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  1. Article: Choosing the right animal model for osteomyelitis research: Considerations and challenges.

    Huang, Shen / Wen, Jing / Zhang, Yiqing / Bai, Xiaochun / Cui, Zhong-Kai

    Journal of orthopaedic translation

    2023  Volume 43, Page(s) 47–65

    Abstract: Osteomyelitis is a debilitating bone disorder characterized by an inflammatory process involving the bone marrow, bone cortex, periosteum, and surrounding soft tissue, which can ultimately result in bone destruction. The etiology of osteomyelitis can be ... ...

    Abstract Osteomyelitis is a debilitating bone disorder characterized by an inflammatory process involving the bone marrow, bone cortex, periosteum, and surrounding soft tissue, which can ultimately result in bone destruction. The etiology of osteomyelitis can be infectious, caused by various microorganisms, or noninfectious, such as chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO). Researchers have turned to animal models to study the pathophysiology of osteomyelitis. However, selecting an appropriate animal model that accurately recapitulates the human pathology of osteomyelitis while controlling for multiple variables that influence different clinical presentations remains a significant challenge. In this review, we present an overview of various animal models used in osteomyelitis research, including rodent, rabbit, avian/chicken, porcine, minipig, canine, sheep, and goat models. We discuss the characteristics of each animal model and the corresponding clinical scenarios that can provide a basic rationale for experimental selection. This review highlights the importance of selecting an appropriate animal model for osteomyelitis research to improve the accuracy of the results and facilitate the development of novel treatment and management strategies.
    Language English
    Publishing date 2023-11-29
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2747531-1
    ISSN 2214-031X
    ISSN 2214-031X
    DOI 10.1016/j.jot.2023.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Polymerizable rotaxane of cucurbituril protecting dopamine based adhesive hydrogels.

    Gao, Yunpeng / Tian, Xin / Xiong, Xueru / Wang, Yushi / Huang, Wen / Shi, Xuetao / Jia, Yong-Guang / Cui, Zhong-Kai

    International journal of biological macromolecules

    2024  Volume 265, Issue Pt 1, Page(s) 130680

    Abstract: The catechol moiety found within mussel proteins plays a pivotal role in enhancing their adhesive properties. Nonetheless, catechol compounds, such as dopamine (DOP) derivatives, are susceptible to oxidation, leading to the formation of quinone. This ... ...

    Abstract The catechol moiety found within mussel proteins plays a pivotal role in enhancing their adhesive properties. Nonetheless, catechol compounds, such as dopamine (DOP) derivatives, are susceptible to oxidation, leading to the formation of quinone. This oxidation process poses a significant challenge in the development of DOP-based hydrogels, hampering their adhesion capabilities and hindering polymerization. To protect DOP moieties from oxidation, DOP and N-(3-aminopropyl)methacrylamide (AMA) moieties were grafted onto the side groups of biocompatible poly(glutamic acid) (PGA). Subsequently, the DOP unit, serving as a second guest, would be captured by a polymerizable rotaxane of cucurbituril (CB[n]), in which the host molecule CB[8] complexed with the first guest, polymerizable methyl viologen (MV), forming a protective function and dynamic cross-linking. Upon exposure to light curing, a composite network emerged through the synergy of covalent cross-linking and supramolecular host-guest complexation of DOP with CB[8]. The generated complexation between DOP and CB[8] could protect the DOP moieties, resulting in photocured hydrogels with exceptional adhesive strength and remarkable tensile capabilities. Moreover, 3D printing technology was used to create various models with these DOP-based hydrogels, demonstrating their promising applications in future.
    MeSH term(s) Hydrogels ; Dopamine ; Adhesives ; Rotaxanes ; Macrocyclic Compounds
    Chemical Substances Hydrogels ; Dopamine (VTD58H1Z2X) ; Adhesives ; Rotaxanes ; Macrocyclic Compounds
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130680
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  3. Article ; Online: A facile and smart strategy to enhance bone regeneration with efficient vitamin D

    Ye, Shuxi / Wen, Jing / Ye, Wen-Hao / Li, Zhen / Huang, Xiaomeng / Chen, Sixu / Ma, Jian-Chao / Wu, Yaohong / Chen, Rongchun / Cui, Zhong-Kai

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 370, Page(s) 140–151

    Abstract: The spontaneous healing of critical-sized bone defects is often limited, posing an increased risk of complications and suboptimal outcomes. Osteogenesis, a complex process central to bone formation, relies significantly on the pivotal role of osteoblasts. ...

    Abstract The spontaneous healing of critical-sized bone defects is often limited, posing an increased risk of complications and suboptimal outcomes. Osteogenesis, a complex process central to bone formation, relies significantly on the pivotal role of osteoblasts. Despite the well-established osteogenic properties of vitamin D
    Language English
    Publishing date 2024-04-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2024.04.033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Hierarchical and Orderly Surface Conductive Networks in Yolk-Shell Fe

    He, Peng / Ma, Wenjun / Xu, Jian / Wang, Yizhe / Cui, Zhong-Kai / Wei, Jie / Zuo, Peiyuan / Liu, Xiaoyun / Zhuang, Qixin

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 40, Page(s) e2302961

    Abstract: Constructing the adjustable surface conductive networks is an innovation that can achieve a balance between enhanced attenuation and impedance mismatch according to the microwave absorption mechanism. However, the traditional design strategies remain ... ...

    Abstract Constructing the adjustable surface conductive networks is an innovation that can achieve a balance between enhanced attenuation and impedance mismatch according to the microwave absorption mechanism. However, the traditional design strategies remain significant challenges in terms of rational selection and controlled growth of conductive components. Herein, a hierarchical construction strategy and quantitative construction technique are employed to introduce conductive metal-organic frameworks (MOFs) derivatives in the classic yolk-shell structure composed of electromagnetic components and the cavity for remarkable optimized performance. Specifically, the surface conductive networks obtained by carbonized ZIF-67 quantitative construction, together with the Fe
    Language English
    Publishing date 2023-06-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202302961
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  5. Article: The Role of Nrf2 in Hearing Loss.

    Li, Dafei / Zhao, Haiyan / Cui, Zhong-Kai / Tian, Guangyong

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 620921

    Abstract: Hearing loss is a major unresolved problem in the world, which has brought a heavy burden to society, economy, and families. Hair cell damage and loss mediated by oxidative stress are considered to be important causes of hearing loss. The nuclear factor ... ...

    Abstract Hearing loss is a major unresolved problem in the world, which has brought a heavy burden to society, economy, and families. Hair cell damage and loss mediated by oxidative stress are considered to be important causes of hearing loss. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant capacity and is involved in the occurrence and development of a series of toxic and chronic diseases associated with oxidative stress. In recent years, studies on the correlation between hearing loss and Nrf2 target have continuously broadened our knowledge, and Nrf2 has become a new strategic target for the development and reuse of hearing protection drugs. This review summarized the correlation of Nrf2 in various types of hearing loss, and the role of drugs in hearing protection through Nrf2 from the literature.
    Language English
    Publishing date 2021-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.620921
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  6. Article ; Online: Abdominal vascular injury caused by lumbar reoperation surgery: A rare case report and literature review.

    Yang, Jia / Zheng, Jia-Le / Pang, Li-Kai / Cui, Zhong-Ning

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.046
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  7. Article ; Online: Intelligent Path-Selection-Aided Decoding of Polar Codes.

    Cui, Hongji / Niu, Kai / Zhong, Shunfu

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 2

    Abstract: CRC-aided successive cancellation list (CA-SCL) decoding is a powerful algorithm that dramatically improves the error performance of polar codes. Path selection is a major issue that affects the decoding latency of SCL decoders. Generally, path selection ...

    Abstract CRC-aided successive cancellation list (CA-SCL) decoding is a powerful algorithm that dramatically improves the error performance of polar codes. Path selection is a major issue that affects the decoding latency of SCL decoders. Generally, path selection is implemented using a metric sorter, which causes its latency to increase as the list grows. In this paper, intelligent path selection (IPS) is proposed as an alternative to the traditional metric sorter. First, we found that in the path selection, only the most reliable paths need to be selected, and it is not necessary to completely sort all paths. Second, based on a neural network model, an intelligent path selection scheme is proposed, including a fully connected network construction, a threshold and a post-processing unit. Simulation results show that the proposed path-selection method can achieve comparable performance gain to the existing methods under SCL/CA-SCL decoding. Compared with the conventional methods, IPS has lower latency for medium and large list sizes. For the proposed hardware structure, IPS's time complexity is O(klog2(L)) where
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25020200
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  8. Article ; Online: Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil

    Zheng Zhang / Jun Yang / Qing Yang / Guangyong Tian / Zhong-Kai Cui

    Frontiers in Molecular Biosciences, Vol

    2021  Volume 8

    Abstract: Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, ... ...

    Abstract Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations.
    Keywords non-phospholipid liposomes ; fungicide ; sustained release ; nanotechnology applications ; cymoxanil ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil.

    Zhang, Zheng / Yang, Jun / Yang, Qing / Tian, Guangyong / Cui, Zhong-Kai

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 627817

    Abstract: Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, ... ...

    Abstract Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations.
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.627817
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  10. Article ; Online: Morphology-Controlled Fabrication Strategy of Hollow Mesoporous Carbon Spheres@f-Fe

    Ma, Wenjun / Tang, Chuanhao / He, Peng / Wu, Xiaohan / Cui, Zhong-Kai / Lin, Shaoliang / Liu, Xiaoyun / Zhuang, Qixin

    ACS applied materials & interfaces

    2022  Volume 14, Issue 30, Page(s) 34985–34996

    Abstract: The design and development of radar--infrared compatible stealth materials are challenging in the field of broadband absorption due to the contradiction of stealth requirements and mechanisms in different frequency bands. However, hollow structures show ... ...

    Abstract The design and development of radar--infrared compatible stealth materials are challenging in the field of broadband absorption due to the contradiction of stealth requirements and mechanisms in different frequency bands. However, hollow structures show great promise for multispectral stealth because they can lengthen the attenuation path of electromagnetic waves (EMWs) for microwave absorption, interrupt the continuity of heat-transport channels, and lower the thermal conductivity to realize infrared stealth. Here, a new morphological fabrication strategy has been developed to efficiently prepare compatible stealth nanomaterials. In a specific hydrothermal process, the confined growth of flake α-Fe
    Language English
    Publishing date 2022-07-23
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c08077
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