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  1. Article ; Online: In Flanders Fields: John McCrae as Physician, Poet, Soldier.

    Young, James C

    Methodist DeBakey cardiovascular journal

    2023  Volume 19, Issue 5, Page(s) 85–88

    Abstract: John McCrae (1872-1918) was a Canadian physician, poet, and soldier who fought and died ...

    Abstract John McCrae (1872-1918) was a Canadian physician, poet, and soldier who fought and died in the First World War. He penned perhaps his most memorable and lasting poem, "In Flanders Fields," shortly after the death of a comrade at the Second Battle of Ypres in 1915. The poem gained almost instant popularity, being used for recruiting efforts and victory bond sales throughout the remainder of the war, and solidified forever the symbol of the poppy as a memorial token for the service members who had perished. His death towards the end of the war, like that of so many others in the perilous years between 1914 and 1918, cut short the trajectory of what had already amounted to a brilliant career. As a close friend of such titans of medicine as William Osler and Harvey Cushing, as well as acquainted with the likes of Rudyard Kipling, it is not difficult to imagine the impact that his passing had upon the future of medicine and literature.
    MeSH term(s) Male ; Humans ; Canada ; Military Personnel ; Physicians
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2544079-2
    ISSN 1947-6108 ; 1947-6108
    ISSN (online) 1947-6108
    ISSN 1947-6108
    DOI 10.14797/mdcvj.1283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Poet's Pen: Two Sonnets by John Keats (1795-1821).

    Young, James B

    Methodist DeBakey cardiovascular journal

    2021  Volume 16, Issue 4, Page(s) 326–327

    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2544079-2
    ISSN 1947-6108 ; 1947-6094
    ISSN (online) 1947-6108
    ISSN 1947-6094
    DOI 10.14797/mdcj-16-4-326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: John Auty: (1926-2013).

    Auty, K / Auty, M / Faragher, T / Harrison, M / Paxton, D / Young, P / Whittem, J

    Australian veterinary journal

    2014  Volume 92, Issue 8, Page(s) 291

    MeSH term(s) Australia ; History, 20th Century ; History, 21st Century ; Veterinary Medicine/history
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 41542-x
    ISSN 1751-0813 ; 0005-0423
    ISSN (online) 1751-0813
    ISSN 0005-0423
    DOI 10.1111/avj.12215
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 550: Show issues Location:
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  4. Article: Erratum to: High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis.

    Kim, Su Hyun / Kim, Yeseul / Jung, Ji Yun / Park, Na Young / Jang, Hyunmin / Hyun, Jae Won / Kim, Ho Jin

    Journal of clinical neurology (Seoul, Korea)

    2020  Volume 16, Issue 1, Page(s) 180

    Abstract: This corrects the article on p. 454 in vol. 15, PMID: 31591832. ...

    Abstract This corrects the article on p. 454 in vol. 15, PMID: 31591832.
    Language English
    Publishing date 2020-01-14
    Publishing country Korea (South)
    Document type Published Erratum
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2020.16.1.180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: John Greaves' Astronomica Quaedam

    Gregg De Young

    Proceedings of Indian National Science Academy, Vol 39, Iss

    Orientalism and Ptolemaic Cosmography in Seventeenth Century England

    2014  Volume 4

    Abstract: John Greaves' Astronomica Quaedam: Orientalism and Ptolemaic Cosmography in Seventeenth Century ...

    Abstract John Greaves' Astronomica Quaedam: Orientalism and Ptolemaic Cosmography in Seventeenth Century England
    Keywords Science ; Q
    Language English
    Publishing date 2014-11-01T00:00:00Z
    Publisher Indian National Science Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis.

    Kim, Su Hyun / Kim, Yeseul / Jung, Ji Yun / Park, Na Young / Jang, Hyunmin / Hyun, Jae Won / Kim, Ho Jin

    Journal of clinical neurology (Seoul, Korea)

    2019  Volume 15, Issue 4, Page(s) 454–460

    Abstract: Background and purpose: The anti-John-Cunningham virus (JCV)-antibody serostatus and index are ...

    Abstract Background and purpose: The anti-John-Cunningham virus (JCV)-antibody serostatus and index are used in the risk stratification of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients treated with natalizumab. However, little information on these parameters is available for Asian countries. The purpose of this study was to determine the rate of seropositivity, index, and longitudinal index evolution in Korean patients with MS.
    Methods: The antibody seroprevalence was analyzed in 355 samples from 187 patients with clinically isolated syndrome or MS using a second-generation, two-step, enzyme-linked immunosorbent assay. A 4-year longitudinal evaluation was applied to 66 patients.
    Results: The overall antibody seroprevalence was 80% (
    Conclusions: The seroprevalence and index of anti-JCV antibodies in Korean patients with MS may be higher than those in Western countries.
    Language English
    Publishing date 2019-10-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2500489-X
    ISSN 2005-5013 ; 1738-6586
    ISSN (online) 2005-5013
    ISSN 1738-6586
    DOI 10.3988/jcn.2019.15.4.454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The John N. Insall Award: Higher Tissue Concentrations of Vancomycin Achieved With Intraosseous Regional Prophylaxis in Revision TKA: A Randomized Controlled Trial.

    Young, Simon W / Zhang, Mei / Moore, Grant A / Pitto, Rocco P / Clarke, Henry D / Spangehl, Mark J

    Clinical orthopaedics and related research

    2018  Volume 476, Issue 1, Page(s) 66–74

    Abstract: Background: In primary TKA, prophylaxis with low-dose vancomycin through intraosseous regional administration (IORA) achieves tissue concentrations six to 10 times higher than systemic administration and was shown to provide more effective prophylaxis ... ...

    Abstract Background: In primary TKA, prophylaxis with low-dose vancomycin through intraosseous regional administration (IORA) achieves tissue concentrations six to 10 times higher than systemic administration and was shown to provide more effective prophylaxis in an animal model. However, in revision TKA, the presence of a tibial implant may compromise IORA injection, and tourniquet deflation during a prolonged procedure may lower tissue concentrations.
    Questions/purposes: (1) Does low-dose IORA reliably provide equal or higher tissue concentrations of vancomycin compared with systemic IV administration in revision TKA? (2) Are tissue concentrations of vancomycin after IORA maintained for the duration of the revision TKA despite a period of tourniquet deflation? (3) Is there any difference in early postoperative (< 6 weeks) complications between IORA and systemic IV administration in revision TKA?
    Methods: Twenty patients undergoing aseptic revision TKA were randomized to two groups. The IV group received 1 g systemic IV prophylactic vancomycin. The IORA group received 500 mg vancomycin as a bolus injection into a tibial intraosseous cannula below an inflated thigh tourniquet before skin incision. In all patients receiving IORA, intraosseous tibial injection was technically possible despite the presence of a tibial implant. Mean procedure length was 3.5 hours in both groups. Mean initial tourniquet inflation was 1.5 hours with a second inflation for a mean of 35 minutes during cementation. During the procedure, subcutaneous fat and bone samples were taken at regular intervals. Tissue vancomycin concentrations were measured using high-performance liquid chromatography.
    Results: Overall geometric mean tissue concentration of vancomycin in fat samples was 3.7 μg/g (95% confidence interval [CI], 2.6-5.2) in the IV group versus 49.3 μg/g in the IORA group (95% CI, 33.2-73.4; ratio between means 13.5; 95% CI, 8.2-22.0; p < 0.001); mean tissue concentrations in femoral bone were 6.4 μg/g (95% CI, 4.5-9.2) in the IV group versus 77.1 μg/g (95% CI, 42.4-140) in the IORA group (ratio between means 12.0; 95% CI, 6.2-23.2; p < 0.001). Vancomycin concentrations in the final subcutaneous fat sample taken before closure were 5.3 times higher in the IORA group versus the IV group (mean ± SD, 18.2 ± 11.6 μg/g IORA versus 3.6 ± 2.5 μg/g; p < 0.001). The intraarticular concentration of vancomycin on postoperative Day 1 drain samples was not different between the two groups with the numbers available (mean 4.6 μg/L in the IV group versus 6.6 μg/g in the IORA group; mean difference 2.0 μg/g; 95% CI, 6.2-23.2; p = 0.08).
    Conclusions: IORA administration of vancomycin in patients undergoing revision TKA resulted in tissue concentrations of vancomycin five to 20 times higher than systemic IV administration despite the lower dose. High tissue concentrations were maintained throughout the procedure despite a period of tourniquet deflation. These preliminary results justify prospective cohort studies, which might focus on broader safety endpoints in more diverse patient populations. We believe that these studies should evaluate patients undergoing revision TKA in particular, because the risk of infection is greater than in patients undergoing primary TKA.
    Level of evidence: Level I, therapeutic study.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Antibiotic Prophylaxis/adverse effects ; Antibiotic Prophylaxis/methods ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/instrumentation ; Awards and Prizes ; Chromatography, High Pressure Liquid ; Drug Monitoring/methods ; Female ; Humans ; Infusions, Intravenous ; Knee Prosthesis/adverse effects ; Male ; Middle Aged ; New Zealand ; Prospective Studies ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/prevention & control ; Reoperation ; Tourniquets ; Treatment Outcome ; Vancomycin/administration & dosage ; Vancomycin/pharmacokinetics
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999.0000000000000013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.188: Show issues Location:
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  8. Article: JOHN BRAXTON HICKS (1823-1897).

    Young, J H

    Medical history

    2006  Volume 4, Issue 2, Page(s) 153–162

    Language English
    Publishing date 2006-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 214353-7
    ISSN 2048-8343 ; 0025-7273
    ISSN (online) 2048-8343
    ISSN 0025-7273
    DOI 10.1017/s0025727300025230
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    In stock of ZB MED Cologne/Königswinter

    Ua II Zs.120: Show issues Location:
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  9. Article: St. John’s Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis

    You, Mikyoung / Lee, Young-Hyun / Kim, Hwa-Jin / Kook, Ji Hyun / Kim, Hyeon-A

    Nutrients. 2020 Oct. 17, v. 12, no. 10

    2020  

    Abstract: ... considered a potential treatment strategy for cancer. We demonstrated the inhibitory effect of St. John’s ...

    Abstract The rational regulation of programmed cell death by means of autophagy and apoptosis has been considered a potential treatment strategy for cancer. We demonstrated the inhibitory effect of St. John’s Wort (SJW) on growth in the triple-negative breast cancer (TNBC) cell line and xenografted mice and its target mechanism concerning autophagic and apoptotic cell death. SJW ethanol extract (SJWE) inhibited proliferation in a dose-dependent manner. SJWE treatment dramatically increased autophagy flux and apoptosis compared with the control. The autophagy inhibitor, 3-methyladenine (3-MA), reversed the SJWE-induced inhibition of cell proliferation and regulation of autophagy and apoptosis, indicating that SJWE induced apoptosis through prodeath autophagy. Furthermore, SJWE inhibited tumor growth and induced autophagy and apoptosis in the tumor of MDA-MB-231 xenografted athymic nude mice. Our results indicate that SJWE might have great potential as a new anticancer therapy for triple-negative breast cancer by inducing prodeath autophagy and apoptosis.
    Keywords apoptosis ; autophagy ; breast neoplasms ; cancer therapy ; cell lines ; cell proliferation ; dose response ; ethanol ; mice ; neoplasm cells ; nutrients
    Language English
    Dates of publication 2020-1017
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12103175
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The John Flynn Placement Program: evidence for repeated rural exposure for medical students.

    Young, Louise / Kent, Lachlan / Walters, Lucie

    The Australian journal of rural health

    2011  Volume 19, Issue 3, Page(s) 147–153

    Abstract: Objective: This paper reports on an evaluation of the John Flynn Placement Program (JFPP ...

    Abstract Objective: This paper reports on an evaluation of the John Flynn Placement Program (JFPP) for medical students. JFPP aims for medical students to experience both rural medicine and rural life as a way of increasing rural career intentions.
    Design: Medical students experience two weeks a year over four years with a rural doctor. Students are evaluated at the end of each placement for clinical and social experiences and career intent. They are followed up annually to monitor career intent. Mentors are evaluated annually on clinical and rural experiences during a placement.
    Setting: The Australian Government has several initiatives to encourage recruitment into rural medicine. One initiative is the JFPP. Students from all medical schools are placed with experienced general practitioners in rural and remote areas 4-7 locations across Australia.
    Participants: Evaluation data from 1450 placements from 2005-2009 are reported.
    Outcome measures: Data are presented highlighting evaluation of student and mentor perceptions of clinical and social experiences. Longitudinal tracking data provide an indication of the success of the program in terms of recruitment into the rural workforce.
    Results: Overall mean for clinical and rural experiences is extremely positive for both students and mentors. After four JFPP placements 65% of students intend to work in rural areas. After one JFPP experience 9% indicate intent to practise as a rural general practitioner while after their fourth JFPP nearly 20% are indicating intent to practise as a rural general practitioner.
    Conclusions: Longitudinal experiences, such as the JFPP, are positively influencing intention to enter the rural workforce but the impact of urban centric vocational training might be negating this impact.
    MeSH term(s) Adolescent ; Adult ; Aged ; Attitude of Health Personnel ; Australia ; Career Choice ; Education, Medical, Undergraduate/organization & administration ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Preceptorship/organization & administration ; Program Evaluation ; Rural Health Services/manpower ; Rural Population ; Students, Medical ; Young Adult
    Language English
    Publishing date 2011-06
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2069573-1
    ISSN 1440-1584 ; 1038-5282
    ISSN (online) 1440-1584
    ISSN 1038-5282
    DOI 10.1111/j.1440-1584.2011.01201.x
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