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  1. Article ; Online: Human-important outcomes and evidence-based medicine during the coronavirus disease 2019 pandemic.

    Jaeschke, Roman / Douketis, James / Nowaczyk, Małgorzata / Guyatt, Gordon

    Polish archives of internal medicine

    2020  Volume 130, Issue 7-8, Page(s) 714–715

    MeSH term(s) Attitude of Health Personnel ; COVID-19 ; Coronavirus Infections/psychology ; Empathy ; Evidence-Based Medicine ; Humans ; Pandemics ; Physician-Patient Relations ; Pneumonia, Viral/psychology ; Professional-Family Relations
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country Poland
    Document type Letter
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.15514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
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  2. Article: Neurological Manifestations of Non-Severe COVID-19-A Multidirectional Approach.

    Udzik, Jakub / Kowalczyk, Anna / Waszczyk, Aleksandra / Nowaczyk, Zuzanna / Barczyszyn, Andrzej / Działa, Karolina / Mularczyk, Maciej / Niekrasz, Małgorzata

    Brain sciences

    2023  Volume 13, Issue 2

    Abstract: COVID-19 remains a significant clinical issue worldwide, with frequent neurological manifestations. In this study, the authors combine data obtained from the patient's medical history, physical examinations, and additional test results in the pursuit of ... ...

    Abstract COVID-19 remains a significant clinical issue worldwide, with frequent neurological manifestations. In this study, the authors combine data obtained from the patient's medical history, physical examinations, and additional test results in the pursuit of any clinically relevant connections. Fifty-eight adult patients hospitalized in the Department of Neurology and Infectiology over a five-months period were retrospectively enrolled in this study. On admission, all patients included in this study were classified as mild or moderate COVID-19 cases, according to the World Health Organization (WHO) guidelines. Laboratory tests, Electroencephalography (EEG), and Magnetic Resonance Imaging (MRI) were performed. There was no statistically significant difference in the Neutrophil-Lymphocyte Ratio (NLR), C-reactive protein (CRP), and Interleukin 6 (IL-6) in patients who reported to the hospital within a week from the symptoms' onset and in those who reported later. In total, 49.06% of patients with eligible EEG recordings presented abnormal brain activity, while 27.59% of the study population had COVID-19-associated MRI findings. EEG and MRI abnormality occurrence did not correlate with the incidence of mild neurological symptoms (headache, olfactory, and gustatory disorders) of the SARS-CoV-2 infection. In three patients in this study population, unprovoked generalized epileptic seizures occurred for the first time in their life. Non-severe SARS-CoV-2 infection causes functional and structural abnormalities within the central nervous system. Brain microhemorrhages are frequently present in non-severe COVID-19 patients. There is no significant association between mild neurological symptoms of COVID-19 and additional test abnormalities. The time from SARS-CoV-2 infection's onset to hospital admission does not seem to influence the prognostic value of CRP, IL-6, and NLR in non-severe COVID-19. Mild-to-moderate SARS-CoV-2 infection can be a trigger factor for epilepsy and epileptic seizures.
    Language English
    Publishing date 2023-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13020355
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  3. Article ; Online: Narrative medicine in clinical genetics practice.

    Nowaczyk, Małgorzata J M

    American journal of medical genetics. Part A

    2012  Volume 158A, Issue 8, Page(s) 1941–1947

    Abstract: Over the last 30 years medicine has undergone a significant paradigm shift. Due to the tremendous advances of modern medicine more and more people are living longer with their illnesses. These people have stories to tell, and they want these stories to ... ...

    Abstract Over the last 30 years medicine has undergone a significant paradigm shift. Due to the tremendous advances of modern medicine more and more people are living longer with their illnesses. These people have stories to tell, and they want these stories to be heard: They are reclaiming their voices. As clinical geneticists we need to hear what these voices are telling us, especially so in our area of clinical care where cures are rare, and disease states can be permanent. Narrative medicine is an important new skill set that hones abilities to do just that.This article highlights how integral narrative medicine is to clinical genetics practice, how geneticists already employ many of its tools and how they practice it diligently every day. I will show how geneticists can further improve their abilities to hear and honor patients' stories by writing and sharing stories with patients and with each other as doctors, counselors, and nurses, social workers and chaplains. The review presents the skills of close reading and how they improve patient care and illustrates how geneticists can, by using reflective writing, reshape their emotions in order to understand them, to let them go, and to make room for more. It presents the major types of illness narratives whose recognition allows us to hear and understand patients' stories. When used, the tools of narrative medicine can result in better patient care.
    MeSH term(s) Genetics, Medical ; Humans ; Narration
    Language English
    Publishing date 2012-06-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.35482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ectomorphic body habitus, microcephaly, developmental delay with characteristic facial phenotype: a new entity?

    Nowaczyk, Małgorzata J M

    Clinical dysmorphology

    2011  Volume 20, Issue 4, Page(s) 200–204

    MeSH term(s) Adolescent ; Child ; Developmental Disabilities/diagnosis ; Face/abnormalities ; Facies ; Humans ; Karyotype ; Male ; Microcephaly/diagnosis ; Phenotype ; Somatotypes
    Language English
    Publishing date 2011-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1121482-x
    ISSN 1473-5717 ; 0962-8827
    ISSN (online) 1473-5717
    ISSN 0962-8827
    DOI 10.1097/MCD.0b013e328349bdb3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Epiphyseal stippling is not a feature of 7-dehydrocholesterol reductase deficiency (Smith-Lemli-Opitz syndrome).

    Nowaczyk, Małgorzata J M

    American journal of medical genetics. Part A

    2011  Volume 155A, Issue 4, Page(s) 940–941

    MeSH term(s) Chondrodysplasia Punctata/congenital ; Humans ; Smith-Lemli-Opitz Syndrome/diagnosis ; Smith-Lemli-Opitz Syndrome/pathology
    Language English
    Publishing date 2011-03-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.33937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The blemmy: A medieval grotesque inspired by iniencephaly?

    Nowaczyk, Małgorzata J M

    American journal of medical genetics. Part A

    2010  Volume 152A, Issue 6, Page(s) 1583–1585

    MeSH term(s) Female ; History, Medieval ; Humans ; Medical Illustration ; Neural Tube Defects/history
    Language English
    Publishing date 2010-05-26
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 1493479-6
    ISSN 1552-4833 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 1552-4825
    DOI 10.1002/ajmg.a.33399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evidence-based medicine and COVID-19: human important outcome measures. Making decisions under conditions of uncertainty

    Jaeschke, Roman / Douketis, James / Nowaczyk, Malgorzata / Guyatt, Gordon

    Polish Archives of Internal Medicine

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #656253
    Database COVID19

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  8. Article: The Role of the N-Terminal Domains of Bacterial Initiator DnaA in the Assembly and Regulation of the Bacterial Replication Initiation Complex.

    Zawilak-Pawlik, Anna / Nowaczyk, Małgorzata / Zakrzewska-Czerwińska, Jolanta

    Genes

    2017  Volume 8, Issue 5

    Abstract: The primary role of the bacterial protein DnaA is to initiate chromosomal replication. The DnaA protein binds to DNA at the origin of chromosomal replication ( ...

    Abstract The primary role of the bacterial protein DnaA is to initiate chromosomal replication. The DnaA protein binds to DNA at the origin of chromosomal replication (
    Language English
    Publishing date 2017-05-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes8050136
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  9. Article ; Online: Smith-Lemli-Opitz syndrome and other disorders of cholesterol biosynthesis: An introduction.

    Nowaczyk, Małgorzata J M / Cunniff, Christopher

    American journal of medical genetics. Part C, Seminars in medical genetics

    2012  Volume 160C, Issue 4, Page(s) 239–241

    Abstract: This issue of Seminars of Medical Genetics features a series of articles on Smith-Lemli-Opitz syndrome and other disorders of endogenous cholesterol synthesis. Clinically, many of these disorders have been known for decades, but only in the last 20 years ...

    Abstract This issue of Seminars of Medical Genetics features a series of articles on Smith-Lemli-Opitz syndrome and other disorders of endogenous cholesterol synthesis. Clinically, many of these disorders have been known for decades, but only in the last 20 years have the molecular genetic and enzymatic defects underlying these disorders been delineated. As a group, disorders of cholesterol synthesis are relatively common and contribute significantly to the burden of human disease. Leading experts in their fields present clinical, behavioral, molecular, and therapeutic aspects of these disorders.
    MeSH term(s) Cholesterol/metabolism ; Humans ; Smith-Lemli-Opitz Syndrome/genetics ; Smith-Lemli-Opitz Syndrome/physiopathology ; Smith-Lemli-Opitz Syndrome/therapy
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2012-11-15
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 2108622-9
    ISSN 1552-4876 ; 0148-7299 ; 1552-4868
    ISSN (online) 1552-4876
    ISSN 0148-7299 ; 1552-4868
    DOI 10.1002/ajmg.c.31344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1376/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: The effect of cranberry juice and a cranberry functional beverage on the growth and metabolic activity of selected oral bacteria.

    Nowaczyk, Paulina M / Bajerska, Joanna / Lasik-Kurdyś, Małgorzata / Radziejewska-Kubzdela, Elżbieta / Szwengiel, Artur / Woźniewicz, Małgorzata

    BMC oral health

    2021  Volume 21, Issue 1, Page(s) 660

    Abstract: Background: The oral microbiota is a significant risk indicator for oral diseases, such as dental caries and periodontal inflammation. Much attention is presently paid to the development of functional foods (e.g. beverages containing cranberry ... ...

    Abstract Background: The oral microbiota is a significant risk indicator for oral diseases, such as dental caries and periodontal inflammation. Much attention is presently paid to the development of functional foods (e.g. beverages containing cranberry constituents, or foods containing probiotics) that may serve as adjuncts for oral disease treatments (e.g. periodontitis and caries). Cranberry fruit, due to its unique chemical composition and antimicrobial potential, is a possible ingredient of such foods. The study aimed to investigate the effects of cranberry juice (CJ) and a cranberry functional beverage (mixture of 80% v/v apple juice, 20% v/v cranberry juice, and 0.25 g/100 mL ground cinnamon; CFB) on the growth and metabolic activity of selected oral bacteria.
    Methods: Serial dilution pour plate method (SDPP) was used to examine the effect of CJ and CFB on the growth of Actinomyces naeslundii, Streptococcus mutans, and Lactobacillus paracasei subsp. paracasei. 48-h electrical impedance measurements (EIM) during the cultivation of A. naeslundii were applied to evaluate the utility of the method as a rapid alternative for the assessment of the antimicrobial potential of cranberry beverages.
    Results: The tested bacteria differed in their susceptibility to the antimicrobial action of CJ and CFB, with L. paracasei subsp. paracasei being least vulnerable to CFB (according to SDPP). Although CJ at a concentration of 0.5 mL/mL, showed a bactericidal effect on the growth of S. mutans, A. naeslundii was more sensitive to CJ (SDPP). Its inhibitory effect on A. naeslundii was seen even at concentrations as small as 0.03125-0.125 mL/mL (SDPP and EIM). On the other hand, S. mutans seemed to be more vulnerable to CFB than A. naeslundii (SDPP).
    Conclusions: CFB may be considered an adjunct in the treatment of oral diseases due to its action against selected oral pathogens, and not against the presumably beneficial L. paracasei subsp. paracasei. Bioelectrical impedance measurements appear to be a quick alternative to evaluating the antimicrobial activity of fruit beverages, but their utility should be confirmed with tests on other bacteria.
    MeSH term(s) Beverages ; Dental Caries/prevention & control ; Fruit ; Humans ; Microbiota ; Streptococcus mutans ; Vaccinium macrocarpon
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-021-02025-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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