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  1. Article ; Online: Does native vitamin D, or active vitamin D modulate the neutralising antibody responses to COVID-19 vaccination in haemodialysis patients?

    Davenport, Andrew

    The International journal of artificial organs

    2024  Volume 47, Issue 4, Page(s) 251–259

    Abstract: Introduction: Several studies have reported that patients with low levels of Vitamin D: Methods: The inhibitory antibody (IC50) responses to several COVID-19 variants following vaccination in a cohort of United Kingdom haemodialysis patients ... ...

    Abstract Introduction: Several studies have reported that patients with low levels of Vitamin D
    Methods: The inhibitory antibody (IC50) responses to several COVID-19 variants following vaccination in a cohort of United Kingdom haemodialysis patients receiving two vaccinations between March 2021 and May 2021 were reviewed.
    Results: A total of 183 haemodialysis patients, 65.5% male, mean age 65.6 ± 14.1 years, 46.4% diabetic, 42.1% white ethnicity, body mass index 26.9 ± 6.5 kg/m
    Conclusions: The response to COVID-19 vaccination was reduced in our elderly haemodialysis patients compared to younger less frail patients, however there was no overall demonstrable effect of either 25-Vitamin D
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/03913988241241204
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    Zs.A 1439: Show issues Location:
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  2. Article ; Online: Is an incremental approach to starting haemodialysis an option for children ?

    Davenport, Andrew

    Journal of nephrology

    2023  Volume 36, Issue 6, Page(s) 1501–1503

    MeSH term(s) Child ; Humans ; Renal Dialysis ; Kidney ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy
    Language English
    Publishing date 2023-06-09
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01686-w
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    Zs.A 3369: Show issues Location:
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  3. Article ; Online: Time for a rethink: modification of diets for frail elderly patients with chronic kidney disease.

    Davenport, Andrew

    Journal of nephrology

    2023  Volume 36, Issue 5, Page(s) 1229–1231

    MeSH term(s) Humans ; Aged ; Frail Elderly ; Renal Insufficiency, Chronic ; Diet
    Language English
    Publishing date 2023-05-15
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01632-w
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    Zs.A 3369: Show issues Location:
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  4. Article ; Online: Reply: Differences in reporting the prevalence of osteoporosis in peritoneal dialysis patients due to variations in bone mineral density measurements.

    Davenport, Andrew

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2023  Volume 43, Issue 4, Page(s) 351–352

    MeSH term(s) Humans ; Bone Density ; Peritoneal Dialysis/adverse effects ; Prevalence ; Osteoporosis/epidemiology ; Osteoporosis/etiology ; Absorptiometry, Photon
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Letter
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608231183285
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  5. Article ; Online: Differences in prevalence of reduced and low bone mineral density between lumbar spine and femoral neck in peritoneal dialysis patients using dual-energy X-ray absorptiometry (DXA).

    Davenport, Andrew

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2023  Volume 43, Issue 4, Page(s) 334–338

    Abstract: The pattern of chronic kidney disease-mineral bone disease has changed following the increase in elderly patients receiving dialysis, with escalating likelihood of osteoporosis, with associated increased fracture risk and mortality. Thus, we wished to ... ...

    Abstract The pattern of chronic kidney disease-mineral bone disease has changed following the increase in elderly patients receiving dialysis, with escalating likelihood of osteoporosis, with associated increased fracture risk and mortality. Thus, we wished to determine the prevalence of osteoporosis in our peritoneal dialysis (PD) cohort. Lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA), and low BMD (osteoporosis) and reduced BMD (osteopenia) defined according to the World Health Organisation
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Absorptiometry, Photon ; Bone Density ; Bone Diseases, Metabolic ; Femur Neck/diagnostic imaging ; Osteoporosis/diagnostic imaging ; Osteoporosis/epidemiology ; Osteoporosis/etiology ; Peritoneal Dialysis/adverse effects ; Prevalence ; Lumbar Vertebrae/diagnostic imaging
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608221146867
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  6. Article ; Online: The changing face of dialyzer membranes and dialyzers.

    Davenport, Andrew

    Seminars in dialysis

    2023  

    Abstract: The key goals for dialysis treatments are to prevent the progressive accumulation of waste products of metabolism and volume overload. Traditionally uremic solutes have been classified according to molecular weight and termed small, middle sized, and ... ...

    Abstract The key goals for dialysis treatments are to prevent the progressive accumulation of waste products of metabolism and volume overload. Traditionally uremic solutes have been classified according to molecular weight and termed small, middle sized, and large solutes. Solute clearance during dialysis sessions will potentially be by diffusion, convection and adsorption. Dialyzer membranes act as a semi-permeable membrane restricting solute removal predominantly by size. Small molecules move faster than large molecules, so small solutes are readily removed by diffusion. Increasing the size of the pores in the membrane will potentially allow middle and larger sized solutes to pass through the dialyzer membrane, although in practice there is a limit to increasing pore sizes to prevent the loss of albumin and other important proteins. Differences in membrane surface and charge will influence protein absorption. The removal of fluid during dialysis depends in part on the hydraulic permeability of the membrane. Combining higher hydraulic permeability and larger sized pores increases convective clearance with solutes moving across the membrane with the water movement. Depending upon dialyzer design, higher hydrostatic pressure as blood enters the dialyzer leads to a variable amount of internal diafiltration, so improving the clearance of middle sized solutes. Although the dialyzer membrane plays a key role in solute clearance, the design of the casing and header also play a role in directing the countercurrent blood and dialysate flows to maximize the surface area available for diffusive and convective clearances.
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1028193-9
    ISSN 1525-139X ; 0894-0959
    ISSN (online) 1525-139X
    ISSN 0894-0959
    DOI 10.1111/sdi.13161
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    Zs.A 2879: Show issues Location:
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  7. Article ; Online: Survey of food offered to United Kingdom haemodialysis patients attending for dialysis sessions in main dialysis centres and satellite units and international comparison.

    Davenport, Andrew

    Renal replacement therapy

    2023  Volume 9, Issue 1, Page(s) 10

    Abstract: Background: Haemodialysis (HD) patients are at increased risk of frailty, sarcopenia and protein energy wasting, all associated with increased mortality. Most of the dialysis day is taken up with travelling to and from dialysis centres and dialysis ... ...

    Abstract Background: Haemodialysis (HD) patients are at increased risk of frailty, sarcopenia and protein energy wasting, all associated with increased mortality. Most of the dialysis day is taken up with travelling to and from dialysis centres and dialysis treatment. The International Society of Nutrition and Metabolism (ISNM) recommend that meals or supplements should be part of standard clinical practice when patients attending for dialysis.
    Results: We surveyed adult UK centres to determine the provision of food to dialysis patients in the United Kingdom (UK). A hot meal was provided by six (8.7%) of the 69 UK adult units, although 16 (23.2%) main centres would potentially provide meals to a restricted number of malnourished patients. Forty-seven (68.1%) centres provided sandwiches, although this was restricted in eight main centres, and 26.2% of units did not provide sandwiches to patients in their satellite dialysis centres. Biscuits were the only nutrition routinely offered in 15 (21.7%) of the main dialysis units, 41.3% of satellite units. Meals were more likely to be offered in Northern Ireland and Scotland compared to England, and 38% of the main dialysis units in England, and 58% of their satellite centres did not routinely offer patients a sandwich compared to none or one centre in Wales, Scotland and Northern Ireland.
    Conclusions: Despite an increasing older, more frail dialysis population in the UK, food provision for dialysis patients has reduced, particularly in England, with < 10% of centres routinely offering hot food, and > 50% of dialysis units now only offering biscuits to their satellite dialysis patients.
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Journal Article
    ISSN 2059-1381
    ISSN (online) 2059-1381
    DOI 10.1186/s41100-023-00466-3
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  8. Article ; Online: Calcium balance in peritoneal dialysis patients treated by continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) cyclers.

    Davenport, Andrew

    Journal of nephrology

    2023  Volume 36, Issue 7, Page(s) 1867–1876

    Abstract: Introduction: Although vascular calcification is a recognised complication for haemodialysis patients, peritoneal dialysis (PD) patients are also at risk. As such we wished to review peritoneal and urinary calcium balance and the effect of calcium ... ...

    Abstract Introduction: Although vascular calcification is a recognised complication for haemodialysis patients, peritoneal dialysis (PD) patients are also at risk. As such we wished to review peritoneal and urinary calcium balance and the effect of calcium containing phosphate binders (CCPBs).
    Methods: Twenty-four-hour peritoneal calcium balance and urinary calcium were reviewed in PD patients undergoing their first assessment of peritoneal membrane function.
    Results: Results from 183 patients, 56.3% male, 30.1% diabetic, mean age 59.4 ± 16.4 years, median 2.0 (2-6) months of PD, 29% treated by automated PD (APD), 26.8% continuous ambulatory (CAPD) and 44.2% APD with a day-time exchange (CCPD) were reviewed. Peritoneal calcium balance was positive in 42.6%, and remained positive in 21.3% after including urinary calcium losses. PD calcium balance was negatively associated with ultrafiltration (odds ratio 0.99 (95% confidence limits 0.98-0.99), p = 0.005. PD calcium balance was lowest with APD (APD - 0.45 (- 0.78 to 0.05) vs CAPD - 0.14 (- 1.18 to 0.59) vs CCPD - 0.03) - 0.48 to 0.5) mmol/day), p < 0.05, with 82.1% of patients with a positive balance prescribed icodextrin, when combining peritoneal and urinary losses. When considering CCPB prescription, then 97.8% of subjects prescribed CCPD had an over-all positive calcium balance.
    Discussion: Over 40% of PD patients had a positive peritoneal calcium balance. Elemental calcium intake from CCPB had a major effect on calcium balance, as median combined peritoneal and urinary calcium losses were < 0.7 mmol/day (26 mg), so caution is required to prevent excessive CCPB prescribing, increasing the exchangeable calcium pool and thus potentially increasing vascular calcification, particularly for anuric patients.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Female ; Peritoneal Dialysis, Continuous Ambulatory/adverse effects ; Peritoneal Dialysis, Continuous Ambulatory/methods ; Calcium ; Dialysis Solutions ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis/methods ; Vascular Calcification/etiology
    Chemical Substances Calcium (SY7Q814VUP) ; Dialysis Solutions ; calcium phosphate (97Z1WI3NDX)
    Language English
    Publishing date 2023-03-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01575-2
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    Zs.A 3369: Show issues Location:
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  9. Article ; Online: Prevalence and determinants of low plasma zinc levels in adult peritoneal dialysis patients.

    Davenport, Andrew

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2023  Volume 78, Page(s) 127171

    Abstract: Objective: Zinc is an essential trace element, being a cofactor for almost 300 enzymes. As zinc is widely available in the diet, the European Best Practice Guidelines do not recommend routine supplementation in dialysis patients. However, some medicines ...

    Abstract Objective: Zinc is an essential trace element, being a cofactor for almost 300 enzymes. As zinc is widely available in the diet, the European Best Practice Guidelines do not recommend routine supplementation in dialysis patients. However, some medicines prescribed to dialysis patients may potentially reduce absorption, and there may be increased losses with dialysis. As older and co-morbid patients are now treated by peritoneal dialysis (PD) we wished to determine the prevalence of patients with low plasma zinc levels.
    Design and methods: We prospectively measured plasma zinc in 550 PD patients attending for their first peritoneal membrane assessment using atomic absorption spectroscopy. Body composition was determined by bioimpedance.
    Results: Plasma zinc was measured in 550 patients, mean age 58.7 years, 60.6% male, mean value 10.8 ± 2.2 umol/L, with 66.5% having low zinc levels (<11.5 umol/L). Normal plasma zinc was associated with haemoglobin (odds ratio (OR) 1.41 (95% confidence limits (95%CL) 1.22-1.63), serum albumin (OR 1.04 (95%CL 1.002-1.087), higher glucose dialysates L/day (OR 1.06 (1.001-1.129), and negatively with 24-hour urinary protein losses (OR 0.786 (95%CL 0.673-0.918) and age (OR 0.985 (95%CL 0.972-1.0). There was no association with dialysis adequacy, original renal disease or dietary protein estimation. Prescription of phosphate binders had no effect on zinc levels (10.7 ± 2.2 vs 10.8 ± 2.3 umol/L).
    Conclusions: Most PD patients had low plasma zinc levels, associated with older age, probably reflecting reduced intake, urinary protein losses, and lower albumin and haemoglobin most likely linked to greater co-morbidity, low grade inflammation and volume expansion requiring higher glucose dialysates.
    MeSH term(s) Prevalence ; Zinc/blood ; Peritoneal Dialysis ; Trace Elements/blood ; Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Spectrophotometry, Atomic ; Dialysis Solutions/chemistry
    Chemical Substances Zinc (J41CSQ7QDS) ; Trace Elements ; Dialysis Solutions
    Language English
    Publishing date 2023-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2023.127171
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    Zs.A 2279: Show issues Location:
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  10. Article ; Online: Weight loss and weight gains in patients starting peritoneal dialysis; the effect of peritonitis.

    Davenport, Andrew

    Nephrology (Carlton, Vic.)

    2023  Volume 28, Issue 7, Page(s) 372–378

    Abstract: Aim: Earlier studies reported that peritoneal dialysis (PD) patients gained fat mass after initiating dialysis. Clinical practice and demographics have changed over time with earlier initiation of dialysis and increasing numbers of elderly, co-morbid ... ...

    Abstract Aim: Earlier studies reported that peritoneal dialysis (PD) patients gained fat mass after initiating dialysis. Clinical practice and demographics have changed over time with earlier initiation of dialysis and increasing numbers of elderly, co-morbid patients. As such, we wished to review changes in body composition with dialysis.
    Methods: Changes in body composition were compared by dual x-ray absorptiometry (DXA) in 151 adult PD patients, 81 males (54.6%), 50 diabetic (30.1%), mean age 60.5 ± 16.7 years, shortly after starting PD and then a median of 24 months later, to allow for the initial impact of dialysis.
    Results: Overall, weight appeared stable (71.7 ± 15.4 vs. 71.9 ± 15.3 kg). On follow-up, total weekly urea clearance fell from 2.29 (1.85-3.0) to 1.93 (1.63-2.4) whereas peritoneal glucose absorption increased from 119 (46-217) to 321 (187-805) mmol/day, p < .001, and estimated dietary protein (nPNA) fell from 0.92 ± 0.23 to 0.86 ± 0.23 g/kg/day, p = .006. However, 69 (45.7%) patients gained weight, with greater change in both lean and fat mass index versus those with weight loss (0.8 [-0.5 to 2.0] vs. -0.7 [-2.1 to 0.2] and 0.9 [-0.1 to 2.3] vs. 0 [-2.6 to 0.8] kg/m
    Conclusion: Dietary protein intake declined over time, and more PD patients lost weight. The major difference between those who gained and lost weight was episodes of peritonitis. Greater attention to nutritional support may potentially reduce loss of lean body mass.
    MeSH term(s) Adult ; Male ; Humans ; Aged ; Middle Aged ; Dietary Proteins ; Renal Dialysis ; Peritoneal Dialysis ; Peritonitis ; Weight Loss ; Weight Gain
    Chemical Substances Dietary Proteins
    Language English
    Publishing date 2023-05-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14161
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