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  1. Article ; Online: Reply to 'Delirium, sleep, COVID-19 and melatonin'.

    D'Agostino, Armando / Zambrelli, Elena

    Sleep medicine

    2020  Volume 75, Page(s) 543

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Delirium ; Humans ; Melatonin ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Melatonin (JL5DK93RCL)
    Keywords covid19
    Language English
    Publishing date 2020-05-25
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2020.05.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5315: Show issues Location:
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  2. Article ; Online: Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review.

    Giuliano, Loretta / Durante, Vania / Battaglia, Giulia / Gasparini, Sara / Zambrelli, Elena / Ermio, Caterina / La Neve, Angela / Mostacci, Barbara

    CNS drugs

    2024  

    Abstract: Background: Sex differences in epilepsy have been described in prevalence, seizure propensity and response to treatment. Therefore, taking into account sex-based differences in epilepsy is important for both diagnostic purposes and therapeutic ... ...

    Abstract Background: Sex differences in epilepsy have been described in prevalence, seizure propensity and response to treatment. Therefore, taking into account sex-based differences in epilepsy is important for both diagnostic purposes and therapeutic considerations. However, little is known about sex differences in adverse effects of antiseizure medications (ASMs).
    Objectives: We performed a systematic review searching for sex differences in adverse effects of ASMs in adult persons with epilepsy (PWE) as part of a wider project aimed to assess sex-based differences in efficacy and adverse effects of ASMs in PWE.
    Methods: We conducted a comprehensive literature search in the PubMed database. The search was conducted with no restriction on publication date, and all results up to April 2020 were included. We included articles written in English, Italian, Spanish, or French that evaluated adverse effects of one or more ASMs in PWE, with specific mention of the two sexes. When appropriate, Newcastle-Ottawa or Jadad scales were used to assess study quality.
    Results: Of 5164 identified studies, only 167 considered sex in the analysis and were therefore included. Significant sex-related differences were found in 58 of those studies. We found a consistently higher frequency of cutaneous adverse effects in females; higher risk of developing general adverse effects on different ASMs in females; stronger risk of adverse effects on bone metabolism in females, mainly on treatment with enzyme-inducing ASMs; a concordant higher risk of visual field loss was noted in males on vigabatrin; an overall worse lipid profile in males; as well as higher leptin levels and higher body mass index in females treated with various ASMs.
    Conclusions: Our analysis has identified some important sex differences in the adverse effects of ASMs. Clinicians should be aware of these differences when informing patients about the risks associated with ASM treatment in PWE.
    Language English
    Publishing date 2024-04-30
    Publishing country New Zealand
    Document type Systematic Review
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-024-01088-x
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  4. Article ; Online: Reply to ‘Delirium, sleep, COVID-19 and melatonin’

    D'Agostino, Armando / Zambrelli, Elena

    Sleep Medicine

    2020  Volume 75, Page(s) 543

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2020.05.027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Living with Epilepsy in Adolescence in Italy: Psychological and Behavioral Impact.

    Turner, Katherine / La Briola, Francesca / Vignoli, Aglaia / Zambrelli, Elena / Chiesa, Valentina / Fongoni, Laura / Baldi, Olivia / Canevini, Maria Paola

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 5

    Abstract: Background: People with epilepsy have a higher prevalence of behavioral and neuropsychiatric comorbidities compared to the general population and those with other chronic medical conditions, although the underlying clinical features remain unclear. The ... ...

    Abstract Background: People with epilepsy have a higher prevalence of behavioral and neuropsychiatric comorbidities compared to the general population and those with other chronic medical conditions, although the underlying clinical features remain unclear. The goal of the current study was to characterize behavioral profiles of adolescents with epilepsy, assess the presence of psychopathological disorders, and investigate the reciprocal interactions among epilepsy, psychological functioning, and their main clinical variables.
    Methods: Sixty-three adolescents with epilepsy were consecutively recruited at the Epilepsy Center, Childhood and Adolescence Neuropsychiatry Unit of Santi Paolo e Carlo hospital in Milan (five of them were excluded) and assessed with a specific questionnaire for psychopathology in adolescence, such as the Questionnaire for the Assessment of Psychopathology in Adolescence (Q-PAD). Q-PAD results were then correlated with the main clinical data.
    Results: 55.2% (32/58) of patients presented at least one emotional disturbance. Body dissatisfaction, anxiety, interpersonal conflicts, family problems, uncertainty about the future, and self-esteem/well-being disorders were frequently reported. Gender and poor control of seizures are associated with specific emotional features (
    Conclusions: These findings highlight the importance of screening for emotional distress, recognition of the impairments, and provision of adequate treatment and follow-up. A pathological score on the Q-PAD should always require the clinician to investigate the presence of behavioral disorders and comorbidities in adolescents with epilepsy.
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11050687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients?

    Zambrelli, Elena / Canevini, Mariapaola / Gambini, Orsola / D'Agostino, Armando

    Sleep medicine

    2020  Volume 70, Page(s) 111

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Delirium ; Humans ; Melatonin ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Sleep Wake Disorders
    Chemical Substances Melatonin (JL5DK93RCL)
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2020.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5315: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Effects of Supplementation With Antioxidant Agents on Sleep in Autism Spectrum Disorder: A Review.

    Zambrelli, Elena / Lividini, Althea / Spadavecchia, Sofia / Turner, Katherine / Canevini, Maria Paola

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 689277

    Abstract: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition, whose etiology remains poorly understood in most cases. Several genetic, epigenetic and environmental factors have been implicated in ASD pathogenesis and numerous studies ... ...

    Abstract Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition, whose etiology remains poorly understood in most cases. Several genetic, epigenetic and environmental factors have been implicated in ASD pathogenesis and numerous studies have provided evidences for increased levels of oxidative stress and reduced antioxidant capacity in patients with ASD. Recent clinical trials explored supplementation with antioxidant agents as a potential therapeutic strategy for ASD, investigating the impact of this treatment on behavioral symptoms and on most common comorbidities of the disease, including sleep disturbances. Among all medical conditions associated to ASD, sleep problems are highly prevalent and are supposed to be positively related to the severity of the disease. Moreover, studies on animal models support the hypothesis of a relationship between oxidative stress and sleep deprivation. The aim of this review is to summarize the current state of the literature on the effect of antioxidant treatment on sleep disturbances in patients with ASD. Twenty-one articles were included in final synthesis. Of them, 15 studies involved Melatonin, 1 Tryptophan and 5 focused on supplementation with other antioxidant agents (namely Coenzyme Q10, L-Carnosine, Luteolin and Quercetin). Despite the high prevalence of comorbid sleep troubles in ASD, there is a paucity of data on the efficacy of antioxidant agents in those patients. Further research is needed to better define the role of antioxidants agents as adjunctive therapy in the management sleep disorders in children and adolescents affected with ASD.
    Language English
    Publishing date 2021-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.689277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Living with Epilepsy in Adolescence in Italy

    Katherine Turner / Francesca La Briola / Aglaia Vignoli / Elena Zambrelli / Valentina Chiesa / Laura Fongoni / Olivia Baldi / Maria Paola Canevini

    Healthcare, Vol 11, Iss 687, p

    Psychological and Behavioral Impact

    2023  Volume 687

    Abstract: Background: People with epilepsy have a higher prevalence of behavioral and neuropsychiatric comorbidities compared to the general population and those with other chronic medical conditions, although the underlying clinical features remain unclear. The ... ...

    Abstract Background: People with epilepsy have a higher prevalence of behavioral and neuropsychiatric comorbidities compared to the general population and those with other chronic medical conditions, although the underlying clinical features remain unclear. The goal of the current study was to characterize behavioral profiles of adolescents with epilepsy, assess the presence of psychopathological disorders, and investigate the reciprocal interactions among epilepsy, psychological functioning, and their main clinical variables. Methods: Sixty-three adolescents with epilepsy were consecutively recruited at the Epilepsy Center, Childhood and Adolescence Neuropsychiatry Unit of Santi Paolo e Carlo hospital in Milan (five of them were excluded) and assessed with a specific questionnaire for psychopathology in adolescence, such as the Questionnaire for the Assessment of Psychopathology in Adolescence (Q-PAD). Q-PAD results were then correlated with the main clinical data. Results: 55.2% (32/58) of patients presented at least one emotional disturbance. Body dissatisfaction, anxiety, interpersonal conflicts, family problems, uncertainty about the future, and self-esteem/well-being disorders were frequently reported. Gender and poor control of seizures are associated with specific emotional features ( p < 0.05). Conclusions: These findings highlight the importance of screening for emotional distress, recognition of the impairments, and provision of adequate treatment and follow-up. A pathological score on the Q-PAD should always require the clinician to investigate the presence of behavioral disorders and comorbidities in adolescents with epilepsy.
    Keywords epilepsy ; adolescence ; behavioral disorders ; psychiatric comorbidities ; Medicine ; R
    Subject code 150 ; 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Sex differences in side effects of antiseizure medications in pediatric patients with epilepsy: A systematic review.

    Giuliano, Loretta / Vecchio, Chiara / Mastrangelo, Vincenzo / Durante, Vania / Zambrelli, Elena / Cantalupo, Gaetano / La Neve, Angela / Ermio, Caterina / Mostacci, Barbara

    Seizure

    2022  Volume 102, Page(s) 6–13

    Abstract: Purpose: To perform a systematic review searching for differences in the side effects of antiseizure medications (ASMs) with respect to sex in pediatric patients with epilepsy.: Methods: We carried out a comprehensive literature search of the PubMed ... ...

    Abstract Purpose: To perform a systematic review searching for differences in the side effects of antiseizure medications (ASMs) with respect to sex in pediatric patients with epilepsy.
    Methods: We carried out a comprehensive literature search of the PubMed database and all results up to April 2020 were included. Titles, abstracts, and full texts of the articles were screened by two independent reviewers. We included all studies evaluating the side effects of ASMs in patients with epilepsy younger than 18 years, with reference to the two sexes. Studies on ASMs used for indications other than epilepsy were excluded.
    Results: A total of 5164 studies were identified. Sixty-seven studies were finally included, 5 of them also including adult patients in the sample. Sixteen studies revealed sex-related differences in side effects of ASMs, disclosing a higher frequency of general side effects in girls: a higher risk of overweight, hyperammonaemia, high leptin levels, and carnitine deficiency in girls on valproic acid; a lower height increase, an increased risk of weight loss, the anecdotical occurrence of acute psychosis in girls on topiramate; a higher risk of retinal toxicity in boys on vigabatrin.
    Conclusion: The effect of sex on susceptibility to side effects of ASMs is poorly investigated with sparse results, and it could be underestimated. The findings of our study point to the presence of sex differences which should be thoroughly investigated to be confirmed, highlighting the need for a systematic evaluation of sex as a determinant variable influencing the response to medications in clinical research.
    MeSH term(s) Adult ; Child ; Humans ; Female ; Male ; Anticonvulsants/adverse effects ; Sex Characteristics ; Epilepsy/epidemiology ; Vigabatrin/therapeutic use ; Topiramate/therapeutic use ; Drug-Related Side Effects and Adverse Reactions/drug therapy
    Chemical Substances Anticonvulsants ; Vigabatrin (GR120KRT6K) ; Topiramate (0H73WJJ391)
    Language English
    Publishing date 2022-09-17
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2022.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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