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  1. Article ; Online: Obsessive compulsive disorder.

    Soomro, G Mustafa

    BMJ clinical evidence

    2012  Volume 2012

    Abstract: Introduction: Obsessions or compulsions that cause personal distress or social dysfunction affect about 1% of adult men and 1.5% of adult women. About half of adults with obsessive compulsive disorder (OCD) have an episodic course, whereas the other ... ...

    Abstract Introduction: Obsessions or compulsions that cause personal distress or social dysfunction affect about 1% of adult men and 1.5% of adult women. About half of adults with obsessive compulsive disorder (OCD) have an episodic course, whereas the other half have continuous problems. Prevalence in children and adolescents is 2.7%. The disorder persists in about 40% of children and adolescents at mean follow-up of 5.7 years.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of initial treatments for obsessive compulsive disorder in adults? What are the effects of initial treatments for obsessive compulsive disorder in children and adolescents? What are the effects of maintenance treatment for obsessive compulsive disorder in adults? What are the effects of maintenance treatment for obsessive compulsive disorder in children and adolescents? What are the effects of treatments for obsessive compulsive disorder in adults who have not responded to initial treatment with serotonin reuptake inhibitors (SRIs)? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2011 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: We found 43 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: addition of antipsychotics to serotonin reuptake inhibitors, behavioural therapy alone or with serotonin reuptake inhibitors, cognitive therapy or cognitive behavioural therapy (CBT) (alone or with serotonin reuptake inhibitors), electroconvulsive therapy, optimum duration of maintenance treatment, psychosurgery, serotonin reuptake inhibitors (citalopram, clomipramine, fluoxetine, fluvoxamine, paroxetine, or sertraline), and transcranial magnetic stimulation.
    MeSH term(s) Electroconvulsive Therapy ; Emotions ; Humans ; Obsessive-Compulsive Disorder/drug therapy ; Psychiatric Status Rating Scales ; Psychosurgery ; Treatment Outcome ; United States Food and Drug Administration
    Language English
    Publishing date 2012-01-18
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of a culturally adapted cognitive behavior therapy-based, third-wave therapy manual.

    Phiri, Peter / Clarke, Isabel / Baxter, Lydia / Zeng, Yu-Tian / Shi, Jian-Qing / Tang, Xin-Yuan / Rathod, Shanaya / Soomro, Mustafa G / Delanerolle, Gayathri / Naeem, Farooq

    World journal of psychiatry

    2023  Volume 13, Issue 1, Page(s) 15–35

    Abstract: Background: Recommendations for psychotherapy have evolved over the years, with cognitive behavioral therapy (CBT) taking precedence since its inception within clinical guidelines in the United Kingdom and United States. The use of CBT for severe mental ...

    Abstract Background: Recommendations for psychotherapy have evolved over the years, with cognitive behavioral therapy (CBT) taking precedence since its inception within clinical guidelines in the United Kingdom and United States. The use of CBT for severe mental illness is now more common globally.
    Aim: To investigate the feasibility and acceptability of a culturally adapted, CBT-based, third-wave therapy manual using the Comprehend, Cope, and Connect approach with individuals from a diverse population presenting to primary and secondary healthcare services.
    Methods: A pilot study was used to assess the feasibility and acceptability of the manualised intervention. Outcome measures were evaluated at baseline, post-intervention and 12 wk-follow up. 32 participants with mental health conditions aged 20-53 years were recruited. Assessments were completed at three time points, using Clinical Outcomes in Routine Evaluation (CORE), Hospital Anxiety and Depression Scale (HADS), Bradford Somatic Inventory and World Health Organization Disability Assessment Schedule 2.0 (WHODAS). The Patient Experience Ques-tionnaire was completed post-treatment.
    Results: Repeated measures of analysis of variance associated with HADS depression, F (2, 36) = 12.81,
    Conclusion: These results indicate the effectiveness and acceptability of the culturally adapted, CBT-based, third-wave therapy manual intervention among minoritized groups with moderate effect sizes. Satisfaction levels and acceptability were highly rated. The viability and cost-effectiveness of this approach should be explored further to support universal implementation across healthcare systems.
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v13.i1.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deliberate self-harm (and attempted suicide).

    Soomro, G Mustafa / Kakhi, Sara

    BMJ clinical evidence

    2015  Volume 2015

    Abstract: Introduction: The lifetime prevalence of deliberate self-harm is about 3% to 5% of the population in Europe and the US, and has been increasing. Familial, biological, and psychosocial factors may contribute. Risks are higher in women and young adults, ... ...

    Abstract Introduction: The lifetime prevalence of deliberate self-harm is about 3% to 5% of the population in Europe and the US, and has been increasing. Familial, biological, and psychosocial factors may contribute. Risks are higher in women and young adults, people who are socially isolated or deprived, and people with psychiatric or personality disorders.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of non-pharmacological treatments for deliberate self-harm in adolescents and adults? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: Twenty-two studies were included. We performed a GRADE evaluation of the quality of evidence for interventions.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: cognitive therapy; continuity of care; dialectical behavioural therapy; emergency card; hospital admission; intensive outpatient follow-up plus outreach; nurse-led case management; problem-solving therapy; psychodynamic interpersonal therapy; and telephone contact.
    Language English
    Publishing date 2015-05-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obsessive compulsive disorder in children and adolescents: duration of maintenance drug treatment.

    Kakhi, Sara / Soomro, G Mustafa

    BMJ clinical evidence

    2015  Volume 2015

    Abstract: Introduction: Obsessions or compulsions that cause personal distress or social dysfunction have been reported to affect about 3% of children and adolescents. In children, the disorder often presents at around 10 years of age. It persists in about 40% of ...

    Abstract Introduction: Obsessions or compulsions that cause personal distress or social dysfunction have been reported to affect about 3% of children and adolescents. In children, the disorder often presents at around 10 years of age. It persists in about 40% of children and adolescents at mean follow-up of 5.7 years. The disorder is disabling with adverse impact on functioning, including education and social/family life.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of maintenance drug treatment for obsessive compulsive disorder in children and adolescents? We searched: Medline, Embase, The Cochrane Library, and other important databases up to June 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: Two studies were included that addressed the question of maintenance drug treatment for Obsessive Compulsive Disorder (OCD) in children and adolescents.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following intervention: optimum duration of maintenance drug treatment with serotonin reuptake inhibitors (SRIs) in children and adolescents.
    Language English
    Publishing date 2015-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Deliberate self-harm (and attempted suicide).

    Soomro, G Mustafa

    BMJ clinical evidence

    2008  Volume 2008

    Abstract: Introduction: The lifetime prevalence of deliberate self-harm is about 3-5% of the population in Europe and the USA, and has been increasing. Familial, biological, and psychosocial factors may contribute. Risks are higher in women and young adults, ... ...

    Abstract Introduction: The lifetime prevalence of deliberate self-harm is about 3-5% of the population in Europe and the USA, and has been increasing. Familial, biological, and psychosocial factors may contribute. Risks are higher in women and young adults, people who are socially isolated or deprived, and people with psychiatric or personality disorders.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for deliberate self-harm in adolescents and adults? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: We found 19 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: cognitive therapy; continuity of care; dialectical behavioural therapy; emergency card; flupentixol depot injection; general practice-based guidelines; hospital admission; intensive outpatient follow-up plus outreach; mianserin; nurse-led case management; oral antipsychotics; paroxetine; problem-solving therapy; psychodynamic interpersonal therapy; and telephone contact.
    MeSH term(s) Cognitive Behavioral Therapy ; Follow-Up Studies ; Humans ; Incidence ; Paroxetine ; Personality Disorders ; Self-Injurious Behavior ; Suicide ; Suicide, Attempted ; Telephone
    Chemical Substances Paroxetine (41VRH5220H)
    Language English
    Publishing date 2008-12-12
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Impact of lockdown relaxation and implementation of the face-covering policy on mental health: A United Kingdom COVID-19 study.

    Rathod, Shanaya / Pallikadavath, Saseendran / Graves, Elizabeth / Rahman, Mohammad Mahbubur / Brooks, Ashlea / Soomro, Mustafa G / Rathod, Pranay / Phiri, Peter

    World journal of psychiatry

    2021  Volume 11, Issue 12, Page(s) 1346–1365

    Abstract: Background: Pandemic mitigation policies, such as lockdown, are known to impact on mental health of individuals. Compulsory face covering under relaxed lockdown restrictions gives assurance of less transmission of airborne infection and has the ... ...

    Abstract Background: Pandemic mitigation policies, such as lockdown, are known to impact on mental health of individuals. Compulsory face covering under relaxed lockdown restrictions gives assurance of less transmission of airborne infection and has the potential to improve mental health of individuals affected by restrictions.
    Aim: To examine the association of the lockdown relaxation and the implementation of the face covering policy on the mental health of the general population and sub-groups in the United Kingdom using interrupted time series model.
    Methods: Using a web-based cross-sectional survey of 28890 United Kingdom adults carried out during May 1, 2020 to July 31, 2020, changes in mental health status using generalised anxiety disorder (GAD-7), and impact of events scale-revised (IES-R) scales are examined, at the dates of the first lockdown relaxation (July 4, 2020) and the subsequent introduction of face covering (July 24, 2020) in United Kingdom. A sharp regression discontinuity design is used to check discontinuities in mental health outcomes at policy-change dates.
    Results: Average GAD-7 scores of participants were 5.6, 5.6 and 4.3 during the lockdown period, the lockdown relaxation phase and the phase of compulsory face covering, respectively, with lower scores indicating lower anxiety levels. Corresponding scores for IES-R were 17.3, 16.8 and 13.4, with lower scores indicating less distress. Easing lockdown measures and subsequent introduction of face covering, on average, reduced GAD-7 by 0.513 (95%CI: 0.913-0.112) and 1.148 (95%CI: 1.800-0.496), respectively. Corresponding reductions in IES-R were 2.620 (95%CI: 4.279-0.961) and 3.449 (95%CI: 5.725-1.172). These imply that both lockdown relaxation and compulsory face-covering have a positive association with mental health scores (GAD-7 and IES-R).
    Conclusion: The differential impact of lockdown and relaxation on the mental health of population sub-groups is evident in this study with future implications for policy. Introduction of face covering in public places had a stronger positive association with mental health than lockdown relaxation.
    Language English
    Publishing date 2021-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v11.i12.1346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Obsessive compulsive disorder.

    Soomro, G Mustafa

    BMJ clinical evidence

    2007  Volume 2007

    Abstract: Introduction: Obsessions or compulsions that cause personal distress or social dysfunction affect about 1% of men and 2% of women. About half of people with obsessive compulsive disorder (OCD) have an episodic course, whereas the other half have ... ...

    Abstract Introduction: Obsessions or compulsions that cause personal distress or social dysfunction affect about 1% of men and 2% of women. About half of people with obsessive compulsive disorder (OCD) have an episodic course, whereas the other half have continuous problems. Up to half of people show improvement of symptoms over time.
    Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of initial treatments for obsessive compulsive disorder in adults? What are the best forms of maintenance treatment for obsessive compulsive disorder in adults? What are the effects of treatments for obsessive compulsive disorder in adults who have not responded to initial treatment with serotonin reuptake inhibitors? We searched: Medline, Embase, The Cochrane Library and other important databases up to July 2006 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
    Results: We found 55 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
    Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: addition of antipsychotics to serotonin reuptake inhibitors; behavioural therapy alone or with serotonin reuptake inhibitors; cognitive therapy or cognitive behavioural therapy (alone or with serotonin reuptake inhibitors); electroconvulsive therapy; serotonin reuptake inhibitors (citalopram, clomipramine, fluoxetine, fluvoxamine, paroxetine, sertraline); and optimum duration of maintenance treatment.
    MeSH term(s) Obsessive-Compulsive Disorder ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2007-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2393858-4
    ISSN 1752-8526 ; 1757-0816 ; 1475-9225
    ISSN (online) 1752-8526
    ISSN 1757-0816 ; 1475-9225
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  8. Article: Deliberate self harm (and attempted suicide).

    Soomro, G Mustafa

    Clinical evidence

    2005  , Issue 13, Page(s) 1200–1211

    MeSH term(s) Antidepressive Agents, Second-Generation/therapeutic use ; Flupenthixol/therapeutic use ; Humans ; Mianserin/therapeutic use ; Paroxetine/therapeutic use ; Psychotherapy ; Self-Injurious Behavior/prevention & control ; Serotonin Uptake Inhibitors/therapeutic use ; Suicide, Attempted/prevention & control
    Chemical Substances Antidepressive Agents, Second-Generation ; Serotonin Uptake Inhibitors ; Mianserin (250PJI13LM) ; Paroxetine (41VRH5220H) ; Flupenthixol (FA0UYH6QUO)
    Language English
    Publishing date 2005-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1495368-7
    ISSN 1462-3846
    ISSN 1462-3846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Obsessive compulsive disorder.

    Soomro, G Mustafa

    Clinical evidence

    2005  , Issue 14, Page(s) 1270–1283

    MeSH term(s) Adult ; Antipsychotic Agents/therapeutic use ; Behavior Therapy ; Cognitive Therapy ; Combined Modality Therapy ; Drug Therapy, Combination ; Humans ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/therapy ; Serotonin Uptake Inhibitors/therapeutic use
    Chemical Substances Antipsychotic Agents ; Serotonin Uptake Inhibitors
    Language English
    Publishing date 2005-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1495368-7
    ISSN 1462-3846
    ISSN 1462-3846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Protecting and promoting editorial independence.

    Bhui, Kamaldeep / O'Brien, Aileen / Upthegrove, Rachel / Tsai, Alexander C / Soomro, Mustafa / Newton-Howes, Giles / Broome, Matthew R / Forrester, Andrew / Casey, Patricia / Doherty, Anne M / Lee, William / Kaufman, Kenneth R

    The British journal of psychiatry : the journal of mental science

    2024  , Page(s) 1–3

    Abstract: We argue that editorial independence, through robust practice of publication ethics and research integrity, promotes good science and prevents bad science. We elucidate the concept of research integrity, and then discuss the dimensions of editorial ... ...

    Abstract We argue that editorial independence, through robust practice of publication ethics and research integrity, promotes good science and prevents bad science. We elucidate the concept of research integrity, and then discuss the dimensions of editorial independence. Best practice guidelines exist, but compliance with these guidelines varies. Therefore, we make recommendations for protecting and strengthening editorial independence.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2024.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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