LIVIVO - Search results -

Search results

Result 1 - 10 of total 52

Search options

Article ; Online: Sensitivity and specificity of body mass index and main risk factors for cardiovascular disease in middle-income urban participants in Guanajuato, Mexico.

Ruiz González, Susana Del Refugio / Monroy Torres, Rebeca / Malacara, Juan Manuel / Guardado-Mendoza, Rodolfo

2022 Volume 39, Issue 5, Page(s) 1027–1036

Abstract: Introduction: Introduction: several studies have questioned body mass index (BMI) as an accurate diagnostic tool for obesity and therefore a predictor of cardiovascular risk. But BMI is widely used currently. Objective: we analyzed the sensitivity and ... ...

Title translation	Sensibilidad y especificidad del índice de masa corporal y principales factores de riesgo de enfermedad cardiovascular en participantes de zona urbana de ingresos medios en Guanajuato, México.
Abstract	Introduction: Introduction: several studies have questioned body mass index (BMI) as an accurate diagnostic tool for obesity and therefore a predictor of cardiovascular risk. But BMI is widely used currently. Objective: we analyzed the sensitivity and specificity of BMI and compared cardiovascular risk factors in middle-income urban participants in Guanajuato, Mexico, at different ages. Design: an analytical and cross-sectional study was carried out in 385 apparently healthy subjects, stratified by age ranges (20 to 59 years old). A high global CVD risk was obtained with the Framingham risk score (Framingham Risk Score > 20 %). The odds ratio was used to assess the association between high global CVD risk and the dietetic and anthropometric variables. Sensitivity, specificity, and correlation statistical analyses were carried out between BMI and other anthropometric variables with high cardiovascular risk, and this was integrated to derive recommendations to improve risk factor detection (p < 0.05 and power of 80 %). Results: a high global CVD risk was found in 4 % of the sample. BMI ≥ 30 kg/m2 had a sensitivity of 77 % for the detection of high cardiovascular risk; waist circumference ≥ 90 cm (men) or ≥ 80 cm (women) and body fat percentage ≥ 2 5% (men) or ≥ 35 % (women) had a sensitivity of 100 %. BMI showed a significant association with high global CVD risk (OR = 6.1; 95 % CI, 1.6-22.6, p < 0.01), but was not able to predict high global CVD risk in at least 30 % of the cases. There was not significative difference by age group for waist circumference, body fat percentage, total cholesterol, and low-density lipoprotein. Regarding the comparison of dietary intake of the stratified population by age group, intake of cholesterol, added sugars, fiber, sodium were highest in the 20 years group. Conclusions: a higher intake of cholesterol, simple sugars, and sodium was observed in the 20-year-old age group. The use of BMI with waist circumference and percentage of body fat used together allow a better assessment of cardiovascular risk. We need to integrate this new recommendation to increase early detection of main risk factors for cardiovascular disease.
MeSH term(s)	Adult ; Body Mass Index ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Female ; Heart Disease Risk Factors ; Humans ; Lipoproteins, LDL ; Male ; Mexico/epidemiology ; Middle Aged ; Monosaccharides ; Risk Factors ; Sodium ; Sugars ; Waist Circumference ; Young Adult
Chemical Substances	Lipoproteins, LDL ; Monosaccharides ; Sugars ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-09-22
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1481223-x
ISSN	1699-5198 ; 0212-1611
ISSN (online)	1699-5198
ISSN	0212-1611
DOI	10.20960/nh.04074
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5078: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comparison between metabolically healthy obesity and metabolically unhealthy obesity by different definitions among Mexican children.

Evia-Viscarra, María Lola / Guardado-Mendoza, Rodolfo

Journal of pediatric endocrinology & metabolism : JPEM

2019 Volume 33, Issue 2, Page(s) 215–222

Abstract: Background There is no consensus on the definition of metabolically healthy obesity (MHO) and the diagnostic criteria in children. Objectives To estimate the prevalence of MHO and compare clinical and biochemical characteristics between MHO and ... ...

Abstract	Background There is no consensus on the definition of metabolically healthy obesity (MHO) and the diagnostic criteria in children. Objectives To estimate the prevalence of MHO and compare clinical and biochemical characteristics between MHO and metabolically unhealthy obesity (MUO), and to evaluate the association between MUO and cardiovascular disease (CVD) risk, anthropometrics and family background using different definitions in children. Methods This was a cross-sectional study. Participants included 224 obese children between the years 2007 and 2017. MHO was defined by three different criteria: (i) absence of metabolic syndrome (MHO-MS), (ii) no insulin resistance (IR) by homeostatic model assessment (HOMA) <3.16 cut-off (MHO-IR3.16) and (iii) absence of IR at <95th percentile for Mexican children (MHO-95th). Results The prevalence of MHO-MS, MHO-IR3.16 and MHO-IR95th was 12.9%, 56.3% and 41.5%, respectively. The prevalence of simultaneous MHO-MS plus MHO-IR95th was 5.36%. Children with MHO-MS vs. MUO-MS showed lower height, weight and body mass index (BMI) percentiles; MHO-IR3.16 vs. MUO-IR3.16 showed lower age, acanthosis, Tanner, waist circumference (WC), waist-to-height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and glucose; and MHO-IR95th vs. MUO-IR95th showed lower acanthosis, WC, DBP, glucose and high high-density lipoprotein cholesterol (HDL-C). MUO-MS was associated with WC > 90th, type 2 diabetes mellitus (T2DM) in first-degree relatives and obesity in siblings. MUO-IR3.16 was associated with pubertal stages, WC > 90th, WHtR > 0.55 and fasting hyperglycemia. MUO-IR95th was associated with WHtR > 0.55 and HDL < 10th. MHO-MS and MHO-IR3.16 or MHO-IR95th did not have agreement. Conclusions The prevalence of MHO varied depending on the definition, although the real MHO with no MS or IR is very low. Low DBP and high HDL-C in MHO were present in any definition. Association of MUO with anthropometric, biochemical and family background differs across definitions.
MeSH term(s)	Adolescent ; Body Mass Index ; Child ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Insulin Resistance ; Male ; Mexico/epidemiology ; Obesity, Metabolically Benign/epidemiology ; Obesity, Metabolically Benign/physiopathology ; Pediatric Obesity/epidemiology ; Pediatric Obesity/physiopathology ; Prevalence ; Prognosis ; Risk Factors ; Waist Circumference
Language	English
Publishing date	2019-12-13
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2019-0077
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2258: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era.

Martínez-López, Yoscelina Estrella / Esquivel-Hernández, Diego A / Sánchez-Castañeda, Jean Paul / Neri-Rosario, Daniel / Guardado-Mendoza, Rodolfo / Resendis-Antonio, Osbaldo

Gut microbes

2022 Volume 14, Issue 1, Page(s) 2111952

Abstract: The association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track the disease and improve the outcomes of pharmacological and non-pharmacological treatments. This enterprise ... ...

Abstract	The association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track the disease and improve the outcomes of pharmacological and non-pharmacological treatments. This enterprise requires new strategies to elucidate the metabolic disturbances occurring in the gut microbiome as the disease progresses. To this end, physiological knowledge and systems biology pave the way for characterizing microbiota and identifying strategies in a move toward healthy compositions. Here, we dissect the recent associations between gut microbiota and T2D. In addition, we discuss recent advances in how drugs, diet, and exercise modulate the microbiome to favor healthy stages. Finally, we present computational approaches for disentangling the metabolic activity underlying host-microbiota codependence. Altogether, we envision that the combination of physiology and computational modeling of microbiota metabolism will drive us to optimize the diagnosis and treatment of T2D patients in a personalized way.
MeSH term(s)	Diabetes Mellitus, Type 2/therapy ; Diet ; Gastrointestinal Microbiome/physiology ; Humans ; Microbiota ; Systems Biology
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2022.2111952
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effect of metformin and metformin/linagliptin on gut microbiota in patients with prediabetes.

Estrella, Martínez-López Yoscelina / Daniel, Neri-Rosario / Armando, Esquivel-Hernández Diego / Cristian, Padron-Manrique / Aarón, Vázquez-Jiménez / Paul, Sánchez-Castañeda Jean / David, Girón-Villalobos / Cristian, Mendoza-Ortíz / de Lourdes, Reyes-Escogido María / Lola, Evia-Viscarra Maria / Alberto, Aguilar-Garcia / Osbaldo, Resendis-Antonio / Rodolfo, Guardado-Mendoza

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9678

Abstract: Lifestyle modifications, metformin, and linagliptin reduce the incidence of type 2 diabetes (T2D) in people with prediabetes. The gut microbiota (GM) may enhance such interventions' efficacy. We determined the effect of linagliptin/metformin (LM) vs ... ...

Abstract	Lifestyle modifications, metformin, and linagliptin reduce the incidence of type 2 diabetes (T2D) in people with prediabetes. The gut microbiota (GM) may enhance such interventions' efficacy. We determined the effect of linagliptin/metformin (LM) vs metformin (M) on GM composition and its relationship to insulin sensitivity (IS) and pancreatic β-cell function (Pβf) in patients with prediabetes. A cross-sectional study was conducted at different times: basal, six, and twelve months in 167 Mexican adults with prediabetes. These treatments increased the abundance of GM SCFA-producing bacteria M (Fusicatenibacter and Blautia) and LM (Roseburia, Bifidobacterium, and [Eubacterium] hallii group). We performed a mediation analysis with structural equation models (SEM). In conclusion, M and LM therapies improve insulin sensitivity and Pβf in prediabetics. GM is partially associated with these improvements since the SEM models suggest a weak association between specific bacterial genera and improvements in IS and Pβf.
MeSH term(s)	Humans ; Metformin/pharmacology ; Metformin/therapeutic use ; Gastrointestinal Microbiome/drug effects ; Prediabetic State/drug therapy ; Prediabetic State/microbiology ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Linagliptin/therapeutic use ; Linagliptin/pharmacology ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/microbiology ; Diabetes Mellitus, Type 2/metabolism ; Insulin Resistance ; Adult ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Aged
Chemical Substances	Metformin (9100L32L2N) ; Linagliptin (3X29ZEJ4R2) ; Hypoglycemic Agents
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60081-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effect of linagliptin plus insulin in comparison to insulin alone on metabolic control and prognosis in hospitalized patients with SARS-CoV-2 infection.

Guardado-Mendoza, Rodolfo / Garcia-Magaña, Miguel Angel / Martínez-Navarro, Liz Jovanna / Macías-Cervantes, Hilda Elizabeth / Aguilar-Guerrero, Rodolfo / Suárez-Pérez, Erick L / Aguilar-García, Alberto

Scientific reports

2022 Volume 12, Issue 1, Page(s) 536

Abstract: To evaluate the effect of the combination of linagliptin and insulin on metabolic control and prognosis in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia. A parallel double-blind ... ...

Abstract	To evaluate the effect of the combination of linagliptin and insulin on metabolic control and prognosis in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia. A parallel double-blind randomized clinical trial including hospitalized patients with SARS-CoV-2 infection and hyperglycemia, randomized to receive 5 mg linagliptin + insulin (LI group) or insulin alone (I group) was performed. The main outcomes were the need for assisted mechanical ventilation and glucose levels during hospitalization. Subjects were screened for eligibility at hospital admission if they were not with assisted mechanical ventilation and presented hyperglycemia, and a total of 73 patients with SARS-CoV-2 infection and hyperglycemia were randomized to the LI group (n = 35) or I group (n = 38). The average hospital stay was 12 ± 1 vs 10 ± 1 days for the I and LI groups, respectively (p = 0.343). There were no baseline clinical differences between the study groups, but the percentage of males was higher in the LI group (26 vs 18, p = 0.030). The improvements in fasting and postprandial glucose levels were better in the LI group that the I group (122 ± 7 vs 149 ± 10, p = 0.033; and 137 ± 7 vs 173 ± 12, p = 0.017, respectively), and insulin requirements tended to be lower in the LI group than the I group. Three patients in the LI group and 12 in the I group required assisted mechanical ventilation (HR 0.258, CI 95% 0.092-0.719, p = 0.009); 2 patients in the LI group and 6 in the I group died after a follow-up of 30 days (p = 0.139). No major side effects were observed. The combination of linagliptin and insulin in hospitalized patients with SARS-CoV-2 infection and hyperglycemia reduced the relative risk of assisted mechanical ventilation by 74% and improved better pre and postprandial glucose levels with lower insulin requirements, and no higher risk of hypoglycemia.This study is registered at clinicaltrials.gov, number NCT04542213 on 09/03/2020.
MeSH term(s)	Blood Glucose/analysis ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/virology ; Drug Therapy, Combination ; Female ; Hospitalization ; Humans ; Hyperglycemia/complications ; Hyperglycemia/drug therapy ; Insulin/therapeutic use ; Length of Stay ; Linagliptin/therapeutic use ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Respiration, Artificial/statistics & numerical data ; SARS-CoV-2/isolation & purification
Chemical Substances	Blood Glucose ; Insulin ; Linagliptin (3X29ZEJ4R2)
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-04511-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Carbohydrate source affects the synthesis of silver nanoparticles by

Reyes-Escogido, María de Lourdes / Meneses-Rodríguez, David / Guardado-Mendoza, Rodolfo

IET nanobiotechnology

2017 Volume 11, Issue 8, Page(s) 1035–1039

Abstract: ... Strains ... ...

Abstract	Strains of
MeSH term(s)	Carbohydrates/chemistry ; Extracellular Polymeric Substance Matrix ; Lactobacillus/classification ; Lactobacillus/metabolism ; Metal Nanoparticles/chemistry ; Silver/chemistry ; Species Specificity
Chemical Substances	Carbohydrates ; Silver (3M4G523W1G)
Language	English
Publishing date	2017-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2264529-9
ISSN	1751-875X ; 1751-8741
ISSN (online)	1751-875X
ISSN	1751-8741
DOI	10.1049/iet-nbt.2017.0107
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Delta del índice neutrófilo linfocito y mortalidad en infección COVID-19.

Rosales-López, Sandra Luz / Fernández-Hernández, Juan Pablo / Hernández-González, Martha Alicia / Solorio-Meza, Sergio Eduardo / González-Carrillo, Pedro Luis / Guardado-Mendoza, Rodolfo

Revista medica del Instituto Mexicano del Seguro Social

2022 Volume 60, Issue 6, Page(s) 640–648

Abstract: Background: Acute respiratory distress syndrome, due to SARS-CoV-2, is a worldwide health problem. The neutrophil-lymphocyte index allows risk stratification in patients with severe and poor prognostic data, since it reflects the inflammatory state.: ... ...

Title translation	Delta of neutrophil lymphocyte index and mortality in covid-19 disease.
Abstract	Background: Acute respiratory distress syndrome, due to SARS-CoV-2, is a worldwide health problem. The neutrophil-lymphocyte index allows risk stratification in patients with severe and poor prognostic data, since it reflects the inflammatory state. Objective: To determine whether the Neutrophil-Lymphocyte Index delta predicts mortality in patients with COVID-19. Material and methods: We conducted a longitudinal, comparative study in patients with COVID-19, older than 18 years, admitted to the ICU. We evaluated HAS, DM, obesity, COPD, asthma, PaO2/FiO2, tomographic severity. On admission and on days 3 and 7 we measured Neutrophil-Lymphocyte Index, SOFA and APACHE score. For statistical analysis, we performed ROC and Kaplan-Meyer curves. Results: We included 180 patients with COVID-19, 63 died (35%). Delta INL1(Day1-day3)>4.11 was associated with mortality (AUC:0.633); sensitivity 55.56% and specificity 77.78%, CI95 0.55-0.70, for delta INL2 (Day1-day7)>8.95 (AUC:0.623); sensitivity 44.44% and specificity 84.62%, CI95 0.54-0.69. Difference in survival was observed for Delta1. SOFA scale >6, was associated with more days of mechanical ventilation and lower PaO2/FiO2 (p<0.001). Conclusions: INL delta between the day of ICU admission and the 3rd day of evolution is a predictor of mortality in critically ill patients.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Neutrophils ; Respiratory Distress Syndrome ; Lymphocytes ; Intensive Care Units ; Retrospective Studies
Language	Spanish
Publishing date	2022-10-25
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	732133-8
ISSN	2448-5667 ; 0443-5117 ; 0484-7849
ISSN (online)	2448-5667
ISSN	0443-5117 ; 0484-7849
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2225: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of linagliptin plus insulin in comparison to insulin alone on metabolic control and prognosis in hospitalized patients with SARS-CoV-2 infection

Rodolfo Guardado-Mendoza / Miguel Angel Garcia-Magaña / Liz Jovanna Martínez-Navarro / Hilda Elizabeth Macías-Cervantes / Rodolfo Aguilar-Guerrero / Erick L. Suárez-Pérez / Alberto Aguilar-García

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 12

Abstract: Abstract To evaluate the effect of the combination of linagliptin and insulin on metabolic control and prognosis in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia. A parallel double- ... ...

Abstract	Abstract To evaluate the effect of the combination of linagliptin and insulin on metabolic control and prognosis in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hyperglycemia. A parallel double-blind randomized clinical trial including hospitalized patients with SARS-CoV-2 infection and hyperglycemia, randomized to receive 5 mg linagliptin + insulin (LI group) or insulin alone (I group) was performed. The main outcomes were the need for assisted mechanical ventilation and glucose levels during hospitalization. Subjects were screened for eligibility at hospital admission if they were not with assisted mechanical ventilation and presented hyperglycemia, and a total of 73 patients with SARS-CoV-2 infection and hyperglycemia were randomized to the LI group (n = 35) or I group (n = 38). The average hospital stay was 12 ± 1 vs 10 ± 1 days for the I and LI groups, respectively (p = 0.343). There were no baseline clinical differences between the study groups, but the percentage of males was higher in the LI group (26 vs 18, p = 0.030). The improvements in fasting and postprandial glucose levels were better in the LI group that the I group (122 ± 7 vs 149 ± 10, p = 0.033; and 137 ± 7 vs 173 ± 12, p = 0.017, respectively), and insulin requirements tended to be lower in the LI group than the I group. Three patients in the LI group and 12 in the I group required assisted mechanical ventilation (HR 0.258, CI 95% 0.092–0.719, p = 0.009); 2 patients in the LI group and 6 in the I group died after a follow-up of 30 days (p = 0.139). No major side effects were observed. The combination of linagliptin and insulin in hospitalized patients with SARS-CoV-2 infection and hyperglycemia reduced the relative risk of assisted mechanical ventilation by 74% and improved better pre and postprandial glucose levels with lower insulin requirements, and no higher risk of hypoglycemia. This study is registered at clinicaltrials.gov, number NCT04542213 on 09/03/2020.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Doxycycline Prevents Preclinical Atherosclerosis, Pancreatic Islet Loss and Improves Insulin Secretion after Glycemic Stimulation: Preclinical Study in Individuals with a High-Fat Diet.

Rodriguez-Hernandez, Alejandrina / Delgado-Machuca, Marina / Guardado-Mendoza, Rodolfo / Mendoza-Hernandez, Martha A / Melnikov, Valery / Delgado-Enciso, Osiris G / Tiburcio-Jimenez, Daniel / Ceja-Espiritu, Gabriel / Hernandez-Fuentes, Gustavo A / Gamboa-Dominguez, Armando / Guzman-Esquivel, Jose / Martinez-Fierro, Margarita L / Rodriguez-Sanchez, Iram P / Delgado-Enciso, Ivan

Biomedicines

2023 Volume 11, Issue 3

Abstract: Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and ... ...

Abstract	Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030717
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online ; Research data: (with research data) Clinical and Metabolic Characteristics among Mexican Children with Different Types of Diabetes Mellitus.

Evia-Viscarra, María Lola / Guardado-Mendoza, Rodolfo / Rodea-Montero, Edel Rafael

PloS one

2016 Volume 11, Issue 12, Page(s) e0168377

Abstract: Background: Current classification of diabetes mellitus (DM) is based on etiology and includes type 1 (T1DM), type 2 (T2DM), gestational, and other. Clinical and pathophysiological characteristics of T1DM and T2DM in the same patient have been ... ...

Abstract	Background: Current classification of diabetes mellitus (DM) is based on etiology and includes type 1 (T1DM), type 2 (T2DM), gestational, and other. Clinical and pathophysiological characteristics of T1DM and T2DM in the same patient have been designated as type 1.5 DM (T1.5DM). Objectives: The aim of this study was to classify pediatric patients with DM based on pancreatic autoimmunity and the presence or absence of overweight/obesity, and to compare the clinical, anthropometric, and biochemical characteristics between children in the different classes of DM. Methods: A sample of 185 patients, recruited (March 2008-April 2015) as part of the Cohort of Mexican Children with DM (CMC-DM); ClinicalTrials.gov, identifier: NCT02722655. The DM classification was made considering pancreatic autoimmunity (via antibodies GAD-65, IAA, and AICA) and the presence or absence of overweight/obesity. Clinical, anthropometric and biochemical variables, grouped by type of DM were compared (Kruskal-Wallis or chi-squared test). Results: The final analysis included 140 children; 18.57% T1ADM, 46.43% T1BDM, 12.14% T1.5DM, and 22.86% T2DM. Fasting C-Peptide (FCP), and hs-CRP levels were higher in T1.5DM and T2DM, and the greatest levels were observed in T1.5DM (p<0.001 and 0.024 respectively). Conclusions: We clearly identified that the etiologic mechanisms of T1DM and T2DM are not mutually exclusive, and we detailed why FCP levels are not critical for the classification system of DM in children. The findings of this study suggest that T1.5DM should be considered during the classification of pediatric DM and might facilitate more tailored approaches to treatment, clinical care and follow-up.
MeSH term(s)	Adolescent ; Autoantibodies/metabolism ; C-Peptide/metabolism ; C-Reactive Protein/metabolism ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diabetes Mellitus/classification ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/immunology ; Diabetes Mellitus/metabolism ; Female ; Humans ; Infant ; Male ; Mexico/epidemiology ; Pancreas/immunology
Chemical Substances	Autoantibodies ; C-Peptide ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0168377
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED