LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article: A Mn(OAc)3-Triggered Formation of Cyclopropanes from Ugi Adducts

Cheibas, Cristina / Vieu, Emilie / Casaretto, Nicolas / Vitale, Maxime / Grimaud, Laurence / El Kaïm, Laurent

2023 Volume 34, Issue 13, Page(s) 1581–1586

Abstract: Ugi adducts involving malonic acid monoesters and dialkoxy-substituted aromatic aldehydes can undergo an oxidative dearomatization when treated with Mn(OAc) 3 leading to the formation of fused cyclopropanes as observed in the Buchner reaction of diazo ... ...

Abstract	Ugi adducts involving malonic acid monoesters and dialkoxy-substituted aromatic aldehydes can undergo an oxidative dearomatization when treated with Mn(OAc) 3 leading to the formation of fused cyclopropanes as observed in the Buchner reaction of diazo compounds.
Keywords	manganese acetate ; Ugi reaction ; radical cyclization ; cyclopropanation
Language	English
Publishing date	2023-01-02
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2005-5220
Database	Thieme publisher's database

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Early Inactivation of Membrane Estrogen Receptor Alpha (ERα) Recapitulates the Endothelial Dysfunction of Aged Mouse Resistance Arteries.

Favre, Julie / Vessieres, Emilie / Guihot, Anne-Laure / Grimaud, Linda / Proux, Coralyne / Loufrani, Laurent / Lenfant, Françoise / Fontaine, Coralie / Arnal, Jean-François / Henrion, Daniel

International journal of molecular sciences

2022 Volume 23, Issue 5

Abstract: Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but it decreases with ageing. As estrogen receptor alpha (Erα encoded ... ...

Abstract	Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but it decreases with ageing. As estrogen receptor alpha (Erα encoded by
MeSH term(s)	Aging/genetics ; Animals ; Estradiol ; Estrogen Receptor alpha/genetics ; Mesenteric Arteries/physiology ; Mice
Chemical Substances	Estrogen Receptor alpha ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2022-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23052862
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Delayed acute bronchiolitis in infants hospitalized for COVID-19.

Grimaud, Emilie / Challiol, Marie / Guilbaud, Camille / Delestrain, Céline / Madhi, Fouad / Ngo, Julien / Epaud, Ralph / Nattes, Elodie

Pediatric pulmonology

2020 Volume 55, Issue 9, Page(s) 2211–2212

MeSH term(s)	Betacoronavirus ; Bronchiolitis ; COVID-19 ; Child ; Coronavirus Infections ; Humans ; Infant ; Internationality ; Pandemics ; Pneumonia, Viral ; Respiratory Syncytial Virus Infections ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24946
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2143: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: 2.3 Exosomes Derived From Endothelial Progenitor Cells Modulate Flow-Induced Remodeling and Increase Vasculogeneis in Mesenteric Arteries of Mice

Joaquim Bobi / Emilie Vessieres / Linda Grimaud / Manel Sabate / Daniel Henrion / Ana Paula Dantas

Artery Research, Vol 25, Iss

2020 Volume 1

Abstract: Exosomes are key regulators of cell-to-cell communication, becoming valuable tool as disease biomarker and in the development of new therapeutic strategies. We aimed to determine the role of endothelial progenitor cell (EPC)-derived exosomes (EXO) in ... ...

Abstract	Exosomes are key regulators of cell-to-cell communication, becoming valuable tool as disease biomarker and in the development of new therapeutic strategies. We aimed to determine the role of endothelial progenitor cell (EPC)-derived exosomes (EXO) in vascular remodelling induced by flow. C57BL/6 mice underwent chronic changes in flow by mesenteric resistance arteries ligation. Arteries were thus submitted to high flow (HF), low flow (LF), or normal flow (NF). The day before surgery mice received I.P. injection with saline or exosomes (3 × 109 particle/kg), following the treatment every 3 days until sacrifice. After 14 days, arteries were studied in vitro in a pressure arteriograph. Increase in diameter and compliance by pressure found in HF arteries were not seen in EXO treated mice (Figure 1A). Decrease in diameter observed in saline treated LF arteries, was also abolished by EXO treatment. Network analysis of miRNA content in exosomes and arterial mRNA expression revealed an increased expression of components involved in angiogenesis/arteriogenesis (Figure 1B), which could contribute to flow maintenance in the tissue. Mesenteric arteries submitted to LF, HF and NF were isolated and placed in Matrigel matrix for angiogenesis analysis. We observed that change in flow is a trigger for vasculogenesis, which is enhanced by EXO treatment (Figure 1C). This study establishes the potential role of EPC-derived exosomes to regulate vascular remodelling during changes in flow. The mechanisms for these effects involve exosome-derived miRNA regulation of a network of mRNAs implicated in collateral angiogenesis/arteriogenesis, which in turn, may contribute to maintenance of tissue homeostasis. Figure 1
Keywords	Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Subject code	610
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis.

Chehaitly, Ahmad / Guihot, Anne-Laure / Proux, Coralyne / Grimaud, Linda / Aurrière, Jade / Legouriellec, Benoit / Rivron, Jordan / Vessieres, Emilie / Tétaud, Clément / Zorzano, Antonio / Procaccio, Vincent / Joubaud, Françoise / Reynier, Pascal / Lenaers, Guy / Loufrani, Laurent / Henrion, Daniel

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 6

Abstract: Flow (shear stress)-mediated dilation (FMD) of resistance arteries is a rapid endothelial response involved in tissue perfusion. FMD is reduced early in cardiovascular diseases, generating a major risk factor for atherosclerosis. As alteration of ... ...

Abstract	Flow (shear stress)-mediated dilation (FMD) of resistance arteries is a rapid endothelial response involved in tissue perfusion. FMD is reduced early in cardiovascular diseases, generating a major risk factor for atherosclerosis. As alteration of mitochondrial fusion reduces endothelial cells' (ECs) sprouting and angiogenesis, we investigated its role in ECs responses to flow. Opa1 silencing reduced ECs (HUVECs) migration and flow-mediated elongation. In isolated perfused resistance arteries, FMD was reduced in
Language	English
Publishing date	2022-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11061078
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Delayed acute bronchiolitis in infants hospitalized for COVID-19

Grimaud, Emilie / Challiol, Marie / Guilbaud, Camille / Delestrain, Céline / Madhi, Fouad / Ngo, Julien / Epaud, Ralph / Nattes, Elodie

Pediatr Pulmonol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #638959
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Early Inactivation of Membrane Estrogen Receptor Alpha (ERα) Recapitulates the Endothelial Dysfunction of Aged Mouse Resistance Arteries

Julie Favre / Emilie Vessieres / Anne-Laure Guihot / Linda Grimaud / Coralyne Proux / Laurent Loufrani / Françoise Lenfant / Coralie Fontaine / Jean-François Arnal / Daniel Henrion

International Journal of Molecular Sciences, Vol 23, Iss 2862, p

2022 Volume 2862

Abstract: Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but it decreases with ageing. As estrogen receptor alpha (Erα encoded by Esr1 ), and more precisely membrane ERα, plays an important role in FMD in young mice in a ... ...

Abstract	Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but it decreases with ageing. As estrogen receptor alpha (Erα encoded by Esr1 ), and more precisely membrane ERα, plays an important role in FMD in young mice in a ligand-independent fashion, we evaluated its influence on this arteriolar function in ageing. We first confirmed that in young (6-month-old) mice, FMD of mesenteric resistance arteries was reduced in Esr1−/− (lacking ERα) and C451A-ERα (lacking membrane ERα). In old (24-month-old) mice, FMD was reduced in WT mice compared to young mice, whereas it was not further decreased in Esr1−/− and C451A-ERα mice. Markers of oxidative stress were similarly increased in old WT and C451A-ERα mice. Reduction in oxidative stress with superoxide dismutase plus catalase or Mito-tempo, which reduces mitochondrial superoxide restored FMD to a normal control level in young C451A-ERα mice as well as in old WT mice and old C451A-ERα mice. Estradiol-mediated dilation was absent in old WT mice. We conclude that oxidative stress is a key event in the decline of FMD, and that an early defect in membrane ERα recapitulates phenotypically and functionally ageing of these resistance arteries. The loss of this function could take part in vascular ageing.
Keywords	estrogen receptors ; shear stress ; flow-mediated dilation ; resistance arteries ; ageing ; endothelium ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Delayed acute bronchiolitis in infants hospitalized for COVID‐19

Grimaud, Emilie / Challiol, Marie / Guilbaud, Camille / Delestrain, Céline / Madhi, Fouad / Ngo, Julien / Epaud, Ralph / Nattes, Elodie

Pediatric Pulmonology

2020 Volume 55, Issue 9, Page(s) 2211–2212

Keywords	Pediatrics, Perinatology, and Child Health ; Pulmonary and Respiratory Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24946
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 2143: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Estrogens and the Angiotensin II Type 2 Receptor Control Flow-Mediated Outward Remodeling in the Female Mouse Mesenteric Artery.

Vessieres, Emilie / Guihot, Anne-Laure / Grimaud, Linda / Rivron, Jordan / Arnal, Jean-François / Loufrani, Laurent / Henrion, Daniel

Journal of vascular research

2020 Volume 58, Issue 1, Page(s) 16–26

Abstract: Flow-mediated outward remodeling (FMR) is involved in postischemic revascularization. Angiotensin II type 2 receptor (AT2R), through activation of T-cell-mediated IL-17 production, and estrogens are involved in FMR. Thus, we investigated the interplay ... ...

Abstract	Flow-mediated outward remodeling (FMR) is involved in postischemic revascularization. Angiotensin II type 2 receptor (AT2R), through activation of T-cell-mediated IL-17 production, and estrogens are involved in FMR. Thus, we investigated the interplay between estrogens and AT2R in FMR using a model of ligation of feed arteries supplying collateral pathways in mouse mesenteric arteries in vivo. Arteries were collected after 2 (inflammatory phase), 4 (diameter expansion phase), and 7 days (remodeling completed). We used AT2R+/+ and AT2R-/- ovariectomized (OVX) female mice treated or not with 17-beta-estradiol (E2). Seven days after ligation, arterial diameter was larger in high flow (HF) compared to normal flow (NF) arteries. FMR was absent in OVX mice and restored by E2. AT2R gene expression was higher in HF than in NF arteries only in E2-treated OVX AT2R+/+ mice. CD11b and TNF alpha levels (inflammatory phase), MMP2 and TIMP1 (extracellular matrix digestion), and NOS3 (diameter expansion phase) expression levels were higher in HF than in NF arteries only in E2-treated AT2R+/+ mice, not in the other groups. Thus, E2 is necessary for AT2R-dependent diameter expansion, possibly through activation of T-cell AT2R, in arteries submitted chronically to high blood flow.
MeSH term(s)	Animals ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Estradiol/pharmacology ; Estrogen Replacement Therapy ; Female ; Gene Expression Regulation ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Mechanotransduction, Cellular ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/metabolism ; Mesenteric Arteries/physiopathology ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Ovariectomy ; Receptor, Angiotensin, Type 2/genetics ; Receptor, Angiotensin, Type 2/metabolism ; Regional Blood Flow ; Stress, Mechanical ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Vascular Remodeling/drug effects ; Mice
Chemical Substances	Agtr2 protein, mouse ; CD11b Antigen ; Itgam protein, mouse ; Receptor, Angiotensin, Type 2 ; Timp1 protein, mouse ; Tissue Inhibitor of Metalloproteinase-1 ; Tnf protein, mouse ; Tumor Necrosis Factor-alpha ; Estradiol (4TI98Z838E) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nos3 protein, mouse (EC 1.14.13.39) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Mmp2 protein, mouse (EC 3.4.24.24)
Language	English
Publishing date	2020-12-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1105259-4
ISSN	1423-0135 ; 1018-1172
ISSN (online)	1423-0135
ISSN	1018-1172
DOI	10.1159/000511799
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 513: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Adverse Events Induced by PD-1/PD-L1 Inhibitors: A Real-World Single-Centre Experience with a Management-Based Approach.

Grimaud, Fabien / Penaranda, Guillaume / Stavris, Chloé / Retornaz, Frédérique / Brunel, Véronique / Cailleres, Sylvie / Pegliasco, Hervé / Le Treut, Jacques / Grisoni, Vincent / Coquet, Emilie / Chiche, Laurent / Rognon, Amélie

Therapeutics and clinical risk management

2021 Volume 17, Page(s) 669–677

Abstract: Aim: To assess the efficacy and tolerance of programmed death-1 (PD-1) and PD-ligand 1 (PD-L1) inhibitors and the impact of a standardised management-based protocol in a real-world setting.: Patients and methods: Data from patients who had received ... ...

Abstract	Aim: To assess the efficacy and tolerance of programmed death-1 (PD-1) and PD-ligand 1 (PD-L1) inhibitors and the impact of a standardised management-based protocol in a real-world setting. Patients and methods: Data from patients who had received anti-PD-(L)1 were collected from our pharmacy database. Clinical response and toxicity were assessed using RECIST criteria and CTCAE version 5.0, respectively. Overall survival (OS) and progression-free survival (PFS) were estimated with the Kaplan-Meier method. Potential prognostic factors were identified using Cox's model. Results: A total of 196 patients and 201 lines of treatment were included (median age: 66 (range: 38-89) years). Types of cancer included non-small cell lung cancer (73%), transitional cell carcinoma (10%), renal cell carcinoma (6%), small cell lung cancer (5%), head and neck squamous cell carcinoma (4%) and classical Hodgkin's lymphoma (1%). Twenty-five (12%) patients had pre-existing autoimmune conditions. Our standardised management-based protocol included 129 (64%) patients. Objective response rate was 29%, median OS was 10 months (IQR: 7-15) and median PFS was 5 months (IQR: 1-22). Patients with an abnormal baseline complete blood count had a worse OS (HR=2.48 [95% CI: 1.24-4.96]; p=0.0103). Thirty-three (16%) patients experienced severe (grade 3 or 4) immune-related adverse event (irAE). There were three (1%) irAE-related deaths. AEs resolved faster when patients were assessed by an internist before anti-PD-(L)1 initiation (p=0.0205). Conclusion: PD-1 and PD-L1 inhibitors are effective and safe in a real-world setting. Implementation of a standardised management-based protocol with internal medicine specialists is an effective way to optimise irAE management.
Language	English
Publishing date	2021-06-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/TCRM.S308194
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito