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Article ; Online: Stigmast-4-en-6β-ol-3-one decreases viability and induces apoptosis and ferroptosis in liver cancer cells by reducing E2F1

Zhiyun Zhang / Jian Wang / Weiping Wan / Zhengchao Shen / Aixue Zuo / Rong Chen / Qinyi Wu / Enli Cai / Feng Huang / Rongping Zhang / Xinan Shi

Animal Cells and Systems, Vol 27, Iss 1, Pp 340-

2023 Volume 352

Abstract: ABSTRACTHepatocellular carcinoma (HCC) is a frequently occurring malignant gastrointestinal cancer. The 5-year survival rate of HCC is still below 8%, and thus, identifying more effective therapeutic methods is needed. Here, we evaluated the effects of ... ...

Abstract	ABSTRACTHepatocellular carcinoma (HCC) is a frequently occurring malignant gastrointestinal cancer. The 5-year survival rate of HCC is still below 8%, and thus, identifying more effective therapeutic methods is needed. Here, we evaluated the effects of Stigmast-4-en-6β-ol-3-one (S463) on the viability and colony formation of liver cancer cells. S463 treatment decreased the viability and induced apoptosis and ferroptosis in liver cancer cells, and also increased cellular malondialdehyde (MDA) and lipid peroxidation levels. In S463 treated cells, the expression level of Bax was increased, and the expression level of GPX4 was reduced, and the cleavage of PARP was improved. We also found that S463 treatment downregulated E2F1 and upregulated p53 at both the mRNA and protein levels. Importantly, rescue experiments revealed that overexpression of E2F1 partially restored S463-induced Bax and p53 upregulation and GPX4 downregulation and counteracted the S463-induced decrease in cell viability and colony formation and the S463-induced increase in MDA and lipid peroxidation levels. Our findings suggest that S463 significantly inhibits viability and colony formation and induces apoptosis and ferroptosis in liver cancer cells via E2F1.
Keywords	Stigmast-4-en-6β-ol-3-one ; liver cancer ; apoptosis ; ferroptosis ; E2F1 ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association between the dietary antioxidant index and relative telomere length of leucocytes in the Chinese population.

Zhao, Linhai / Jin, Wenjia / Zhang, Tiantian / Lu, Yufu / Liu, Qiumei / Cai, Jiansheng / Luo, Lei / Teng, Kaisheng / Guan, Qinyi / Wu, Songju / Rong, Jiahui / Liang, Yu Jian / Cao, Jiejing / Qin, Lidong / Huang, Chuwu / Wang, Xuexiu / Li, You / Zhang, Zhiyong / Qin, Jian

The British journal of nutrition

2023 Volume 131, Issue 6, Page(s) 1031–1040

Abstract: Dietary antioxidant indices (DAI) may be potentially associated with relative telomere length (RTL) of leucocytes. This study aimed to investigate the relationship between DAI and RTL. A cross-sectional study involving 1656 participants was conducted. A ... ...

Abstract	Dietary antioxidant indices (DAI) may be potentially associated with relative telomere length (RTL) of leucocytes. This study aimed to investigate the relationship between DAI and RTL. A cross-sectional study involving 1656 participants was conducted. A generalised linear regression model and a restricted cubic spline model were used to assess the correlation of DAI and its components with RTL. Generalised linear regression analysis revealed that DAI (
MeSH term(s)	Humans ; Male ; Female ; Antioxidants ; Cross-Sectional Studies ; Vitamin E ; Telomere ; China
Chemical Substances	Antioxidants ; Vitamin E (1406-18-4)
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114523002544
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Article ; Online: Demand Analysis and Management Suggestion: Sharing Epidemiological Data Among Medical Institutions in Megacities for Epidemic Prevention and Control.

Cai, Qinyi / Mi, Yiqun / Chu, Zhaowu / Zheng, Yuanyi / Chen, Fang / Liu, Yicheng

Journal of Shanghai Jiaotong University (science)

2020 Volume 25, Issue 2, Page(s) 137–139

Abstract: During the prevention of coronavirus disease 2019 (COVID-19), epidemiological data is essential for controlling the source of infection, cutting off the route of transmission, and protecting vulnerable populations. Following Law of the People's Republic ... ...

Abstract	During the prevention of coronavirus disease 2019 (COVID-19), epidemiological data is essential for controlling the source of infection, cutting off the route of transmission, and protecting vulnerable populations. Following Law of the People's Republic of China on Prevention and Treatment of Infectious Diseases and other related regulations, medical institutions have been authorized to collect the detailed information of patients, while it is still a formidable task in megacities because of the significant patient mobility and the existing information sharing barrier. As a smart city which strengthens precise epidemic prevention and control, Shanghai has established a multi-department platform named "one-net management" on dynamic information monitoring. By sharing epidemiological data with medical institutions under a safe environment, we believe that the ability to prevent and control epidemics among medical institutions will be effectively and comprehensively improved.
Keywords	covid19
Language	English
Publishing date	2020-04-07
Publishing country	China
Document type	Journal Article
ZDB-ID	2630146-5
ISSN	1995-8188 ; 1007-1172
ISSN (online)	1995-8188
ISSN	1007-1172
DOI	10.1007/s12204-020-2166-3
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Article ; Online: qHBsAg for the Identification of Liver Histological Abnormalities in HBeAg-Negative Chronic Hepatitis B Patients with Normal and Mildly Elevated ALT Levels.

Gan, Qinyi / Huang, Yan / Zhu, Chuanwu / Zhao, Shuang / Fu, Haoshuang / Cai, Minghao / Wang, Jiexiao / Zhang, Chenxi / Guo, Simin / Cao, Zhujun / Xie, Qing

Canadian journal of gastroenterology & hepatology

2022 Volume 2022, Page(s) 8695196

Abstract: Backgrounds: Noninvasive detection of histological abnormalities remains challenging in patients with HBeAg-negative chronic HBV infection with normal or mildly elevated levels of alanine aminotransferase (ALT). This study aimed to assess the utility of ...

Abstract	Backgrounds: Noninvasive detection of histological abnormalities remains challenging in patients with HBeAg-negative chronic HBV infection with normal or mildly elevated levels of alanine aminotransferase (ALT). This study aimed to assess the utility of serum quantitative hepatitis B surface antigen (qHBsAg) in identifying significant histological lesions in this population. Methods: This is a single-center study with retrospective analysis of 392 treatment-naive patients of HBeAg-negative chronic HBV infection with normal or mildly elevated levels of ALT. Results: In this cohort, significant necroinflammation and fibrosis were found in 69.4% and 61.5% of patients, respectively. Patients with qHBsAg >1000 IU/mL ( Conclusions: A significantly higher proportion of patients with histological abnormalities were found in patients with qHBsAg >1000 IU/mL than those without. The qHBsAg level together with age, AST, and family history of HBV infection could be used as an algorithm to help noninvasive patient selection for antiviral therapy.
MeSH term(s)	Adult ; Alanine Transaminase ; DNA, Viral ; Fibrosis ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Hepatitis B virus/genetics ; Hepatitis B, Chronic ; Humans ; Liver/pathology ; Retrospective Studies
Chemical Substances	DNA, Viral ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2022-07-14
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2762182-0
ISSN	2291-2797 ; 1916-7237 ; 0835-7900
ISSN (online)	2291-2797 ; 1916-7237
ISSN	0835-7900
DOI	10.1155/2022/8695196
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Article ; Online: Alteration of Bile Acids and Omega-6 PUFAs Are Correlated With the Progression and Prognosis of Drug-Induced Liver Injury.

Zhao, Shuang / Fu, Haoshuang / Zhou, Tianhui / Cai, Minghao / Huang, Yan / Gan, Qinyi / Zhang, Chenxi / Qian, Cong / Wang, Jiexiao / Zhang, Zhenglan / Wang, Xiaolin / Xiang, Xiaogang / Xie, Qing

Frontiers in immunology

2022 Volume 13, Page(s) 772368

Abstract: Background & aims: Drug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI. The mechanisms underlying the severity and chronicity of DILI are poorly elucidated and the ... ...

Abstract	Background & aims: Drug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI. The mechanisms underlying the severity and chronicity of DILI are poorly elucidated and the biomarkers are limited. Metabolites and gut microbiota played a crucial role in the development of various liver diseases. Herein, a systematic analysis of serum metabolites and gut microbiota was performed in DILI patients, aiming to identify metabolites correlated with the progression and clinical prognosis of DILI. Methods: Various serum metabolites were quantitated using a metabolite array technology in this prospective study. Gut microbiome compositions and the expression profiles of liver genes were determined in patients with DILI and healthy controls. Results: Metabolomic analysis revealed that bile acids (BAs) and polyunsaturated fatty acids (PUFAs) were closely related to DILI severity and chronicity respectively. The ratios of serum primary/secondary BAs and omega-6/omega-3 PUFAs were elevated in DILI patients. A model established by adrenic acid (AdA) and aspartic acid (Asp) exerts good performance for predicting the chronicity of DLIL. Hepatic transcriptome revealed enhanced expression of PUFA peroxidation and supressed expression of BA synthesis related genes in DILI patients. In addition, Lactic acid bacteria and BA converting bacteria were increased in gut of DILI patients. Besides, elevated serum malondialdehyde (MDA) and fibroblast growth factor 19 (FGF19) was observed in DILI patients. Conclusion: BAs and PUFAs could be potent markers for the severity and chronicity of DILI respectively. The panel of AdA and Asp could be ideal predictive model for the risk of chronicity at the acute stage of DILI. Gut microbiota might act as a negative feedback mechanism to maintain the homeostasis of BAs and PUFAs
MeSH term(s)	Bile Acids and Salts ; Biomarkers ; Chemical and Drug Induced Liver Injury/diagnosis ; Humans ; Prognosis ; Prospective Studies
Chemical Substances	Bile Acids and Salts ; Biomarkers
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.772368
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Article ; Online: Application of Fatty Liver Inhibition of Progression Algorithm and Steatosis, Activity, and Fibrosis Score to Assess the Impact of Non-Alcoholic Fatty Liver on Untreated Chronic Hepatitis B Patients.

Huang, Yan / Gan, Qinyi / Lai, Rongtao / Wang, Weijing / Guo, Simin / Sheng, Zike / Chen, Lu / Guo, Qing / Cai, Wei / Wang, Hui / Zhao, Gangde / Cao, Zhujun / Xie, Qing

Frontiers in cellular and infection microbiology

2022 Volume 11, Page(s) 733348

Abstract: Backgrounds and purpose: Concurrent non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is a frequent and increasingly concerning problem because of the NAFLD pandemic. Admittedly, NAFLD can progress to non-alcoholic ... ...

Abstract	Backgrounds and purpose: Concurrent non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is a frequent and increasingly concerning problem because of the NAFLD pandemic. Admittedly, NAFLD can progress to non-alcoholic steatohepatitis (NASH) and severe fibrosis. Direct evidence of the fibrotic effect of NAFLD or NASH in chronic hepatitis B virus (HBV) infection remains lacking. We aimed to reveal the influence of concurrent histologically proven fatty liver diseases in fibrogenesis with chronic HBV infection. Methods: We performed a retrospective cross-sectional study on a liver biopsy population of CHB patients without excessive alcohol intake to evaluate the prevalence of concurrent histologically proven NAFLD or NASH according to the fatty liver inhibition of progression (FLIP) algorithm and its association with the liver fibrosis stage. Results: Among 1,081 CHB patients, concurrent NAFLD was found in 404 patients (37.4%), among whom 24.0% (97/404) have NASH. The presence of NASH was an independent predictor of significant fibrosis (odds ratio (OR), 2.53; 95% CI, 1.52-4.21; Conclusions: Concurrent NAFLD is common in CHB patients, and NASH is an independent risk factor potentiating significant fibrosis by 2.53-fold and severe fibrosis by 1.83-fold. While coping with chronic HBV infection, routine assessment of co-existing NAFLD or NASH is also important.
MeSH term(s)	Algorithms ; Biopsy ; Cross-Sectional Studies ; Fibrosis ; Hepatitis B, Chronic ; Humans ; Liver/pathology ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/pathology ; Retrospective Studies
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.733348
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Article ; Online: Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice.

Shao, Wenhua / Jargalsaikhan, Orgil / Ichimura-Shimizu, Mayuko / Cai, Qinyi / Ogawa, Hirohisa / Miyakami, Yuko / Atsumi, Kengo / Tomita, Mitsuru / Sutoh, Mitsuko / Toyohara, Shunji / Hokao, Ryoji / Kudo, Yasusei / Oya, Takeshi / Tsuneyama, Koichi

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: Male Tsumura-Suzuki Obese Diabetes (TSOD) mice, a spontaneous metabolic syndrome model, develop non-alcoholic steatohepatitis and liver tumors by feeding on a standard mouse diet. Nearly 70% of liver tumors express glutamine synthetase (GS), a marker of ... ...

Abstract	Male Tsumura-Suzuki Obese Diabetes (TSOD) mice, a spontaneous metabolic syndrome model, develop non-alcoholic steatohepatitis and liver tumors by feeding on a standard mouse diet. Nearly 70% of liver tumors express glutamine synthetase (GS), a marker of hepatocellular carcinoma. In contrast, approximately 30% are GS-negative without prominent nuclear or structural atypia. In this study, we examined the characteristics of the GS-negative tumors of TSOD mice. Twenty male TSOD mice were sacrificed at 40 weeks and a total of 21 tumors were analyzed by HE staining and immunostaining of GS, liver fatty acid-binding protein (L-FABP), serum amyloid A (SAA), and beta-catenin. With immunostaining for GS, six (29%) tumors were negative. Based on the histological and immunohistological characteristics, six GS-negative tumors were classified into several subtypes of human hepatocellular adenoma (HCA). One large tumor showed generally similar findings to inflammatory HCA, but contained small atypical foci with GS staining and partial nuclear beta-catenin expression suggesting malignant transformation. GS-negative tumors of TSOD mice contained features similar to various subtypes of HCA. Different HCA subtypes occurring in the same liver have been reported in humans; however, the diversity of patient backgrounds limits the ability to conduct a detailed, multifaceted analysis. TSOD mice may share similar mechanisms of HCA development as in humans. It is timely to review the pathogenesis of HCA from both genetic and environmental perspectives, and it is expected that TSOD mice will make further contributions in this regard.
MeSH term(s)	Adenoma, Liver Cell/etiology ; Adenoma, Liver Cell/metabolism ; Animals ; Carcinoma, Hepatocellular/metabolism ; Diabetes Mellitus ; Fatty Acid-Binding Proteins/metabolism ; Glutamate-Ammonia Ligase/genetics ; Glutamate-Ammonia Ligase/metabolism ; Humans ; Immunohistochemistry ; Liver Neoplasms/metabolism ; Male ; Metabolic Syndrome/complications ; Mice ; Mice, Obese ; Non-alcoholic Fatty Liver Disease/etiology ; Serum Amyloid A Protein/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Fatty Acid-Binding Proteins ; Serum Amyloid A Protein ; beta Catenin ; Glutamate-Ammonia Ligase (EC 6.3.1.2)
Language	English
Publishing date	2022-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911923
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Article ; Online: A simple-to-use tool for predicting response to peginterferon in HBV DNA suppressed chronic hepatitis B patients in China.

Ren, Peipei / Li, Hu / Huang, Yan / Jiang, Jiayuan / Guo, Simin / Cao, Zhujun / Zhang, Chenxi / Zhou, Tianhui / Gan, Qinyi / Zhao, Shuang / Chen, Lichang / Guo, Qing / Cai, Wei / Wang, Hui / Hu, Peng / Xie, Qing

Antiviral research

2021 Volume 194, Page(s) 105163

Abstract: Background: Rational administration of peginterferon can remarkably reduce serum HBsAg level and improve the rate of HBsAg loss. Considering the high cost and adverse drug reaction of peginterferon, we aimed to develop a simple-to-use scoring system at ... ...

Abstract	Background: Rational administration of peginterferon can remarkably reduce serum HBsAg level and improve the rate of HBsAg loss. Considering the high cost and adverse drug reaction of peginterferon, we aimed to develop a simple-to-use scoring system at early stage of treatment to predict low HBsAg level or HBsAg clearance at the end of treatment in virological suppression chronic hepatitis B (CHB) patients. Methods: Non-cirrhotic CHB patients with NA (nucleoside/nucleotide analogues)-induced virological suppression initiated either by add-on or switch-to peginterferon for ≥ 48 weeks were enrolled from January 2012 to June 2017 in these two tertiary centers. The retrospective experiment identified 320 suitable patients, including 192 in training and 128 in validation cohorts. Results: Using logistic regression, a simple-to-use scoring system integrating baseline HBsAg level <1000 IU/mL, HBsAg decline >0.5 log at week 12 and ALT flare at week 12 was developed in the training cohort and good for predicting HBsAg <100 IU/mL, HBsAg <10 IU/mL and HBsAg loss at the end of 48-week treatment. The area under receiver operating characteristics curve was 0.84, 0.86 or 0.78 in the training cohort and 0.88, 0.79 or 0.81 in the validation cohort, respectively. Conclusions: Our simple-to-use scoring system may guide for clinicians to decide whether to continue peginterferon in CHB patients to achieve low HBsAg levels or HBsAg clearance at the end of treatment, which might lead more cost-effective decision and get more patients to reach functional cures in Chinese population.
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; China ; DNA, Viral/blood ; Female ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/therapy ; Humans ; Interferon alpha-2/therapeutic use ; Male ; Polyethylene Glycols/therapeutic use ; Research Design ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Antiviral Agents ; DNA, Viral ; Hepatitis B Surface Antigens ; Interferon alpha-2 ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2021-08-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2021.105163
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Article ; Online: Photodissociation of particulate nitrate as a source of daytime tropospheric Cl

Peng, Xiang / Wang, Tao / Wang, Weihao / Ravishankara, A R / George, Christian / Xia, Men / Cai, Min / Li, Qinyi / Salvador, Christian Mark / Lau, Chiho / Lyu, Xiaopu / Poon, Chun Nan / Mellouki, Abdelwahid / Mu, Yujing / Hallquist, Mattias / Saiz-Lopez, Alfonso / Guo, Hai / Herrmann, Hartmut / Yu, Chuan /

Dai, Jianing / Wang, Yanan / Wang, Xinke / Yu, Alfred / Leung, Kenneth / Lee, Shuncheng / Chen, Jianmin

Nature communications

2022 Volume 13, Issue 1, Page(s) 939

Abstract: Chlorine atoms (Cl) are highly reactive and can strongly influence the abundances of climate and air quality-relevant trace gases. Despite extensive research on molecular chlorine ( ... ...

Abstract	Chlorine atoms (Cl) are highly reactive and can strongly influence the abundances of climate and air quality-relevant trace gases. Despite extensive research on molecular chlorine (Cl
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28383-9
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Article: Demand Analysis and Management Suggestion: Sharing Epidemiological Data Among Medical Institutions in Megacities for Epidemic Prevention and Control

Cai, Qinyi / Mi, Yiqun / Chu, Zhaowu / Zheng, Yuanyi / Chen, Fang / Liu, Yicheng

J. Shanghai Jiaotong Univ. Sci.

Abstract	During the prevention of coronavirus disease 2019 (COVID-19), epidemiological data is essential for controlling the source of infection, cutting off the route of transmission, and protecting vulnerable populations. Following Law of the People’s Republic of China on Prevention and Treatment of Infectious Diseases and other related regulations, medical institutions have been authorized to collect the detailed information of patients, while it is still a formidable task in megacities because of the significant patient mobility and the existing information sharing barrier. As a smart city which strengthens precise epidemic prevention and control, Shanghai has established a multi-department platform named “one-net management” on dynamic information monitoring. By sharing epidemiological data with medical institutions under a safe environment, we believe that the ability to prevent and control epidemics among medical institutions will be effectively and comprehensively improved.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #62641
Database	COVID19

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