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Article ; Online: Estrus cycle-dependent working memory effects of prefrontal cortex corticotropin-releasing factor neurotransmission.

Berridge, Craig W / Martin, Andrea J / Hupalo, Sofiya / Nicol, Shannon E

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2022 Volume 47, Issue 12, Page(s) 2016–2023

Abstract: The prefrontal cortex (PFC) supports a diversity of cognitive processes. Impairment in PFC-dependent cognition is associated with multiple psychiatric disorders, including those known to display sex differences. Our ability to treat this impairment is ... ...

Abstract	The prefrontal cortex (PFC) supports a diversity of cognitive processes. Impairment in PFC-dependent cognition is associated with multiple psychiatric disorders, including those known to display sex differences. Our ability to treat this impairment is limited, in part due to an incomplete understanding of the neural mechanisms that support PFC-dependent cognition. In previous studies in male rats, we demonstrated that corticotropin-releasing factor (CRF) receptors and neurons in caudal dorsomedial PFC (dmPFC) regulate PFC-dependent working memory. Subcortically, CRF can exert sex-specific actions, a subset of which are ovarian steroid dependent. To date, the cognitive actions of dmPFC CRF neurotransmission in females are unknown. To address this gap, the current studies examined the effects of chemogenetic and pharmacological manipulations of CRF receptors and neurons within the dmPFC of female rats tested in a spatial working memory task. Outside of proestrus, activation of both CRF receptors and neurons in the caudal, but not rostral, dmPFC impaired working memory. Meanwhile, blockade of CRF receptors in the caudal dmPFC or globally in the brain, improved working memory performance, similar to that seen in males. In contrast, these effects were not observed during proestrus. These observations demonstrate that while CRF neurotransmission in the PFC regulates working memory similarly in males and females, these actions are not observed in females when ovarian steroids are at peak levels.
MeSH term(s)	Animals ; Corticotropin-Releasing Hormone/metabolism ; Estrus ; Female ; Male ; Memory, Short-Term ; Prefrontal Cortex ; Rats ; Receptors, Corticotropin-Releasing Hormone/metabolism ; Synaptic Transmission
Chemical Substances	Receptors, Corticotropin-Releasing Hormone ; Corticotropin-Releasing Hormone (9015-71-8)
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-022-01349-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2379: Show issues

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Article: Becoming female: Ovarian differentiation from an evolutionary perspective.

Nicol, Barbara / Estermann, Martin A / Yao, Humphrey H-C / Mellouk, Namya

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 944776

Abstract: Differentiation of the bipotential gonadal primordium into ovaries and testes is a common process among vertebrate species. While vertebrate ovaries eventually share the same functions of producing oocytes and estrogens, ovarian differentiation relies on ...

Abstract	Differentiation of the bipotential gonadal primordium into ovaries and testes is a common process among vertebrate species. While vertebrate ovaries eventually share the same functions of producing oocytes and estrogens, ovarian differentiation relies on different morphogenetic, cellular, and molecular cues depending on species. The aim of this review is to highlight the conserved and divergent features of ovarian differentiation through an evolutionary perspective. From teleosts to mammals, each clade or species has a different story to tell. For this purpose, this review focuses on three specific aspects of ovarian differentiation: ovarian morphogenesis, the evolution of the role of estrogens on ovarian differentiation and the molecular pathways involved in granulosa cell determination and maintenance.
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.944776
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Article ; Online: Amylose AL, du diagnostic au traitement.

Villesuzanne, Camille / Jaccard, Arnaud / Nicol, Martin

La Revue du praticien

2021 Volume 70, Issue 10, Page(s) 1137–1141

Abstract: Al amyloidosis, from diagnosis to treatment. AL amyloidosis is a rare hemopathy characterized by immunoglobulin light chains deposits in almost all organs causing organ failure. The main issue is the early diagnosis, which must be made in front of an ... ...

Title translation	AL amyloidosis, from diagnosis to treatment.
Abstract	Al amyloidosis, from diagnosis to treatment. AL amyloidosis is a rare hemopathy characterized by immunoglobulin light chains deposits in almost all organs causing organ failure. The main issue is the early diagnosis, which must be made in front of an unexplained non-specific symptomatology, especially cardiac or renal, in frequently elderly patients with monoclonal gammopathy. Non-invasive biopsies should be made for histological confirmation revealing positive congo red and birefringent yellow-green deposits in polarized light specific for amyloidosis. Severity is assessed by biological markers of cardiac involvement. The treatment consists in eliminating the plasma or lympho-plasma cell dyscrasia secreting the amyloidogenic light chain, and in proposing supportive care specific to this pathology.
MeSH term(s)	Aged ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Humans ; Immunoglobulin Light Chains ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/therapy ; Kidney ; Paraproteinemias/diagnosis ; Paraproteinemias/therapy
Chemical Substances	Immunoglobulin Light Chains
Language	French
Publishing date	2021-03-19
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Ua VI Zs.433: Show issues

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Article ; Online: Timing and predictors of definite stent thrombosis in comatose survivors of out-of-hospital cardiac arrest undergoing percutaneous coronary intervention and therapeutic hypothermia (ST-OHCA study).

Rauber, Martin / Nicol, Philipp / Sabic, Emina / Joner, Michael / Noc, Marko

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2022 Volume 18, Issue 9, Page(s) 740–748

Abstract: Background: Incidence of stent thrombosis (ST) in comatose survivors of out-of-hospital cardiac arrest (OHCA) undergoing immediate percutaneous coronary intervention (PCI) and therapeutic hypothermia (TH) varies considerably, from 2.7% to 31.2%, in ... ...

Abstract	Background: Incidence of stent thrombosis (ST) in comatose survivors of out-of-hospital cardiac arrest (OHCA) undergoing immediate percutaneous coronary intervention (PCI) and therapeutic hypothermia (TH) varies considerably, from 2.7% to 31.2%, in retrospective studies. Aims: We aimed to investigate occurrence, timing and predictors of definite ST. Methods: We prospectively investigated consecutive comatose survivors of OHCA with presumed cardiac aetiology undergoing immediate PCI with drug-eluting stents (DES) and TH targeted at 32-34°C admitted between August 2016 and July 2021. Repeat coronary angiography (CAG) was performed if ST was suspected and systematically between day 8-12 in the absence of clinical signs. All deceased patients underwent autopsy and histopathological analysis. Results: Among 362 comatose survivors of OHCA, immediate PCI with stenting was performed in 169 patients (47%). Since 18 patients did not complete follow-up, 151 patients were ultimately enrolled in ST analysis. Definite ST was confirmed in 29 patients (19.2%; 95% confidence interval [CI]: 12.9%-25.6%) either by CAG (n=18) or autopsy (n=11). ST occurred within 3 days in 62% and presented with at least one clinical sign in 79%. Survival with good neurological recovery was observed in 17% of patients with ST and in 60% of patients without ST (p<0.001). Independent predictors of ST were longer prehospital resuscitation, lower arterial pH and increased creatinine on admission. Conclusions: The incidence of definite ST in comatose survivors of OHCA undergoing immediate PCI and TH targeted at 32-34°C is substantial (19.2%) and significantly higher than in other PCI subsets despite systematic use of contemporary DES and anticoagulation/antiplatelet treatment.
MeSH term(s)	Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Percutaneous Coronary Intervention/adverse effects ; Coma/etiology ; Retrospective Studies ; Creatinine ; Hypothermia, Induced/adverse effects ; Stents/adverse effects ; Thrombosis/therapy ; Anticoagulants ; Survivors
Chemical Substances	Creatinine (AYI8EX34EU) ; Anticoagulants
Language	English
Publishing date	2022-07-22
Publishing country	France
Document type	Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJ-D-22-00336
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Zs.A 6680: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 571: Show issues

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Article ; Online: The European Association of Preventive Cardiology Aviation and Occupational Cardiology Task Force.

Nicol, Edward D / Holdsworth, David A / Halle, Martin / Davos, Constantinos H

European heart journal

2021 Volume 42, Issue 21, Page(s) 2030–2033

MeSH term(s)	Advisory Committees ; Aviation ; Cardiology ; Europe ; Humans ; Societies, Medical
Language	English
Publishing date	2021-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehab205
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Book: Gottesklang und Fingersatz

Nicol, Martin

Beethovens Klaviersonaten als religiöses Erlebnis

(Veröffentlichungen des Beethoven-Hauses, Bonn - Für Kenner und Liebhaber)

2015

Author's details	Martin Nicol
Series title	Veröffentlichungen des Beethoven-Hauses, Bonn - Für Kenner und Liebhaber
Keywords	Rezeption ; Religiosität ; Klaviersonate
Language	German
Size	VIII, 308 S., Ill., Noten, 24 cm
Publisher	Verl. Beethoven-Haus
Publishing place	Bonn
Document type	Book
ISBN	9783881881371 ; 3881881379
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Energy Resolved Mass Spectrometry for Interoperable Non-resonant Collisional Spectra in Metabolomics.

Hueber, Amandine / Kulyk, Hanna / Damont, Annelaure / Nicol, Edith / Alves, Sandra / Liuu, Sophie / Green, Martin / Bertrand-Michel, Justine / Cenac, Nicolas / Fenaille, François / Tabet, Jean-Claude

Journal of the American Society for Mass Spectrometry

2024 Volume 35, Issue 5, Page(s) 834–838

Abstract: In untargeted metabolomics, the unambiguous identification of metabolites remains a major challenge. This requires high-quality spectral libraries for reliable metabolite identification, which is essential for translating metabolomics data into ... ...

Abstract	In untargeted metabolomics, the unambiguous identification of metabolites remains a major challenge. This requires high-quality spectral libraries for reliable metabolite identification, which is essential for translating metabolomics data into meaningful biological information. Several attempts have been made to generate reproducible product ion spectra (PIS) under a low collision energy (
MeSH term(s)	Metabolomics/methods ; Mass Spectrometry/methods ; Amino Acids/analysis ; Amino Acids/chemistry ; Amino Acids/metabolism
Chemical Substances	Amino Acids
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1021/jasms.3c00410
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Zs.A 4618: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 241: Show issues

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Article: Impact of Ambient Temperature Sample Storage on the Equine Fecal Microbiota.

Martin de Bustamante, Michelle / Plummer, Caryn / MacNicol, Jennifer / Gomez, Diego

Animals : an open access journal from MDPI

2021 Volume 11, Issue 3

Abstract: Sample storage conditions are an important factor in fecal microbiota analyses in general. The objective of this study was to investigate the effect of sample storage at room temperature on the equine fecal microbiota composition. Fecal samples were ... ...

Abstract	Sample storage conditions are an important factor in fecal microbiota analyses in general. The objective of this study was to investigate the effect of sample storage at room temperature on the equine fecal microbiota composition. Fecal samples were collected from 11 healthy horses. Each sample was divided into 7 sealed aliquots. One aliquot was immediately frozen at -80 °C; the remaining aliquots were stored at room temperature (21 to 22 °C) with one transferred to the freezer at each of the following time points: 6, 12, 24, 48, 72 and 96 h. The Illumina MiSeq sequencer was used for high-throughput sequencing of the V4 region of the 16S rRNA gene. Fibrobacteraceae (
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11030819
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Fecal Bacterial Microbiota in Horses with Equine Recurrent Uveitis.

Martin de Bustamante, Michelle / Gomez, Diego / MacNicol, Jennifer / Hamor, Ralph / Plummer, Caryn

Animals : an open access journal from MDPI

2021 Volume 11, Issue 3

Abstract: The objective of this study was to describe and compare the fecal bacterial microbiota of horses with equine recurrent uveitis (ERU) and healthy horses using next-generation sequencing techniques. Fecal samples were collected from 15 client-owned horses ... ...

Abstract	The objective of this study was to describe and compare the fecal bacterial microbiota of horses with equine recurrent uveitis (ERU) and healthy horses using next-generation sequencing techniques. Fecal samples were collected from 15 client-owned horses previously diagnosed with ERU on complete ophthalmic examination. For each fecal sample obtained from a horse with ERU, a sample was collected from an environmentally matched healthy control with no evidence of ocular disease. The Illumina MiSeq sequencer was used for high-throughput sequencing of the V4 region of the 16S rRNA gene. The relative abundance of predominant taxa, and alpha and beta diversity indices were calculated and compared between groups. The phyla Firmicutes, Bacteroidetes, Verrucomicrobia, and Proteobacteria predominated in both ERU and control horses, accounting for greater than 60% of sequences. Based on linear discriminant analysis effect size (LEfSe), no taxa were found to be enriched in either group. No significant differences were observed in alpha and beta diversity indices between groups (
Language	English
Publishing date	2021-03-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11030745
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Article ; Online: Bespoke Fuzzy Logic Design to Automate a Better Understanding of Running Gait Analysis.

Young, Fraser / Stuart, Samuel / McNicol, Robert / Morris, Rosie / Downs, Craig / Coleman, Martin / Godfrey, Alan

IEEE journal of biomedical and health informatics

2023 Volume 27, Issue 5, Page(s) 2178–2185

Abstract: Running gait assessment and running shoe recommendation is important for the injury prevention of runners who exhibit different skill-levels and running styles. Traditionally, running gait assessment for shoe recommendation relies upon a combination of ... ...

Abstract	Running gait assessment and running shoe recommendation is important for the injury prevention of runners who exhibit different skill-levels and running styles. Traditionally, running gait assessment for shoe recommendation relies upon a combination of trained professionals (e.g., sports-therapists, physiotherapists) and complex equipment such as motion or pressure sensors, often incurring a high-cost to the consumer. Despite this, assessments are still prone to subjectivity, and may differ between assessors. Alternatively, methods to provide low-cost, reproduceable gait assessment has become a necessity, especially within a habitual (low-resource) context, with many traditional methods generally unavailable due to the need of professional assistance and more recently the COVID-19 pandemic. Fuzzy logic has shown to be an effective tool in the assessment and identification of gait by providing the potential for a high-accuracy methodology, while retaining a low computational cost; ideal for applications within embedded systems. Here, we present a novel shoe recommendation fuzzy inference system from the classification of two key running gait parameters, foot strike and pronation from a single foot mounted internet of thing (IoT) enabled wearable inertial measurement unit. The fuzzy approach provides excellent (ICC > 0.9) accuracy, while significantly increasing the resolution of the gait assessment technique, providing a more detailed running gait analysis.
MeSH term(s)	Humans ; Gait Analysis ; Fuzzy Logic ; Pandemics ; COVID-19 ; Gait ; Running ; Shoes ; Biomechanical Phenomena
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2022.3189594
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Zs.A 5483: Show issues

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