Surveillance Unit between October 2018 and October 2019 inclusive. ...

Abstract	Objective: To determine the incidence of fetal alcohol syndrome (FAS) in the UK in children aged 0-16 years. Design: Active surveillance was undertaken through the British Paediatric Surveillance Unit between October 2018 and October 2019 inclusive. Data were collected from reporting clinicians using standardised questionnaires. Patients: Children aged 0-16 years in the UK and Ireland with a diagnosis of FAS seen in the previous month. This study did not include children with fetal alcohol spectrum disorder. Main outcome measures: Demographic details (including age and ethnicity), details of exposure, growth parameters, neurological and cognitive diagnoses, and service usage. Results: 148 notifications were received. After exclusions and withdrawals, there were 10 confirmed and 37 probable cases (analysed together). Just 24 of these children were newly diagnosed with FAS during the surveillance period, giving an estimated incidence rate of 3.4/100 000 live births (95% CI 2.2 to 5.0); their median age at diagnosis was just over 5 years and they were diagnosed between 3 months and 14 years 3 months of age. Conclusions: The estimated incidence rate of FAS is lower than reported by similar studies and there was a wide variation in the age that cases were diagnosed. This, combined with the fact that many cases were notified and then withdrawn or excluded, suggests that in the UK there is a lack of consistency and certainty in diagnosing FAS. The study findings strongly support the need to educate key professionals involved in the care of infants and children at risk of FAS.
MeSH term(s)	Infant ; Child ; Pregnancy ; Female ; Humans ; Fetal Alcohol Spectrum Disorders/diagnosis ; Fetal Alcohol Spectrum Disorders/epidemiology ; Ethnicity ; Ireland/epidemiology ; Population Surveillance ; United Kingdom/epidemiology
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2023-325571
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Article ; Online: Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences.

Rekima, Akila / van den Elsen, Lieke / Isnard, Charlotte / Smyth, Danielle J / Lynn, Miriam A / Yee, Tee / Stevens, Natalie E / Machado, Savannah / Divakara, Nivedithaa / Bhasin, Maheshwar / Tjiam, M Christian / Rowel, Candia / Servant, Florence / Burcelin, Remy / Locksley, Richard / Maizels, Rick / Lynn, David J / Egwang, Thomas / Verhasselt, Valérie

Allergy

2024

Language	English
Publishing date	2024-02-13
Publishing country	Denmark
Document type	Letter
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.16054
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Article ; Online: Development of a multiplex droplet digital PCR assay for simultaneous detection and quantification of Escherichia coli, E. marmotae, and E. ruysiae in water samples.

Moinet, Marie / Collis, Rose M / Rogers, Lynn / Devane, Megan L / Biggs, Patrick J / Stott, Rebecca / Marshall, Jonathan / Muirhead, Richard / Cookson, Adrian L

Journal of microbiological methods

2024 Volume 220, Page(s) 106909

Abstract: Escherichia coli are widely used by water quality managers as Fecal Indicator Bacteria, but current quantification methods do not differentiate them from benign, environmental Escherichia species such as E. marmotae (formerly named cryptic clade V) or E. ...

Abstract	Escherichia coli are widely used by water quality managers as Fecal Indicator Bacteria, but current quantification methods do not differentiate them from benign, environmental Escherichia species such as E. marmotae (formerly named cryptic clade V) or E. ruysiae (cryptic clades III and IV). Reliable and specific techniques for their identification are required to avoid confounding microbial water quality assessments. To address this, a multiplex droplet digital PCR (ddPCR) assay targeting lipB (E. coli and E. ruysiae) and bglC (E. marmotae) was designed. The ddPCR performance was assessed using in silico analysis; genomic DNA from 40 local, international, and reference strains of target and non-target coliforms; and spiked water samples in a range relevant to water quality managers (1 to 1000 cells/100 mL). Results were compared to an analogous quantitative PCR (qPCR) and the Colilert method. Both PCR assays showed excellent sensitivity with a limit of detection of 0.05 pg/μL and 0.005 pg/μl for ddPCR and qPCR respectively, and of quantification of 0.5 pg/μL of genomic DNA. The ddPCR allowed differentiation and quantification of three Escherichia species per run by amplitude multiplexing and showed a high concordance with concentrations measured by Colilert once proportional bias was accounted for. In silico specificity testing underlined the possibility to further detect and distinguish Escherichia cryptic clade VI. Finally, the applicability of the ddPCR was successfully tested on environmental water samples where E. marmotae and E. ruysiae potentially confound E. coli counts based on the Most Probable Number method, highlighting the utility of this novel ddPCR as an efficient and rapid discriminatory test to improve water quality assessments.
MeSH term(s)	Real-Time Polymerase Chain Reaction/methods ; Escherichia coli ; Bacteria ; Water Quality ; DNA
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604916-3
ISSN	1872-8359 ; 0167-7012
ISSN (online)	1872-8359
ISSN	0167-7012
DOI	10.1016/j.mimet.2024.106909
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Article ; Online: Modeling the enigma of complex disease etiology.

Schriml, Lynn M / Lichenstein, Richard / Bisordi, Katharine / Bearer, Cynthia / Baron, J Allen / Greene, Carol

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 148

Abstract: Background: Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of key etiological factors, we ... ...

Abstract	Background: Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of key etiological factors, we developed and tested a complex disease model that encompasses diverse factors that in combination result in complex diseases. This model was developed to address the challenges of classifying complex diseases given the evolving nature of understanding of disease and interaction and contributions of genetic, environmental, and social factors. Methods: Here we present a new approach for modeling complex diseases that integrates the multiple contributing genetic, epigenetic, environmental, host and social pathogenic effects causing disease. The model was developed to provide a guide for capturing diverse mechanisms of complex diseases. Assessment of disease drivers for asthma, diabetes and fetal alcohol syndrome tested the model. Results: We provide a detailed rationale for a model representing the classification of complex disease using three test conditions of asthma, diabetes and fetal alcohol syndrome. Model assessment resulted in the reassessment of the three complex disease classifications and identified driving factors, thus improving the model. The model is robust and flexible to capture new information as the understanding of complex disease improves. Conclusions: The Human Disease Ontology's Complex Disease model offers a mechanism for defining more accurate disease classification as a tool for more precise clinical diagnosis. This broader representation of complex disease, therefore, has implications for clinicians and researchers who are tasked with creating evidence-based and consensus-based recommendations and for public health tracking of complex disease. The new model facilitates the comparison of etiological factors between complex, common and rare diseases and is available at the Human Disease Ontology website.
MeSH term(s)	Pregnancy ; Female ; Humans ; Fetal Alcohol Spectrum Disorders ; Diabetes Mellitus ; Causality ; Asthma
Language	English
Publishing date	2023-02-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-03987-x
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