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Article ; Online: Spatial Representation of Hippocampal Place Cells in a T-Maze with an Aversive Stimulation.

Okada, Sakura / Igata, Hideyoshi / Sasaki, Takuya / Ikegaya, Yuji

2017 Volume 11, Page(s) 101

Abstract: ... of place cell ensembles in the dorsal hippocampal CA1 region of rats performing a T-maze alternation task ...

Abstract	The hippocampus contains place cells representing spaces in an environment, and these place cells have been suggested to play a fundamental role in the formation of a cognitive map for spatial processing. However, how alterations in the firing patterns of place cells in response to aversive events encode the locations tied to these aversive events is unknown. Here, we analyzed spiking patterns of place cell ensembles in the dorsal hippocampal CA1 region of rats performing a T-maze alternation task with an aversive air-puff stimulation applied at a specific location on one side of a trajectory. The intensity of the air puff was adjusted so that the rats decreased their running speed before passing the aversive location. The addition of the aversive stimulus induced reorganization of place cell ensembles on both left and right trajectories with and without the aversive stimulus, respectively. Specifically, the animals showed a more abundant spatial representation in the vicinity of the aversive location. Removing the aversive stimulus induced new spatial firing patterns on both of the trajectories that differed from those both before and during application of the aversive stimulus. These results demonstrate that hippocampal spatial maps are flexibly reorganized to represent particular aversive events.
MeSH term(s)	Action Potentials ; Animals ; Avoidance Learning/physiology ; Electrodes, Implanted ; Hippocampus/physiology ; Male ; Maze Learning/physiology ; Neuronal Plasticity/physiology ; Physical Stimulation ; Place Cells/physiology ; Rats, Long-Evans ; Running/physiology ; Space Perception/physiology
Language	English
Publishing date	2017-12-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2452968-0
ISSN	1662-5110 ; 1662-5110
ISSN (online)	1662-5110
ISSN	1662-5110
DOI	10.3389/fncir.2017.00101
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Article ; Online: Awake hippocampal synchronous events are incorporated into offline neuronal reactivation.

Yagi, Saichiro / Igata, Hideyoshi / Ikegaya, Yuji / Sasaki, Takuya

Cell reports

2023 Volume 42, Issue 8, Page(s) 112871

Abstract: Learning novel experiences reorganizes hippocampal neuronal circuits, represented as coordinated reactivation patterns in post-experience offline states for memory consolidation. This study examines how awake synchronous events during a novel run are ... ...

Abstract	Learning novel experiences reorganizes hippocampal neuronal circuits, represented as coordinated reactivation patterns in post-experience offline states for memory consolidation. This study examines how awake synchronous events during a novel run are related to post-run reactivation patterns. The disruption of awake sharp-wave ripples inhibited experience-induced increases in the contributions of neurons to post-experience synchronous events. Hippocampal place cells that participate more in awake synchronous events are more strongly reactivated during post-experience synchronous events. Awake synchronous neuronal patterns, in cooperation with place-selective firing patterns, determine cell ensembles that undergo pronounced increases and decreases in their correlated spikes. Taken together, awake synchronous events are fundamental for identifying hippocampal neuronal ensembles to be incorporated into synchronous reactivation during subsequent offline states, thereby facilitating memory consolidation.
MeSH term(s)	Wakefulness/physiology ; Hippocampus/physiology ; Neurons/physiology ; Learning ; Place Cells/physiology
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112871
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Article: In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559.

Kusumoto, Keiji / Igata, Hideki / Abe, Akemi / Ikeda, Shota / Tsuboi, Ayako / Imamiya, Eikoh / Fukumoto, Shoji / Shiraishi, Mitsuru / Watanabe, Toshifumi

British journal of pharmacology

2002 Volume 135, Issue 8, Page(s) 1995–2003

Abstract: ... inhibitor, T-162559 ((5E,7S)-[7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H)-quinolinylideneamino ... reperfusion injury in rats and rabbits. 2. T-162559 inhibited human platelet NHE-1 in a concentration-dependent ... respectively. T-162559 also inhibited rat NHE-1 with an IC(50) value of 14+/-2 nmol l(-1), which was five and ...

Abstract	1. We investigated the inhibitory effects of a non-acylguanidine Na(+)-H(+) exchange (NHE) inhibitor, T-162559 ((5E,7S)-[7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H)-quinolinylideneamino] guanidine dimethanesulphonate), on NHE-1, and its cardioprotective effect against ischaemia and reperfusion injury in rats and rabbits. 2. T-162559 inhibited human platelet NHE-1 in a concentration-dependent manner, with an IC(50) value of 13+/-3 nmol l(-1), making it 16 and three times more potent than cariporide IC(50): 209+/-75 nmol l(-1), P<0.01) and eniporide (IC(50): 40+/-11 nmol l(-1), P=0.066), respectively. T-162559 also inhibited rat NHE-1 with an IC(50) value of 14+/-2 nmol l(-1), which was five and three times lower than that of cariporide (IC(50): 75+/-7 nmol l(-1), P<0.01) and eniporide (IC(50): 44+/-2 nmol l(-1), P<0.01), respectively. 3. T-162559 inhibited, in a concentration-dependent manner, the reduction in cardiac contractility, progression of cardiac contracture, and increase in lactate dehydrogenase release after global ischaemia and reperfusion in perfused rat hearts. The inhibitory effects of T-162559 were observed at a lower concentration range (10 - 100 nmol l(-1)) than with cariporide and eniporide. T-162559 did not alter basal cardiac contractility or coronary flow after reperfusion, suggesting that it exerts direct cardioprotective effects on the heart. 4. Intravenous administration of T-162559 (0.03 and 0.1 mg kg(-1)) significantly inhibited the progression of myocardial infarction induced by left coronary artery occlusion and reperfusion in rabbits; the infarct size normalized by area at risk was 74+/-6% in the vehicle group, and 47+/-5% and 51+/-7% in the T-162559-0.03 mg kg(-1) and T-162559-0.1 mg kg(-1) groups (both P<0.05), respectively. 5. These results indicate that the new structural NHE-1 inhibitor T-162559 is more potent than cariporide and eniporide and possesses a cardioprotective effect against ischaemia and reperfusion injury in rat and rabbit models.
MeSH term(s)	Animals ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/pharmacology ; Dose-Response Relationship, Drug ; Guanidines/administration & dosage ; Guanidines/chemistry ; Guanidines/pharmacology ; Humans ; In Vitro Techniques ; Injections, Intravenous ; Male ; Myocardial Infarction/pathology ; Myocardial Infarction/prevention & control ; Myocardial Ischemia/drug therapy ; Myocardial Reperfusion Injury/drug therapy ; Quinolines/administration & dosage ; Quinolines/chemistry ; Quinolines/pharmacology ; Rabbits ; Rats ; Rats, Wistar ; Sodium-Hydrogen Exchangers/antagonists & inhibitors ; Sulfones/pharmacology
Chemical Substances	(7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H)-quinolinylideneamino)guanidine ; Cardiotonic Agents ; Guanidines ; Quinolines ; Sodium-Hydrogen Exchangers ; Sulfones ; cariporide (7E3392891K) ; eniporide (7IGF9182QU)
Language	English
Publishing date	2002-04
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1038/sj.bjp.0704647
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Article ; Online: Rupture of Sinus of Valsalva Causing Fistula Between Left Coronary Sinus and Left Atrium.

Igata, Sachiyo / Hang, Calvin T / Lin, Andrew Y / Hsu, Jonathan / DeMaria, Anthony N

CASE (Philadelphia, Pa.)

2023 Volume 7, Issue 3, Page(s) 89–92

Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Case Reports
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2022.11.004
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Article ; Online: Low placental weight may be involved in the etiology of congenital cryptorchidism in neonatal boys.

Igata, Yuhei / Sakemi, Yoshihiro / Fujikawa, Ryota / Nakashima, Toshinori / Yamashita, Hironori / Sugino, Noriko / Shono, Takeshi

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 289, Page(s) 136–139

Abstract: Introduction: Several factors have been reported to be associated with the etiology of cryptorchidism; however, clear evidence regarding the risk factors for cryptorchidism is elusive. In the present study, we evaluated the clinical characteristics of ... ...

Abstract	Introduction: Several factors have been reported to be associated with the etiology of cryptorchidism; however, clear evidence regarding the risk factors for cryptorchidism is elusive. In the present study, we evaluated the clinical characteristics of cryptorchidism using the common neonatal intensive-care unit (NICU) database of the National Hospital Organization and explored one of possible factors associated with the development of cryptorchidism. Methods: A total of 7882 male neonates were included in this study. We separated them into two groups: those without cryptorchidism (n = 7852) and those with cryptorchidism (n = 30) at the time of discharge from the NICU. Cryptorchidism was defined as a condition in which the testis was located out of the scrotum on the route of descent at the time of NICU discharge. The associations between cryptorchidism and the maternal, placental, and neonatal information were analyzed. Analyses were performed statistically to compare nominal variables between the groups using Fisher's direct establishment calculation method and logistic regression analyses. Results: Univariate analyses showed the placental weight <10% tile (odds ratio 3.31, 95% confidence interval [CI] 1.18-8.64), birth height <-2 standard deviations (SD) (odds ratio 3.65, 95% CI 0.92-10.6), birth weight <-2SD (odds ratio 4.06, 95% CI 1.55-9.51), and small for gestational age (odds ratio 3.82, 95% CI 1.46-8.97) were significantly associated with the development of cryptorchidism. Multivariate analyses showed that placental weight <10th percentile (odds ratio 2.86, 95% CI 1.11-7.44) was significantly associated with the development of cryptorchidism. Discussion: Although, this study population was limited to infants admitted to the ICU, the data indicated a possible association between low placental weight and the development of cryptorchidism in neonatal boys.
MeSH term(s)	Pregnancy ; Infant ; Infant, Newborn ; Humans ; Female ; Male ; Cryptorchidism/epidemiology ; Cryptorchidism/etiology ; Placenta ; Causality ; Risk Factors
Language	English
Publishing date	2023-08-26
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.08.378
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Article: The Molecular Mechanism of Exercise for Treatment of Patients with Major Depression: A Preliminary Report on the Dynamics of Metabolites of Nitric Oxide and Catecholamines.

Ikenouchi, Atsuko / Okamoto, Naomichi / Igata, Ryohei / Natsuyama, Tomoya / Yoshimura, Reiji

Journal of integrative neuroscience

2022 Volume 21, Issue 4, Page(s) 123

Abstract: Background: There has been increasing evidence that exercise therapy is effective in the treatment and prevention of major depression (MD). However, the basic molecular mechanisms underlying the effects of exercise on MD remain unclear. We conducted a ... ...

Abstract	Background: There has been increasing evidence that exercise therapy is effective in the treatment and prevention of major depression (MD). However, the basic molecular mechanisms underlying the effects of exercise on MD remain unclear. We conducted a preliminary study to clarify the effect of exercise therapy on MD, focusing on the dynamics of nitric oxide (NO) and catecholamine metabolites, which have been found to be associated with MD. Methods: Eleven outpatients with mild to moderate MD and 37 healthy controls (HC) were included in the study. The participants' clinical records and questionnaires were screened for their past medical history. For their exercise therapy, the participants were instructed to walk the equivalent of 17.5 kcal/kg/week for 8 weeks. Blood samples were collected from all participants at baseline, 4 weeks, and 8 weeks after the start of exercise therapy, and plasma metabolites of NO (NOx), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were analyzed. We also assessed the 17-item Hamilton Rating Scale for Depression (HRSD-17) in patients with MD. A mixed-effects regression model was used to compare the mean values by time (baseline, 4, and 8 weeks) for the three corresponding groups (NOx, MHPG, and HVA). Results: HRSD-17 scores decreased significantly in the MD group after 8 weeks of exercise therapy. NOx and MHPG increased, but there was no significant change in HVA in the MD group after the exercise therapy. NOx decreased after exercise, and HVA increased significantly from baseline after 4 weeks of exercise but decreased after 8 weeks of exercise in the HC group. Conclusions: The effects of exercise on NOx, MHPG, and HVA may differ between MD and HC. The potential mechanisms for the benefits of walking exercise in MD patients will be the subject for future research.
MeSH term(s)	Catecholamines/therapeutic use ; Depression ; Depressive Disorder, Major/therapy ; Homovanillic Acid/metabolism ; Homovanillic Acid/therapeutic use ; Humans ; Methoxyhydroxyphenylglycol/metabolism ; Methoxyhydroxyphenylglycol/therapeutic use ; Nitric Oxide/therapeutic use
Chemical Substances	Catecholamines ; Nitric Oxide (31C4KY9ESH) ; Methoxyhydroxyphenylglycol (534-82-7) ; Homovanillic Acid (X77S6GMS36)
Language	English
Publishing date	2022-07-22
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2136427-8
ISSN	0219-6352
ISSN	0219-6352
DOI	10.31083/j.jin2104123
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Article ; Online: Role of Quantitation of Saline Bubble Studies in Patients with Liver Cirrhosis.

Igata, Sachiyo / Kono, Yuko / Van Houten, Thomas / Hang, Calvin T / Cotter, Bruno R / Strachan, Monet G / Morikawa, Nagisa / DeMaria, Anthony N

Ultrasound in medicine & biology

2023 Volume 49, Issue 8, Page(s) 1804–1810

Abstract: Objective: Microbubble contrast echocardiography with a late positive signal enables the detection of intrapulmonary vascular dilation, including hepatopulmonary syndrome, in patients with end-stage liver disease. We assessed the relationship between ... ...

Abstract	Objective: Microbubble contrast echocardiography with a late positive signal enables the detection of intrapulmonary vascular dilation, including hepatopulmonary syndrome, in patients with end-stage liver disease. We assessed the relationship between the severity of bubble study and clinical outcome. Methods: We retrospectively analyzed 163 consecutive patients with liver cirrhosis who underwent an echocardiogram with bubble study from 2018 to 2021. Patients who were diagnosed with a late positive signal were divided into three groups: grade 1 (1-9 bubbles), grade 2 (10-30 bubbles) and grade 3 (>30 bubbles). Results: Fifty-six percent of the patients had a late positive bubble study (grade 1: 31%, grade 2: 23%, grade 3: 46%). Patients with grade 3 had a significantly higher international normalized ratio, model for end-stage liver disease score and Child-Pugh score and a lower peripheral oxygen saturation compared with patients with a negative study. In patients undergoing liver transplant (LT), survival rates were similar among the groups (3-mo: >87%, 1-y: >87%, 2-y: >83%). However, survival rate was lower in grade 3 patients without LT (3-mo: 81%, 1-y: 64%, 2-y: 39%). Conclusion: Patients with grade 3 had much worse mortality without LT compared with other groups. However, after LT, all grades had equal survival. Therefore, patients with grade 3 may be considered as higher priority for LT.
MeSH term(s)	Humans ; End Stage Liver Disease ; Retrospective Studies ; Severity of Illness Index ; Liver Cirrhosis/diagnostic imaging ; Liver Transplantation
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2023.04.003
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Article ; Online: Prioritized experience replays on a hippocampal predictive map for learning.

Igata, Hideyoshi / Ikegaya, Yuji / Sasaki, Takuya

Proceedings of the National Academy of Sciences of the United States of America

2020 Volume 118, Issue 1

Abstract: Hippocampal cells are central to spatial and predictive representations, and experience replays by place cells are crucial for learning and memory. Nonetheless, how hippocampal replay patterns dynamically change during the learning process remains to be ... ...

Abstract	Hippocampal cells are central to spatial and predictive representations, and experience replays by place cells are crucial for learning and memory. Nonetheless, how hippocampal replay patterns dynamically change during the learning process remains to be elucidated. Here, we designed a spatial task in which rats learned a new behavioral trajectory for reward. We found that as rats updated their behavioral strategies for a novel salient location, hippocampal cell ensembles increased theta-sequences and sharp wave ripple-associated synchronous spikes that preferentially replayed salient locations and reward-related contexts in reverse order. The directionality and contents of the replays progressively varied with learning, including an optimized path that had never been exploited by the animals, suggesting prioritized replays of significant experiences on a predictive map. Online feedback blockade of sharp wave ripples during a learning process inhibited stabilizing optimized behavior. These results implicate learning-associated experience replays that act to learn and reinforce specific behavioral strategies.
MeSH term(s)	Animals ; Brain/metabolism ; Brain/physiology ; Hippocampus/metabolism ; Hippocampus/physiology ; Learning/physiology ; Male ; Memory/physiology ; Neurons/physiology ; Place Cells/metabolism ; Rats ; Rats, Long-Evans ; Reinforcement, Psychology ; Reward ; Spatial Learning/physiology
Language	English
Publishing date	2020-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2011266118
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Zs.A 1148: Show issues

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Article ; Online: Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation.

Igata, Tomoka / Tanaka, Hiroshi / Etoh, Kan / Hong, Seonghyeon / Tani, Naoki / Koga, Tomoaki / Nakao, Mitsuyoshi

PloS one

2022 Volume 17, Issue 1, Page(s) e0262488

Abstract: Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SETD8 ... ...

Abstract	Cellular senescence is accompanied by metabolic and epigenomic remodeling, but the transcriptional mechanism of this process is unclear. Our previous RNA interference-based screen of chromatin factors found that lysine methyltransferases including SETD8 and NSD2 inhibited the senescence program in cultured fibroblasts. Here, we report that loss of the zinc finger and homeobox protein 3 (ZHX3), a ubiquitously expressed transcription repressor, induced senescence-associated gene expression and mitochondrial-nucleolar activation. Chromatin immunoprecipitation-sequencing analyses of growing cells revealed that ZHX3 was enriched at the transcription start sites of senescence-associated genes such as the cyclin-dependent kinase inhibitor (ARF-p16INK4a) gene and ribosomal RNA (rRNA) coding genes. ZHX3 expression was consistently downregulated in cells with replicative or oncogene-induced senescence. Mass spectrometry-based proteomics identified 28 proteins that interacted with ZHX3, including ATP citrate lyase and RNA metabolism proteins. Loss of ZHX3 or ZHX3-interaction partners by knockdown similarly induced the expression of p16INK4a and rRNA genes. Zhx3-knockout mice showed upregulation of p16INK4a in the testes, thymus and skeletal muscle tissues, together with relatively short survival periods in males. These data suggested that ZHX3 plays an essential role in transcriptional control to prevent cellular senescence.
MeSH term(s)	Animals ; Cell Nucleolus/genetics ; Cell Proliferation/genetics ; Cellular Senescence/genetics ; Chromatin/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; DNA Replication/genetics ; Down-Regulation/genetics ; Epigenomics/methods ; Female ; Fibroblasts/physiology ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Homeodomain Proteins/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/genetics ; RNA, Ribosomal/genetics ; Repressor Proteins/genetics ; Transcription Initiation Site/physiology ; Up-Regulation/genetics
Chemical Substances	Chromatin ; Cyclin-Dependent Kinase Inhibitor p16 ; Homeodomain Proteins ; RNA, Ribosomal ; Repressor Proteins ; ZHX3 protein, human
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0262488
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Article: Increased Stimulation Intensity Helped to Cope with Prolonged Seizures During the Next Round of Modified Electroconvulsive Therapy: A Case Report.

Katsumura, Tetsuya / Okamoto, Naomichi / Tesen, Hirofumi / Igata, Ryohei / Ikenouchi, Atsuko / Yoshimura, Reiji

International medical case reports journal

2022 Volume 15, Page(s) 385–387

Abstract: Background: Numerous protocols exist to counteract prolonged seizures during modified electroconvulsive therapy (mECT), such as anaesthetic adjustments and ventilation. Evidence on methods for deciding whether to continue with the next round of mECT ... ...

Abstract	Background: Numerous protocols exist to counteract prolonged seizures during modified electroconvulsive therapy (mECT), such as anaesthetic adjustments and ventilation. Evidence on methods for deciding whether to continue with the next round of mECT after a prolonged seizure and to prevent recurrent seizures is currently not well established. Case presentation: The patient was a 76-year-old woman with major depressive disorder. She suffered from depressive symptoms such as decreased appetite, anxiety, and agitation. She was admitted to our hospital for mECT for the fifth time. The mECT was bilateral and started at 35% stimulus intensity, and effective convulsions were obtained for the first time. During the 8th mECT at the same intensity (35% stimulus intensity), an unexpected prolonged seizure of 966 s (over 16 minutes) occurred. The seizure was abruptly stopped with diazepam 10 mg and midazolam 2 mg. During the ninth mECT session, the stimulation intensity was increased to 50%, which resulted in effective seizures and no prolonged seizures. Subsequently, appropriate convulsions were obtained with the same stimulation intensity, and she completed 12 sessions. Her depressive symptoms improved, and she was discharged on the 45th day of hospitalization. Conclusion: Prolonged seizures in mECT can be prevented by raising the stimulation intensity during the following cycle.
Language	English
Publishing date	2022-07-22
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495077-4
ISSN	1179-142X
ISSN	1179-142X
DOI	10.2147/IMCRJ.S374983
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