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  1. Article ; Online: Death as a metric for outcome: Dusk between day and night.

    Laupland, Kevin B

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2022  Volume 7, Issue 4, Page(s) 296–299

    Language English
    Publishing date 2022-11-29
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2022-06-09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preventing healthcare-related infections among older adults: a focus on cross-transmission of antibiotic-resistant bacteria.

    Laupland, Kevin B

    Expert review of anti-infective therapy

    2022  Volume 20, Issue 9, Page(s) 1171–1178

    Abstract: Introduction: Older individuals (i.e. age ≥65 years) are at increased risk for development of infections including those due to antimicrobial-resistant bacteria, and transmission may occur between institutional and community settings.: Areas covered: ...

    Abstract Introduction: Older individuals (i.e. age ≥65 years) are at increased risk for development of infections including those due to antimicrobial-resistant bacteria, and transmission may occur between institutional and community settings.
    Areas covered: This article reviews infections in older individuals with a specific focus on healthcare-related and antimicrobial resistant infections. A structured narrative review was performed to identify articles published in English since 2010. Themes included defining the scope of the problem, establishing characteristics of older individuals that impact the burden of resistant infections, and interventions aimed at minimizing their impact.
    Expert opinion: Older individuals suffer a high burden of illness related to antimicrobial resistant infections. Individuals with chronic illnesses, frailty, and residents of nursing homes are at highest risk. Clinical trials have shown that antimicrobial stewardship interventions may reduce antibiotic use in nursing homes without compromising safety. Antimicrobial resistant bacteria are prevalent among nursing home residents, and bundled infection prevention and control interventions can reduce their transmission. Transmission of antimicrobial resistant bacteria occurs among older adults across hospital and institutional settings, which may further spread to the community. The burden of infections in older adults is expected to increase in the coming years and represents a healthcare and research priority.
    MeSH term(s) Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Bacteria ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Delivery of Health Care ; Humans ; Nursing Homes
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-07-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2022.2099375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6106: Show issues Location:
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  3. Article ; Online: Infectious diseases as the human population enters a stationary phase.

    Laupland, Kevin B / Keynan, Yoav

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2023  Volume 8, Issue 3, Page(s) 172–175

    Language English
    Publishing date 2023-11-29
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2023-06-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Can microbiologists and infectious diseases physicians contribute to the management of bronchiectasis? A view from Down Under.

    Grimwood, Keith / Laupland, Kevin B

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2023  Volume 8, Issue 3, Page(s) 161–164

    Language English
    Publishing date 2023-11-29
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2023-07-05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Are blood cultures the infectious diseases faecal immunochemical test?

    Laupland, Kevin B / Keynan, Yoav

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2023  Volume 8, Issue 2, Page(s) 111–115

    Language English
    Publishing date 2023-09-18
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2023-01-31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proteus species bloodstream infections: Comparative epidemiology of three species.

    Laupland, Kevin B / Edwards, Felicity / Harris, Patrick N A

    Diagnostic microbiology and infectious disease

    2024  Volume 109, Issue 2, Page(s) 116286

    Abstract: Background: Although Proteus species are occasional causes of serious infections, their epidemiology has not been well defined. The objective was to describe the overall and species-specific occurrence and determinants of Proteus species bloodstream ... ...

    Abstract Background: Although Proteus species are occasional causes of serious infections, their epidemiology has not been well defined. The objective was to describe the overall and species-specific occurrence and determinants of Proteus species bloodstream infection (BSI) in a large Australian population.
    Methods: All Queensland residents with Proteus species BSI identified within the publicly funded healthcare system between 2000 and 2019 were included.
    Results: A total of 2,143 incident episodes of Proteus species BSI were identified among 2,079 Queensland residents. The prevalence of comorbid illness differed with higher Charlson comorbidity scores observed with P. penneri and P. vulgaris, and higher prevalence of liver disease with P. penneri, higher comorbid cancer with P. vulgaris, and lower diabetes and renal disease prevalence with P. mirabilis BSIs.
    Conclusion: This study provides novel information on the epidemiology of Proteus species BSI.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1845: Show issues Location:
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  7. Article ; Online: Update on Staphylococcus aureus bacteraemia.

    Tabah, Alexis / Laupland, Kevin B

    Current opinion in critical care

    2022  Volume 28, Issue 5, Page(s) 495–504

    Abstract: Purpose of review: To review recently published evidence relevant to Staphylococcus aureus bacteremia (SAB).: Recent findings: Staphylococcus aureus is the most common pathogen causing co-infections and superinfections in patients with COVID-19. ... ...

    Abstract Purpose of review: To review recently published evidence relevant to Staphylococcus aureus bacteremia (SAB).
    Recent findings: Staphylococcus aureus is the most common pathogen causing co-infections and superinfections in patients with COVID-19. Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia ratios have sharply risen during the pandemic. SAB mortality is 18% at 1 month and 27% at 3 months but has gradually decreased over the last 30 years. Recurrences and reinfections are common (9%). Standardised items to define complicated SAB, and a new cut-off defining persisting bacteremia after 2 days with positive blood cultures have been proposed. Multiple antibiotic combinations have been trialled including vancomycin or daptomycin with β-lactams, fosfomycin, or clindamycin, without significant results. In the recently published guidelines, vancomycin remains the first line of treatment for MRSA bacteremia. For the management of methicillin-susceptible Staphylococcus aureus , cefazolin less frequently causes acute kidney injury than flucloxacillin, and when susceptibility is demonstrated, de-escalation to penicillin G is suggested.
    Summary: Our review confirms that Staphylococcus aureus represents a special aetiology among all causes of bloodstream infections. Pending results of platform and larger trials, its distinct epidemiology and determinants mandate careful integration of clinical variables and best available evidence to optimize patient outcomes.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; COVID-19 ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4999: Show issues Location:
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  8. Article ; Online: Time to positivity is a risk factor for death among patients with bloodstream infections: a population-based cohort.

    Laupland, Kevin B / Edwards, Felicity / Dettrick, Zoe / Harris, Patrick N A

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  

    Abstract: Objectives: Studies examining time to positivity (TTP) of blood cultures as a risk factor for death have shown conflicting results. The study objective was to examine the effect of TTP on all-cause-30-day case-fatality among a population-based cohort of ...

    Abstract Objectives: Studies examining time to positivity (TTP) of blood cultures as a risk factor for death have shown conflicting results. The study objective was to examine the effect of TTP on all-cause-30-day case-fatality among a population-based cohort of patients with bloodstream infections (BSI).
    Methods: A retrospective cohort study including all residents of Queensland, Australia with incident monomicrobial BSI managed in the publicly funded healthcare system from 2000 to 2019 was performed. Clinical, TTP and all-cause 30-day case-fatality information was obtained from state-wide sources.
    Results: A cohort of 88 314 patients was assembled. The median TTP was 14 hours, with 5th, 25th, 75th, and 95th percentiles of 4, 10, 20, and 53 hours, respectively. The TTP varied significantly by BSI aetiology. The 30-day all-cause case-fatality rate was 2606/17 879 (14.6%), 2834/24 272 (11.7%), 2378/20 359 (11.7%), and 2752/22 431 (12.3%) within the first, second, third, and fourth TTP quartiles, respectively (p < 0.0001). After adjustment for age, sex, onset, comorbidity, and focus of infection, TTP within 10 hours (first quartile) was associated with a significantly increased risk for death (odds ratio 1.43; 95% CI, 1.35-1.50; p < 0.001). After adjustment for confounding variables (odds ratio; 95% CI), TTP within the first quartile for Staphylococcus aureus (1.56; 1.41-1.73), Streptococcus pneumoniae (1.91; 1.49-2.46), β-hemolytic streptococci (1.23; 1.00-1.50), Pseudomonas species (2.23; 1.85-2.69), Escherichia coli (1.37; 1.23-1.53), Enterobacterales (1.38; 1.16-1.63), other Gram-negatives (1.68; 1.36-2.06), and anaerobes (1.58; 1.28-1.94) increased the risk for case-fatality.
    Discussion: This population-based analysis provides evidence that TTP is an important determinant of mortality among patients with BSI.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.03.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 284: Show issues

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  9. Article ; Online: Impact of climate change on amoeba and the bacteria they host.

    Heilmann, Ashley / Rueda, Zulma / Alexander, David / Laupland, Kevin B / Keynan, Yoav

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2024  Volume 9, Issue 1, Page(s) 1–5

    Language English
    Publishing date 2024-03-29
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2023-09-08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Central line associated and primary bloodstream infections.

    Stewart, Adam G / Laupland, Kevin B / Tabah, Alexis

    Current opinion in critical care

    2023  Volume 29, Issue 5, Page(s) 423–429

    Abstract: Purpose of review: Primary and intravascular catheter-associated bloodstream infections (CA-BSIs) represent an important clinical entity in the intensive care unit (ICU) being associated with significant morbidity and mortality. The purpose of this ... ...

    Abstract Purpose of review: Primary and intravascular catheter-associated bloodstream infections (CA-BSIs) represent an important clinical entity in the intensive care unit (ICU) being associated with significant morbidity and mortality. The purpose of this review was to examine the recently published data on epidemiology and management of CA-BSI and other primary BSIs specifically within the context of the ICU.
    Recent findings: In critically ill patients, the pooled prevalence of primary and CA-BSI from contemporary studies was 19.7-40.7% and 26.4-37.3% of all BSIs, respectively. Failure to achieve source control (i.e., removal of catheter in CA-BSI) is associated with higher mortality. Higher severity scores and durations of ICU stay and catheter insertion are well established risk factors for CA-BSI. The use of prevention bundles when inserting a central venous line is able to reduce CA-BSI incidence from 4 to 1.6 episodes per 1000 central venous catheter days. Differential time-to-positivity of paired blood cultures may assist in the diagnosis of CA-BSI.
    Summary: Primary BSI is frequently observed in ICU cohorts and has a poor effect on outcome. Surveillance for BSI among patients admitted to ICUs is fundamental to inform healthcare service delivery, design preventive approaches, to track resistance, and detect emerging pathogens.
    MeSH term(s) Humans ; Central Venous Catheters ; Catheter-Related Infections/epidemiology ; Hospitalization ; Intensive Care Units ; Sepsis
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001082
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