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  1. Article: Mechanical Study of Jian-Gan-Xiao-Zhi Decoction on Nonalcoholic Fatty Liver Disease Based on Integrated Network Pharmacology and Untargeted Metabolomics.

    Cao, Yong-Jun / Li, Han-Zhou / Zhao, Jie / Sun, Yu-Meng / Jin, Xiao-Wen / Lv, Shu-Quan / Luo, Jun-Yu / Fang, Xi-Xing / Wen, Wei-Bo / Liao, Jia-Bao

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 2264394

    Abstract: Jian-Gan-Xiao-Zhi decoction (JGXZ) has demonstrated beneficial effects on nonalcoholic fatty liver ...

    Abstract Jian-Gan-Xiao-Zhi decoction (JGXZ) has demonstrated beneficial effects on nonalcoholic fatty liver disease (NAFLD). However, the mechanisms by which JGXZ improve NAFLD are still unclear.
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/2264394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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  2. Article ; Online: Jian-Gan-Xiao-Zhi decoction ameliorates high-fat high-carbohydrate diet-induced non-alcoholic fatty liver disease and insulin resistance by regulating the AMPK/JNK pathway

    Xue-Hua Xie / Jia-Bao Liao / Fang Fang / Jie Zhao / Yong-Jun Cao / Huan-Tian Cui / Hong-Wu Wang / Zhai-Yi Zhang / Zhao-Hui Sun / Yuan Yin / Wei-Bo Wen

    Traditional Medicine Research, Vol 6, Iss 1, Pp 4-

    2021  Volume 4

    Abstract: ... diabetes. Our previous studies have demonstrated that Jian-Gan-Xiao-Zhi decoction (JGXZ) could be effective ...

    Abstract Background: Non-alcoholic fatty liver disease (NAFLD) can cause insulin resistance (IR) and diabetes. Our previous studies have demonstrated that Jian-Gan-Xiao-Zhi decoction (JGXZ) could be effective for the treatment of NAFLD and IR. However, the possible mechanism underlying the effects of JGXZ on NAFLD and IR remains unknown. Methods: Fifty rats received a high-fat high-carbohydrate (HFHC) diet for 12 weeks to induce NAFLD. After 4 weeks of HFHC treatment, rats were orally treated with JGXZ (8, 16, and 32 g/kg weight) for 8 weeks. Ten rats in the control group received standard chow. In the positive control group, rats were orally treated with metformin (90 mg/kg weight) for 8 weeks. After JGXZ and metformin treatment, H&E staining was conducted on rat livers and serum biochemical markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), and total cholesterol (TC), were measured using test kits. Moreover, a fasting blood glucose test and an oral glucose tolerance test (OGTT) were conducted. Serum levels of insulin were determined using ELISA kit, and the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. The levels of total insulin receptor substrate-1 (IRS1), AMP-activated protein kinase-α (AMPKα) and c-Jun N-terminal kinase (JNK) as well as the levels of phosphorylation of IRS1 (p-IRS1), phosphorylation of AMPK (p-AMPK) and phosphorylation of JNK (p-JNK) were measured using western blotting. Results: The body weights in JGXZ low-, middle-, and high-dose groups were lower than those in the model group (P < 0.05, P < 0.01, P < 0.01, respectively). The serum levels of AST (P < 0.05 in JGXZ middle- and high-dose groups), ALT (P < 0.01 in JGXZ middle-dose group and P < 0.05 in JGXZ high-dose group), TG (P < 0.01 in JGXZ middle- and high-dose groups), and TC (P < 0.01) upon JGXZ treatment were lower those than in NAFLD model rats. H&E staining showed that JGXZ treatment reduced steatosis of the hepatocytes in NAFLD model rats. JGXZ decreased the levels of fasting blood glucose (P < 0.01), HOMA-IR (P < 0.01), AUC (area under the curve) of the OGTT (P < 0.05) and p-IRS1 (P < 0.01 in JGXZ middle- and high-dose groups, P < 0.05 in JGXZ low-dose groups). Moreover, JGXZ regulated the hepatic AMPKα/JNK pathway in NAFLD model rats, which reflected the induction of p-AMPKα and inhibition of p-JNK. Conclusion: This study showed that JGXZ improved liver function and reduced steatosis of the hepatocytes in NAFLD model rats. Moreover, JGXZ improved IR in NAFLD model rats. The possible mechanism underlying the effects of JGXZ on NAFLD and IR involves the modulation of the AMPK/JNK pathway.
    Keywords jian-gan-xiao-zhi decoction ; non-alcoholic fatty liver disease ; insulin resistance ; ampk/jnk pathway ; Medicine ; R ; Miscellaneous systems and treatments ; RZ409.7-999
    Subject code 630
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hong Kong Gold Orchid Science and Technology Co., Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Natural Products in Liver Fibrosis Management: A Five-year Review.

    Wang, Tao / Lu, Zhuo / Sun, Gui-Feng / He, Kai-Yi / Chen, Zhi-Ping / Qu, Xin-Hui / Han, Xiao-Jian

    Current medicinal chemistry

    2024  

    Abstract: Liver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for ... ...

    Abstract Liver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance disease prediction, and improve our understanding of the interaction between various underlying conditions and the liver. Notably, natural products used in traditional medicine systems worldwide and demonstrating diverse biochemical and pharmacological activities are increasingly recognized for their potential in treating liver fibrosis. This review aims to comprehensively understand liver fibrosis, emphasizing the molecular mechanisms and advancements in exploring natural products' antifibrotic potential over the past five years. It also acknowledges the challenges in their development and seeks to underscore their potency in enhancing patient prognosis and reducing the global burden of liver disease.
    Language English
    Publishing date 2024-02-14
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673288458240203064112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
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  4. Article ; Online: Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion.

    Zhang, Kun / Wang, Tao / Sun, Gui-Feng / Xiao, Jin-Xing / Jiang, Li-Ping / Tou, Fang-Fang / Qu, Xin-Hui / Han, Xiao-Jian

    Free radical biology & medicine

    2023  Volume 205, Page(s) 47–61

    Abstract: Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin is a biguanide drug that exerts strong effects on multiple diseases. This ...

    Abstract Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin is a biguanide drug that exerts strong effects on multiple diseases. This study aims to evaluate the protective effect of metformin against retinal I/R injury and its underlying mechanism. I/R induced reduction in retina thickness and cell number in ganglion cell layer, and metformin alleviated I/R-induced retinal injury. Both retinal I/R and simulated ischemia/reperfusion (SIR) in R28 cells down-regulated expression of mitochondrial fusion protein Mfn2 and OPA1, which led to mitochondrial fission. Metformin also alleviated damage in R28 cells, and reversed the alteration in Mfn2 and OPA1, mitochondrial fission and mitochondrial membrane potential (MMP) disruption-induced by I/R or SIR as well. Intriguingly, inhibition of AMPK by compound C or siRNA prevented metformin-mediated up-regulation of Mfn2 and OPA1. Compound C and knockdown of Mfn2 or OPA1 dramatically alleviated the protective effect of metformin against intracellular ROS generation, MMP disruption, mitochondrial fission and loss of RGCs in ganglion cell layer induced by SIR or I/R. Moreover, scavenging mitochondrial ROS (mito-ROS) by mito-TEMPO exerted the similar protection against I/R-induced retinal injury or SIR-induced damage in R28 cells as metformin. Our data show for the first time that metformin protects against retinal I/R injury through AMPK-mediated mitochondrial fusion and the decreased mito-ROS generation. These findings might also repurpose metformin as a therapeutic agent for retinal I/R injury.
    MeSH term(s) Humans ; Metformin/pharmacology ; AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Mitochondrial Dynamics ; Reactive Oxygen Species/metabolism ; Retina/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Apoptosis
    Chemical Substances Metformin (9100L32L2N) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Reactive Oxygen Species
    Language English
    Publishing date 2023-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2023.05.019
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    Zs.A 2109: Show issues Location:
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  5. Article: Editorial: Immune modulation in tumor microenvironment: New perspectives for cancer immunotherapy.

    Deng, Zimu / Sun, Xuejun / Cao, Jian / Xiao, Qian

    Frontiers in cell and developmental biology

    2023  Volume 10, Page(s) 1103705

    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1103705
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  6. Article: Response surface optimization of light conditions for organic matter accumulation in two different shapes of

    Jian-Fei, Sun / Meng-Hui, Shang / Xiao-Nan, Zang

    Frontiers in nutrition

    2023  Volume 9, Page(s) 1047685

    Abstract: Arthrospira ... ...

    Abstract Arthrospira platensis
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.1047685
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  7. Article ; Online: Neutrophil-Lymphocyte Ratio Can be Used as a Predictor of Prognosis in Patients With Heart Failure.

    Ren, Jian / Wang, Xiao-Yuan / Sun, Ying

    Angiology

    2023  , Page(s) 33197231201927

    Language English
    Publishing date 2023-09-10
    Publishing country United States
    Document type Letter
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231201927
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  8. Article: The efficacy and safety of

    He, Xiao-Jian / Wang, Xiao-Ling / Sun, Dong-Jie / Huang, Xiao-Yan / Liu, Gang / Li, Da-Zhou / Lin, Hai-Lan / Zeng, Xiang-Peng / Li, Dong-Liang / Wang, Wen

    Therapeutic advances in gastroenterology

    2023  Volume 16, Page(s) 17562848221147763

    Abstract: Background: We previously reported that antofloxacin-based bismuth quadruple therapy was safe and effective for : Objective: To investigate the effect of adding : Design: Single-center, prospective randomized controlled study.: Methods: A total ...

    Abstract Background: We previously reported that antofloxacin-based bismuth quadruple therapy was safe and effective for
    Objective: To investigate the effect of adding
    Design: Single-center, prospective randomized controlled study.
    Methods: A total of 172 patients with
    Results: There were no statistically significant differences in the eradication rates of
    Conclusion: Although the addition of
    Trial registration number: ChiCTR2200056931.
    Language English
    Publishing date 2023-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848221147763
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  9. Article ; Online: Treating leukemia: differentiation therapy for mIDH2 AML.

    Sun, Xiao-Jian / Chen, Sai-Juan / Chen, Zhu

    Cell research

    2019  Volume 29, Issue 6, Page(s) 427–428

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute
    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-019-0173-4
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    Zs.A 5283: Show issues Location:
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  10. Article ; Online: Digital twin-driven dynamic monitoring system of the upper limb force.

    Guo, Yanbin / Liu, Yingbin / Sun, Wenxuan / Yu, Shuai / Han, Xiao-Jian / Qu, Xin-Hui / Wang, Guoping

    Computer methods in biomechanics and biomedical engineering

    2023  , Page(s) 1–13

    Abstract: Digital twin represents the core technology to realize the dynamic monitoring of complex industrial systems. However, the human body, as the most complex system in the physical world, digital twin is rarely applied in it. In this study, we successfully ... ...

    Abstract Digital twin represents the core technology to realize the dynamic monitoring of complex industrial systems. However, the human body, as the most complex system in the physical world, digital twin is rarely applied in it. In this study, we successfully demonstrated a digital twin in the human biomedical application by proposing a dynamic monitoring system of the upper limb force. In this system, the real upper limb drives the motion of the virtual one in real-time and dynamically updates the force. Meanwhile, the virtual upper limb feeds back the monitoring-results of the force to the controller of the real upper limb
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071764-7
    ISSN 1476-8259 ; 1025-5842
    ISSN (online) 1476-8259
    ISSN 1025-5842
    DOI 10.1080/10255842.2023.2254881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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