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Article ; Online: A retrospective study of people with familial hypercholesterolaemia in a Belgian lipid clinic.

Ide, V / De Cock, D / Pazmino, S / Vangoitsenhoven, R / Van der Schueren, B / Mertens, A

2023 Volume 79, Issue 1, Page(s) 58–67

Abstract: Background: Familial hypercholesterolaemia (FH) is a genetic disease characterised by hypercholesterolaemia and premature cardiovascular events. Early diagnosis and treatment can reduce the cardiovascular burden. We describe the characteristics of ... ...

Abstract	Background: Familial hypercholesterolaemia (FH) is a genetic disease characterised by hypercholesterolaemia and premature cardiovascular events. Early diagnosis and treatment can reduce the cardiovascular burden. We describe the characteristics of patients with heterozygous FH followed in a tertiary hospital in Belgium. Methods: We retrospectively studied a population of 321 patients with definite heterozygous FH who visited the UZ Leuven lipid clinic at least once between 1 January 2016 and 31 December 2020. Data are represented as mean ± SD. Results: The age at time of diagnosis of FH was 39 ± 18 years. Patients with atherosclerotic disease (secondary prevention) were older ( Conclusions: In this Belgian population, people with heterozygous FH remain undertreated. Reaching treatment targets in FH seems possible, although this requires combination treatment (with PCSK9-targeted therapy) in most patients. Earlier diagnosis of FH, more extensive lipid-lowering treatment and reimbursement options and a more holistic approach are needed to lower LDL-C and cardiovascular risk in patients with FH.
MeSH term(s)	Humans ; Male ; Young Adult ; Adult ; Middle Aged ; Proprotein Convertase 9 ; Cholesterol, LDL ; Retrospective Studies ; Belgium/epidemiology ; Risk Factors ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/therapy ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Anticholesteremic Agents/therapeutic use
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Anticholesteremic Agents
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2023.2266647
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Article ; Online: A Case of Bovine Linear Keratosis.

Deprez, P / Cock, H DE / Sustronck, B / Muylle, E / Ducatelle, R

Veterinary dermatology

2021 Volume 6, Issue 1, Page(s) 45–49

Abstract: ... des lésions macro et microscopiques. [Deprez, P., De Coole, H., Sustronk, B., Muille, E., Ducatelle, R. A case ...

Abstract	Résumé- Cet article décrit un cas de nevus épidermique linéaire unilatéral chez un veau de six mois. Histologiquement, les lésions consistaient en une alternance de zones d'hiper et de parakératose avec une inflammation dermique distincte. Le diagnostic de nevus linéaire inflammatoire a été posé sur la base des lésions macro et microscopiques. [Deprez, P., De Coole, H., Sustronk, B., Muille, E., Ducatelle, R. A case of bovine linear keratosis (A propos d'un cas de kératose linéaire chez un bovin). Resumen- En este artículo se describe un caso de nevos epidérmicos lineares unilaterales en un bo vino de seis meses de edad. Las lesiones histológicas consistian zonas donde se alternaba hiper i paraqueratosis, mientras que la dermis presentaba una marcada inflamación. Se diagnosticó un nevo epidérmico verrucoso linear e inflamatorio a partir de las lesiones clinicas e histopatológicas [A case of bovine linear keratosis (Un caso de queratosis linear bovina). Abstract- This report describes a case of unilateral linear epidermal nevi in a 6-month-old bovine. Histologicalli, the lesions consisted of alternating areas of hiper- and parakeratosis with a distinct dermal inflammation. A diagnosis of inflammatori linear verrucous epidermal nevus was made based on the clinical and histopathological lesions.
Language	English
Publishing date	2021-10-14
Publishing country	England
Document type	Case Reports
ZDB-ID	2011122-8
ISSN	1365-3164 ; 0959-4493
ISSN (online)	1365-3164
ISSN	0959-4493
DOI	10.1111/j.1365-3164.1995.tb00040.x
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Article ; Online: Psychosocial Burden Predicts Sustained Remission in Early Rheumatoid Arthritis: Unraveling the Complex Interplay of Well-Being and Disease Activity.

Doumen, Michaël / De Cock, Diederik / Pazmino, Sofia / Bertrand, Delphine / Joly, Johan / Westhovens, René / Verschueren, Patrick

Arthritis care & research

2022 Volume 75, Issue 4, Page(s) 758–767

Abstract: ... Revised Illness Perception Questionnaire (IPQ-R), and the Utrecht Coping List. These psychosocial ... with higher SF-36 scores and more positive IPQ-R outcomes at week 16. Among patients in DAS28-CRP remission ...

Abstract	Objective: This study investigated how psychosocial aspects of disease affect the probability of achieving sustained remission in early rheumatoid arthritis (RA) and explored the directionality of this relationship. Methods: Data were analyzed from the randomized controlled Care in Early RA trial. Sustained remission was defined as a continued Disease Activity Score in 28 joints using the C-reactive protein level (DAS28-CRP) of <2.6 from weeks 16 to 104. Patients completed the Short Form 36 (SF-36) health survey, Revised Illness Perception Questionnaire (IPQ-R), and the Utrecht Coping List. These psychosocial variables were studied at baseline and at week 16 as predictors of sustained remission with logistic regression. Next, subgroups of patients in remission at week 16 were identified by Latent Profile Analysis based on these psychosocial indicators. Time to first loss of remission was then compared between groups by Cox proportional hazards regression. Finally, directionality of associations between psychosocial indicators and DAS28-CRP was explored with cross-lagged panel models (CLPMs). Results: Sustained DAS28-CRP remission was associated with higher SF-36 scores and less passive coping at baseline and with higher SF-36 scores and more positive IPQ-R outcomes at week 16. Among patients in DAS28-CRP remission at week 16 (n = 287), 2 subgroups were identified: a low psychosocial burden group (n = 231 of 287) and a high psychosocial burden group (n = 56 of 287). The low psychosocial burden group retained remission longer (hazard ratio 0.51 [0.35-0.73]). In the CLPM, temporal relationships between psychosocial well-being and DAS28-CRP were complex, bidirectional, and disease-phase dependent. Conclusion: Suboptimal psychosocial well-being and negative illness perceptions predicted lower probability of sustained remission in an early RA cohort. Illness perceptions appeared to become more clinically relevant with time. Finally, 1 in 5 patients showed worse psychosocial outcomes despite early remission, and these patients tended to lose remission earlier.
MeSH term(s)	Humans ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Logistic Models ; Remission Induction ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24847
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Article ; Online: Trends in TB and HIV care and treatment cascade, Kenya, 2008-2018.

Weyenga, H / Onyango, E / Katana, A K / Pathmanathan, I / Sidibe, K / Shah, N S / Ngugi, E W / Waruingi, R N / Ng Ang A, L / De Cock, K M

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2022 Volume 26, Issue 7, Page(s) 623–628

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Incidence ; Kenya/epidemiology ; Prevalence ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
Language	English
Publishing date	2022-07-19
Publishing country	France
Document type	Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.21.0408
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Article ; Online: Response to Unmet needs in the treatment of rheumatoid arthritis. An observational study and a real-life experience from a single university center.

De Cock, D / Vanhoffelen, E / Stouten, V / Verschueren, P / Westhovens, R

Seminars in arthritis and rheumatism

2019 Volume 50, Issue 2, Page(s) e6

MeSH term(s)	Arthritis, Rheumatoid ; Health Services Needs and Demand ; Humans ; Universities
Language	English
Publishing date	2019-07-13
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2019.06.022
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Article ; Online: Updates to the modern diagnosis of GERD: Lyon consensus 2.0.

Gut

2024 Volume 73, Issue 2, Page(s) 361–371

Abstract: The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusive. An ... ...

Abstract	The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusive. An international core and working group was assembled to evaluate research since publication of the original Lyon Consensus, and to vote on statements collaboratively developed to update criteria. The Lyon Consensus 2.0 provides a modern definition of actionable GERD, where evidence from oesophageal testing supports revising, escalating or personalising GERD management for the symptomatic patient. Symptoms that have a high versus low likelihood of relationship to reflux episodes are described. Unproven versus proven GERD define diagnostic strategies and testing options. Patients with no prior GERD evidence (unproven GERD) are studied using prolonged wireless pH monitoring or catheter-based pH or pH-monitoring off antisecretory medication, while patients with conclusive GERD evidence (proven GERD) and persisting symptoms are evaluated using pH-impedance monitoring while on optimised antisecretory therapy. The major changes from the original Lyon Consensus criteria include establishment of Los Angeles grade B oesophagitis as conclusive GERD evidence, description of metrics and thresholds to be used with prolonged wireless pH monitoring, and inclusion of parameters useful in diagnosis of refractory GERD when testing is performed on antisecretory therapy in proven GERD. Criteria that have not performed well in the diagnosis of actionable GERD have been retired. Personalisation of investigation and management to each patient's unique presentation will optimise GERD diagnosis and management.
MeSH term(s)	Humans ; Esophageal pH Monitoring ; Consensus ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/therapy ; Esophagitis/drug therapy ; Proton Pump Inhibitors/therapeutic use
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2023-330616
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Article ; Online: Reply to 'Intraocular lens calcification following endothelial keratoplasty: a message for all cataract surgeons'.

De Cock, R / Fajgenbaum, M A P

Eye (London, England)

2015 Volume 29, Issue 7, Page(s) 984–985

MeSH term(s)	Calcinosis/etiology ; Descemet Stripping Endothelial Keratoplasty ; Humans ; Lenses, Intraocular ; Postoperative Complications
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2015.50
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Article ; Online: Belgian rheumatologists' preferences regarding measures of disease activity in patients with rheumatoid arthritis: results from a mixed-methods study.

De Cock, D / Buckinx, E / Pazmino, S / Bertrand, D / Stouten, V / Westhovens, R / Verschueren, P

Rheumatology international

2021 Volume 42, Issue 5, Page(s) 815–823

Abstract: The reliability and clinical usefulness of the different composite disease activity scores and their individual components in Rheumatoid Arthritis (RA) are still debated. This study investigated which measures of disease activity were preferred by ... ...

Abstract	The reliability and clinical usefulness of the different composite disease activity scores and their individual components in Rheumatoid Arthritis (RA) are still debated. This study investigated which measures of disease activity were preferred by rheumatologists. A mixed-method study was performed. First, ten Belgian rheumatologists were invited for individual interviews on their current practice and preferences for measurement of RA disease activity. Results of this qualitative study and evidence from literature served as input for developing a survey. This survey asked rheumatologists to rate preferred standard disease activity score(s), their individual components, ultrasound and related patient-reported outcomes (PROs), by maximum difference scaling. The relative importance score (RIS) for each indicator was calculated using hierarchical Bayes modeling. The qualitative study included 6/10 invited rheumatologists. Composite scores and components were perceived as useful, while PROs were found subjective. Interestingly, ultrasound was used to mediate discrepancies between physician and patient. The survey based on this was sent to 244 Belgian rheumatologists, 83/244 (34%) responded, including 66/83 (80%) complete and 17/83 (20%) incomplete surveys (two missing essential information). Most rheumatologists (75/81, 93%) used a disease activity score and 68/81 (84%) preferred the DAS28-CRP. Swollen joint count obtained the highest mean ± SD RIS (22.54 ± 2.64), followed by DAS28 ESR/CRP (20.61 ± 4.06), ultrasound (16.47 ± 7.97), CRP (13.34 ± 6.11) and physician's global assessment (12.59 ± 7.83). PROs including fatigue, pain, and patient's global assessment, and Health Assessment Questionnaire, obtained the lowest mean RIS (0.34-2.54). Rheumatologists place more faith in self-assessed disease activity components or in laboratory tests. Trust in PROs to evaluate disease activity is low in clinical practice.
MeSH term(s)	Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/drug therapy ; Bayes Theorem ; Belgium ; Humans ; Reproducibility of Results ; Rheumatologists ; Severity of Illness Index ; Surveys and Questionnaires
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2021-10-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-05020-0
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Article ; Online: Treatment response and several patient-reported outcomes are early determinants of future self-efficacy in rheumatoid arthritis.

Doumen, Michaël / De Cock, Diederik / Pazmino, Sofia / Bertrand, Delphine / Joly, Johan / Westhovens, René / Verschueren, Patrick

Arthritis research & therapy

2021 Volume 23, Issue 1, Page(s) 269

Abstract: ... Short-Form 36 (SF-36), Revised Illness Perception Questionnaire (IPQ-R), Utrecht Coping List (UCL ... with higher self-efficacy. While patient-reported factors (HAQ, SF-36, RAQoL, IPQ-R, pain, fatigue and ... vitality, mental health and role emotional; IPQ-R illness coherence, treatment control, emotional ...

Abstract	Background: Self-efficacy, or patients' confidence in their ability to control disease and its consequences, was recently prioritised in EULAR recommendations for inflammatory arthritis self-management strategies. However, it remains unclear which factors influence self-efficacy in early rheumatoid arthritis (RA). Methods: Data were analysed from the 2-year RCT Care in early RA (CareRA), which studied remission-induction treatment regimens for early RA. Participants completed the Arthritis Self-Efficacy Scale (ASES), Short-Form 36 (SF-36), Revised Illness Perception Questionnaire (IPQ-R), Utrecht Coping List (UCL), RAQoL and Health Assessment Questionnaire (HAQ). Depending on time to first remission (DAS28-CRP < 2.6) and persistence of remission, treatment response was defined as persistent response, secondary failure, delayed response, late response or non-response. The association between ASES scores and clinical/psychosocial factors was explored with Spearman correlation and multivariate linear mixed models. Baseline predictors of week 104 ASES were identified with exploratory linear regression followed by multiple regression of significant predictors adjusted for DAS28-CRP, HAQ, treatment arm, treatment response, cumulative CRP/SJC28 and demographic/serologic confounders. Results: All 379 patients had a recent diagnosis of RA and were DMARD-naïve at study initiation. Most patients were women (69%) and RF/ACPA-positive (66%), and the mean (SD) age was 52 (13) years. For all tested outcome measures, better perceived health correlated with higher self-efficacy. While patient-reported factors (HAQ, SF-36, RAQoL, IPQ-R, pain, fatigue and patient's global assessment) showed moderate/strong correlations with ASES scores, correlations with physician-reported factors (physician's global assessment, SJC28), TJC28 and DAS28-CRP were weak. Only more favourable outcomes on patient-reported factors and DAS28-CRP were associated with higher ASES scores at each time point. An earlier, persistent treatment response predicted higher ASES scores at both weeks 52 and 104. Significant baseline predictors of week 104 ASES included HAQ; SF-36 mental component score, vitality, mental health and role emotional; IPQ-R illness coherence, treatment control, emotional representations and consequences; UCL Passive reacting; and the RAQoL. Conclusions: Patient-reported outcomes and treatment response were early determinants of long-term self-efficacy in an early RA trial. These results provide further relevance for the window of opportunity in an early treat-to-target strategy and could help to timely identify patients who might benefit from self-management interventions. Trial registration: EudraCT 2008-007225-39.
MeSH term(s)	Adult ; Aged ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Self Efficacy ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-021-02651-3
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Article ; Online: Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations.

Krijger, Inge M / Strating, Max / van Gent-Pelzer, Marga / van der Lee, Theo A J / Burt, Sara A / Schroeten, Fleur H / de Vries, Robin / de Cock, Marieke / Maas, Miriam / Meerburg, Bastiaan G

Pest management science

2022 Volume 79, Issue 3, Page(s) 989–995

Abstract: ... of rodenticide resistance amongst R. norvegicus and house mice Mus musculus in the Netherlands, we tested ... of 1801 rodent samples were collected throughout the country consisting of 1404 R. norvegicus and 397 M ... musculus. In total, 15% of R. norvegicus [95% confidence interval (CI): 13-17%] and 38% of M. musculus (95 ...

Abstract	Background: Resistance to rodenticides has been reported globally and poses a considerable problem for efficacy in pest control. The most-documented resistance to rodenticides in commensal rodents is associated with mutations in the Vkorc1 gene, in particular in codon 139. Resistance to anticoagulant rodenticides has been reported in the Netherlands since 1989. A study from 2013 showed that 25% of 169 Norway rats (Rattus norvegicus) had a mutation at codon 139 of the Vkorc1 gene. To gain insight in the current status of rodenticide resistance amongst R. norvegicus and house mice Mus musculus in the Netherlands, we tested these rodents for mutations in codon 139 of the Vkorc1 gene. In addition, we collected data from pest controllers on their use of rodenticides and experience with rodenticide resistance. Results: A total of 1801 rodent samples were collected throughout the country consisting of 1404 R. norvegicus and 397 M. musculus. In total, 15% of R. norvegicus [95% confidence interval (CI): 13-17%] and 38% of M. musculus (95% CI: 33-43%) carried a genetic mutation at codon 139 of the Vkorc1 gene. Conclusion: This study demonstrates genetic mutations at codon 139 of the Vkorc1 gene in M. musculus in the Netherlands. Resistance to anticoagulant rodenticides is present in R. norvegicus and M. musculus in multiple regions in the Netherlands. The results of this comprehensive study provide a baseline and facilitate trend analyses of Vkorc1 codon 139 mutations and evaluation of integrated pest management (IPM) strategies as these are enrolled in the Netherlands. © 2022 The Dutch Pest and Wildlife. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
MeSH term(s)	Mice ; Rats ; Animals ; Rodenticides/pharmacology ; Netherlands ; Vitamin K Epoxide Reductases/genetics ; Mutation ; Anticoagulants/pharmacology ; Codon ; Drug Resistance/genetics ; Membrane Proteins/genetics
Chemical Substances	Rodenticides ; Vitamin K Epoxide Reductases (EC 1.17.4.4) ; Anticoagulants ; Codon ; VKORC1 protein, mouse (EC 1.17.4.4) ; Membrane Proteins ; VKORC1 protein, rat (EC 1.17.4.4)
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7261
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