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Article ; Online: Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19.

Chang, Aiquan / Yu, Jingyou

2022 Volume 14, Issue 2

Abstract: The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, ... ...

Abstract	The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, morbidity, and mortality. Several highly efficacious vaccines are actively being deployed around the globe to expedite mass vaccination and control of COVID-19. Notably, viral vectored vaccines (VVVs) are among the first to be approved for global distribution and use. In this review, we examine the humoral, cellular, and innate immune responses elicited by viral vectors, and the immune correlates of protection against COVID-19 in preclinical and clinical studies. We also discuss the durability and breadth of immune response induced by VVVs and boosters. Finally, we present challenges associated with VVVs and offer solutions for overcoming certain limitations of current vaccine regimens. Collectively, this review provides the rationale for expanding the portfolio of VVVs against SARS-CoV-2.
MeSH term(s)	Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Clinical Trials as Topic ; Disease Models, Animal ; Genetic Vectors/immunology ; Immunity, Cellular ; Immunity, Humoral ; Immunity, Innate ; Immunization, Secondary ; Immunogenicity, Vaccine ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Vaccination ; Viral Vaccines/classification ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines
Language	English
Publishing date	2022-02-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14020380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19

Chang, Aiquan / Yu, Jingyou

Viruses. 2022 Feb. 12, v. 14, no. 2

2022

Abstract	The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, morbidity, and mortality. Several highly efficacious vaccines are actively being deployed around the globe to expedite mass vaccination and control of COVID-19. Notably, viral vectored vaccines (VVVs) are among the first to be approved for global distribution and use. In this review, we examine the humoral, cellular, and innate immune responses elicited by viral vectors, and the immune correlates of protection against COVID-19 in preclinical and clinical studies. We also discuss the durability and breadth of immune response induced by VVVs and boosters. Finally, we present challenges associated with VVVs and offer solutions for overcoming certain limitations of current vaccine regimens. Collectively, this review provides the rationale for expanding the portfolio of VVVs against SARS-CoV-2.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; durability ; geographical distribution ; immune response ; immunogenicity ; morbidity ; mortality ; pandemic ; vaccination ; vaccines
Language	English
Dates of publication	2022-0212
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14020380
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Omicron breakthrough infected individuals show enhanced nasal antibody responses and preserved T cell responses against the EG.5.1 and BA.2.86.

Zhu, Zheng / Li, Shixiong / Fan, Junhao / Shang, Shihao / Zhang, Yao / Zi, Qiong / Zheng, Jihao / Wang, Dongfang / Mou, Xiaoli / Liu, Kepu / Lv, Maoxin / Yuan, Jianlin / Wang, Zhongfang / Yu, Jingyou

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29537

MeSH term(s)	Humans ; Antibody Formation ; T-Lymphocytes
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29537
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emerging Role of LY6E in Virus-Host Interactions.

Yu, Jingyou / Liu, Shan-Lu

Viruses

2019 Volume 11, Issue 11

Abstract: As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging ... ...

Abstract	As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in the modulation of viral infection. Consequently, viral infection and associated pathogenesis have been associated with altered LY6E gene expression. The interaction between viruses and the host immune system has offered insights into the biology of LY6E. In this review, we summarize the current knowledge of LY6E in the context of viral infection, particularly viral entry.
MeSH term(s)	Animals ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Antigens, Surface/physiology ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; GPI-Linked Proteins/physiology ; Host-Pathogen Interactions ; Humans ; Receptors, Cell Surface/metabolism ; Species Specificity ; Virus Diseases/metabolism ; Virus Diseases/virology ; Virus Internalization ; Virus Physiological Phenomena ; Viruses/classification ; Viruses/metabolism
Chemical Substances	Antigens, Surface ; GPI-Linked Proteins ; LY6E protein, human ; Receptors, Cell Surface
Language	English
Publishing date	2019-11-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v11111020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Emerging Role of LY6E in Virus–Host Interactions

Yu, Jingyou / Liu, Shan-Lu

Viruses. 2019 Nov. 03, v. 11, no. 11

2019

Abstract	As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in the modulation of viral infection. Consequently, viral infection and associated pathogenesis have been associated with altered LY6E gene expression. The interaction between viruses and the host immune system has offered insights into the biology of LY6E. In this review, we summarize the current knowledge of LY6E in the context of viral infection, particularly viral entry.
Keywords	T-lymphocytes ; antigens ; carcinogenesis ; cell physiology ; gene expression ; host-pathogen relationships ; loci ; u-plasminogen activator ; viruses
Language	English
Dates of publication	2019-1103
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v11111020
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Muscle-inspired soft robots based on bilateral dielectric elastomer actuators.

Yang, Yale / Li, Dengfeng / Sun, Yanhua / Wu, Mengge / Su, Jingyou / Li, Ying / Yu, Xinge / Li, Lu / Yu, Junsheng

Microsystems & nanoengineering

2023 Volume 9, Page(s) 124

Abstract: Muscle groups perform their functions in the human body via bilateral muscle actuation, which brings bionic inspiration to artificial robot design. Building soft robotic systems with artificial muscles and multiple control dimensions could be an ... ...

Abstract	Muscle groups perform their functions in the human body via bilateral muscle actuation, which brings bionic inspiration to artificial robot design. Building soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft robots. Here, we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft robots. To construct this bilateral actuator, a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle, and polymer films manufactured with specific shapes served as the actuator frame. By end-to-end connecting these bilateral actuators, a gear-shaped 3D soft robot with diverse motion capabilities could be developed, benefiting from adjustable actuation combinations. Lying on the ground with all feet on the ground, a crawling soft robot with dexterous movement along multiple directions was realized. Moreover, the directional steering was instantaneous and efficient. With two feet standing on the ground, it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2° slope. Finally, inspired by the orbicularis oris muscle in the mouth, a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was demonstrated. The bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility, which provides a very valuable reference for the design of highly controllable soft robots.
Language	English
Publishing date	2023-10-07
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-023-00592-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Attenuated

Vidal, Samuel J / Sellers, Daniel / Yu, Jingyou / Wakabayashi, Shoko / Sixsmith, Jaimie / Aid, Malika / Barrett, Julia / Stevens, Sage F / Liu, Xiaowen / Li, Wenjun / Plumlee, Courtney R / Urdahl, Kevin B / Martinot, Amanda J / Barouch, Dan H

iScience

2023 Volume 26, Issue 6, Page(s) 106963

Abstract: Bacillus Calmette-Guérin (BCG) remains the only approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next-generation TB vaccines typically use a murine aerosol model with a supraphysiologic challenge dose. Here, we show ... ...

Abstract	Bacillus Calmette-Guérin (BCG) remains the only approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next-generation TB vaccines typically use a murine aerosol model with a supraphysiologic challenge dose. Here, we show that the protective efficacy of a live attenuated
Language	English
Publishing date	2023-05-28
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106963
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Approaches and Challenges in SARS-CoV-2 Vaccine Development

Dagotto, Gabriel / Yu, Jingyou / Barouch, Dan H.

Cell Host & Microbe

2020 Volume 28, Issue 3, Page(s) 364–370

Keywords	Microbiology ; Parasitology ; Virology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2278004-X
ISSN	1931-3128
ISSN	1931-3128
DOI	10.1016/j.chom.2020.08.002
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Approaches and Challenges in SARS-CoV-2 Vaccine Development.

Dagotto, Gabriel / Yu, Jingyou / Barouch, Dan H

Cell host & microbe

2020 Volume 28, Issue 3, Page(s) 364–370

Abstract: The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates ... ...

Abstract	The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.
MeSH term(s)	Animals ; Antigens, Viral/chemistry ; Antigens, Viral/genetics ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Host Microbial Interactions/immunology ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunity, Innate ; Models, Animal ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Primates ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/immunology ; Viral Vaccines/isolation & purification
Chemical Substances	Antigens, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2020.08.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.

Yu, Jingyou / Liu, Shan-Lu

Viruses

2018 Volume 10, Issue 8

Abstract: Interferon inducible transmembrane proteins (IFITMs) are one of several IFN-stimulated genes (ISGs) that restrict entry of enveloped viruses, including flaviviruses, filoviruses and retroviruses. It has been recently reported that in U87 glioblastoma ... ...

Abstract	Interferon inducible transmembrane proteins (IFITMs) are one of several IFN-stimulated genes (ISGs) that restrict entry of enveloped viruses, including flaviviruses, filoviruses and retroviruses. It has been recently reported that in U87 glioblastoma cells IFITM proteins inhibit HIV-1 entry in a co-receptor-dependent manner, that is, IFITM1 is more inhibitory on CCR5 tropic HIV-1 whereas IFITM2/3 confers a greater suppression of CXCR4 counterparts. However, how entry of HIV-1 with distinct co-receptor usage is modulated by different IFITM orthologs in physiologically relevant CD4⁺ T cells and monocytes/macrophages has not been investigated in detail. Here, we report that overexpression of IFITM1, 2 and 3 in human CD4⁺ HuT78 cells, SupT1 cells, monocytic THP-1 cells and U87 cells expressing CD4 and co-receptor CCR5 or CXCR4, suppressed entry of CXCR4 tropic viruses NL4.3 and HXB2, CCR5 tropic viruses AD8 and JRFL, dual tropic 89.6 virus, as well as a panel of 32 transmitted founder (T/F) viruses, with a consistent order of potency, that is, IFITM3 > IFITM2 > IFITM1. Consistent with previous reports, we found that some CCR5-using HIV-1 isolates, such as AD8 and JRFL, were relatively resistant to inhibition by IFITM2 and IFITM3, although the effect can be cell-type dependent. However, in no case have we observed that IFITM1 had a stronger inhibition on entry of any HIV-1 strains tested, including those of CCR5-using T/Fs. We knocked down the endogenous IFITMs in peripheral blood mononuclear cells (PBMCs) and purified CD4⁺ T cells and observed that, while this treatment did greatly enhance the multiple-round of HIV-1 replication but had modest effect to rescue the single-round HIV-1 infection, reinforcing our previous conclusion that the predominant effect of IFITMs on HIV-1 infection is in viral producer cells, rather than in target cells to block viral entry. Overall, our results argue against the idea that IFITM proteins distinguish co-receptors CCR5 and CXCR4 to inhibit entry but emphasize that the predominant role of IFITMs on HIV-1 is in producer cells that intrinsically impair the viral infectivity.
MeSH term(s)	Antigens, Differentiation/genetics ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Gene Knockdown Techniques ; HIV-1/physiology ; Humans ; Membrane Proteins/genetics ; RNA, Small Interfering ; RNA-Binding Proteins/genetics ; Receptors, CCR5/genetics ; Receptors, CCR5/physiology ; Receptors, CXCR4/genetics ; Receptors, CXCR4/physiology ; Receptors, Virus/genetics ; Receptors, Virus/physiology ; THP-1 Cells ; Virus Internalization
Chemical Substances	Antigens, Differentiation ; CCR5 protein, human ; CXCR4 protein, human ; IFITM2 protein, human ; IFITM3 protein, human ; Membrane Proteins ; RNA, Small Interfering ; RNA-Binding Proteins ; Receptors, CCR5 ; Receptors, CXCR4 ; Receptors, Virus ; leu-13 antigen
Keywords	covid19
Language	English
Publishing date	2018-08-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v10080413
Database	MEDical Literature Analysis and Retrieval System OnLINE

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