LIVIVO - Search results -

Search results

Result 1 - 10 of total 171

Search options

Article: Potential innovative targets in the treatment of pain: Combined µ and NOP receptor agonists.

Leo, Raphael J

2021 Volume 17, Issue 4, Page(s) 277–283

Abstract: Opioid analgesics are potent and widely used medications employed to manage moderate-to-severe acute pain; their utility in the management of chronic inflammatory and neuropathic pain is modest and is beset with adverse effects and concerns related to ... ...

Abstract	Opioid analgesics are potent and widely used medications employed to manage moderate-to-severe acute pain; their utility in the management of chronic inflammatory and neuropathic pain is modest and is beset with adverse effects and concerns related to abuse and addiction. The discovery of the nonclassical opioid, ie, the nociception/orphanin receptor (NOP), has sparked interest into another possible analgesic target. Preclinical studies have demonstrated pain mitigating effects associated with NOP receptor activation while simultaneously reducing conventional µ-opioid-related ad-verse and euphoric effects. Consequently, agents possessing dual agonism of both µ and NOP receptor activations present an innovative and promising potential target for pain management.
Language	English
Publishing date	2021-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2397614-7
ISSN	1551-7489
ISSN	1551-7489
DOI	10.5055/jom.2021.0659
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6563: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recreational 2-Methyl-2-Butanol Use: An Emerging Wave of Misuse of an Ethanol Substitute on the Horizon?

Syed, Alia N / Leo, Raphael J

The primary care companion for CNS disorders

2022 Volume 24, Issue 6

MeSH term(s)	Humans ; Ethanol/adverse effects ; Pentanols
Chemical Substances	tert-amyl alcohol (69C393R11Z) ; Ethanol (3K9958V90M) ; Pentanols
Language	English
Publishing date	2022-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.22cr03292
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mania Associated With Rhodiola Rosea: An Adaptogen With Antidepressant Effects.

Whig, Rahat / Leo, Raphael J

The primary care companion for CNS disorders

2022 Volume 24, Issue 2

MeSH term(s)	Antidepressive Agents/adverse effects ; Humans ; Mania ; Plant Extracts/adverse effects ; Rhodiola
Chemical Substances	Antidepressive Agents ; Plant Extracts
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.21cr02980
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Phenibut: A Novel Nootropic With Abuse Potential.

Mash, Jaime E / Leo, Raphael J

The primary care companion for CNS disorders

2020 Volume 22, Issue 4

MeSH term(s)	Adult ; Humans ; Male ; Nootropic Agents/adverse effects ; Substance Withdrawal Syndrome/etiology ; Substance-Related Disorders/etiology ; gamma-Aminobutyric Acid/adverse effects ; gamma-Aminobutyric Acid/analogs & derivatives
Chemical Substances	Nootropic Agents ; gamma-Aminobutyric Acid (56-12-2) ; 4-amino-3-phenylbutyric acid (T2M58D6LA8)
Language	English
Publishing date	2020-08-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.19l02587
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Impact of the COVID-19 Pandemic on National Institutes of Health-Funded Researchers and Their Projects: The Role of Age, Sex, Experience, and Team Size.

Burnett, Wendy J / Agbali, Raphael / Silva, Jeane / De Leo, Gianluca

Public health reports (Washington, D.C. : 1974)

2022 Volume 138, Issue 2, Page(s) 315–322

Abstract: Objectives: The COVID-19 pandemic has disrupted the social life, work environment, and well-being of millions of people. We examined COVID-19's impact on National Institutes of Health (NIH)-funded extramural principal investigators (PIs) affiliated with ...

Abstract	Objectives: The COVID-19 pandemic has disrupted the social life, work environment, and well-being of millions of people. We examined COVID-19's impact on National Institutes of Health (NIH)-funded extramural principal investigators (PIs) affiliated with public health and preventive medicine departments across the country and their projects; assessed PIs' confidence in achieving project goals; and investigated the role of age, sex, experience, and team size on PIs' confidence in achieving project goals during the pandemic. Methods: We sent an anonymous online survey in January 2021 to 1076 extramural PIs affiliated with public health and preventive medicine departments at US institutions; 133 (12.4%) responded. We examined the impact of COVID-19 on the PIs, their project team operations, and their confidence that project objectives would be met, using Likert scales based on age, sex, team size, and PI experience. Results: Of 126 PIs, 94 (74.6%) felt that their day-to-day professional life was impacted a lot or a great deal by COVID-19. More female PIs than male PIs reported that their level of stress changed because of the COVID-19 pandemic. Of 125 PIs, 67 (53.6%) made major adjustments to research operations, 46 (36.8%) made minor adjustments, 5 (4.0%) halted research, and 7 (5.6%) reported not being affected. Of 123 PIs, 89 (72.4%) reported not using NIH COVID-19 accommodations. PIs who led projects 4 or 5 times felt more confident about meeting their research objectives than PIs who led projects 2 or 3 times. Conclusions: Future studies should investigate how to develop more engaging support and communication strategies to assist NIH researchers in mitigating the effects of pandemics or large-scale emergencies.
MeSH term(s)	United States/epidemiology ; Humans ; Male ; Female ; Pandemics/prevention & control ; Biomedical Research ; COVID-19/epidemiology ; Surveys and Questionnaires ; National Institutes of Health (U.S.)
Language	English
Publishing date	2022-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	120953-x
ISSN	1468-2877 ; 0033-3549
ISSN (online)	1468-2877
ISSN	0033-3549
DOI	10.1177/00333549221133809
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Un I Zs.150: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 479: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tianeptine Sodium: A Nootropic With Potentially Lethal Consequences.

Lucaj, Simon / Leo, Raphael J

The primary care companion for CNS disorders

2018 Volume 20, Issue 4

MeSH term(s)	Adult ; Analgesics/administration & dosage ; Analgesics/toxicity ; Back Pain/drug therapy ; Humans ; Male ; Nootropic Agents/administration & dosage ; Nootropic Agents/toxicity ; Substance-Related Disorders ; Thiazepines/administration & dosage ; Thiazepines/toxicity
Chemical Substances	Analgesics ; Nootropic Agents ; Thiazepines ; tianeptine (0T493YFU8O)
Language	English
Publishing date	2018-07-19
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7772
ISSN (online)	2155-7780
ISSN	2155-7772
DOI	10.4088/PCC.17l02205
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Complete anatomic segmentectomy shows improved oncologic outcomes compared to incomplete anatomic segmentectomy.

McAllister, Miles A / Rochefort, Matthew M / Ugalde Figueroa, Paula / Leo, Rachel / Sugarbaker, Evert A / Singh, Anupama / Herrera-Zamora, Julio / Barcelos, Rafael R / Mazzola, Emanuele / Heiling, Hillary / Jaklitsch, Michael T / Bueno, Raphael / Swanson, Scott J

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2024 Volume 65, Issue 3

Abstract: Objectives: To compare oncologic outcomes after segmentectomy with division of segmental bronchus, artery and vein (complete anatomic segmentectomy) versus segmentectomy with division of <3 segmental structures (incomplete anatomic segmentectomy).: ... ...

Abstract	Objectives: To compare oncologic outcomes after segmentectomy with division of segmental bronchus, artery and vein (complete anatomic segmentectomy) versus segmentectomy with division of <3 segmental structures (incomplete anatomic segmentectomy). Methods: We conducted a single-centre, retrospective analysis of patients undergoing segmentectomy from March 2005 to May 2020. Operative reports were audited to classify procedures as complete or incomplete anatomic segmentectomy. Patients who underwent neoadjuvant therapy or pulmonary resection beyond indicated segments were excluded. Survival was estimated with Kaplan-Meier models and compared using log-rank tests. Cox proportional hazards models were used to estimate hazard ratios (HRs) for death. Cumulative incidence functions for loco-regional recurrence were compared with Gray's test, with death considered a competing event. Cox and Fine-Gray models were used to estimate cause-specific and subdistribution HRs, respectively, for loco-regional recurrence. Results: Of 390 cases, 266 (68.2%) were complete and 124 were incomplete anatomic segmentectomy. Demographics, pulmonary function, tumour size, stage and perioperative outcomes did not significantly differ between groups. Surgical margins were negative in all but 1 case. Complete anatomic segmentectomy was associated with improved lymph node dissection (5 vs 2 median nodes sampled; P < 0.001). Multivariable analysis revealed reduced incidence of loco-regional recurrence (cause-specific HR = 0.42; 95% confidence interval 0.22-0.80; subdistribution HR = 0.43; 95% confidence interval 0.23-0.81), and non-significant improvement in overall survival (HR = 0.66; 95% confidence interval: 0.43-1.00) after complete versus incomplete anatomic segmentectomy. Conclusions: This single-centre experience suggests complete anatomic segmentectomy provides superior loco-regional control and may improve survival relative to incomplete anatomic segmentectomy. We recommend surgeons perform complete anatomic segmentectomy and lymph node dissection whenever possible.
MeSH term(s)	Humans ; Lung Neoplasms ; Carcinoma, Non-Small-Cell Lung ; Pneumonectomy/methods ; Retrospective Studies ; Treatment Outcome ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging
Language	English
Publishing date	2024-02-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezae089
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2303: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Predictors of Prolonged Hospital Stay After Segmentectomy.

Pezeshkian, Fatemehsadat / Leo, Rachel / McAllister, Miles A / Singh, Anupama / Mazzola, Emanuele / Hooshmand, Fatemeh / Herrera-Zamora, Julio / Silvestri, Mia / Ribeiro Barcelos, Rafael / Bueno, Raphael / Ugalde Figueroa, Paula / Jaklitsch, Michael T / Swanson, Scott J

The Journal of thoracic and cardiovascular surgery

2024

Abstract: Objective: Segmentectomy is becoming the standard of care for small, peripheral non-small cell lung cancer. To improve perioperative management in this population, this study aims to identify factors influencing hospital length of stay after ... ...

Abstract	Objective: Segmentectomy is becoming the standard of care for small, peripheral non-small cell lung cancer. To improve perioperative management in this population, this study aims to identify factors influencing hospital length of stay after segmentectomy. Methods: Patients who underwent segmentectomy for any indication between 01/2018-05/2023 were identified using a prospectively maintained institutional database. Multivariable logistic regression models were used to estimate associations between clinical features and prolonged (≥ 3days) hospital stay. A nomogram was designed to understand better, and possibly calculate the individual risk of prolonged hospital stays. Results: In total, 533 cases were included; 337 (63%) were females. Median age was 66 years (IQR: 63-75). The median size of resected lesions was 1.6cm (IQR 1.3-2.1). Median hospital stay was 3 days (IQR: 2-4). Major adverse events occurred in 31 (5.8%) cases. The 30-day readmission rate was 5.8% (n=31). There was no 30-day mortality; 90-day mortality was <1%. Patients older than 75 years (OR=2.01, 95%CI: 1.15-3.57, P=0.02), those with FEV1 < 88% predicted (OR = 1.99, 95%CI: 1.38-2.89, P<0.001), or positive smoking history (OR=1.72, 95%CI: 1.15-2.60, P=0.01) were more likely to have prolonged hospital stays after segmentectomy. A nomogram accounting for age, sex, FEV1, body mass index, smoking history, and comorbidities was created to predict the probability of prolonged hospital stay with an AUC of 0.66. Conclusions: Older patients, those with reduced pulmonary function, current, and past smokers have elevated risk for prolonged hospital stays after segmentectomy. Validation of our nomogram could improve perioperative risk stratification in segmentectomy patients.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2024.04.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.104: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A systematic review of the utility of anticonvulsant pharmacotherapy in the treatment of vulvodynia pain.

Leo, Raphael J

The journal of sexual medicine

2013 Volume 10, Issue 8, Page(s) 2000–2008

Abstract: Introduction: Anticonvulsants have increasingly been invoked in the treatment of vulvodynia. However, the evidence supporting this treatment approach has not been systematically assessed.: Aim: The study aims to evaluate the efficacy of ... ...

Abstract	Introduction: Anticonvulsants have increasingly been invoked in the treatment of vulvodynia. However, the evidence supporting this treatment approach has not been systematically assessed. Aim: The study aims to evaluate the efficacy of anticonvulsant pharmacotherapy in the treatment of vulvodynia. Methods: A comprehensive search of the available literature was conducted. Main outcome measure: An assessment of the methodological quality of published reports addressing the utility of anticonvulsants in the treatment of vulvodynia was undertaken. Results: The search yielded nine published reports, i.e., one open-label trial, six nonexperimental studies, and two case reports. A number of methodological shortcomings were identified in several of the reports with respect to study design, including small sample sizes, lack of placebo or other comparison groups, inadequate outcome measures, among others. The vast majority of studies employed gabapentin. Evidence supporting the benefit of anticonvulsants studied to date was limited, i.e., based predominantly upon descriptive/observational reports. There were no systematic investigations into the comparative efficacy of different anticonvulsant agents in the treatment of vulvodynia. Conclusion: Although some vulvodynia-afflicted patients derive symptom relief from anticonvulsants, there is, as yet, insufficient evidence to support the recommendation of anticonvulsant pharmacotherapy in the treatment of vulvodynia. Additional investigations, employing randomized controlled trials, are warranted.
MeSH term(s)	Amines/adverse effects ; Amines/therapeutic use ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Cyclohexanecarboxylic Acids/adverse effects ; Cyclohexanecarboxylic Acids/therapeutic use ; Female ; Humans ; Middle Aged ; Substance Withdrawal Syndrome ; Vulvodynia/drug therapy ; gamma-Aminobutyric Acid/adverse effects ; gamma-Aminobutyric Acid/therapeutic use
Chemical Substances	Amines ; Anticonvulsants ; Cyclohexanecarboxylic Acids ; gamma-Aminobutyric Acid (56-12-2) ; gabapentin (6CW7F3G59X)
Language	English
Publishing date	2013-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1111/jsm.12200
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6417: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 505: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Male genital self-mutilation: a systematic review of psychiatric disorders and psychosocial factors.

Veeder, Thomas A / Leo, Raphael J

General hospital psychiatry

2017 Volume 44, Page(s) 43–50

Abstract: Objective: To identify psychiatric diagnoses and psychosocial factors associated with intentional male genital self-mutilation (GSM) of specific injury subtypes.: Methods: A search of MEDLINE, EMBASE, PsycINFO, PubMed, Web of Science and CINAHL for ... ...

Abstract	Objective: To identify psychiatric diagnoses and psychosocial factors associated with intentional male genital self-mutilation (GSM) of specific injury subtypes. Methods: A search of MEDLINE, EMBASE, PsycINFO, PubMed, Web of Science and CINAHL for cases of GSM was conducted until December 2015, based on GSM and related terms. Cases were examined for injury subtype, psychiatric diagnosis and psychosocial factors. Chi-square analyses were employed to determine differences in frequency of such factors across injury subtypes. Results: Data were obtained from 173 cases: genital mutilation (n=21), penile amputation (n=62), castration (n=56) and combined amputation/castration (n=34). Common psychiatric disorders included schizophrenia spectrum (49%), substance use (18.5%), personality (15.9%) and gender dysphoric disorders (15.3%). Chi-square analyses revealed that schizophrenia spectrum disorders occurred significantly more often among auto-amputates as compared with self-castrators or mutilators. Gender dysphoria occurred significantly more often among self-castrators than auto-amputates. No significant differences emerged regarding psychosocial factors across GSM subtypes. However, associations were observed between psychosocial factors and psychiatric diagnoses. Although altogether not commonly reported, experiential factors were reported in 82% of psychotic individuals. Treatment inaccessibility was noted among 71% of gender dysphorics engaging in auto-castration. Conclusion: Clinicians must consider the diverse range of psychiatric disorders and psychosocial factors underlying GSM.
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	392299-6
ISSN	1873-7714 ; 0163-8343
ISSN (online)	1873-7714
ISSN	0163-8343
DOI	10.1016/j.genhosppsych.2016.09.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1584: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito