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  1. Article: Delving Into COVID-19 Vaccination-Induced Anaphylaxis: Are mRNA Vaccines Safe in Mast Cell Disorders?

    Azenha Rama, T / Álvarez-Twose, I

    Journal of investigational allergology & clinical immunology

    2021  Volume 31, Issue 2, Page(s) 193–195

    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; Adult ; Anaphylaxis/etiology ; Anaphylaxis/prevention & control ; BNT162 Vaccine ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Excipients/adverse effects ; Female ; Histamine H1 Antagonists/therapeutic use ; Humans ; Male ; Mastocytosis ; SARS-CoV-2/immunology ; Tryptases/blood ; Tryptases/deficiency ; Vaccination/adverse effects ; Vaccines, Synthetic/adverse effects ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Excipients ; Histamine H1 Antagonists ; Vaccines, Synthetic ; Tryptases (EC 3.4.21.59) ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-02-12
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3487: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Defining hereditary alpha-tryptasemia as a risk/modifying factor for anaphylaxis: are we there yet?

    Couto, M L / Silva, M / Barbosa, M J / Ferreira, F / Fragoso, A S / Azenha Rama, T

    European annals of allergy and clinical immunology

    2023  Volume 55, Issue 4, Page(s) 152–160

    Abstract: Summary: Hereditary α-tryptasemia (HαT) is a common autosomal dominant genetic trait with variable penetrance associated with increased serum baseline tryptase (SBT) levels. Clinical manifestations may range from an absence of symptoms to overtly severe ...

    Abstract Summary: Hereditary α-tryptasemia (HαT) is a common autosomal dominant genetic trait with variable penetrance associated with increased serum baseline tryptase (SBT) levels. Clinical manifestations may range from an absence of symptoms to overtly severe and recurrent anaphylaxis. Symptoms have been claimed to result from excessive activation of EGF-like module-containing mucin-like hormone receptor-like 2 (EMR2) and protease-activated receptor 2 (PAR-2) receptors by α/β-tryptase heterotetramers. Herein, we aimed to review the evidence on whether HαT can be considered a hereditary risk factor or a modifying factor for anaphylaxis.Increased SBT levels have been linked to an increased risk of anaphylaxis. Likewise, recent studies have shown that HαT might be associated with a higher risk of developing anaphylaxis and more severe anaphylaxis. The same has also been shown for patients with clonal mast cell disorders, in whom the co-existence of HαT might lead to a greater propensity for severe, potentially life-threatening anaphylaxis. However, studies leading to such conclusions are generally limited in sample size, while other studies have shown opposing results. As such, further studies investigating the potential association of HαT with anaphylaxis caused by different triggers, and different severity grades, in both patients with clonal mast cell activation syndromes and the general population are still needed.
    MeSH term(s) Humans ; Anaphylaxis/diagnosis ; Anaphylaxis/genetics ; Mast Cells ; Mast Cell Activation Syndrome ; Mastocytosis/diagnosis ; Risk Factors ; Tryptases/genetics
    Chemical Substances Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2023-03-16
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2105540-3
    ISSN 1764-1489 ; 0397-9148
    ISSN 1764-1489 ; 0397-9148
    DOI 10.23822/EurAnnACI.1764-1489.288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2037: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Hypersensitivity to the Moderna COVID-19 Vaccine Caused by Tromethamine: PEG Is Not Always the Culprit Excipient.

    Azenha Rama, T / Moço Coutinho, R / Mota, D / Moreira, A / Cernadas, J

    Journal of investigational allergology & clinical immunology

    2021  Volume 32, Issue 5, Page(s) 414–415

    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; COVID-19/prevention & control ; Excipients/adverse effects ; Humans ; Hypersensitivity ; Tromethamine
    Chemical Substances Excipients ; Tromethamine (023C2WHX2V) ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2021-12-20
    Publishing country Spain
    Document type Letter
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3487: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Nasal Bacteriomes of Patients with Asthma and Allergic Rhinitis Show Unique Composition, Structure, Function and Interactions.

    Pérez-Losada, Marcos / Castro-Nallar, Eduardo / Laerte Boechat, José / Delgado, Luis / Azenha Rama, Tiago / Berrios-Farías, Valentín / Oliveira, Manuela

    Microorganisms

    2023  Volume 11, Issue 3

    Abstract: Allergic rhinitis and asthma are major public health concerns and economic burdens worldwide. However, little is known about nasal bacteriome dysbiosis during allergic rhinitis, alone or associated with asthma comorbidity. To address this knowledge gap ... ...

    Abstract Allergic rhinitis and asthma are major public health concerns and economic burdens worldwide. However, little is known about nasal bacteriome dysbiosis during allergic rhinitis, alone or associated with asthma comorbidity. To address this knowledge gap we applied 16S rRNA high-throughput sequencing to 347 nasal samples from participants with asthma (AS = 12), allergic rhinitis (AR = 53), allergic rhinitis with asthma (ARAS = 183) and healthy controls (CT = 99). One to three of the most abundant phyla, and five to seven of the dominant genera differed significantly (
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11030683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The oral bacteriomes of patients with allergic rhinitis and asthma differ from that of healthy controls.

    Pérez-Losada, Marcos / Castro-Nallar, Eduardo / Laerte Boechat, José / Delgado, Luís / Azenha Rama, Tiago / Berrios-Farías, Valentín / Oliveira, Manuela

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1197135

    Abstract: Allergic rhinitis and asthma are two of the most common chronic respiratory diseases in developed countries and have become a major public health concern. Substantial evidence has suggested a strong link between respiratory allergy and upper airway ... ...

    Abstract Allergic rhinitis and asthma are two of the most common chronic respiratory diseases in developed countries and have become a major public health concern. Substantial evidence has suggested a strong link between respiratory allergy and upper airway dysbacteriosis, but the role of the oral bacteriota is still poorly understood. Here we used 16S rRNA massive parallel sequencing to characterize the oral bacteriome of 344 individuals with allergic rhinitis (AR), allergic rhinitis with asthma (ARAS), asthma (AS) and healthy controls (CT). Four of the most abundant (>2%) phyla (Actinobacteriota, Firmicutes, Fusobacteriota, and Proteobacteria) and 10 of the dominant genera (
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1197135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.

    Paiva, Ricardo S / Ramos, Camila V / Azenha, Sara R / Alves, Carolina / Basto, Afonso P / Graca, Luis / Martins, Vera C

    European journal of immunology

    2021  Volume 51, Issue 8, Page(s) 1968–1979

    Abstract: ... progenitors and in T-cell precursors. Since the expression profile of Ppic in the hematoimmune system was ... suggestive that it could play a role in hematopoiesis and/or T lymphocyte differentiation, we sought to test ... show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ, and γδ T ...

    Abstract Peptidyl-prolyl cis-trans isomerase C (Ppic) is expressed in several bone marrow (BM) hematopoietic progenitors and in T-cell precursors. Since the expression profile of Ppic in the hematoimmune system was suggestive that it could play a role in hematopoiesis and/or T lymphocyte differentiation, we sought to test that hypothesis in vivo. Specifically, we generated a Ppic-deficient mouse model by targeting the endogenous locus by CRISPR/Cas9 and tested the requirement of Ppic in hematopoiesis. Several immune cell lineages covering BM progenitors, lymphocyte precursors, as well as mature cells at the periphery were analyzed. While most lineages were unaffected, invariant NKT (iNKT) cells were reduced in percentage and absolute cell numbers in the Ppic-deficient thymus. This affected the most mature stages in the thymus, S2 and S3, and the phenotype was maintained at the periphery. Additionally, immature transitional T1 and T2 B lymphocytes were increased in the Ppic-deficient spleen, but the phenotype was lost in mature B lymphocytes. In sum, our data show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ, and γδ T lymphocytes in vivo in the steady state, while being involved in B- and iNKT cell differentiation.
    MeSH term(s) Animals ; Cell Differentiation/immunology ; Cyclophilin C/immunology ; Cyclophilin C/metabolism ; Mice ; Mice, Inbred C57BL ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism
    Chemical Substances Cyclophilin C (EC 5.2.1.8)
    Language English
    Publishing date 2021-05-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 489: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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